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Q9P2H0

- K1377_HUMAN

UniProt

Q9P2H0 - K1377_HUMAN

Protein

Uncharacterized protein KIAA1377

Gene

KIAA1377

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May participate in cytokinesis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein KIAA1377
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29264. KIAA1377.

    Subcellular locationi

    Midbody 1 Publication

    GO - Cellular componenti

    1. midbody Source: UniProtKB-SubCell

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti65684. Monomelic amyotrophy.
    PharmGKBiPA143485517.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11171117Uncharacterized protein KIAA1377PRO_0000248831Add
    BLAST

    Proteomic databases

    PaxDbiQ9P2H0.
    PRIDEiQ9P2H0.

    PTM databases

    PhosphoSiteiQ9P2H0.

    Expressioni

    Tissue specificityi

    Expressed in brain, lung, skeletal muscle, kidney, pancreas, testis and ovary.1 Publication

    Gene expression databases

    ArrayExpressiQ9P2H0.
    BgeeiQ9P2H0.
    CleanExiHS_KIAA1377.
    GenevestigatoriQ9P2H0.

    Organism-specific databases

    HPAiHPA038381.
    HPA038399.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BARD1Q997282EBI-473176,EBI-473181
    FEZ1Q996892EBI-473176,EBI-396435
    GADD45GO952572EBI-473176,EBI-448202
    GIT1Q9Y2X72EBI-473176,EBI-466061
    HTTP428582EBI-473176,EBI-466029
    KAT5Q929932EBI-473176,EBI-399080
    KAT7O952512EBI-473176,EBI-473199

    Protein-protein interaction databases

    BioGridi121617. 77 interactions.
    IntActiQ9P2H0. 92 interactions.
    MINTiMINT-1425828.
    STRINGi9606.ENSP00000263468.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2H0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili49 – 12173Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG84728.
    HOGENOMiHOG000113165.
    HOVERGENiHBG081836.
    InParanoidiQ9P2H0.
    OMAiSERLHYI.
    OrthoDBiEOG7JHM4Q.
    PhylomeDBiQ9P2H0.
    TreeFamiTF336632.

    Family and domain databases

    InterProiIPR028257. KIAA1377.
    [Graphical view]
    PfamiPF15352. K1377. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P2H0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAGRPGTRS AVGELGTESS DNLDRAPLGP RESGGHHRPG SYLDMKIHLE     50
    KNLEEERQIL LQQQKICRNR ARKYFVESNR RKKAFEEKRK EQEEKEHQIR 100
    EQILQQRKQK FEEVTEKFQR AHVPLSQRRK AVSRKPVPPL EEALKQIQES 150
    NLKSEVNLPF SRRPTINWRA IDSALPSALS KNDHKHQKQL LSKINCEKEM 200
    NENMRATLAT SKNVFQLKLE ETQKLLEDQH LSNLQKFGDE VNQITNSETL 250
    SSIDSLEATE HEEIYLTLNK EHSTSIQRNT ISLKPANMQS TNLSCFDEDK 300
    LAFSKTQHIN NWLTNLDASN TQNVTAFSDI LSKSNVLPSW EYFNSKEQNP 350
    SPLNGTVERA TNTANNSVPF VSSPPMFVLD KKCEKTSETS TMRTTDSTSG 400
    AFKRERPLVT ESPTFKFSKS QSTSDSLTQE VATFPDQEKY SELNQENGTT 450
    SIPTSCVPVA TPLVLPSNIQ SARPSAKNSI HIKEIDAVQC SDKLDELKDG 500
    KEEEIKYFNC NKEELPLFSD SFQDAYIPHN PDSKDEKQKL AETSSLSNVT 550
    SNYDFVGQHK KMKYNIHERN GVRFLKSILK KESKYEHGYL KALIINQSFK 600
    FGNQKAAAIR DSIELTKEKG AEIPKTIKKL RWFDETSNIE NNAENSHSLK 650
    NKTGTTQQHS QQFHIQSGAG SNIISVSTCA VNSADTKKSR EDSISENVTT 700
    LGGSGADHMP LNCFIPSGYN FAKHAWPASK KEESKIPVHD DSKTKQGKPQ 750
    RGRAKIIRKP GSAKVQSGFI CTNRKGAVIQ PQSASKVNIF TQAQGKLIIP 800
    CPPPQSTSNI RSGKNIQVSQ CQPVTPENPQ NIITHNSFNS KHVLPTEHSL 850
    NQWNQESSSP LSNACSDLVT VIPSLPSYCS SECQTFAKIN HSNGTQAVAR 900
    QDATLYCTQR SPVCEESYPS VTLRTAEEES VPLWKRGPNV LHQNKRATGS 950
    TVMRRKRIAE TKRRNILEQK RQNPGSVGQK YSEQINNFGQ SVLLSSSEPK 1000
    QTTRGTSYIE EVSDSTSEFL MAENLVKASV PEDEILTVLN SKQIQKSNLP 1050
    LNKTQQFNIC TLSAEEQKIL ESLNDLSERL HYIQESICKN PSIKNTLQII 1100
    PLLEKREDRT SSCRDKR 1117
    Length:1,117
    Mass (Da):125,870
    Last modified:May 18, 2010 - v3
    Checksum:iEF181D0177691D00
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti178 – 1781A → T.
    Corresponds to variant rs11225086 [ dbSNP | Ensembl ].
    VAR_027363
    Natural varianti238 – 2381G → C.2 Publications
    Corresponds to variant rs7926728 [ dbSNP | Ensembl ].
    VAR_027364
    Natural varianti275 – 2751S → Y.
    Corresponds to variant rs11225089 [ dbSNP | Ensembl ].
    VAR_027365
    Natural varianti281 – 2811I → T.
    Corresponds to variant rs11225090 [ dbSNP | Ensembl ].
    VAR_027366
    Natural varianti302 – 3021A → T.
    Corresponds to variant rs11225091 [ dbSNP | Ensembl ].
    VAR_027367
    Natural varianti668 – 6681G → S May be associated with susceptibility to monomelic amyotrophy. 1 Publication
    Corresponds to variant rs76022391 [ dbSNP | Ensembl ].
    VAR_068173
    Natural varianti710 – 7101P → S.
    Corresponds to variant rs7109614 [ dbSNP | Ensembl ].
    VAR_027368
    Natural varianti1021 – 10211M → T.
    Corresponds to variant rs7111429 [ dbSNP | Ensembl ].
    VAR_027369
    Natural varianti1077 – 10771S → N.2 Publications
    Corresponds to variant rs6590942 [ dbSNP | Ensembl ].
    VAR_027370

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003383 Genomic DNA. No translation available.
    AB037798 mRNA. Translation: BAA92615.1.
    CCDSiCCDS31658.1.
    RefSeqiNP_065853.3. NM_020802.3.
    UniGeneiHs.156352.

    Genome annotation databases

    EnsembliENST00000263468; ENSP00000263468; ENSG00000110318.
    GeneIDi57562.
    KEGGihsa:57562.
    UCSCiuc001pgm.3. human.

    Polymorphism databases

    DMDMi296439319.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003383 Genomic DNA. No translation available.
    AB037798 mRNA. Translation: BAA92615.1 .
    CCDSi CCDS31658.1.
    RefSeqi NP_065853.3. NM_020802.3.
    UniGenei Hs.156352.

    3D structure databases

    ProteinModelPortali Q9P2H0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121617. 77 interactions.
    IntActi Q9P2H0. 92 interactions.
    MINTi MINT-1425828.
    STRINGi 9606.ENSP00000263468.

    PTM databases

    PhosphoSitei Q9P2H0.

    Polymorphism databases

    DMDMi 296439319.

    Proteomic databases

    PaxDbi Q9P2H0.
    PRIDEi Q9P2H0.

    Protocols and materials databases

    DNASUi 57562.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263468 ; ENSP00000263468 ; ENSG00000110318 .
    GeneIDi 57562.
    KEGGi hsa:57562.
    UCSCi uc001pgm.3. human.

    Organism-specific databases

    GeneCardsi GC11P101819.
    HGNCi HGNC:29264. KIAA1377.
    HPAi HPA038381.
    HPA038399.
    MIMi 614634. gene.
    neXtProti NX_Q9P2H0.
    Orphaneti 65684. Monomelic amyotrophy.
    PharmGKBi PA143485517.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84728.
    HOGENOMi HOG000113165.
    HOVERGENi HBG081836.
    InParanoidi Q9P2H0.
    OMAi SERLHYI.
    OrthoDBi EOG7JHM4Q.
    PhylomeDBi Q9P2H0.
    TreeFami TF336632.

    Miscellaneous databases

    GeneWikii KIAA1377.
    GenomeRNAii 57562.
    NextBioi 64066.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2H0.
    Bgeei Q9P2H0.
    CleanExi HS_KIAA1377.
    Genevestigatori Q9P2H0.

    Family and domain databases

    InterProi IPR028257. KIAA1377.
    [Graphical view ]
    Pfami PF15352. K1377. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-238 AND ASN-1077.
    2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-1117, TISSUE SPECIFICITY, VARIANTS CYS-238 AND ASN-1077.
      Tissue: Brain.
    3. "From midbody protein-protein interaction network construction to novel regulators in cytokinesis."
      Chen T.C., Lee S.A., Hong T.M., Shih J.Y., Lai J.M., Chiou H.Y., Yang S.C., Chan C.H., Kao C.Y., Yang P.C., Huang C.Y.
      J. Proteome Res. 8:4943-4953(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "Exome sequencing identifies KIAA1377 and C5orf42 as susceptibility genes for monomelic amyotrophy."
      Lim Y.M., Koh I., Park Y.M., Kim J.J., Kim D.S., Kim H.J., Baik K.H., Choi H.Y., Yang G.S., Also-Rallo E., Tizzano E.F., Gamez J., Park K., Yoo H.W., Lee J.K., Kim K.K.
      Neuromuscul. Disord. 22:394-400(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-668.

    Entry informationi

    Entry nameiK1377_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2H0
    Secondary accession number(s): Q4G0U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Depletion of KIAA1377 by siRNA results in an increase in cytokinesis aberrant cells.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3