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Protein

Signal-induced proliferation-associated 1-like protein 2

Gene

SIPA1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 2
Short name:
SIPA1-like protein 2
Gene namesi
Name:SIPA1L2
Synonyms:KIAA1389
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23800. SIPA1L2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi57568.
OpenTargetsiENSG00000116991.
PharmGKBiPA134933243.

Polymorphism and mutation databases

BioMutaiSIPA1L2.
DMDMi85681894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567491 – 1722Signal-induced proliferation-associated 1-like protein 2Add BLAST1722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148PhosphoserineCombined sources1
Modified residuei379PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1244PhosphoserineBy similarity1
Modified residuei1461PhosphoserineCombined sources1
Modified residuei1472PhosphoserineBy similarity1
Modified residuei1478PhosphoserineCombined sources1
Modified residuei1488PhosphoserineCombined sources1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1552PhosphoserineCombined sources1
Modified residuei1591PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2F8.
MaxQBiQ9P2F8.
PaxDbiQ9P2F8.
PeptideAtlasiQ9P2F8.
PRIDEiQ9P2F8.

PTM databases

iPTMnetiQ9P2F8.
PhosphoSitePlusiQ9P2F8.

Expressioni

Gene expression databases

BgeeiENSG00000116991.
CleanExiHS_SIPA1L2.
GenevisibleiQ9P2F8. HS.

Organism-specific databases

HPAiHPA024181.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AP3M1Q9Y2T25EBI-10326741,EBI-2371151
DDX6P261964EBI-10326741,EBI-351257

Protein-protein interaction databases

BioGridi121621. 28 interactors.
IntActiQ9P2F8. 21 interactors.
STRINGi9606.ENSP00000262861.

Structurei

3D structure databases

ProteinModelPortaliQ9P2F8.
SMRiQ9P2F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini595 – 812Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini950 – 1026PDZPROSITE-ProRule annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1654 – 1712Sequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-Gly4
Compositional biasi1125 – 1128Poly-Ser4
Compositional biasi1321 – 1384Ser-richAdd BLAST64

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOVERGENiHBG056135.
InParanoidiQ9P2F8.
KOiK17702.
OMAiEFIMLIE.
OrthoDBiEOG091G016P.
PhylomeDBiQ9P2F8.
TreeFamiTF318626.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR031203. SIPA1L2.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF7. PTHR15711:SF7. 3 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2F8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS
60 70 80 90 100
LNASNSNETG GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE
110 120 130 140 150
SRSQTSYESI TSVLQNGQSD QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ
160 170 180 190 200
RGLHPIRQRS NSDVTISDID AEDVLDQNAV NPNTGAALHR EYGSTSSIDR
210 220 230 240 250
QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI SPSLHAAAQI
260 270 280 290 300
SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS
310 320 330 340 350
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN
360 370 380 390 400
VGKRKNITTG ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG
410 420 430 440 450
KSNDLVLSCP YFRNETGGEG DRRIALSRAN SSSFSSGESC SFESSLSSHC
460 470 480 490 500
TNAGVSVLEV PRENQPIHRE KVKRYIIEHI DLGAYYYRKF FYGKEHQNYF
510 520 530 540 550
GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL TTLRGAILED
560 570 580 590 600
AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE
610 620 630 640 650
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF
660 670 680 690 700
SKYRAQLDNK TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR
710 720 730 740 750
HIGNDIVTIV FQEPGALPFT PKSIRSHFQH VFVIVKVHNP CTENVCYSVG
760 770 780 790 800
VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL LAKVINAENA AHKSEKFRAM
810 820 830 840 850
ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK VKPRKDAHLF
860 870 880 890 900
SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV
910 920 930 940 950
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE
960 970 980 990 1000
MTLRRNGLGQ LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA
1010 1020 1030 1040 1050
TLTHEQMIDL LRTSVTVKVV IIQPHDDGSP RRGCSELCRI PMVEYKLDSE
1060 1070 1080 1090 1100
GTPCEYKTPF RRNTTWHRVP TPALQPLSRA SPIPGTPDRL PCQQLLQQAQ
1110 1120 1130 1140 1150
AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP QVGYDGCQSP
1160 1170 1180 1190 1200
LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ
1210 1220 1230 1240 1250
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP
1260 1270 1280 1290 1300
ELLGLTYIKG ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA
1310 1320 1330 1340 1350
ADVSGPDDEP AKLYSVHGYA STISAGSAAE GSMGDLSEIS SHSSGSHHSG
1360 1370 1380 1390 1400
SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP GSMSKPYHRQ GAVNKYVIGW
1410 1420 1430 1440 1450
KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA VAETQHVLSK
1460 1470 1480 1490 1500
EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS
1510 1520 1530 1540 1550
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD
1560 1570 1580 1590 1600
GSLSDKSKCA DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH
1610 1620 1630 1640 1650
HTSYLDQRVA SFCTLTDMQH GQDLEGAQEL PLCVDPGSGK EFMDTTGERS
1660 1670 1680 1690 1700
PSPLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES
1710 1720
QTATAQLRKF TEWFFTTIDK KS
Length:1,722
Mass (Da):190,438
Last modified:January 10, 2006 - v2
Checksum:iC99E808CD6B156B1
GO
Isoform 2 (identifier: Q9P2F8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-926: Missing.
     927-940: NCAEDIREIVQRLV → MSPCFSFIGCKLCS
     1588-1605: Missing.

Show »
Length:778
Mass (Da):84,536
Checksum:iBAB3E9A97733DBCB
GO

Sequence cautioni

The sequence BAA92627 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14273 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1288S → P in BAB14273 (PubMed:14702039).Curated1
Sequence conflicti1308D → V in BAB14273 (PubMed:14702039).Curated1
Sequence conflicti1702T → I in BAB14273 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04915349T → A.Corresponds to variant rs16857502dbSNPEnsembl.1
Natural variantiVAR_0491541322T → A.4 PublicationsCorresponds to variant rs2275307dbSNPEnsembl.1
Natural variantiVAR_0491551403S → L.Corresponds to variant rs1547742dbSNPEnsembl.1
Natural variantiVAR_0611831424M → L.Corresponds to variant rs3210731dbSNPEnsembl.1
Natural variantiVAR_0491561639G → S.Corresponds to variant rs2275303dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109201 – 926Missing in isoform 2. 2 PublicationsAdd BLAST926
Alternative sequenceiVSP_010921927 – 940NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0109221588 – 1605Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168879 mRNA. Translation: AAO12530.1.
AK022852 mRNA. Translation: BAB14273.1. Different initiation.
AK093191 mRNA. Translation: BAC04090.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73408.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73409.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22919.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22920.1.
AB037810 mRNA. Translation: BAA92627.1. Different initiation.
CH471098 Genomic DNA. Translation: EAW69972.1.
BC013119 mRNA. Translation: AAH13119.2.
BC082251 mRNA. Translation: AAH82251.1.
CCDSiCCDS41474.1. [Q9P2F8-1]
RefSeqiNP_065859.3. NM_020808.4. [Q9P2F8-1]
XP_005273268.1. XM_005273211.2. [Q9P2F8-1]
XP_005273269.1. XM_005273212.4. [Q9P2F8-1]
XP_005273270.1. XM_005273213.4. [Q9P2F8-1]
XP_011542545.1. XM_011544243.2. [Q9P2F8-1]
XP_016857385.1. XM_017001896.1. [Q9P2F8-1]
UniGeneiHs.745009.

Genome annotation databases

EnsembliENST00000262861; ENSP00000262861; ENSG00000116991. [Q9P2F8-1]
ENST00000308942; ENSP00000309102; ENSG00000116991. [Q9P2F8-2]
ENST00000366630; ENSP00000355589; ENSG00000116991. [Q9P2F8-1]
GeneIDi57568.
KEGGihsa:57568.
UCSCiuc001hvf.4. human. [Q9P2F8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168879 mRNA. Translation: AAO12530.1.
AK022852 mRNA. Translation: BAB14273.1. Different initiation.
AK093191 mRNA. Translation: BAC04090.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73408.1.
AL356965, AL157409 Genomic DNA. Translation: CAH73409.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22919.1.
AL157409, AL356965 Genomic DNA. Translation: CAI22920.1.
AB037810 mRNA. Translation: BAA92627.1. Different initiation.
CH471098 Genomic DNA. Translation: EAW69972.1.
BC013119 mRNA. Translation: AAH13119.2.
BC082251 mRNA. Translation: AAH82251.1.
CCDSiCCDS41474.1. [Q9P2F8-1]
RefSeqiNP_065859.3. NM_020808.4. [Q9P2F8-1]
XP_005273268.1. XM_005273211.2. [Q9P2F8-1]
XP_005273269.1. XM_005273212.4. [Q9P2F8-1]
XP_005273270.1. XM_005273213.4. [Q9P2F8-1]
XP_011542545.1. XM_011544243.2. [Q9P2F8-1]
XP_016857385.1. XM_017001896.1. [Q9P2F8-1]
UniGeneiHs.745009.

3D structure databases

ProteinModelPortaliQ9P2F8.
SMRiQ9P2F8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121621. 28 interactors.
IntActiQ9P2F8. 21 interactors.
STRINGi9606.ENSP00000262861.

PTM databases

iPTMnetiQ9P2F8.
PhosphoSitePlusiQ9P2F8.

Polymorphism and mutation databases

BioMutaiSIPA1L2.
DMDMi85681894.

Proteomic databases

EPDiQ9P2F8.
MaxQBiQ9P2F8.
PaxDbiQ9P2F8.
PeptideAtlasiQ9P2F8.
PRIDEiQ9P2F8.

Protocols and materials databases

DNASUi57568.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262861; ENSP00000262861; ENSG00000116991. [Q9P2F8-1]
ENST00000308942; ENSP00000309102; ENSG00000116991. [Q9P2F8-2]
ENST00000366630; ENSP00000355589; ENSG00000116991. [Q9P2F8-1]
GeneIDi57568.
KEGGihsa:57568.
UCSCiuc001hvf.4. human. [Q9P2F8-1]

Organism-specific databases

CTDi57568.
DisGeNETi57568.
GeneCardsiSIPA1L2.
HGNCiHGNC:23800. SIPA1L2.
HPAiHPA024181.
MIMi611609. gene.
neXtProtiNX_Q9P2F8.
OpenTargetsiENSG00000116991.
PharmGKBiPA134933243.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOVERGENiHBG056135.
InParanoidiQ9P2F8.
KOiK17702.
OMAiEFIMLIE.
OrthoDBiEOG091G016P.
PhylomeDBiQ9P2F8.
TreeFamiTF318626.

Miscellaneous databases

ChiTaRSiSIPA1L2. human.
GeneWikiiSIPA1L2.
GenomeRNAii57568.
PROiQ9P2F8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116991.
CleanExiHS_SIPA1L2.
GenevisibleiQ9P2F8. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR031203. SIPA1L2.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF7. PTHR15711:SF7. 3 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSI1L2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2F8
Secondary accession number(s): Q2TV88
, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.