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Q9P2G1

- AKIB1_HUMAN

UniProt

Q9P2G1 - AKIB1_HUMAN

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Protein
Ankyrin repeat and IBR domain-containing protein 1
Gene
ANKIB1, KIAA1386
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri333 – 38351RING-type 1; atypical
Add
BLAST
Zinc fingeri402 – 47877IBR-type; degenerate
Add
BLAST
Zinc fingeri519 – 54830RING-type 2; degenerate
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and IBR domain-containing protein 1
Gene namesi
Name:ANKIB1
Synonyms:KIAA1386
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:22215. ANKIB1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 10891088Ankyrin repeat and IBR domain-containing protein 1
PRO_0000066892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei737 – 7371Phosphoserine3 Publications

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9P2G1.
PaxDbiQ9P2G1.
PRIDEiQ9P2G1.

PTM databases

PhosphoSiteiQ9P2G1.

Expressioni

Gene expression databases

ArrayExpressiQ9P2G1.
BgeeiQ9P2G1.
CleanExiHS_ANKIB1.
GenevestigatoriQ9P2G1.

Organism-specific databases

HPAiHPA019358.
HPA021780.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-2687890,EBI-721550

Protein-protein interaction databases

BioGridi119973. 4 interactions.
IntActiQ9P2G1. 2 interactions.
STRINGi9606.ENSP00000265742.

Structurei

3D structure databases

ProteinModelPortaliQ9P2G1.
SMRiQ9P2G1. Positions 30-197, 225-731.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 7430ANK 1
Add
BLAST
Repeati144 – 17330ANK 2
Add
BLAST
Repeati851 – 87020UIM
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili575 – 64066 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the RBR family.
Contains 2 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG327249.
HOGENOMiHOG000033880.
HOVERGENiHBG083226.
InParanoidiQ9P2G1.
KOiK11967.
OMAiNNPAIKW.
OrthoDBiEOG7T7GSP.
PhylomeDBiQ9P2G1.
TreeFamiTF331104.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003903. Ubiquitin-int_motif.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF01485. IBR. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
SM00726. UIM. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50330. UIM. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2G1-1 [UniParc]FASTAAdd to Basket

« Hide

MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNTSY GEPYQHNTPL     50
HYAARHGMNK ILGTFLGRDG NPNKRNVHNE TSMHLLCMGP QIMISEGALH 100
PRLARPTEDD FRRADCLQMI LKWKGAKLDQ GEYERAAIDA VDNKKNTPLH 150
YAAASGMKAC VELLVKHGGD LFAENENKDT PCDCAEKQHH KDLALNLESQ 200
MVFSRDPEAE EIEAEYAALD KREPYEGLRP QDLRRLKDML IVETADMLQA 250
PLFTAEALLR AHDWDREKLL EAWMSNPENC CQRSGVQMPT PPPSGYNAWD 300
TLPSPRTPRT TRSSVTSPDE ISLSPGDLDT SLCDICMCSI SVFEDPVDMP 350
CGHDFCRGCW ESFLNLKIQE GEAHNIFCPA YDCFQLVPVD IIESVVSKEM 400
DKRYLQFDIK AFVENNPAIK WCPTPGCDRA VRLTKQGSNT SGSDTLSFPL 450
LRAPAVDCGK GHLFCWECLG EAHEPCDCQT WKNWLQKITE MKPEELVGVS 500
EAYEDAANCL WLLTNSKPCA NCKSPIQKNE GCNHMQCAKC KYDFCWICLE 550
EWKKHSSSTG GYYRCTRYEV IQHVEEQSKE MTVEAEKKHK RFQELDRFMH 600
YYTRFKNHEH SYQLEQRLLK TAKEKMEQLS RALKETEGGC PDTTFIEDAV 650
HVLLKTRRIL KCSYPYGFFL EPKSTKKEIF ELMQTDLEMV TEDLAQKVNR 700
PYLRTPRHKI IKAACLVQQK RQEFLASVAR GVAPADSPEA PRRSFAGGTW 750
DWEYLGFASP EEYAEFQYRR RHRQRRRGDV HSLLSNPPDP DEPSESTLDI 800
PEGGSSSRRP GTSVVSSASM SVLHSSSLRD YTPASRSENQ DSLQALSSLD 850
EDDPNILLAI QLSLQESGLA LDEETRDFLS NEASLGAIGT SLPSRLDSVP 900
RNTDSPRAAL SSSELLELGD SLMRLGAEND PFSTDTLSSH PLSEARSDFC 950
PSSSDPDSAG QDPNINDNLL GNIMAWFHDM NPQSIALIPP ATTEISADSQ 1000
LPCIKDGSEG VKDVELVLPE DSMFEDASVS EGRGTQIEEN PLEENILAGE 1050
AASQAGDSGN EAANRGDGSD VSSQTPQTSS DWLEQVHLV 1089
Length:1,089
Mass (Da):122,002
Last modified:July 24, 2007 - v3
Checksum:i038570CD3887FF44
GO

Sequence cautioni

The sequence AAH63861.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA91537.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA92624.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1016 – 10161L → M.3 Publications
Corresponds to variant rs38794 [ dbSNP | Ensembl ].
VAR_030862

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti929 – 9291N → S in BAA91537. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037807 mRNA. Translation: BAA92624.1. Different initiation.
AC000118 Genomic DNA. No translation available.
AC000120 Genomic DNA. No translation available.
AC004539 Genomic DNA. No translation available.
AC007566 Genomic DNA. No translation available.
BC063861 mRNA. Translation: AAH63861.1. Different initiation.
BC073893 mRNA. Translation: AAH73893.1.
AK001179 mRNA. Translation: BAA91537.1. Different initiation.
AL137349 mRNA. Translation: CAB70704.1.
CCDSiCCDS47639.1.
PIRiT46423.
RefSeqiNP_061877.1. NM_019004.1.
XP_005250514.1. XM_005250457.1.
UniGeneiHs.83293.

Genome annotation databases

EnsembliENST00000265742; ENSP00000265742; ENSG00000001629.
GeneIDi54467.
KEGGihsa:54467.
UCSCiuc003ulw.2. human.

Polymorphism databases

DMDMi158937428.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037807 mRNA. Translation: BAA92624.1 . Different initiation.
AC000118 Genomic DNA. No translation available.
AC000120 Genomic DNA. No translation available.
AC004539 Genomic DNA. No translation available.
AC007566 Genomic DNA. No translation available.
BC063861 mRNA. Translation: AAH63861.1 . Different initiation.
BC073893 mRNA. Translation: AAH73893.1 .
AK001179 mRNA. Translation: BAA91537.1 . Different initiation.
AL137349 mRNA. Translation: CAB70704.1 .
CCDSi CCDS47639.1.
PIRi T46423.
RefSeqi NP_061877.1. NM_019004.1.
XP_005250514.1. XM_005250457.1.
UniGenei Hs.83293.

3D structure databases

ProteinModelPortali Q9P2G1.
SMRi Q9P2G1. Positions 30-197, 225-731.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119973. 4 interactions.
IntActi Q9P2G1. 2 interactions.
STRINGi 9606.ENSP00000265742.

PTM databases

PhosphoSitei Q9P2G1.

Polymorphism databases

DMDMi 158937428.

Proteomic databases

MaxQBi Q9P2G1.
PaxDbi Q9P2G1.
PRIDEi Q9P2G1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265742 ; ENSP00000265742 ; ENSG00000001629 .
GeneIDi 54467.
KEGGi hsa:54467.
UCSCi uc003ulw.2. human.

Organism-specific databases

CTDi 54467.
GeneCardsi GC07P091875.
H-InvDB HIX0006840.
HGNCi HGNC:22215. ANKIB1.
HPAi HPA019358.
HPA021780.
neXtProti NX_Q9P2G1.
PharmGKBi PA134941469.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327249.
HOGENOMi HOG000033880.
HOVERGENi HBG083226.
InParanoidi Q9P2G1.
KOi K11967.
OMAi NNPAIKW.
OrthoDBi EOG7T7GSP.
PhylomeDBi Q9P2G1.
TreeFami TF331104.

Miscellaneous databases

GenomeRNAii 54467.
NextBioi 56745.
PROi Q9P2G1.

Gene expression databases

ArrayExpressi Q9P2G1.
Bgeei Q9P2G1.
CleanExi HS_ANKIB1.
Genevestigatori Q9P2G1.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003903. Ubiquitin-int_motif.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF01485. IBR. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
SM00726. UIM. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50330. UIM. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-1016.
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin and Uterus.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 540-1089, VARIANT MET-1016.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1089, VARIANT MET-1016.
    Tissue: Testis.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
    Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
    Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2.

Entry informationi

Entry nameiAKIB1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2G1
Secondary accession number(s): Q6GMS4
, Q6P3S9, Q9NTD7, Q9NW49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks one Cys residue in the IBR-type zinc finger domain that is one of the conserved features of the family.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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