Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centrosomal protein of 126 kDa

Gene

CEP126

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236).2 Publications

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • cytoplasmic microtubule organization Source: UniProtKB
  • mitotic spindle organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110318-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 126 kDa1 PublicationImported
Gene namesi
Name:CEP1261 PublicationImported
Synonyms:KIAA1377
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29264. CEP126.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • ciliary base Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • midbody Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi57562.
Orphaneti65684. Monomelic amyotrophy.
PharmGKBiPA143485517.

Polymorphism and mutation databases

BioMutaiKIAA1377.
DMDMi296439319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488311 – 1117Centrosomal protein of 126 kDaAdd BLAST1117

Proteomic databases

PaxDbiQ9P2H0.
PeptideAtlasiQ9P2H0.
PRIDEiQ9P2H0.

PTM databases

iPTMnetiQ9P2H0.
PhosphoSitePlusiQ9P2H0.

Expressioni

Tissue specificityi

Expressed in brain, lung, skeletal muscle, kidney, pancreas, testis and ovary.1 Publication

Gene expression databases

BgeeiENSG00000110318.
CleanExiHS_KIAA1377.
ExpressionAtlasiQ9P2H0. baseline and differential.
GenevisibleiQ9P2H0. HS.

Organism-specific databases

HPAiHPA038381.
HPA038399.

Interactioni

Subunit structurei

Interacts with DCTN1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BARD1Q997282EBI-473176,EBI-473181
FEZ1Q996892EBI-473176,EBI-396435
GADD45GO952572EBI-473176,EBI-448202
GIT1Q9Y2X72EBI-473176,EBI-466061
HTTP428582EBI-473176,EBI-466029
KAT5Q929932EBI-473176,EBI-399080
KAT7O952512EBI-473176,EBI-473199

Protein-protein interaction databases

BioGridi121617. 78 interactors.
IntActiQ9P2H0. 94 interactors.
MINTiMINT-1425828.
STRINGi9606.ENSP00000263468.

Structurei

3D structure databases

ProteinModelPortaliQ9P2H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 121Sequence analysisAdd BLAST73

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFM4. Eukaryota.
ENOG4111KUI. LUCA.
HOGENOMiHOG000113165.
HOVERGENiHBG081836.
InParanoidiQ9P2H0.
OrthoDBiEOG091G0215.
PhylomeDBiQ9P2H0.
TreeFamiTF336632.

Family and domain databases

InterProiIPR028257. CEP126.
[Graphical view]
PfamiPF15352. K1377. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAGRPGTRS AVGELGTESS DNLDRAPLGP RESGGHHRPG SYLDMKIHLE
60 70 80 90 100
KNLEEERQIL LQQQKICRNR ARKYFVESNR RKKAFEEKRK EQEEKEHQIR
110 120 130 140 150
EQILQQRKQK FEEVTEKFQR AHVPLSQRRK AVSRKPVPPL EEALKQIQES
160 170 180 190 200
NLKSEVNLPF SRRPTINWRA IDSALPSALS KNDHKHQKQL LSKINCEKEM
210 220 230 240 250
NENMRATLAT SKNVFQLKLE ETQKLLEDQH LSNLQKFGDE VNQITNSETL
260 270 280 290 300
SSIDSLEATE HEEIYLTLNK EHSTSIQRNT ISLKPANMQS TNLSCFDEDK
310 320 330 340 350
LAFSKTQHIN NWLTNLDASN TQNVTAFSDI LSKSNVLPSW EYFNSKEQNP
360 370 380 390 400
SPLNGTVERA TNTANNSVPF VSSPPMFVLD KKCEKTSETS TMRTTDSTSG
410 420 430 440 450
AFKRERPLVT ESPTFKFSKS QSTSDSLTQE VATFPDQEKY SELNQENGTT
460 470 480 490 500
SIPTSCVPVA TPLVLPSNIQ SARPSAKNSI HIKEIDAVQC SDKLDELKDG
510 520 530 540 550
KEEEIKYFNC NKEELPLFSD SFQDAYIPHN PDSKDEKQKL AETSSLSNVT
560 570 580 590 600
SNYDFVGQHK KMKYNIHERN GVRFLKSILK KESKYEHGYL KALIINQSFK
610 620 630 640 650
FGNQKAAAIR DSIELTKEKG AEIPKTIKKL RWFDETSNIE NNAENSHSLK
660 670 680 690 700
NKTGTTQQHS QQFHIQSGAG SNIISVSTCA VNSADTKKSR EDSISENVTT
710 720 730 740 750
LGGSGADHMP LNCFIPSGYN FAKHAWPASK KEESKIPVHD DSKTKQGKPQ
760 770 780 790 800
RGRAKIIRKP GSAKVQSGFI CTNRKGAVIQ PQSASKVNIF TQAQGKLIIP
810 820 830 840 850
CPPPQSTSNI RSGKNIQVSQ CQPVTPENPQ NIITHNSFNS KHVLPTEHSL
860 870 880 890 900
NQWNQESSSP LSNACSDLVT VIPSLPSYCS SECQTFAKIN HSNGTQAVAR
910 920 930 940 950
QDATLYCTQR SPVCEESYPS VTLRTAEEES VPLWKRGPNV LHQNKRATGS
960 970 980 990 1000
TVMRRKRIAE TKRRNILEQK RQNPGSVGQK YSEQINNFGQ SVLLSSSEPK
1010 1020 1030 1040 1050
QTTRGTSYIE EVSDSTSEFL MAENLVKASV PEDEILTVLN SKQIQKSNLP
1060 1070 1080 1090 1100
LNKTQQFNIC TLSAEEQKIL ESLNDLSERL HYIQESICKN PSIKNTLQII
1110
PLLEKREDRT SSCRDKR
Length:1,117
Mass (Da):125,870
Last modified:May 18, 2010 - v3
Checksum:iEF181D0177691D00
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027363178A → T.Corresponds to variant rs11225086dbSNPEnsembl.1
Natural variantiVAR_027364238G → C.2 PublicationsCorresponds to variant rs7926728dbSNPEnsembl.1
Natural variantiVAR_027365275S → Y.Corresponds to variant rs11225089dbSNPEnsembl.1
Natural variantiVAR_027366281I → T.Corresponds to variant rs11225090dbSNPEnsembl.1
Natural variantiVAR_027367302A → T.Corresponds to variant rs11225091dbSNPEnsembl.1
Natural variantiVAR_068173668G → S May be associated with susceptibility to monomelic amyotrophy. 1 PublicationCorresponds to variant rs76022391dbSNPEnsembl.1
Natural variantiVAR_027368710P → S.Corresponds to variant rs7109614dbSNPEnsembl.1
Natural variantiVAR_0273691021M → T.Corresponds to variant rs7111429dbSNPEnsembl.1
Natural variantiVAR_0273701077S → N.2 PublicationsCorresponds to variant rs6590942dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003383 Genomic DNA. No translation available.
AB037798 mRNA. Translation: BAA92615.1.
CCDSiCCDS31658.1.
RefSeqiNP_065853.3. NM_020802.3.
UniGeneiHs.156352.

Genome annotation databases

EnsembliENST00000263468; ENSP00000263468; ENSG00000110318.
GeneIDi57562.
KEGGihsa:57562.
UCSCiuc001pgm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003383 Genomic DNA. No translation available.
AB037798 mRNA. Translation: BAA92615.1.
CCDSiCCDS31658.1.
RefSeqiNP_065853.3. NM_020802.3.
UniGeneiHs.156352.

3D structure databases

ProteinModelPortaliQ9P2H0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121617. 78 interactors.
IntActiQ9P2H0. 94 interactors.
MINTiMINT-1425828.
STRINGi9606.ENSP00000263468.

PTM databases

iPTMnetiQ9P2H0.
PhosphoSitePlusiQ9P2H0.

Polymorphism and mutation databases

BioMutaiKIAA1377.
DMDMi296439319.

Proteomic databases

PaxDbiQ9P2H0.
PeptideAtlasiQ9P2H0.
PRIDEiQ9P2H0.

Protocols and materials databases

DNASUi57562.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263468; ENSP00000263468; ENSG00000110318.
GeneIDi57562.
KEGGihsa:57562.
UCSCiuc001pgm.4. human.

Organism-specific databases

CTDi57562.
DisGeNETi57562.
GeneCardsiCEP126.
HGNCiHGNC:29264. CEP126.
HPAiHPA038381.
HPA038399.
MIMi614634. gene.
neXtProtiNX_Q9P2H0.
Orphaneti65684. Monomelic amyotrophy.
PharmGKBiPA143485517.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFM4. Eukaryota.
ENOG4111KUI. LUCA.
HOGENOMiHOG000113165.
HOVERGENiHBG081836.
InParanoidiQ9P2H0.
OrthoDBiEOG091G0215.
PhylomeDBiQ9P2H0.
TreeFamiTF336632.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110318-MONOMER.

Miscellaneous databases

ChiTaRSiKIAA1377. human.
GeneWikiiKIAA1377.
GenomeRNAii57562.
PROiQ9P2H0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110318.
CleanExiHS_KIAA1377.
ExpressionAtlasiQ9P2H0. baseline and differential.
GenevisibleiQ9P2H0. HS.

Family and domain databases

InterProiIPR028257. CEP126.
[Graphical view]
PfamiPF15352. K1377. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCE126_HUMAN
AccessioniPrimary (citable) accession number: Q9P2H0
Secondary accession number(s): Q4G0U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of CEP126 by siRNA results in an increase in cytokinesis aberrant cells.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.