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Q9P2F8

- SI1L2_HUMAN

UniProt

Q9P2F8 - SI1L2_HUMAN

Protein

Signal-induced proliferation-associated 1-like protein 2

Gene

SIPA1L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal-induced proliferation-associated 1-like protein 2
    Short name:
    SIPA1-like protein 2
    Gene namesi
    Name:SIPA1L2
    Synonyms:KIAA1389
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23800. SIPA1L2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933243.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17221722Signal-induced proliferation-associated 1-like protein 2PRO_0000056749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481Phosphoserine3 Publications
    Modified residuei1029 – 10291Phosphoserine1 Publication
    Modified residuei1461 – 14611Phosphoserine2 Publications
    Modified residuei1478 – 14781Phosphoserine2 Publications
    Modified residuei1488 – 14881Phosphoserine1 Publication
    Modified residuei1549 – 15491Phosphoserine1 Publication
    Modified residuei1552 – 15521Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9P2F8.
    PaxDbiQ9P2F8.
    PRIDEiQ9P2F8.

    PTM databases

    PhosphoSiteiQ9P2F8.

    Expressioni

    Gene expression databases

    BgeeiQ9P2F8.
    CleanExiHS_SIPA1L2.
    GenevestigatoriQ9P2F8.

    Organism-specific databases

    HPAiHPA024181.
    HPA053693.

    Interactioni

    Protein-protein interaction databases

    BioGridi121621. 7 interactions.
    IntActiQ9P2F8. 9 interactions.
    STRINGi9606.ENSP00000262861.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2F8.
    SMRiQ9P2F8. Positions 484-816, 949-1027.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini595 – 812218Rap-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini950 – 102677PDZPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1654 – 171259Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi60 – 634Poly-Gly
    Compositional biasi1125 – 11284Poly-Ser
    Compositional biasi1321 – 138464Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG279955.
    HOVERGENiHBG056135.
    InParanoidiQ9P2F8.
    KOiK17702.
    OMAiAENFVTT.
    OrthoDBiEOG7DVD9F.
    PhylomeDBiQ9P2F8.
    TreeFamiTF318626.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR021818. DUF3401.
    IPR001478. PDZ.
    IPR000331. Rap_GAP_dom.
    [Graphical view]
    PfamiPF11881. DUF3401. 1 hit.
    PF00595. PDZ. 1 hit.
    PF02145. Rap_GAP. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50085. RAPGAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2F8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS     50
    LNASNSNETG GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE 100
    SRSQTSYESI TSVLQNGQSD QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ 150
    RGLHPIRQRS NSDVTISDID AEDVLDQNAV NPNTGAALHR EYGSTSSIDR 200
    QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI SPSLHAAAQI 250
    SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS 300
    EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN 350
    VGKRKNITTG ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG 400
    KSNDLVLSCP YFRNETGGEG DRRIALSRAN SSSFSSGESC SFESSLSSHC 450
    TNAGVSVLEV PRENQPIHRE KVKRYIIEHI DLGAYYYRKF FYGKEHQNYF 500
    GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL TTLRGAILED 550
    AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE 600
    QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF 650
    SKYRAQLDNK TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR 700
    HIGNDIVTIV FQEPGALPFT PKSIRSHFQH VFVIVKVHNP CTENVCYSVG 750
    VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL LAKVINAENA AHKSEKFRAM 800
    ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK VKPRKDAHLF 850
    SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV 900
    IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE 950
    MTLRRNGLGQ LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA 1000
    TLTHEQMIDL LRTSVTVKVV IIQPHDDGSP RRGCSELCRI PMVEYKLDSE 1050
    GTPCEYKTPF RRNTTWHRVP TPALQPLSRA SPIPGTPDRL PCQQLLQQAQ 1100
    AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP QVGYDGCQSP 1150
    LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ 1200
    KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP 1250
    ELLGLTYIKG ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA 1300
    ADVSGPDDEP AKLYSVHGYA STISAGSAAE GSMGDLSEIS SHSSGSHHSG 1350
    SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP GSMSKPYHRQ GAVNKYVIGW 1400
    KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA VAETQHVLSK 1450
    EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS 1500
    FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD 1550
    GSLSDKSKCA DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH 1600
    HTSYLDQRVA SFCTLTDMQH GQDLEGAQEL PLCVDPGSGK EFMDTTGERS 1650
    PSPLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES 1700
    QTATAQLRKF TEWFFTTIDK KS 1722
    Length:1,722
    Mass (Da):190,438
    Last modified:January 10, 2006 - v2
    Checksum:iC99E808CD6B156B1
    GO
    Isoform 2 (identifier: Q9P2F8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-926: Missing.
         927-940: NCAEDIREIVQRLV → MSPCFSFIGCKLCS
         1588-1605: Missing.

    Show »
    Length:778
    Mass (Da):84,536
    Checksum:iBAB3E9A97733DBCB
    GO

    Sequence cautioni

    The sequence BAA92627.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14273.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1288 – 12881S → P in BAB14273. (PubMed:14702039)Curated
    Sequence conflicti1308 – 13081D → V in BAB14273. (PubMed:14702039)Curated
    Sequence conflicti1702 – 17021T → I in BAB14273. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti49 – 491T → A.
    Corresponds to variant rs16857502 [ dbSNP | Ensembl ].
    VAR_049153
    Natural varianti1322 – 13221T → A.4 Publications
    Corresponds to variant rs2275307 [ dbSNP | Ensembl ].
    VAR_049154
    Natural varianti1403 – 14031S → L.
    Corresponds to variant rs1547742 [ dbSNP | Ensembl ].
    VAR_049155
    Natural varianti1424 – 14241M → L.
    Corresponds to variant rs3210731 [ dbSNP | Ensembl ].
    VAR_061183
    Natural varianti1639 – 16391G → S.
    Corresponds to variant rs2275303 [ dbSNP | Ensembl ].
    VAR_049156

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 926926Missing in isoform 2. 2 PublicationsVSP_010920Add
    BLAST
    Alternative sequencei927 – 94014NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2. 2 PublicationsVSP_010921Add
    BLAST
    Alternative sequencei1588 – 160518Missing in isoform 2. 2 PublicationsVSP_010922Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY168879 mRNA. Translation: AAO12530.1.
    AK022852 mRNA. Translation: BAB14273.1. Different initiation.
    AK093191 mRNA. Translation: BAC04090.1.
    AL356965, AL157409 Genomic DNA. Translation: CAH73408.1.
    AL356965, AL157409 Genomic DNA. Translation: CAH73409.1.
    AL157409, AL356965 Genomic DNA. Translation: CAI22919.1.
    AL157409, AL356965 Genomic DNA. Translation: CAI22920.1.
    AB037810 mRNA. Translation: BAA92627.1. Different initiation.
    CH471098 Genomic DNA. Translation: EAW69972.1.
    BC013119 mRNA. Translation: AAH13119.2.
    BC082251 mRNA. Translation: AAH82251.1.
    CCDSiCCDS41474.1. [Q9P2F8-1]
    RefSeqiNP_065859.3. NM_020808.3. [Q9P2F8-1]
    XP_005273266.1. XM_005273209.2. [Q9P2F8-1]
    XP_005273268.1. XM_005273211.1. [Q9P2F8-1]
    XP_005273269.1. XM_005273212.2. [Q9P2F8-1]
    XP_005273270.1. XM_005273213.2. [Q9P2F8-1]
    XP_005273271.1. XM_005273214.1. [Q9P2F8-1]
    XP_006711861.1. XM_006711798.1. [Q9P2F8-1]
    UniGeneiHs.745009.

    Genome annotation databases

    EnsembliENST00000262861; ENSP00000262861; ENSG00000116991. [Q9P2F8-1]
    ENST00000308942; ENSP00000309102; ENSG00000116991. [Q9P2F8-2]
    ENST00000366630; ENSP00000355589; ENSG00000116991. [Q9P2F8-1]
    GeneIDi57568.
    KEGGihsa:57568.
    UCSCiuc001hvf.3. human. [Q9P2F8-2]
    uc001hvg.3. human. [Q9P2F8-1]

    Polymorphism databases

    DMDMi85681894.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY168879 mRNA. Translation: AAO12530.1 .
    AK022852 mRNA. Translation: BAB14273.1 . Different initiation.
    AK093191 mRNA. Translation: BAC04090.1 .
    AL356965 , AL157409 Genomic DNA. Translation: CAH73408.1 .
    AL356965 , AL157409 Genomic DNA. Translation: CAH73409.1 .
    AL157409 , AL356965 Genomic DNA. Translation: CAI22919.1 .
    AL157409 , AL356965 Genomic DNA. Translation: CAI22920.1 .
    AB037810 mRNA. Translation: BAA92627.1 . Different initiation.
    CH471098 Genomic DNA. Translation: EAW69972.1 .
    BC013119 mRNA. Translation: AAH13119.2 .
    BC082251 mRNA. Translation: AAH82251.1 .
    CCDSi CCDS41474.1. [Q9P2F8-1 ]
    RefSeqi NP_065859.3. NM_020808.3. [Q9P2F8-1 ]
    XP_005273266.1. XM_005273209.2. [Q9P2F8-1 ]
    XP_005273268.1. XM_005273211.1. [Q9P2F8-1 ]
    XP_005273269.1. XM_005273212.2. [Q9P2F8-1 ]
    XP_005273270.1. XM_005273213.2. [Q9P2F8-1 ]
    XP_005273271.1. XM_005273214.1. [Q9P2F8-1 ]
    XP_006711861.1. XM_006711798.1. [Q9P2F8-1 ]
    UniGenei Hs.745009.

    3D structure databases

    ProteinModelPortali Q9P2F8.
    SMRi Q9P2F8. Positions 484-816, 949-1027.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121621. 7 interactions.
    IntActi Q9P2F8. 9 interactions.
    STRINGi 9606.ENSP00000262861.

    PTM databases

    PhosphoSitei Q9P2F8.

    Polymorphism databases

    DMDMi 85681894.

    Proteomic databases

    MaxQBi Q9P2F8.
    PaxDbi Q9P2F8.
    PRIDEi Q9P2F8.

    Protocols and materials databases

    DNASUi 57568.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262861 ; ENSP00000262861 ; ENSG00000116991 . [Q9P2F8-1 ]
    ENST00000308942 ; ENSP00000309102 ; ENSG00000116991 . [Q9P2F8-2 ]
    ENST00000366630 ; ENSP00000355589 ; ENSG00000116991 . [Q9P2F8-1 ]
    GeneIDi 57568.
    KEGGi hsa:57568.
    UCSCi uc001hvf.3. human. [Q9P2F8-2 ]
    uc001hvg.3. human. [Q9P2F8-1 ]

    Organism-specific databases

    CTDi 57568.
    GeneCardsi GC01M232533.
    HGNCi HGNC:23800. SIPA1L2.
    HPAi HPA024181.
    HPA053693.
    MIMi 611609. gene.
    neXtProti NX_Q9P2F8.
    PharmGKBi PA134933243.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279955.
    HOVERGENi HBG056135.
    InParanoidi Q9P2F8.
    KOi K17702.
    OMAi AENFVTT.
    OrthoDBi EOG7DVD9F.
    PhylomeDBi Q9P2F8.
    TreeFami TF318626.

    Miscellaneous databases

    GeneWikii SIPA1L2.
    GenomeRNAii 57568.
    NextBioi 64082.
    PROi Q9P2F8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P2F8.
    CleanExi HS_SIPA1L2.
    Genevestigatori Q9P2F8.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR021818. DUF3401.
    IPR001478. PDZ.
    IPR000331. Rap_GAP_dom.
    [Graphical view ]
    Pfami PF11881. DUF3401. 1 hit.
    PF00595. PDZ. 1 hit.
    PF02145. Rap_GAP. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50085. RAPGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Matsuura K., Kohu K., Akiyama T.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-1322.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1322.
    5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1722 (ISOFORM 1), VARIANT ALA-1322.
      Tissue: Brain.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1065-1722 (ISOFORM 2), VARIANT ALA-1322.
      Tissue: Ovary and Salivary gland.
    7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1478, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1461; SER-1549 AND SER-1552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-1029, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSI1L2_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2F8
    Secondary accession number(s): Q2TV88
    , Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3