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Q9P2G1

- AKIB1_HUMAN

UniProt

Q9P2G1 - AKIB1_HUMAN

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Protein

Ankyrin repeat and IBR domain-containing protein 1

Gene

ANKIB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri333 – 38351RING-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 47877IBR-type; degenerateAdd
BLAST
Zinc fingeri519 – 54830RING-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and IBR domain-containing protein 1
Gene namesi
Name:ANKIB1
Synonyms:KIAA1386
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:22215. ANKIB1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 10891088Ankyrin repeat and IBR domain-containing protein 1PRO_0000066892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei737 – 7371Phosphoserine3 Publications

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9P2G1.
PaxDbiQ9P2G1.
PRIDEiQ9P2G1.

PTM databases

PhosphoSiteiQ9P2G1.

Expressioni

Gene expression databases

BgeeiQ9P2G1.
CleanExiHS_ANKIB1.
ExpressionAtlasiQ9P2G1. baseline and differential.
GenevestigatoriQ9P2G1.

Organism-specific databases

HPAiHPA019358.
HPA021780.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-2687890,EBI-721550

Protein-protein interaction databases

BioGridi119973. 5 interactions.
IntActiQ9P2G1. 2 interactions.
STRINGi9606.ENSP00000265742.

Structurei

3D structure databases

ProteinModelPortaliQ9P2G1.
SMRiQ9P2G1. Positions 48-194, 511-568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 7430ANK 1Add
BLAST
Repeati144 – 17330ANK 2Add
BLAST
Repeati851 – 87020UIMAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili575 – 64066Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the RBR family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 IBR-type zinc finger.Curated
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 1 UIM (ubiquitin-interacting motif) repeat.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri333 – 38351RING-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 47877IBR-type; degenerateAdd
BLAST
Zinc fingeri519 – 54830RING-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG327249.
GeneTreeiENSGT00770000120508.
HOGENOMiHOG000033880.
HOVERGENiHBG083226.
InParanoidiQ9P2G1.
KOiK11967.
OMAiNNPAIKW.
OrthoDBiEOG7T7GSP.
PhylomeDBiQ9P2G1.
TreeFamiTF331104.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003903. Ubiquitin-int_motif.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF01485. IBR. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
SM00726. UIM. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50330. UIM. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNTSY GEPYQHNTPL
60 70 80 90 100
HYAARHGMNK ILGTFLGRDG NPNKRNVHNE TSMHLLCMGP QIMISEGALH
110 120 130 140 150
PRLARPTEDD FRRADCLQMI LKWKGAKLDQ GEYERAAIDA VDNKKNTPLH
160 170 180 190 200
YAAASGMKAC VELLVKHGGD LFAENENKDT PCDCAEKQHH KDLALNLESQ
210 220 230 240 250
MVFSRDPEAE EIEAEYAALD KREPYEGLRP QDLRRLKDML IVETADMLQA
260 270 280 290 300
PLFTAEALLR AHDWDREKLL EAWMSNPENC CQRSGVQMPT PPPSGYNAWD
310 320 330 340 350
TLPSPRTPRT TRSSVTSPDE ISLSPGDLDT SLCDICMCSI SVFEDPVDMP
360 370 380 390 400
CGHDFCRGCW ESFLNLKIQE GEAHNIFCPA YDCFQLVPVD IIESVVSKEM
410 420 430 440 450
DKRYLQFDIK AFVENNPAIK WCPTPGCDRA VRLTKQGSNT SGSDTLSFPL
460 470 480 490 500
LRAPAVDCGK GHLFCWECLG EAHEPCDCQT WKNWLQKITE MKPEELVGVS
510 520 530 540 550
EAYEDAANCL WLLTNSKPCA NCKSPIQKNE GCNHMQCAKC KYDFCWICLE
560 570 580 590 600
EWKKHSSSTG GYYRCTRYEV IQHVEEQSKE MTVEAEKKHK RFQELDRFMH
610 620 630 640 650
YYTRFKNHEH SYQLEQRLLK TAKEKMEQLS RALKETEGGC PDTTFIEDAV
660 670 680 690 700
HVLLKTRRIL KCSYPYGFFL EPKSTKKEIF ELMQTDLEMV TEDLAQKVNR
710 720 730 740 750
PYLRTPRHKI IKAACLVQQK RQEFLASVAR GVAPADSPEA PRRSFAGGTW
760 770 780 790 800
DWEYLGFASP EEYAEFQYRR RHRQRRRGDV HSLLSNPPDP DEPSESTLDI
810 820 830 840 850
PEGGSSSRRP GTSVVSSASM SVLHSSSLRD YTPASRSENQ DSLQALSSLD
860 870 880 890 900
EDDPNILLAI QLSLQESGLA LDEETRDFLS NEASLGAIGT SLPSRLDSVP
910 920 930 940 950
RNTDSPRAAL SSSELLELGD SLMRLGAEND PFSTDTLSSH PLSEARSDFC
960 970 980 990 1000
PSSSDPDSAG QDPNINDNLL GNIMAWFHDM NPQSIALIPP ATTEISADSQ
1010 1020 1030 1040 1050
LPCIKDGSEG VKDVELVLPE DSMFEDASVS EGRGTQIEEN PLEENILAGE
1060 1070 1080
AASQAGDSGN EAANRGDGSD VSSQTPQTSS DWLEQVHLV
Length:1,089
Mass (Da):122,002
Last modified:July 24, 2007 - v3
Checksum:i038570CD3887FF44
GO

Sequence cautioni

The sequence AAH63861.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91537.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA92624.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti929 – 9291N → S in BAA91537. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1016 – 10161L → M.3 Publications
Corresponds to variant rs38794 [ dbSNP | Ensembl ].
VAR_030862

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037807 mRNA. Translation: BAA92624.1. Different initiation.
AC000118 Genomic DNA. No translation available.
AC000120 Genomic DNA. No translation available.
AC004539 Genomic DNA. No translation available.
AC007566 Genomic DNA. No translation available.
BC063861 mRNA. Translation: AAH63861.1. Different initiation.
BC073893 mRNA. Translation: AAH73893.1.
AK001179 mRNA. Translation: BAA91537.1. Different initiation.
AL137349 mRNA. Translation: CAB70704.1.
CCDSiCCDS47639.1.
PIRiT46423.
RefSeqiNP_061877.1. NM_019004.1.
XP_005250514.1. XM_005250457.1.
UniGeneiHs.83293.

Genome annotation databases

EnsembliENST00000265742; ENSP00000265742; ENSG00000001629.
GeneIDi54467.
KEGGihsa:54467.
UCSCiuc003ulw.2. human.

Polymorphism databases

DMDMi158937428.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037807 mRNA. Translation: BAA92624.1 . Different initiation.
AC000118 Genomic DNA. No translation available.
AC000120 Genomic DNA. No translation available.
AC004539 Genomic DNA. No translation available.
AC007566 Genomic DNA. No translation available.
BC063861 mRNA. Translation: AAH63861.1 . Different initiation.
BC073893 mRNA. Translation: AAH73893.1 .
AK001179 mRNA. Translation: BAA91537.1 . Different initiation.
AL137349 mRNA. Translation: CAB70704.1 .
CCDSi CCDS47639.1.
PIRi T46423.
RefSeqi NP_061877.1. NM_019004.1.
XP_005250514.1. XM_005250457.1.
UniGenei Hs.83293.

3D structure databases

ProteinModelPortali Q9P2G1.
SMRi Q9P2G1. Positions 48-194, 511-568.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119973. 5 interactions.
IntActi Q9P2G1. 2 interactions.
STRINGi 9606.ENSP00000265742.

PTM databases

PhosphoSitei Q9P2G1.

Polymorphism databases

DMDMi 158937428.

Proteomic databases

MaxQBi Q9P2G1.
PaxDbi Q9P2G1.
PRIDEi Q9P2G1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265742 ; ENSP00000265742 ; ENSG00000001629 .
GeneIDi 54467.
KEGGi hsa:54467.
UCSCi uc003ulw.2. human.

Organism-specific databases

CTDi 54467.
GeneCardsi GC07P091875.
H-InvDB HIX0006840.
HGNCi HGNC:22215. ANKIB1.
HPAi HPA019358.
HPA021780.
neXtProti NX_Q9P2G1.
PharmGKBi PA134941469.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327249.
GeneTreei ENSGT00770000120508.
HOGENOMi HOG000033880.
HOVERGENi HBG083226.
InParanoidi Q9P2G1.
KOi K11967.
OMAi NNPAIKW.
OrthoDBi EOG7T7GSP.
PhylomeDBi Q9P2G1.
TreeFami TF331104.

Miscellaneous databases

ChiTaRSi ANKIB1. human.
GenomeRNAii 54467.
NextBioi 56745.
PROi Q9P2G1.

Gene expression databases

Bgeei Q9P2G1.
CleanExi HS_ANKIB1.
ExpressionAtlasi Q9P2G1. baseline and differential.
Genevestigatori Q9P2G1.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003903. Ubiquitin-int_motif.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF01485. IBR. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
SM00726. UIM. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50330. UIM. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-1016.
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin and Uterus.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 540-1089, VARIANT MET-1016.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1089, VARIANT MET-1016.
    Tissue: Testis.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
    Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
    Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2.

Entry informationi

Entry nameiAKIB1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2G1
Secondary accession number(s): Q6GMS4
, Q6P3S9, Q9NTD7, Q9NW49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 24, 2007
Last modified: November 26, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks one Cys residue in the IBR-type zinc finger domain that is one of the conserved features of the family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3