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Q9P2F8

- SI1L2_HUMAN

UniProt

Q9P2F8 - SI1L2_HUMAN

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Protein

Signal-induced proliferation-associated 1-like protein 2

Gene

SIPA1L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 2
Short name:
SIPA1-like protein 2
Gene namesi
Name:SIPA1L2
Synonyms:KIAA1389
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23800. SIPA1L2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17221722Signal-induced proliferation-associated 1-like protein 2PRO_0000056749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481Phosphoserine3 Publications
Modified residuei1029 – 10291Phosphoserine1 Publication
Modified residuei1461 – 14611Phosphoserine2 Publications
Modified residuei1478 – 14781Phosphoserine2 Publications
Modified residuei1488 – 14881Phosphoserine1 Publication
Modified residuei1549 – 15491Phosphoserine1 Publication
Modified residuei1552 – 15521Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P2F8.
PaxDbiQ9P2F8.
PRIDEiQ9P2F8.

PTM databases

PhosphoSiteiQ9P2F8.

Expressioni

Gene expression databases

BgeeiQ9P2F8.
CleanExiHS_SIPA1L2.
GenevestigatoriQ9P2F8.

Organism-specific databases

HPAiHPA024181.
HPA053693.

Interactioni

Protein-protein interaction databases

BioGridi121621. 10 interactions.
IntActiQ9P2F8. 9 interactions.
STRINGi9606.ENSP00000262861.

Structurei

3D structure databases

ProteinModelPortaliQ9P2F8.
SMRiQ9P2F8. Positions 484-816, 949-1027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini595 – 812218Rap-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini950 – 102677PDZPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1654 – 171259Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 634Poly-Gly
Compositional biasi1125 – 11284Poly-Ser
Compositional biasi1321 – 138464Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG279955.
GeneTreeiENSGT00760000119182.
HOVERGENiHBG056135.
InParanoidiQ9P2F8.
KOiK17702.
OMAiAENFVTT.
OrthoDBiEOG7DVD9F.
PhylomeDBiQ9P2F8.
TreeFamiTF318626.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR021818. DUF3401.
IPR001478. PDZ.
IPR000331. Rap_GAP_dom.
[Graphical view]
PfamiPF11881. DUF3401. 1 hit.
PF00595. PDZ. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P2F8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS
60 70 80 90 100
LNASNSNETG GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE
110 120 130 140 150
SRSQTSYESI TSVLQNGQSD QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ
160 170 180 190 200
RGLHPIRQRS NSDVTISDID AEDVLDQNAV NPNTGAALHR EYGSTSSIDR
210 220 230 240 250
QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI SPSLHAAAQI
260 270 280 290 300
SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS
310 320 330 340 350
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN
360 370 380 390 400
VGKRKNITTG ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG
410 420 430 440 450
KSNDLVLSCP YFRNETGGEG DRRIALSRAN SSSFSSGESC SFESSLSSHC
460 470 480 490 500
TNAGVSVLEV PRENQPIHRE KVKRYIIEHI DLGAYYYRKF FYGKEHQNYF
510 520 530 540 550
GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL TTLRGAILED
560 570 580 590 600
AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE
610 620 630 640 650
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF
660 670 680 690 700
SKYRAQLDNK TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR
710 720 730 740 750
HIGNDIVTIV FQEPGALPFT PKSIRSHFQH VFVIVKVHNP CTENVCYSVG
760 770 780 790 800
VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL LAKVINAENA AHKSEKFRAM
810 820 830 840 850
ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK VKPRKDAHLF
860 870 880 890 900
SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV
910 920 930 940 950
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE
960 970 980 990 1000
MTLRRNGLGQ LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA
1010 1020 1030 1040 1050
TLTHEQMIDL LRTSVTVKVV IIQPHDDGSP RRGCSELCRI PMVEYKLDSE
1060 1070 1080 1090 1100
GTPCEYKTPF RRNTTWHRVP TPALQPLSRA SPIPGTPDRL PCQQLLQQAQ
1110 1120 1130 1140 1150
AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP QVGYDGCQSP
1160 1170 1180 1190 1200
LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ
1210 1220 1230 1240 1250
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP
1260 1270 1280 1290 1300
ELLGLTYIKG ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA
1310 1320 1330 1340 1350
ADVSGPDDEP AKLYSVHGYA STISAGSAAE GSMGDLSEIS SHSSGSHHSG
1360 1370 1380 1390 1400
SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP GSMSKPYHRQ GAVNKYVIGW
1410 1420 1430 1440 1450
KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA VAETQHVLSK
1460 1470 1480 1490 1500
EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS
1510 1520 1530 1540 1550
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD
1560 1570 1580 1590 1600
GSLSDKSKCA DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH
1610 1620 1630 1640 1650
HTSYLDQRVA SFCTLTDMQH GQDLEGAQEL PLCVDPGSGK EFMDTTGERS
1660 1670 1680 1690 1700
PSPLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES
1710 1720
QTATAQLRKF TEWFFTTIDK KS
Length:1,722
Mass (Da):190,438
Last modified:January 10, 2006 - v2
Checksum:iC99E808CD6B156B1
GO
Isoform 2 (identifier: Q9P2F8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-926: Missing.
     927-940: NCAEDIREIVQRLV → MSPCFSFIGCKLCS
     1588-1605: Missing.

Show »
Length:778
Mass (Da):84,536
Checksum:iBAB3E9A97733DBCB
GO

Sequence cautioni

The sequence BAA92627.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14273.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1288 – 12881S → P in BAB14273. (PubMed:14702039)Curated
Sequence conflicti1308 – 13081D → V in BAB14273. (PubMed:14702039)Curated
Sequence conflicti1702 – 17021T → I in BAB14273. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491T → A.
Corresponds to variant rs16857502 [ dbSNP | Ensembl ].
VAR_049153
Natural varianti1322 – 13221T → A.4 Publications
Corresponds to variant rs2275307 [ dbSNP | Ensembl ].
VAR_049154
Natural varianti1403 – 14031S → L.
Corresponds to variant rs1547742 [ dbSNP | Ensembl ].
VAR_049155
Natural varianti1424 – 14241M → L.
Corresponds to variant rs3210731 [ dbSNP | Ensembl ].
VAR_061183
Natural varianti1639 – 16391G → S.
Corresponds to variant rs2275303 [ dbSNP | Ensembl ].
VAR_049156

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 926926Missing in isoform 2. 2 PublicationsVSP_010920Add
BLAST
Alternative sequencei927 – 94014NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2. 2 PublicationsVSP_010921Add
BLAST
Alternative sequencei1588 – 160518Missing in isoform 2. 2 PublicationsVSP_010922Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168879 mRNA. Translation: AAO12530.1.
AK022852 mRNA. Translation: BAB14273.1. Different initiation.
AK093191 mRNA. Translation: BAC04090.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73408.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73409.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22919.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22920.1.
AB037810 mRNA. Translation: BAA92627.1. Different initiation.
CH471098 Genomic DNA. Translation: EAW69972.1.
BC013119 mRNA. Translation: AAH13119.2.
BC082251 mRNA. Translation: AAH82251.1.
CCDSiCCDS41474.1. [Q9P2F8-1]
RefSeqiNP_065859.3. NM_020808.3. [Q9P2F8-1]
XP_005273266.1. XM_005273209.2. [Q9P2F8-1]
XP_005273268.1. XM_005273211.1. [Q9P2F8-1]
XP_005273269.1. XM_005273212.2. [Q9P2F8-1]
XP_005273270.1. XM_005273213.2. [Q9P2F8-1]
XP_005273271.1. XM_005273214.1. [Q9P2F8-1]
XP_006711861.1. XM_006711798.1. [Q9P2F8-1]
UniGeneiHs.745009.

Genome annotation databases

EnsembliENST00000262861; ENSP00000262861; ENSG00000116991. [Q9P2F8-1]
ENST00000308942; ENSP00000309102; ENSG00000116991. [Q9P2F8-2]
ENST00000366630; ENSP00000355589; ENSG00000116991. [Q9P2F8-1]
GeneIDi57568.
KEGGihsa:57568.
UCSCiuc001hvf.3. human. [Q9P2F8-2]
uc001hvg.3. human. [Q9P2F8-1]

Polymorphism databases

DMDMi85681894.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168879 mRNA. Translation: AAO12530.1 .
AK022852 mRNA. Translation: BAB14273.1 . Different initiation.
AK093191 mRNA. Translation: BAC04090.1 .
AL356965 , AL157409 Genomic DNA. Translation: CAH73408.1 .
AL356965 , AL157409 Genomic DNA. Translation: CAH73409.1 .
AL157409 , AL356965 Genomic DNA. Translation: CAI22919.1 .
AL157409 , AL356965 Genomic DNA. Translation: CAI22920.1 .
AB037810 mRNA. Translation: BAA92627.1 . Different initiation.
CH471098 Genomic DNA. Translation: EAW69972.1 .
BC013119 mRNA. Translation: AAH13119.2 .
BC082251 mRNA. Translation: AAH82251.1 .
CCDSi CCDS41474.1. [Q9P2F8-1 ]
RefSeqi NP_065859.3. NM_020808.3. [Q9P2F8-1 ]
XP_005273266.1. XM_005273209.2. [Q9P2F8-1 ]
XP_005273268.1. XM_005273211.1. [Q9P2F8-1 ]
XP_005273269.1. XM_005273212.2. [Q9P2F8-1 ]
XP_005273270.1. XM_005273213.2. [Q9P2F8-1 ]
XP_005273271.1. XM_005273214.1. [Q9P2F8-1 ]
XP_006711861.1. XM_006711798.1. [Q9P2F8-1 ]
UniGenei Hs.745009.

3D structure databases

ProteinModelPortali Q9P2F8.
SMRi Q9P2F8. Positions 484-816, 949-1027.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121621. 10 interactions.
IntActi Q9P2F8. 9 interactions.
STRINGi 9606.ENSP00000262861.

PTM databases

PhosphoSitei Q9P2F8.

Polymorphism databases

DMDMi 85681894.

Proteomic databases

MaxQBi Q9P2F8.
PaxDbi Q9P2F8.
PRIDEi Q9P2F8.

Protocols and materials databases

DNASUi 57568.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262861 ; ENSP00000262861 ; ENSG00000116991 . [Q9P2F8-1 ]
ENST00000308942 ; ENSP00000309102 ; ENSG00000116991 . [Q9P2F8-2 ]
ENST00000366630 ; ENSP00000355589 ; ENSG00000116991 . [Q9P2F8-1 ]
GeneIDi 57568.
KEGGi hsa:57568.
UCSCi uc001hvf.3. human. [Q9P2F8-2 ]
uc001hvg.3. human. [Q9P2F8-1 ]

Organism-specific databases

CTDi 57568.
GeneCardsi GC01M232533.
HGNCi HGNC:23800. SIPA1L2.
HPAi HPA024181.
HPA053693.
MIMi 611609. gene.
neXtProti NX_Q9P2F8.
PharmGKBi PA134933243.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279955.
GeneTreei ENSGT00760000119182.
HOVERGENi HBG056135.
InParanoidi Q9P2F8.
KOi K17702.
OMAi AENFVTT.
OrthoDBi EOG7DVD9F.
PhylomeDBi Q9P2F8.
TreeFami TF318626.

Miscellaneous databases

ChiTaRSi SIPA1L2. human.
GeneWikii SIPA1L2.
GenomeRNAii 57568.
NextBioi 64082.
PROi Q9P2F8.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2F8.
CleanExi HS_SIPA1L2.
Genevestigatori Q9P2F8.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR021818. DUF3401.
IPR001478. PDZ.
IPR000331. Rap_GAP_dom.
[Graphical view ]
Pfami PF11881. DUF3401. 1 hit.
PF00595. PDZ. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Matsuura K., Kohu K., Akiyama T.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-1322.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1322.
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1722 (ISOFORM 1), VARIANT ALA-1322.
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1065-1722 (ISOFORM 2), VARIANT ALA-1322.
    Tissue: Ovary and Salivary gland.
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461; SER-1549 AND SER-1552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1029, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSI1L2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2F8
Secondary accession number(s): Q2TV88
, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 10, 2006
Last modified: November 26, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3