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Q9P2H0

- K1377_HUMAN

UniProt

Q9P2H0 - K1377_HUMAN

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Protein

Uncharacterized protein KIAA1377

Gene
KIAA1377
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May participate in cytokinesis.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1377
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29264. KIAA1377.

Subcellular locationi

Midbody 1 Publication

GO - Cellular componenti

  1. midbody Source: UniProtKB-SubCell
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

Orphaneti65684. Monomelic amyotrophy.
PharmGKBiPA143485517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11171117Uncharacterized protein KIAA1377PRO_0000248831Add
BLAST

Proteomic databases

PaxDbiQ9P2H0.
PRIDEiQ9P2H0.

PTM databases

PhosphoSiteiQ9P2H0.

Expressioni

Tissue specificityi

Expressed in brain, lung, skeletal muscle, kidney, pancreas, testis and ovary.1 Publication

Gene expression databases

ArrayExpressiQ9P2H0.
BgeeiQ9P2H0.
CleanExiHS_KIAA1377.
GenevestigatoriQ9P2H0.

Organism-specific databases

HPAiHPA038381.
HPA038399.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BARD1Q997282EBI-473176,EBI-473181
FEZ1Q996892EBI-473176,EBI-396435
GADD45GO952572EBI-473176,EBI-448202
GIT1Q9Y2X72EBI-473176,EBI-466061
HTTP428582EBI-473176,EBI-466029
KAT5Q929932EBI-473176,EBI-399080
KAT7O952512EBI-473176,EBI-473199

Protein-protein interaction databases

BioGridi121617. 77 interactions.
IntActiQ9P2H0. 92 interactions.
MINTiMINT-1425828.
STRINGi9606.ENSP00000263468.

Structurei

3D structure databases

ProteinModelPortaliQ9P2H0.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili49 – 12173 Reviewed predictionAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG84728.
HOGENOMiHOG000113165.
HOVERGENiHBG081836.
InParanoidiQ9P2H0.
OMAiSERLHYI.
OrthoDBiEOG7JHM4Q.
PhylomeDBiQ9P2H0.
TreeFamiTF336632.

Family and domain databases

InterProiIPR028257. KIAA1377.
[Graphical view]
PfamiPF15352. K1377. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2H0-1 [UniParc]FASTAAdd to Basket

« Hide

MLAGRPGTRS AVGELGTESS DNLDRAPLGP RESGGHHRPG SYLDMKIHLE     50
KNLEEERQIL LQQQKICRNR ARKYFVESNR RKKAFEEKRK EQEEKEHQIR 100
EQILQQRKQK FEEVTEKFQR AHVPLSQRRK AVSRKPVPPL EEALKQIQES 150
NLKSEVNLPF SRRPTINWRA IDSALPSALS KNDHKHQKQL LSKINCEKEM 200
NENMRATLAT SKNVFQLKLE ETQKLLEDQH LSNLQKFGDE VNQITNSETL 250
SSIDSLEATE HEEIYLTLNK EHSTSIQRNT ISLKPANMQS TNLSCFDEDK 300
LAFSKTQHIN NWLTNLDASN TQNVTAFSDI LSKSNVLPSW EYFNSKEQNP 350
SPLNGTVERA TNTANNSVPF VSSPPMFVLD KKCEKTSETS TMRTTDSTSG 400
AFKRERPLVT ESPTFKFSKS QSTSDSLTQE VATFPDQEKY SELNQENGTT 450
SIPTSCVPVA TPLVLPSNIQ SARPSAKNSI HIKEIDAVQC SDKLDELKDG 500
KEEEIKYFNC NKEELPLFSD SFQDAYIPHN PDSKDEKQKL AETSSLSNVT 550
SNYDFVGQHK KMKYNIHERN GVRFLKSILK KESKYEHGYL KALIINQSFK 600
FGNQKAAAIR DSIELTKEKG AEIPKTIKKL RWFDETSNIE NNAENSHSLK 650
NKTGTTQQHS QQFHIQSGAG SNIISVSTCA VNSADTKKSR EDSISENVTT 700
LGGSGADHMP LNCFIPSGYN FAKHAWPASK KEESKIPVHD DSKTKQGKPQ 750
RGRAKIIRKP GSAKVQSGFI CTNRKGAVIQ PQSASKVNIF TQAQGKLIIP 800
CPPPQSTSNI RSGKNIQVSQ CQPVTPENPQ NIITHNSFNS KHVLPTEHSL 850
NQWNQESSSP LSNACSDLVT VIPSLPSYCS SECQTFAKIN HSNGTQAVAR 900
QDATLYCTQR SPVCEESYPS VTLRTAEEES VPLWKRGPNV LHQNKRATGS 950
TVMRRKRIAE TKRRNILEQK RQNPGSVGQK YSEQINNFGQ SVLLSSSEPK 1000
QTTRGTSYIE EVSDSTSEFL MAENLVKASV PEDEILTVLN SKQIQKSNLP 1050
LNKTQQFNIC TLSAEEQKIL ESLNDLSERL HYIQESICKN PSIKNTLQII 1100
PLLEKREDRT SSCRDKR 1117
Length:1,117
Mass (Da):125,870
Last modified:May 18, 2010 - v3
Checksum:iEF181D0177691D00
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti178 – 1781A → T.
Corresponds to variant rs11225086 [ dbSNP | Ensembl ].
VAR_027363
Natural varianti238 – 2381G → C.2 Publications
Corresponds to variant rs7926728 [ dbSNP | Ensembl ].
VAR_027364
Natural varianti275 – 2751S → Y.
Corresponds to variant rs11225089 [ dbSNP | Ensembl ].
VAR_027365
Natural varianti281 – 2811I → T.
Corresponds to variant rs11225090 [ dbSNP | Ensembl ].
VAR_027366
Natural varianti302 – 3021A → T.
Corresponds to variant rs11225091 [ dbSNP | Ensembl ].
VAR_027367
Natural varianti668 – 6681G → S May be associated with susceptibility to monomelic amyotrophy. 1 Publication
Corresponds to variant rs76022391 [ dbSNP | Ensembl ].
VAR_068173
Natural varianti710 – 7101P → S.
Corresponds to variant rs7109614 [ dbSNP | Ensembl ].
VAR_027368
Natural varianti1021 – 10211M → T.
Corresponds to variant rs7111429 [ dbSNP | Ensembl ].
VAR_027369
Natural varianti1077 – 10771S → N.2 Publications
Corresponds to variant rs6590942 [ dbSNP | Ensembl ].
VAR_027370

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003383 Genomic DNA. No translation available.
AB037798 mRNA. Translation: BAA92615.1.
CCDSiCCDS31658.1.
RefSeqiNP_065853.3. NM_020802.3.
UniGeneiHs.156352.

Genome annotation databases

EnsembliENST00000263468; ENSP00000263468; ENSG00000110318.
GeneIDi57562.
KEGGihsa:57562.
UCSCiuc001pgm.3. human.

Polymorphism databases

DMDMi296439319.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003383 Genomic DNA. No translation available.
AB037798 mRNA. Translation: BAA92615.1 .
CCDSi CCDS31658.1.
RefSeqi NP_065853.3. NM_020802.3.
UniGenei Hs.156352.

3D structure databases

ProteinModelPortali Q9P2H0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121617. 77 interactions.
IntActi Q9P2H0. 92 interactions.
MINTi MINT-1425828.
STRINGi 9606.ENSP00000263468.

PTM databases

PhosphoSitei Q9P2H0.

Polymorphism databases

DMDMi 296439319.

Proteomic databases

PaxDbi Q9P2H0.
PRIDEi Q9P2H0.

Protocols and materials databases

DNASUi 57562.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263468 ; ENSP00000263468 ; ENSG00000110318 .
GeneIDi 57562.
KEGGi hsa:57562.
UCSCi uc001pgm.3. human.

Organism-specific databases

CTDi 57562.
GeneCardsi GC11P101819.
HGNCi HGNC:29264. KIAA1377.
HPAi HPA038381.
HPA038399.
MIMi 614634. gene.
neXtProti NX_Q9P2H0.
Orphaneti 65684. Monomelic amyotrophy.
PharmGKBi PA143485517.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84728.
HOGENOMi HOG000113165.
HOVERGENi HBG081836.
InParanoidi Q9P2H0.
OMAi SERLHYI.
OrthoDBi EOG7JHM4Q.
PhylomeDBi Q9P2H0.
TreeFami TF336632.

Miscellaneous databases

GeneWikii KIAA1377.
GenomeRNAii 57562.
NextBioi 64066.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9P2H0.
Bgeei Q9P2H0.
CleanExi HS_KIAA1377.
Genevestigatori Q9P2H0.

Family and domain databases

InterProi IPR028257. KIAA1377.
[Graphical view ]
Pfami PF15352. K1377. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-238 AND ASN-1077.
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-1117, TISSUE SPECIFICITY, VARIANTS CYS-238 AND ASN-1077.
    Tissue: Brain.
  3. "From midbody protein-protein interaction network construction to novel regulators in cytokinesis."
    Chen T.C., Lee S.A., Hong T.M., Shih J.Y., Lai J.M., Chiou H.Y., Yang S.C., Chan C.H., Kao C.Y., Yang P.C., Huang C.Y.
    J. Proteome Res. 8:4943-4953(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Exome sequencing identifies KIAA1377 and C5orf42 as susceptibility genes for monomelic amyotrophy."
    Lim Y.M., Koh I., Park Y.M., Kim J.J., Kim D.S., Kim H.J., Baik K.H., Choi H.Y., Yang G.S., Also-Rallo E., Tizzano E.F., Gamez J., Park K., Yoo H.W., Lee J.K., Kim K.K.
    Neuromuscul. Disord. 22:394-400(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-668.

Entry informationi

Entry nameiK1377_HUMAN
AccessioniPrimary (citable) accession number: Q9P2H0
Secondary accession number(s): Q4G0U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of KIAA1377 by siRNA results in an increase in cytokinesis aberrant cells (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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