Q9P2F8 (SI1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Signal-induced proliferation-associated 1-like protein 2
Short name=SIPA1-like protein 2

Gene names

Name:	SIPA1L2
Synonyms:	KIAA1389

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1722 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 PDZ (DHR) domain. Contains 1 Rap-GAP domain.
Sequence caution	The sequence BAA92627.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14273.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2F8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2F8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-926: Missing.
     927-940: NCAEDIREIVQRLV → MSPCFSFIGCKLCS
     1588-1605: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1722	1722	Signal-induced proliferation-associated 1-like protein 2		PRO_0000056749
Regions
	Domain	595 – 812	218	Rap-GAP
	Domain	950 – 1026	77	PDZ
	Coiled coil	1654 – 1712	59	Potential
	Compositional bias	60 – 63	4	Poly-Gly
	Compositional bias	1125 – 1128	4	Poly-Ser
	Compositional bias	1321 – 1384	64	Ser-rich
Amino acid modifications
	Modified residue	148	1	Phosphoserine Ref.8 Ref.9 Ref.12
	Modified residue	1029	1	Phosphoserine Ref.12
	Modified residue	1244	1	Phosphoserine By similarity
	Modified residue	1406	1	Phosphoserine By similarity
	Modified residue	1461	1	Phosphoserine Ref.10 Ref.11
	Modified residue	1478	1	Phosphoserine Ref.7 Ref.8
	Modified residue	1488	1	Phosphoserine Ref.9
	Modified residue	1549	1	Phosphoserine Ref.11
	Modified residue	1552	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	1 – 926	926	Missing in isoform 2.		VSP_010920
	Alternative sequence	927 – 940	14	NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2.		VSP_010921
	Alternative sequence	1588 – 1605	18	Missing in isoform 2.		VSP_010922
	Natural variant	49	1	T → A. Corresponds to variant rs16857502 [ dbSNP | Ensembl ].		VAR_049153
	Natural variant	1322	1	T → A. Ref.1 Ref.4 Ref.5 Ref.6 Corresponds to variant rs2275307 [ dbSNP | Ensembl ].		VAR_049154
	Natural variant	1403	1	S → L. Corresponds to variant rs1547742 [ dbSNP | Ensembl ].		VAR_049155
	Natural variant	1424	1	M → L. Corresponds to variant rs3210731 [ dbSNP | Ensembl ].		VAR_061183
	Natural variant	1639	1	G → S. Corresponds to variant rs2275303 [ dbSNP | Ensembl ].		VAR_049156
Experimental info
	Sequence conflict	1288	1	S → P in BAB14273. Ref.2
	Sequence conflict	1308	1	D → V in BAB14273. Ref.2
	Sequence conflict	1702	1	T → I in BAB14273. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: C99E808CD6B156B1	FASTA	1,722	190,438
	10 20 30 40 50 60 MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS LNASNSNETG 70 80 90 100 110 120 GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE SRSQTSYESI TSVLQNGQSD 130 140 150 160 170 180 QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ RGLHPIRQRS NSDVTISDID AEDVLDQNAV 190 200 210 220 230 240 NPNTGAALHR EYGSTSSIDR QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI 250 260 270 280 290 300 SPSLHAAAQI SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS 310 320 330 340 350 360 EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN VGKRKNITTG 370 380 390 400 410 420 ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG KSNDLVLSCP YFRNETGGEG 430 440 450 460 470 480 DRRIALSRAN SSSFSSGESC SFESSLSSHC TNAGVSVLEV PRENQPIHRE KVKRYIIEHI 490 500 510 520 530 540 DLGAYYYRKF FYGKEHQNYF GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL 550 560 570 580 590 600 TTLRGAILED AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE 610 620 630 640 650 660 QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF SKYRAQLDNK 670 680 690 700 710 720 TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR HIGNDIVTIV FQEPGALPFT 730 740 750 760 770 780 PKSIRSHFQH VFVIVKVHNP CTENVCYSVG VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL 790 800 810 820 830 840 LAKVINAENA AHKSEKFRAM ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK 850 860 870 880 890 900 VKPRKDAHLF SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV 910 920 930 940 950 960 IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE MTLRRNGLGQ 970 980 990 1000 1010 1020 LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA TLTHEQMIDL LRTSVTVKVV 1030 1040 1050 1060 1070 1080 IIQPHDDGSP RRGCSELCRI PMVEYKLDSE GTPCEYKTPF RRNTTWHRVP TPALQPLSRA 1090 1100 1110 1120 1130 1140 SPIPGTPDRL PCQQLLQQAQ AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP 1150 1160 1170 1180 1190 1200 QVGYDGCQSP LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ 1210 1220 1230 1240 1250 1260 KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP ELLGLTYIKG 1270 1280 1290 1300 1310 1320 ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA ADVSGPDDEP AKLYSVHGYA 1330 1340 1350 1360 1370 1380 STISAGSAAE GSMGDLSEIS SHSSGSHHSG SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP 1390 1400 1410 1420 1430 1440 GSMSKPYHRQ GAVNKYVIGW KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA 1450 1460 1470 1480 1490 1500 VAETQHVLSK EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS 1510 1520 1530 1540 1550 1560 FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD GSLSDKSKCA 1570 1580 1590 1600 1610 1620 DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH HTSYLDQRVA SFCTLTDMQH 1630 1640 1650 1660 1670 1680 GQDLEGAQEL PLCVDPGSGK EFMDTTGERS PSPLTGKVNQ LELILRQLQT DLRKEKQDKA 1690 1700 1710 1720 VLQAEVQHLR QDNMRLQEES QTATAQLRKF TEWFFTTIDK KS
	Isoform 2 [UniParc]. Checksum: BAB3E9A97733DBCB	FASTA	778	84,536
	10 20 30 40 50 60 MSPCFSFIGC KLCSIVTRGC ETVEMTLRRN GLGQLGFHVN FEGIVADVEP FGFAWKAGLR 70 80 90 100 110 120 QGSRLVEICK VAVATLTHEQ MIDLLRTSVT VKVVIIQPHD DGSPRRGCSE LCRIPMVEYK 130 140 150 160 170 180 LDSEGTPCEY KTPFRRNTTW HRVPTPALQP LSRASPIPGT PDRLPCQQLL QQAQAAIPRS 190 200 210 220 230 240 TSFDRKLPDG TRSSPSNQSS SSDPGPGGSG PWRPQVGYDG CQSPLLLEHQ GSGPLECDGA 250 260 270 280 290 300 REREDTMEAS RHPETKWHGP PSKVLGSYKE RALQKDGSCK DSPNKLSHIG DKSCSSHSSS 310 320 330 340 350 360 NTLSSNTSSN SDDKHFGSGD LMDPELLGLT YIKGASTDSG IDTAPCMPAT ILGPVHLAGS 370 380 390 400 410 420 RSLIHSRAEQ WADAADVSGP DDEPAKLYSV HGYASTISAG SAAEGSMGDL SEISSHSSGS 430 440 450 460 470 480 HHSGSPSAHC SKSSGSLDSS KVYIVSHSSG QQVPGSMSKP YHRQGAVNKY VIGWKKSEGS 490 500 510 520 530 540 PPPEEPEVTE CPGMYSEMDV MSTATQHQTV VGDAVAETQH VLSKEDFLKL MLPDSPLVEE 550 560 570 580 590 600 GRRKFSFYGN LSPRRSLYRT LSDESICSNR RGSSFGSSRS SVLDQALPND ILFSTTPPYH 610 620 630 640 650 660 STLPPRAHPA PSMGSLRNEF WFSDGSLSDK SKCADPGLMP LPDTATGLDW THLVDAARAF 670 680 690 700 710 720 EDQRVASFCT LTDMQHGQDL EGAQELPLCV DPGSGKEFMD TTGERSPSPL TGKVNQLELI 730 740 750 760 770 LRQLQTDLRK EKQDKAVLQA EVQHLRQDNM RLQEESQTAT AQLRKFTEWF FTTIDKKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Matsuura K., Kohu K., Akiyama T. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-1322.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1322.
[5]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1722 (ISOFORM 1), VARIANT ALA-1322. Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1065-1722 (ISOFORM 2), VARIANT ALA-1322. Tissue: Ovary and Salivary gland.
[7]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1478, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1478, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1488, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461, MASS SPECTROMETRY.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461; SER-1549 AND SER-1552, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1029, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY168879 mRNA. Translation: AAO12530.1. AK022852 mRNA. Translation: BAB14273.1. Different initiation. AK093191 mRNA. Translation: BAC04090.1. AL356965, AL157409 Genomic DNA. Translation: CAH73408.1. AL356965, AL157409 Genomic DNA. Translation: CAH73409.1. AL157409, AL356965 Genomic DNA. Translation: CAI22919.1. AL157409, AL356965 Genomic DNA. Translation: CAI22920.1. AB037810 mRNA. Translation: BAA92627.1. Different initiation. CH471098 Genomic DNA. Translation: EAW69972.1. BC013119 mRNA. Translation: AAH13119.2. BC082251 mRNA. Translation: AAH82251.1.
IPI	IPI00444572. IPI00444573.
RefSeq	NP_065859.3. NM_020808.3.
UniGene	Hs.268774.
3D structure databases
ProteinModelPortal	Q9P2F8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2F8. 5 interactions.
PTM databases
PhosphoSite	Q9P2F8.
Polymorphism databases
DMDM	85681894.
Proteomic databases
PaxDb	Q9P2F8.
PRIDE	Q9P2F8.
Protocols and materials databases
DNASU	57568.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262861; ENSP00000262861; ENSG00000116991. ENST00000308942; ENSP00000309102; ENSG00000116991. ENST00000366630; ENSP00000355589; ENSG00000116991.
GeneID	57568.
KEGG	hsa:57568.
UCSC	uc001hvf.3. human. uc001hvg.3. human.
Organism-specific databases
CTD	57568.
GeneCards	GC01M232533.
HGNC	HGNC:23800. SIPA1L2.
HPA	HPA024181.
MIM	611609. gene.
neXtProt	NX_Q9P2F8.
PharmGKB	PA134933243.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279955.
HOVERGEN	HBG056135.
InParanoid	Q9P2F8.
OMA	AENFVTT.
OrthoDB	EOG4QNMV9.
Gene expression databases
Bgee	Q9P2F8.
CleanEx	HS_SIPA1L2.
Genevestigator	Q9P2F8.
GermOnline	ENSG00000116991. Homo sapiens.
Family and domain databases
InterPro	IPR021818. DUF3401. IPR001478. PDZ. IPR000331. Rap_GAP_dom. [Graphical view]
Pfam	PF11881. DUF3401. 1 hit. PF00595. PDZ. 1 hit. PF02145. Rap_GAP. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. PS50085. RAPGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57568.
NextBio	64082.
SOURCE	Search...

Entry information

Entry name

SI1L2_HUMAN

Accession

Primary (citable) accession number: Q9P2F8
Secondary accession number(s): Q2TV88 , Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.