Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and IBR domain-containing protein 1

Gene

ANKIB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei532By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 383RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST51
Zinc fingeri402 – 478IBR-type; degenerateAdd BLAST77
Zinc fingeri519 – 548RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000001629-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and IBR domain-containing protein 1 (EC:2.3.2.-By similarity)
Gene namesi
Name:ANKIB1
Synonyms:KIAA1386
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22215. ANKIB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54467.
OpenTargetsiENSG00000001629.
PharmGKBiPA134941469.

Polymorphism and mutation databases

BioMutaiANKIB1.
DMDMi158937428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000668922 – 1089Ankyrin repeat and IBR domain-containing protein 1Add BLAST1088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei737PhosphoserineCombined sources1
Modified residuei884PhosphoserineCombined sources1
Modified residuei911PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9P2G1.
MaxQBiQ9P2G1.
PaxDbiQ9P2G1.
PeptideAtlasiQ9P2G1.
PRIDEiQ9P2G1.

PTM databases

iPTMnetiQ9P2G1.
PhosphoSitePlusiQ9P2G1.

Expressioni

Gene expression databases

BgeeiENSG00000001629.
CleanExiHS_ANKIB1.
ExpressionAtlasiQ9P2G1. baseline and differential.
GenevisibleiQ9P2G1. HS.

Organism-specific databases

HPAiHPA019358.
HPA021780.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-2687890,EBI-721550

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119973. 4 interactors.
IntActiQ9P2G1. 2 interactors.
STRINGi9606.ENSP00000265742.

Structurei

3D structure databases

ProteinModelPortaliQ9P2G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 74ANK 1Add BLAST30
Repeati144 – 173ANK 2Add BLAST30
Domaini851 – 870UIMPROSITE-ProRule annotationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili575 – 640Sequence analysisAdd BLAST66

Domaini

Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity

Sequence similaritiesi

Belongs to the RBR family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 IBR-type zinc finger.Curated
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 1 UIM (ubiquitin-interacting motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 383RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST51
Zinc fingeri402 – 478IBR-type; degenerateAdd BLAST77
Zinc fingeri519 – 548RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1815. Eukaryota.
ENOG410XP9Y. LUCA.
GeneTreeiENSGT00840000129790.
HOGENOMiHOG000033880.
HOVERGENiHBG083226.
InParanoidiQ9P2G1.
KOiK11967.
OMAiNNPAIKW.
OrthoDBiEOG091G00NA.
PhylomeDBiQ9P2G1.
TreeFamiTF331104.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR003903. UIM_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR11685. PTHR11685. 2 hits.
PfamiPF00023. Ank. 2 hits.
PF01485. IBR. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50330. UIM. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNTSY GEPYQHNTPL
60 70 80 90 100
HYAARHGMNK ILGTFLGRDG NPNKRNVHNE TSMHLLCMGP QIMISEGALH
110 120 130 140 150
PRLARPTEDD FRRADCLQMI LKWKGAKLDQ GEYERAAIDA VDNKKNTPLH
160 170 180 190 200
YAAASGMKAC VELLVKHGGD LFAENENKDT PCDCAEKQHH KDLALNLESQ
210 220 230 240 250
MVFSRDPEAE EIEAEYAALD KREPYEGLRP QDLRRLKDML IVETADMLQA
260 270 280 290 300
PLFTAEALLR AHDWDREKLL EAWMSNPENC CQRSGVQMPT PPPSGYNAWD
310 320 330 340 350
TLPSPRTPRT TRSSVTSPDE ISLSPGDLDT SLCDICMCSI SVFEDPVDMP
360 370 380 390 400
CGHDFCRGCW ESFLNLKIQE GEAHNIFCPA YDCFQLVPVD IIESVVSKEM
410 420 430 440 450
DKRYLQFDIK AFVENNPAIK WCPTPGCDRA VRLTKQGSNT SGSDTLSFPL
460 470 480 490 500
LRAPAVDCGK GHLFCWECLG EAHEPCDCQT WKNWLQKITE MKPEELVGVS
510 520 530 540 550
EAYEDAANCL WLLTNSKPCA NCKSPIQKNE GCNHMQCAKC KYDFCWICLE
560 570 580 590 600
EWKKHSSSTG GYYRCTRYEV IQHVEEQSKE MTVEAEKKHK RFQELDRFMH
610 620 630 640 650
YYTRFKNHEH SYQLEQRLLK TAKEKMEQLS RALKETEGGC PDTTFIEDAV
660 670 680 690 700
HVLLKTRRIL KCSYPYGFFL EPKSTKKEIF ELMQTDLEMV TEDLAQKVNR
710 720 730 740 750
PYLRTPRHKI IKAACLVQQK RQEFLASVAR GVAPADSPEA PRRSFAGGTW
760 770 780 790 800
DWEYLGFASP EEYAEFQYRR RHRQRRRGDV HSLLSNPPDP DEPSESTLDI
810 820 830 840 850
PEGGSSSRRP GTSVVSSASM SVLHSSSLRD YTPASRSENQ DSLQALSSLD
860 870 880 890 900
EDDPNILLAI QLSLQESGLA LDEETRDFLS NEASLGAIGT SLPSRLDSVP
910 920 930 940 950
RNTDSPRAAL SSSELLELGD SLMRLGAEND PFSTDTLSSH PLSEARSDFC
960 970 980 990 1000
PSSSDPDSAG QDPNINDNLL GNIMAWFHDM NPQSIALIPP ATTEISADSQ
1010 1020 1030 1040 1050
LPCIKDGSEG VKDVELVLPE DSMFEDASVS EGRGTQIEEN PLEENILAGE
1060 1070 1080
AASQAGDSGN EAANRGDGSD VSSQTPQTSS DWLEQVHLV
Length:1,089
Mass (Da):122,002
Last modified:July 24, 2007 - v3
Checksum:i038570CD3887FF44
GO

Sequence cautioni

The sequence AAH63861 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91537 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92624 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti929N → S in BAA91537 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0308621016L → M.3 PublicationsCorresponds to variant rs38794dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037807 mRNA. Translation: BAA92624.1. Different initiation.
AC000118 Genomic DNA. No translation available.
AC000120 Genomic DNA. No translation available.
AC004539 Genomic DNA. No translation available.
AC007566 Genomic DNA. No translation available.
BC063861 mRNA. Translation: AAH63861.1. Different initiation.
BC073893 mRNA. Translation: AAH73893.1.
AK001179 mRNA. Translation: BAA91537.1. Different initiation.
AL137349 mRNA. Translation: CAB70704.1.
CCDSiCCDS47639.1.
PIRiT46423.
RefSeqiNP_061877.1. NM_019004.1.
UniGeneiHs.83293.

Genome annotation databases

EnsembliENST00000265742; ENSP00000265742; ENSG00000001629.
GeneIDi54467.
KEGGihsa:54467.
UCSCiuc003ulw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037807 mRNA. Translation: BAA92624.1. Different initiation.
AC000118 Genomic DNA. No translation available.
AC000120 Genomic DNA. No translation available.
AC004539 Genomic DNA. No translation available.
AC007566 Genomic DNA. No translation available.
BC063861 mRNA. Translation: AAH63861.1. Different initiation.
BC073893 mRNA. Translation: AAH73893.1.
AK001179 mRNA. Translation: BAA91537.1. Different initiation.
AL137349 mRNA. Translation: CAB70704.1.
CCDSiCCDS47639.1.
PIRiT46423.
RefSeqiNP_061877.1. NM_019004.1.
UniGeneiHs.83293.

3D structure databases

ProteinModelPortaliQ9P2G1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119973. 4 interactors.
IntActiQ9P2G1. 2 interactors.
STRINGi9606.ENSP00000265742.

PTM databases

iPTMnetiQ9P2G1.
PhosphoSitePlusiQ9P2G1.

Polymorphism and mutation databases

BioMutaiANKIB1.
DMDMi158937428.

Proteomic databases

EPDiQ9P2G1.
MaxQBiQ9P2G1.
PaxDbiQ9P2G1.
PeptideAtlasiQ9P2G1.
PRIDEiQ9P2G1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265742; ENSP00000265742; ENSG00000001629.
GeneIDi54467.
KEGGihsa:54467.
UCSCiuc003ulw.2. human.

Organism-specific databases

CTDi54467.
DisGeNETi54467.
GeneCardsiANKIB1.
H-InvDBHIX0006840.
HGNCiHGNC:22215. ANKIB1.
HPAiHPA019358.
HPA021780.
neXtProtiNX_Q9P2G1.
OpenTargetsiENSG00000001629.
PharmGKBiPA134941469.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1815. Eukaryota.
ENOG410XP9Y. LUCA.
GeneTreeiENSGT00840000129790.
HOGENOMiHOG000033880.
HOVERGENiHBG083226.
InParanoidiQ9P2G1.
KOiK11967.
OMAiNNPAIKW.
OrthoDBiEOG091G00NA.
PhylomeDBiQ9P2G1.
TreeFamiTF331104.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000001629-MONOMER.

Miscellaneous databases

ChiTaRSiANKIB1. human.
GenomeRNAii54467.
PROiQ9P2G1.

Gene expression databases

BgeeiENSG00000001629.
CleanExiHS_ANKIB1.
ExpressionAtlasiQ9P2G1. baseline and differential.
GenevisibleiQ9P2G1. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR003903. UIM_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR11685. PTHR11685. 2 hits.
PfamiPF00023. Ank. 2 hits.
PF01485. IBR. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50330. UIM. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKIB1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2G1
Secondary accession number(s): Q6GMS4
, Q6P3S9, Q9NTD7, Q9NW49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks one Cys residue in the IBR-type zinc finger domain that is one of the conserved features of the family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.