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Q9P2F8 (SI1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal-induced proliferation-associated 1-like protein 2

Short name=SIPA1-like protein 2
Gene names
Name:SIPA1L2
Synonyms:KIAA1389
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1722 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain.

Contains 1 Rap-GAP domain.

Sequence caution

The sequence BAA92627.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB14273.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Molecular functionGTPase activation
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of small GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P2F8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P2F8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-926: Missing.
     927-940: NCAEDIREIVQRLV → MSPCFSFIGCKLCS
     1588-1605: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17221722Signal-induced proliferation-associated 1-like protein 2
PRO_0000056749

Regions

Domain595 – 812218Rap-GAP
Domain950 – 102677PDZ
Coiled coil1654 – 171259 Potential
Compositional bias60 – 634Poly-Gly
Compositional bias1125 – 11284Poly-Ser
Compositional bias1321 – 138464Ser-rich

Amino acid modifications

Modified residue1481Phosphoserine Ref.8 Ref.9 Ref.13
Modified residue10291Phosphoserine Ref.13
Modified residue14611Phosphoserine Ref.11 Ref.12
Modified residue14781Phosphoserine Ref.7 Ref.8
Modified residue14881Phosphoserine Ref.9
Modified residue15491Phosphoserine Ref.12
Modified residue15521Phosphoserine Ref.12

Natural variations

Alternative sequence1 – 926926Missing in isoform 2.
VSP_010920
Alternative sequence927 – 94014NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2.
VSP_010921
Alternative sequence1588 – 160518Missing in isoform 2.
VSP_010922
Natural variant491T → A.
Corresponds to variant rs16857502 [ dbSNP | Ensembl ].
VAR_049153
Natural variant13221T → A. Ref.1 Ref.4 Ref.5 Ref.6
Corresponds to variant rs2275307 [ dbSNP | Ensembl ].
VAR_049154
Natural variant14031S → L.
Corresponds to variant rs1547742 [ dbSNP | Ensembl ].
VAR_049155
Natural variant14241M → L.
Corresponds to variant rs3210731 [ dbSNP | Ensembl ].
VAR_061183
Natural variant16391G → S.
Corresponds to variant rs2275303 [ dbSNP | Ensembl ].
VAR_049156

Experimental info

Sequence conflict12881S → P in BAB14273. Ref.2
Sequence conflict13081D → V in BAB14273. Ref.2
Sequence conflict17021T → I in BAB14273. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: C99E808CD6B156B1

FASTA1,722190,438
        10         20         30         40         50         60 
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS LNASNSNETG 

        70         80         90        100        110        120 
GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE SRSQTSYESI TSVLQNGQSD 

       130        140        150        160        170        180 
QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ RGLHPIRQRS NSDVTISDID AEDVLDQNAV 

       190        200        210        220        230        240 
NPNTGAALHR EYGSTSSIDR QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI 

       250        260        270        280        290        300 
SPSLHAAAQI SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS 

       310        320        330        340        350        360 
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN VGKRKNITTG 

       370        380        390        400        410        420 
ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG KSNDLVLSCP YFRNETGGEG 

       430        440        450        460        470        480 
DRRIALSRAN SSSFSSGESC SFESSLSSHC TNAGVSVLEV PRENQPIHRE KVKRYIIEHI 

       490        500        510        520        530        540 
DLGAYYYRKF FYGKEHQNYF GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL 

       550        560        570        580        590        600 
TTLRGAILED AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE 

       610        620        630        640        650        660 
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF SKYRAQLDNK 

       670        680        690        700        710        720 
TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR HIGNDIVTIV FQEPGALPFT 

       730        740        750        760        770        780 
PKSIRSHFQH VFVIVKVHNP CTENVCYSVG VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL 

       790        800        810        820        830        840 
LAKVINAENA AHKSEKFRAM ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK 

       850        860        870        880        890        900 
VKPRKDAHLF SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV 

       910        920        930        940        950        960 
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE MTLRRNGLGQ 

       970        980        990       1000       1010       1020 
LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA TLTHEQMIDL LRTSVTVKVV 

      1030       1040       1050       1060       1070       1080 
IIQPHDDGSP RRGCSELCRI PMVEYKLDSE GTPCEYKTPF RRNTTWHRVP TPALQPLSRA 

      1090       1100       1110       1120       1130       1140 
SPIPGTPDRL PCQQLLQQAQ AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP 

      1150       1160       1170       1180       1190       1200 
QVGYDGCQSP LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ 

      1210       1220       1230       1240       1250       1260 
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP ELLGLTYIKG 

      1270       1280       1290       1300       1310       1320 
ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA ADVSGPDDEP AKLYSVHGYA 

      1330       1340       1350       1360       1370       1380 
STISAGSAAE GSMGDLSEIS SHSSGSHHSG SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP 

      1390       1400       1410       1420       1430       1440 
GSMSKPYHRQ GAVNKYVIGW KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA 

      1450       1460       1470       1480       1490       1500 
VAETQHVLSK EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS 

      1510       1520       1530       1540       1550       1560 
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD GSLSDKSKCA 

      1570       1580       1590       1600       1610       1620 
DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH HTSYLDQRVA SFCTLTDMQH 

      1630       1640       1650       1660       1670       1680 
GQDLEGAQEL PLCVDPGSGK EFMDTTGERS PSPLTGKVNQ LELILRQLQT DLRKEKQDKA 

      1690       1700       1710       1720 
VLQAEVQHLR QDNMRLQEES QTATAQLRKF TEWFFTTIDK KS 

« Hide

Isoform 2 [UniParc].

Checksum: BAB3E9A97733DBCB
Show »

FASTA77884,536

References

« Hide 'large scale' references
[1]Matsuura K., Kohu K., Akiyama T.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-1322.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1322.
[5]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1722 (ISOFORM 1), VARIANT ALA-1322.
Tissue: Brain.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1065-1722 (ISOFORM 2), VARIANT ALA-1322.
Tissue: Ovary and Salivary gland.
[7]"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461; SER-1549 AND SER-1552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1029, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY168879 mRNA. Translation: AAO12530.1.
AK022852 mRNA. Translation: BAB14273.1. Different initiation.
AK093191 mRNA. Translation: BAC04090.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73408.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73409.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22919.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22920.1.
AB037810 mRNA. Translation: BAA92627.1. Different initiation.
CH471098 Genomic DNA. Translation: EAW69972.1.
BC013119 mRNA. Translation: AAH13119.2.
BC082251 mRNA. Translation: AAH82251.1.
RefSeqNP_065859.3. NM_020808.3.
XP_005273266.1. XM_005273209.2.
XP_005273268.1. XM_005273211.1.
XP_005273269.1. XM_005273212.2.
XP_005273270.1. XM_005273213.2.
XP_005273271.1. XM_005273214.1.
UniGeneHs.745009.

3D structure databases

ProteinModelPortalQ9P2F8.
SMRQ9P2F8. Positions 484-816, 949-1027.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121621. 7 interactions.
IntActQ9P2F8. 9 interactions.
STRING9606.ENSP00000262861.

PTM databases

PhosphoSiteQ9P2F8.

Polymorphism databases

DMDM85681894.

Proteomic databases

PaxDbQ9P2F8.
PRIDEQ9P2F8.

Protocols and materials databases

DNASU57568.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262861; ENSP00000262861; ENSG00000116991. [Q9P2F8-1]
ENST00000308942; ENSP00000309102; ENSG00000116991. [Q9P2F8-2]
ENST00000366630; ENSP00000355589; ENSG00000116991. [Q9P2F8-1]
GeneID57568.
KEGGhsa:57568.
UCSCuc001hvf.3. human. [Q9P2F8-2]
uc001hvg.3. human. [Q9P2F8-1]

Organism-specific databases

CTD57568.
GeneCardsGC01M232533.
HGNCHGNC:23800. SIPA1L2.
HPAHPA024181.
HPA053693.
MIM611609. gene.
neXtProtNX_Q9P2F8.
PharmGKBPA134933243.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279955.
HOVERGENHBG056135.
InParanoidQ9P2F8.
KOK17702.
OMAAENFVTT.
OrthoDBEOG7DVD9F.
PhylomeDBQ9P2F8.
TreeFamTF318626.

Gene expression databases

BgeeQ9P2F8.
CleanExHS_SIPA1L2.
GenevestigatorQ9P2F8.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR021818. DUF3401.
IPR001478. PDZ.
IPR000331. Rap_GAP_dom.
[Graphical view]
PfamPF11881. DUF3401. 1 hit.
PF00595. PDZ. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSIPA1L2.
GenomeRNAi57568.
NextBio64082.
PROQ9P2F8.
SOURCESearch...

Entry information

Entry nameSI1L2_HUMAN
AccessionPrimary (citable) accession number: Q9P2F8
Secondary accession number(s): Q2TV88 expand/collapse secondary AC list , Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 10, 2006
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM