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Protein

Ankyrin repeat and IBR domain-containing protein 1

Gene

ANKIB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.By similarity

Caution

Lacks one Cys residue in the IBR-type zinc finger domain that is one of the conserved features of the family.Curated

Catalytic activityi

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei532By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 383RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST51
Zinc fingeri402 – 478IBR-type; degenerateAdd BLAST77
Zinc fingeri519 – 548RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and IBR domain-containing protein 1 (EC:2.3.2.31By similarity)
Gene namesi
Name:ANKIB1
Synonyms:KIAA1386
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000001629.9
HGNCiHGNC:22215 ANKIB1
neXtProtiNX_Q9P2G1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi54467
OpenTargetsiENSG00000001629
PharmGKBiPA134941469

Polymorphism and mutation databases

BioMutaiANKIB1
DMDMi158937428

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000668922 – 1089Ankyrin repeat and IBR domain-containing protein 1Add BLAST1088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei737PhosphoserineCombined sources1
Modified residuei884PhosphoserineCombined sources1
Modified residuei911PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9P2G1
MaxQBiQ9P2G1
PaxDbiQ9P2G1
PeptideAtlasiQ9P2G1
PRIDEiQ9P2G1
ProteomicsDBi83810

PTM databases

iPTMnetiQ9P2G1
PhosphoSitePlusiQ9P2G1

Expressioni

Gene expression databases

BgeeiENSG00000001629
CleanExiHS_ANKIB1
ExpressionAtlasiQ9P2G1 baseline and differential
GenevisibleiQ9P2G1 HS

Organism-specific databases

HPAiHPA019358
HPA021780

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-2687890,EBI-721550

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119973, 4 interactors
ELMiQ9P2G1
IntActiQ9P2G1, 2 interactors
STRINGi9606.ENSP00000265742

Structurei

3D structure databases

ProteinModelPortaliQ9P2G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 74ANK 1Add BLAST30
Repeati144 – 173ANK 2Add BLAST30
Domaini851 – 870UIMPROSITE-ProRule annotationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili575 – 640Sequence analysisAdd BLAST66

Domaini

Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity

Sequence similaritiesi

Belongs to the RBR family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 383RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST51
Zinc fingeri402 – 478IBR-type; degenerateAdd BLAST77
Zinc fingeri519 – 548RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1815 Eukaryota
ENOG410XP9Y LUCA
GeneTreeiENSGT00890000139392
HOGENOMiHOG000033880
HOVERGENiHBG083226
InParanoidiQ9P2G1
KOiK11967
OMAiNNPAIKW
OrthoDBiEOG091G00NA
PhylomeDBiQ9P2G1
TreeFamiTF331104

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR031127 E3_UB_ligase_RBR
IPR002867 IBR_dom
IPR003903 UIM_dom
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR11685 PTHR11685, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF01485 IBR, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00647 IBR, 2 hits
SM00184 RING, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50330 UIM, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNTSY GEPYQHNTPL
60 70 80 90 100
HYAARHGMNK ILGTFLGRDG NPNKRNVHNE TSMHLLCMGP QIMISEGALH
110 120 130 140 150
PRLARPTEDD FRRADCLQMI LKWKGAKLDQ GEYERAAIDA VDNKKNTPLH
160 170 180 190 200
YAAASGMKAC VELLVKHGGD LFAENENKDT PCDCAEKQHH KDLALNLESQ
210 220 230 240 250
MVFSRDPEAE EIEAEYAALD KREPYEGLRP QDLRRLKDML IVETADMLQA
260 270 280 290 300
PLFTAEALLR AHDWDREKLL EAWMSNPENC CQRSGVQMPT PPPSGYNAWD
310 320 330 340 350
TLPSPRTPRT TRSSVTSPDE ISLSPGDLDT SLCDICMCSI SVFEDPVDMP
360 370 380 390 400
CGHDFCRGCW ESFLNLKIQE GEAHNIFCPA YDCFQLVPVD IIESVVSKEM
410 420 430 440 450
DKRYLQFDIK AFVENNPAIK WCPTPGCDRA VRLTKQGSNT SGSDTLSFPL
460 470 480 490 500
LRAPAVDCGK GHLFCWECLG EAHEPCDCQT WKNWLQKITE MKPEELVGVS
510 520 530 540 550
EAYEDAANCL WLLTNSKPCA NCKSPIQKNE GCNHMQCAKC KYDFCWICLE
560 570 580 590 600
EWKKHSSSTG GYYRCTRYEV IQHVEEQSKE MTVEAEKKHK RFQELDRFMH
610 620 630 640 650
YYTRFKNHEH SYQLEQRLLK TAKEKMEQLS RALKETEGGC PDTTFIEDAV
660 670 680 690 700
HVLLKTRRIL KCSYPYGFFL EPKSTKKEIF ELMQTDLEMV TEDLAQKVNR
710 720 730 740 750
PYLRTPRHKI IKAACLVQQK RQEFLASVAR GVAPADSPEA PRRSFAGGTW
760 770 780 790 800
DWEYLGFASP EEYAEFQYRR RHRQRRRGDV HSLLSNPPDP DEPSESTLDI
810 820 830 840 850
PEGGSSSRRP GTSVVSSASM SVLHSSSLRD YTPASRSENQ DSLQALSSLD
860 870 880 890 900
EDDPNILLAI QLSLQESGLA LDEETRDFLS NEASLGAIGT SLPSRLDSVP
910 920 930 940 950
RNTDSPRAAL SSSELLELGD SLMRLGAEND PFSTDTLSSH PLSEARSDFC
960 970 980 990 1000
PSSSDPDSAG QDPNINDNLL GNIMAWFHDM NPQSIALIPP ATTEISADSQ
1010 1020 1030 1040 1050
LPCIKDGSEG VKDVELVLPE DSMFEDASVS EGRGTQIEEN PLEENILAGE
1060 1070 1080
AASQAGDSGN EAANRGDGSD VSSQTPQTSS DWLEQVHLV
Length:1,089
Mass (Da):122,002
Last modified:July 24, 2007 - v3
Checksum:i038570CD3887FF44
GO

Sequence cautioni

The sequence AAH63861 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91537 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92624 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti929N → S in BAA91537 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0308621016L → M3 PublicationsCorresponds to variant dbSNP:rs38794Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037807 mRNA Translation: BAA92624.1 Different initiation.
AC000118 Genomic DNA No translation available.
AC000120 Genomic DNA No translation available.
AC004539 Genomic DNA No translation available.
AC007566 Genomic DNA No translation available.
BC063861 mRNA Translation: AAH63861.1 Different initiation.
BC073893 mRNA Translation: AAH73893.1
AK001179 mRNA Translation: BAA91537.1 Different initiation.
AL137349 mRNA Translation: CAB70704.1
CCDSiCCDS47639.1
PIRiT46423
RefSeqiNP_061877.1, NM_019004.1
UniGeneiHs.83293

Genome annotation databases

EnsembliENST00000265742; ENSP00000265742; ENSG00000001629
GeneIDi54467
KEGGihsa:54467
UCSCiuc003ulw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAKIB1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2G1
Secondary accession number(s): Q6GMS4
, Q6P3S9, Q9NTD7, Q9NW49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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