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Protein

Storkhead-box protein 2

Gene

STOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • embryo development Source: UniProtKB
  • maternal placenta development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Storkhead-box protein 2
Gene namesi
Name:STOX2
Synonyms:KIAA1392
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25450. STOX2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670861.

Polymorphism and mutation databases

BioMutaiSTOX2.
DMDMi166223490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926Storkhead-box protein 2PRO_0000313629Add
BLAST

Proteomic databases

EPDiQ9P2F5.
MaxQBiQ9P2F5.
PaxDbiQ9P2F5.
PeptideAtlasiQ9P2F5.
PRIDEiQ9P2F5.

PTM databases

iPTMnetiQ9P2F5.
PhosphoSiteiQ9P2F5.

Expressioni

Gene expression databases

BgeeiQ9P2F5.
CleanExiHS_STOX2.
ExpressionAtlasiQ9P2F5. baseline and differential.
GenevisibleiQ9P2F5. HS.

Organism-specific databases

HPAiHPA049776.

Interactioni

Protein-protein interaction databases

BioGridi121295. 3 interactions.
IntActiQ9P2F5. 2 interactions.
STRINGi9606.ENSP00000311257.

Structurei

3D structure databases

ProteinModelPortaliQ9P2F5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3897. Eukaryota.
ENOG410ZJ97. LUCA.
GeneTreeiENSGT00520000055589.
HOGENOMiHOG000060142.
HOVERGENiHBG061105.
InParanoidiQ9P2F5.
OMAiAPREGCF.
OrthoDBiEOG7FFMQW.
PhylomeDBiQ9P2F5.
TreeFamiTF331863.

Family and domain databases

InterProiIPR019391. Storkhead-box_winged-helix.
[Graphical view]
PfamiPF10264. Stork_head. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKTRSTTLR RAWPSSDFSD RASDRMRSRS EKDYRLHKRF PAAFAPQASR
60 70 80 90 100
GYMTSGDVSP ISMSPISQSQ FIPLGEILCL AISAMNSARK PVTQEALMEH
110 120 130 140 150
LTTCFPGVPT PSQEILRHTL NTLVRERKIY PTPDGYFIVT PQTYFITPSL
160 170 180 190 200
IRTNSKWYHL DERIPDRSQC TSPQPGTITP SASGCVRERT LPRNHCDSCH
210 220 230 240 250
CCREDVHSTH APTLQRKSAK DCKDPYCPPS LCQVPPTEKS KSTVNFSYKT
260 270 280 290 300
ETLSKPKDSE KQSKKFGLKL FRLSFKKDKT KQLANFSAQF PPEEWPLRDE
310 320 330 340 350
DTPATIPREV EMEIIRRINP DLTVENVMRH TALMKKLEEE KAQRSKAGSS
360 370 380 390 400
AHHSGRSKKS RTHRKSHGKS RSHSKTRVSK GDPSDGSHLD IPAEREYDFC
410 420 430 440 450
DPLTRVPREG CFIIEHKGDN FIMHSNTNVL ESHFPMTPEW DVSGELAKRR
460 470 480 490 500
TEMPFPEPSR GSSHSKVHRS HSHTQDRRSR NERSNKAKER SRSMDNSKGP
510 520 530 540 550
LGASSLGTPE DLAEGCSQDD QTPSQSYIDD STLRPAQTVS LQRAHISSTS
560 570 580 590 600
YKEVCIPEIV SGSKEPSSAC SLLEPGKPPE SLPSYGELNS CPTKTATDDY
610 620 630 640 650
FQCNTSSETV LTAPSPLGKN KEDHDTLTLA EGVKKLSPSD RQVPHSSREP
660 670 680 690 700
VGHKEESPKG PGGGPAASGG VAEGIANGRL VQHHGAEPSS LDKRKEIFSK
710 720 730 740 750
DTLFKPLHST LSVNSYHKSS LSLLKSHPKT PADTLPGRCE KLEPSLGTSA
760 770 780 790 800
AQAMPASQRQ QESGGNQEAS FDYYNVSDDD DSEEGANKNT EEEKNREDVG
810 820 830 840 850
TMQWLLEREK ERDLQRKFEK NLTLLAPKET DSSSNQRATH SARLDSMDSS
860 870 880 890 900
SITVDSGFNS PRTRESLASN TSSIVESNRR QNPALSPAHG GAGPAFNFRA
910 920
SAEPPTNEAE KLQKPSNCLQ ASVTSV
Length:926
Mass (Da):102,671
Last modified:January 15, 2008 - v2
Checksum:iC387E93B35EC7A57
GO
Isoform 2 (identifier: Q9P2F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-863: T → N
     864-926: Missing.

Show »
Length:863
Mass (Da):96,123
Checksum:i9C444139BFA8AD58
GO

Sequence cautioni

The sequence BAA92630.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei863 – 8631T → N in isoform 2. 1 PublicationVSP_030072
Alternative sequencei864 – 92663Missing in isoform 2. 1 PublicationVSP_030073Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037813 mRNA. Translation: BAA92630.1. Different initiation.
AK289840 mRNA. Translation: BAF82529.1.
CH471056 Genomic DNA. Translation: EAX04684.1.
BC146754 mRNA. Translation: AAI46755.1.
AL390216 mRNA. Translation: CAB99230.1.
CCDSiCCDS47167.1. [Q9P2F5-1]
PIRiT51887.
RefSeqiNP_064610.1. NM_020225.2. [Q9P2F5-1]
UniGeneiHs.21958.
Hs.696657.

Genome annotation databases

EnsembliENST00000308497; ENSP00000311257; ENSG00000173320. [Q9P2F5-1]
GeneIDi56977.
KEGGihsa:56977.
UCSCiuc003ivz.2. human. [Q9P2F5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037813 mRNA. Translation: BAA92630.1. Different initiation.
AK289840 mRNA. Translation: BAF82529.1.
CH471056 Genomic DNA. Translation: EAX04684.1.
BC146754 mRNA. Translation: AAI46755.1.
AL390216 mRNA. Translation: CAB99230.1.
CCDSiCCDS47167.1. [Q9P2F5-1]
PIRiT51887.
RefSeqiNP_064610.1. NM_020225.2. [Q9P2F5-1]
UniGeneiHs.21958.
Hs.696657.

3D structure databases

ProteinModelPortaliQ9P2F5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121295. 3 interactions.
IntActiQ9P2F5. 2 interactions.
STRINGi9606.ENSP00000311257.

PTM databases

iPTMnetiQ9P2F5.
PhosphoSiteiQ9P2F5.

Polymorphism and mutation databases

BioMutaiSTOX2.
DMDMi166223490.

Proteomic databases

EPDiQ9P2F5.
MaxQBiQ9P2F5.
PaxDbiQ9P2F5.
PeptideAtlasiQ9P2F5.
PRIDEiQ9P2F5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308497; ENSP00000311257; ENSG00000173320. [Q9P2F5-1]
GeneIDi56977.
KEGGihsa:56977.
UCSCiuc003ivz.2. human. [Q9P2F5-1]

Organism-specific databases

CTDi56977.
GeneCardsiSTOX2.
HGNCiHGNC:25450. STOX2.
HPAiHPA049776.
neXtProtiNX_Q9P2F5.
PharmGKBiPA142670861.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3897. Eukaryota.
ENOG410ZJ97. LUCA.
GeneTreeiENSGT00520000055589.
HOGENOMiHOG000060142.
HOVERGENiHBG061105.
InParanoidiQ9P2F5.
OMAiAPREGCF.
OrthoDBiEOG7FFMQW.
PhylomeDBiQ9P2F5.
TreeFamiTF331863.

Miscellaneous databases

ChiTaRSiSTOX2. human.
GenomeRNAii56977.
PROiQ9P2F5.

Gene expression databases

BgeeiQ9P2F5.
CleanExiHS_STOX2.
ExpressionAtlasiQ9P2F5. baseline and differential.
GenevisibleiQ9P2F5. HS.

Family and domain databases

InterProiIPR019391. Storkhead-box_winged-helix.
[Graphical view]
PfamiPF10264. Stork_head. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-863 (ISOFORM 2).
    Tissue: Melanoma.

Entry informationi

Entry nameiSTOX2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2F5
Secondary accession number(s): A6H8U4, Q9NPS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.