Q9P2F6 (RHG20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 20

Alternative name(s):
Rho-type GTPase-activating protein 20

Gene names

Name:	ARHGAP20
Synonyms:	KIAA1391

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1191 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.
Tissue specificity	Expressed predominantly in the brain. Lower expression is found in lymph nodes. Ref.1
Developmental stage	Low expression is found in fetal liver. Ref.1
Involvement in disease	A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.
Sequence similarities	Contains 1 PH domain. Contains 1 Ras-associating domain. Contains 1 Rho-GAP domain.
Caution	The translocation involving this gene was originally published as t(X;11)(q13;23) (Ref.1), but BRWD3 is localized to Xq21 and not to Xq13.
Sequence caution	The sequence AAH39340.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH39340.1 differs from that shown. Reason: Probable cloning artifact. The sequence BAA92629.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAF84979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAF84979.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Tumor suppressor
Molecular function	GTPase activation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2F6-1)

Also known as: 1ad;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2F6-2)

Also known as: 1be;

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTK → MTFWIIIN

Isoform 3 (identifier: Q9P2F6-3)

Also known as: 1c;

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCT → MSARERQPAL

Isoform 4 (identifier: Q9P2F6-4)

Also known as: 1e; 1d;

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1191

1191

Rho GTPase-activating protein 20

PRO_0000283086

Regions

Domain

78 – 180

103

PH

Domain

194 – 295

102

Ras-associating

Domain

365 – 551

187

Rho-GAP

Compositional bias

934 – 973

40

Ser-rich

Natural variations

Alternative sequence

1 – 36

36

Missing in isoform 4.

VSP_024296

Alternative sequence

1 – 34

34

MEAMS…GSCTK → MTFWIIIN in isoform 2.

VSP_024294

Alternative sequence

1 – 33

33

MEAMS…GGSCT → MSARERQPAL in isoform 3.

VSP_024295

Natural variant

522

1

A → T.
Corresponds to variant rs7936020 [ dbSNP | Ensembl ].

VAR_031489

Natural variant

632

1

G → D. Ref.6
Corresponds to variant rs17853925 [ dbSNP | Ensembl ].

VAR_031490

Secondary structure

1

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1191

Helix Strand Turn

Details...

Helix

367 – 370

4

Helix

372 – 374

3

Helix

378 – 390

13

Helix

391 – 393

3

Turn

395 – 399

5

Helix

404 – 415

12

Helix

427 – 439

13

Turn

442 – 447

6

Helix

448 – 450

3

Helix

451 – 456

6

Helix

457 – 459

3

Beta strand

460 – 462

3

Helix

463 – 474

12

Helix

479 – 496

18

Helix

499 – 502

4

Helix

506 – 517

12

Helix

526 – 550

25

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (1ad) [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 1837B9DF0655AF41	FASTA	1,191	132,608
	10 20 30 40 50 60 MEAMSPQQET LGGQPGRSSS LTGVSRLAGG SCTKKKMKTL AERRRSAPSL ILDKALQKRP 70 80 90 100 110 120 TTRDSPSASV DTCTFLSSLV CSNRTLLIDG RAELKRGLQR QERHLFLFND LFVVAKIKYN 130 140 150 160 170 180 NNFKIKNKIK LTDMWTASCV DEVGEGNTNA MKSFVLGWPT VNFVATFSSP EQKDKWLSLL 190 200 210 220 230 240 QRYINLEKEK DYPKSIPLKI FAKDIGNCAY SKTITVMNSD TANEVINMSL PMLGITGSER 250 260 270 280 290 300 DYQLWVNSGK EEAPYPLIGH EYPYGIKMSH LRDSALLTPG SKDSTTPFNL QEPFLMEQLP 310 320 330 340 350 360 REMQCQFILK PSRLAAAQQL SDSGHKTFKR RRSIINWAFW RGSSTHLDNL PSSPTSPMPG 370 380 390 400 410 420 QLFGISLPNI CENDNLPKPV LDMLFFLNQK GPLTKGIFRQ SANVKSCREL KEKLNSGVEV 430 440 450 460 470 480 HLDCESIFVI ASVLKDFLRN IPGSIFSSDL YDHWVSVMDQ GNDEEKINTV QRLLDQLPRA 490 500 510 520 530 540 NVVLLRYLFG VLHNIEQHSS SNQMTAFNLA VCVAPSILWP PASSSPELEN EFTKKVSLLI 550 560 570 580 590 600 QFLIENCLRI FGEEITSLFR EVSVRCDTRE NASDISCFQL NDSSYDSLEN ELNEDVDAPC 610 620 630 640 650 660 SDLVKKLGQG SRSMDSVLTL SDYDLDQPEV EGLLTLSDFD LAHSKDEDVQ MKRPLESKPV 670 680 690 700 710 720 NILVYTKIPL RDHARAPSAM CTPSYLSTAA ANAAKSLRRH RRCSEPSIDY LDSKLSYLRE 730 740 750 760 770 780 FYQKKLRKSS CDAILSQKDE DYLKQNQPLQ EEGKTCFKQS LVTGTDVSKK NATTQNTKKK 790 800 810 820 830 840 SLSGSEGNHV KLFPKSKPVA ISVASYSPMS SQDHSKNQPF DVNTSGYSPP HTADALKGPR 850 860 870 880 890 900 THRRCSEPNI EDQNRKLTYL RGIYSKKQHK TSCEAGLLHG EEDYLKRHKS LQMEGQKLIN 910 920 930 940 950 960 QSLVMGIEVG KSSATNQNTE KVLPPRLNLC PRTSYSSLSS PGTSPSGSSV SSQDSAFSQI 970 980 990 1000 1010 1020 SEHSVFTPTE TSSPIDCTFQ AQRKREDLSP DFSNASHVSG MPGPSSGQAC SRPAYTKKDT 1030 1040 1050 1060 1070 1080 MEWHSQMHSV TLHPSTWLRN GVASLKNWSL KKKAKAARPE EEKIASPKGP LEPPPHASGV 1090 1100 1110 1120 1130 1140 PEANSLQEEQ KDLPLRAAEG LSPVQSAQRC SSSPFQDSER HCSSPFSLVE SRLKLCMKSH 1150 1160 1170 1180 1190 EEIEPGSQSS SGSLPWERAS ASSWTLEDAT SPDSGPTVVC DIEDRYLTKD I
	Isoform 2 (1be) [UniParc]. Checksum: DFAA6B800B24583C	FASTA	1,165	130,235
	10 20 30 40 50 60 MTFWIIINKK MKTLAERRRS APSLILDKAL QKRPTTRDSP SASVDTCTFL SSLVCSNRTL 70 80 90 100 110 120 LIDGRAELKR GLQRQERHLF LFNDLFVVAK IKYNNNFKIK NKIKLTDMWT ASCVDEVGEG 130 140 150 160 170 180 NTNAMKSFVL GWPTVNFVAT FSSPEQKDKW LSLLQRYINL EKEKDYPKSI PLKIFAKDIG 190 200 210 220 230 240 NCAYSKTITV MNSDTANEVI NMSLPMLGIT GSERDYQLWV NSGKEEAPYP LIGHEYPYGI 250 260 270 280 290 300 KMSHLRDSAL LTPGSKDSTT PFNLQEPFLM EQLPREMQCQ FILKPSRLAA AQQLSDSGHK 310 320 330 340 350 360 TFKRRRSIIN WAFWRGSSTH LDNLPSSPTS PMPGQLFGIS LPNICENDNL PKPVLDMLFF 370 380 390 400 410 420 LNQKGPLTKG IFRQSANVKS CRELKEKLNS GVEVHLDCES IFVIASVLKD FLRNIPGSIF 430 440 450 460 470 480 SSDLYDHWVS VMDQGNDEEK INTVQRLLDQ LPRANVVLLR YLFGVLHNIE QHSSSNQMTA 490 500 510 520 530 540 FNLAVCVAPS ILWPPASSSP ELENEFTKKV SLLIQFLIEN CLRIFGEEIT SLFREVSVRC 550 560 570 580 590 600 DTRENASDIS CFQLNDSSYD SLENELNEDV DAPCSDLVKK LGQGSRSMDS VLTLSDYDLD 610 620 630 640 650 660 QPEVEGLLTL SDFDLAHSKD EDVQMKRPLE SKPVNILVYT KIPLRDHARA PSAMCTPSYL 670 680 690 700 710 720 STAAANAAKS LRRHRRCSEP SIDYLDSKLS YLREFYQKKL RKSSCDAILS QKDEDYLKQN 730 740 750 760 770 780 QPLQEEGKTC FKQSLVTGTD VSKKNATTQN TKKKSLSGSE GNHVKLFPKS KPVAISVASY 790 800 810 820 830 840 SPMSSQDHSK NQPFDVNTSG YSPPHTADAL KGPRTHRRCS EPNIEDQNRK LTYLRGIYSK 850 860 870 880 890 900 KQHKTSCEAG LLHGEEDYLK RHKSLQMEGQ KLINQSLVMG IEVGKSSATN QNTEKVLPPR 910 920 930 940 950 960 LNLCPRTSYS SLSSPGTSPS GSSVSSQDSA FSQISEHSVF TPTETSSPID CTFQAQRKRE 970 980 990 1000 1010 1020 DLSPDFSNAS HVSGMPGPSS GQACSRPAYT KKDTMEWHSQ MHSVTLHPST WLRNGVASLK 1030 1040 1050 1060 1070 1080 NWSLKKKAKA ARPEEEKIAS PKGPLEPPPH ASGVPEANSL QEEQKDLPLR AAEGLSPVQS 1090 1100 1110 1120 1130 1140 AQRCSSSPFQ DSERHCSSPF SLVESRLKLC MKSHEEIEPG SQSSSGSLPW ERASASSWTL 1150 1160 EDATSPDSGP TVVCDIEDRY LTKDI
	Isoform 3 (1c) [UniParc]. Checksum: 4A148F7B05DA3586	FASTA	1,168	130,485
	10 20 30 40 50 60 MSARERQPAL KKKMKTLAER RRSAPSLILD KALQKRPTTR DSPSASVDTC TFLSSLVCSN 70 80 90 100 110 120 RTLLIDGRAE LKRGLQRQER HLFLFNDLFV VAKIKYNNNF KIKNKIKLTD MWTASCVDEV 130 140 150 160 170 180 GEGNTNAMKS FVLGWPTVNF VATFSSPEQK DKWLSLLQRY INLEKEKDYP KSIPLKIFAK 190 200 210 220 230 240 DIGNCAYSKT ITVMNSDTAN EVINMSLPML GITGSERDYQ LWVNSGKEEA PYPLIGHEYP 250 260 270 280 290 300 YGIKMSHLRD SALLTPGSKD STTPFNLQEP FLMEQLPREM QCQFILKPSR LAAAQQLSDS 310 320 330 340 350 360 GHKTFKRRRS IINWAFWRGS STHLDNLPSS PTSPMPGQLF GISLPNICEN DNLPKPVLDM 370 380 390 400 410 420 LFFLNQKGPL TKGIFRQSAN VKSCRELKEK LNSGVEVHLD CESIFVIASV LKDFLRNIPG 430 440 450 460 470 480 SIFSSDLYDH WVSVMDQGND EEKINTVQRL LDQLPRANVV LLRYLFGVLH NIEQHSSSNQ 490 500 510 520 530 540 MTAFNLAVCV APSILWPPAS SSPELENEFT KKVSLLIQFL IENCLRIFGE EITSLFREVS 550 560 570 580 590 600 VRCDTRENAS DISCFQLNDS SYDSLENELN EDVDAPCSDL VKKLGQGSRS MDSVLTLSDY 610 620 630 640 650 660 DLDQPEVEGL LTLSDFDLAH SKDEDVQMKR PLESKPVNIL VYTKIPLRDH ARAPSAMCTP 670 680 690 700 710 720 SYLSTAAANA AKSLRRHRRC SEPSIDYLDS KLSYLREFYQ KKLRKSSCDA ILSQKDEDYL 730 740 750 760 770 780 KQNQPLQEEG KTCFKQSLVT GTDVSKKNAT TQNTKKKSLS GSEGNHVKLF PKSKPVAISV 790 800 810 820 830 840 ASYSPMSSQD HSKNQPFDVN TSGYSPPHTA DALKGPRTHR RCSEPNIEDQ NRKLTYLRGI 850 860 870 880 890 900 YSKKQHKTSC EAGLLHGEED YLKRHKSLQM EGQKLINQSL VMGIEVGKSS ATNQNTEKVL 910 920 930 940 950 960 PPRLNLCPRT SYSSLSSPGT SPSGSSVSSQ DSAFSQISEH SVFTPTETSS PIDCTFQAQR 970 980 990 1000 1010 1020 KREDLSPDFS NASHVSGMPG PSSGQACSRP AYTKKDTMEW HSQMHSVTLH PSTWLRNGVA 1030 1040 1050 1060 1070 1080 SLKNWSLKKK AKAARPEEEK IASPKGPLEP PPHASGVPEA NSLQEEQKDL PLRAAEGLSP 1090 1100 1110 1120 1130 1140 VQSAQRCSSS PFQDSERHCS SPFSLVESRL KLCMKSHEEI EPGSQSSSGS LPWERASASS 1150 1160 WTLEDATSPD SGPTVVCDIE DRYLTKDI
	Isoform 4 (1e) (1d) [UniParc]. Checksum: EA4FF49422FE282E	FASTA	1,155	128,960
	10 20 30 40 50 60 MKTLAERRRS APSLILDKAL QKRPTTRDSP SASVDTCTFL SSLVCSNRTL LIDGRAELKR 70 80 90 100 110 120 GLQRQERHLF LFNDLFVVAK IKYNNNFKIK NKIKLTDMWT ASCVDEVGEG NTNAMKSFVL 130 140 150 160 170 180 GWPTVNFVAT FSSPEQKDKW LSLLQRYINL EKEKDYPKSI PLKIFAKDIG NCAYSKTITV 190 200 210 220 230 240 MNSDTANEVI NMSLPMLGIT GSERDYQLWV NSGKEEAPYP LIGHEYPYGI KMSHLRDSAL 250 260 270 280 290 300 LTPGSKDSTT PFNLQEPFLM EQLPREMQCQ FILKPSRLAA AQQLSDSGHK TFKRRRSIIN 310 320 330 340 350 360 WAFWRGSSTH LDNLPSSPTS PMPGQLFGIS LPNICENDNL PKPVLDMLFF LNQKGPLTKG 370 380 390 400 410 420 IFRQSANVKS CRELKEKLNS GVEVHLDCES IFVIASVLKD FLRNIPGSIF SSDLYDHWVS 430 440 450 460 470 480 VMDQGNDEEK INTVQRLLDQ LPRANVVLLR YLFGVLHNIE QHSSSNQMTA FNLAVCVAPS 490 500 510 520 530 540 ILWPPASSSP ELENEFTKKV SLLIQFLIEN CLRIFGEEIT SLFREVSVRC DTRENASDIS 550 560 570 580 590 600 CFQLNDSSYD SLENELNEDV DAPCSDLVKK LGQGSRSMDS VLTLSDYDLD QPEVEGLLTL 610 620 630 640 650 660 SDFDLAHSKD EDVQMKRPLE SKPVNILVYT KIPLRDHARA PSAMCTPSYL STAAANAAKS 670 680 690 700 710 720 LRRHRRCSEP SIDYLDSKLS YLREFYQKKL RKSSCDAILS QKDEDYLKQN QPLQEEGKTC 730 740 750 760 770 780 FKQSLVTGTD VSKKNATTQN TKKKSLSGSE GNHVKLFPKS KPVAISVASY SPMSSQDHSK 790 800 810 820 830 840 NQPFDVNTSG YSPPHTADAL KGPRTHRRCS EPNIEDQNRK LTYLRGIYSK KQHKTSCEAG 850 860 870 880 890 900 LLHGEEDYLK RHKSLQMEGQ KLINQSLVMG IEVGKSSATN QNTEKVLPPR LNLCPRTSYS 910 920 930 940 950 960 SLSSPGTSPS GSSVSSQDSA FSQISEHSVF TPTETSSPID CTFQAQRKRE DLSPDFSNAS 970 980 990 1000 1010 1020 HVSGMPGPSS GQACSRPAYT KKDTMEWHSQ MHSVTLHPST WLRNGVASLK NWSLKKKAKA 1030 1040 1050 1060 1070 1080 ARPEEEKIAS PKGPLEPPPH ASGVPEANSL QEEQKDLPLR AAEGLSPVQS AQRCSSSPFQ 1090 1100 1110 1120 1130 1140 DSERHCSSPF SLVESRLKLC MKSHEEIEPG SQSSSGSLPW ERASASSWTL EDATSPDSGP 1150 TVVCDIEDRY LTKDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes." Kalla C., Nentwich H., Schlotter M., Mertens D., Wildenberger K., Doehner H., Stilgenbauer S., Lichter P. Genes Chromosomes Cancer 42:128-143(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, CHROMOSOMAL TRANSLOCATION WITH BRWD3.
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 436-1185 (ISOFORMS 1/2/3/4). Tissue: Testis.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 436-1185 (ISOFORMS 1/2/3/4), VARIANT ASP-632. Tissue: Testis.
[7]	"Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats." Katoh M., Katoh M. Int. J. Oncol. 23:1471-1476(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY496263 mRNA. Translation: AAS45466.1.
AY496264 mRNA. Translation: AAS45467.1.
AY496265 mRNA. Translation: AAS45468.1.
AY496266 mRNA. Translation: AAS45469.1.
AY496267 mRNA. Translation: AAS45470.1.
AB037812 mRNA. Translation: BAA92629.1. Different initiation.
EF444953 Genomic DNA. Translation: ACA05945.1.
EF444953 Genomic DNA. Translation: ACA05946.1.
CH471065 Genomic DNA. Translation: EAW67134.1.
AK292290 mRNA. Translation: BAF84979.1. Sequence problems.
BC039340 mRNA. Translation: AAH39340.1. Sequence problems.

IPI

IPI00012622.
IPI00478558.
IPI00844252.
IPI00844419.
IPI00844483.

PIR

C59436.

RefSeq

NP_001245344.1. NM_001258415.1.
NP_001245345.1. NM_001258416.1.
NP_001245346.1. NM_001258417.1.
NP_001245347.1. NM_001258418.1.
NP_065860.2. NM_020809.3.

UniGene

Hs.6136.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3MSX	X-ray	1.65	B	351-551	[»]

ProteinModelPortal

Q9P2F6.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9P2F6. 1 interaction.

PTM databases

PhosphoSite

Q9P2F6.

Polymorphism databases

DMDM

143458429.

Proteomic databases

PaxDb

Q9P2F6.

PRIDE

Q9P2F6.

Protocols and materials databases

DNASU

57569.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000260283; ENSP00000260283; ENSG00000137727.
ENST00000357139; ENSP00000349660; ENSG00000137727.
ENST00000524756; ENSP00000432076; ENSG00000137727.
ENST00000527598; ENSP00000431399; ENSG00000137727.
ENST00000528829; ENSP00000436319; ENSG00000137727.
ENST00000529591; ENSP00000437905; ENSG00000137727.
ENST00000533353; ENSP00000436522; ENSG00000137727.

GeneID

57569.

KEGG

hsa:57569.

UCSC

uc001pky.1. human.
uc001pkz.1. human.
uc001plb.2. human.

Organism-specific databases

CTD

57569.

GeneCards

GC11M110447.

H-InvDB

HIX0010100.

HGNC

HGNC:18357. ARHGAP20.

HPA

HPA038458.

MIM

609568. gene.

neXtProt

NX_Q9P2F6.

PharmGKB

PA134963885.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG271519.

HOVERGEN

HBG061748.

InParanoid

Q9P2F6.

OMA

INQSLVM.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

Q9P2F6.

CleanEx

HS_ARHGAP20.

Genevestigator

Q9P2F6.

Family and domain databases

Gene3D

1.10.555.10. 1 hit.
2.30.29.30. 1 hit.

InterPro

IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]

Pfam

PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]

SMART

SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]

SUPFAM

SSF48350. Rho_GAP. 1 hit.

PROSITE

PS50003. PH_DOMAIN. False negative.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

ProtoNet

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Other

EvolutionaryTrace

Q9P2F6.

GenomeRNAi

57569.

NextBio

64086.

SOURCE

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Entry information

Entry name

RHG20_HUMAN

Accession

Primary (citable) accession number: Q9P2F6
Secondary accession number(s): A8K8C5 , B0YIW7, B0YIW8, Q6RJU1, Q6RJU2, Q6RJU3, Q6RJU5, Q8IXS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.