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Protein

Ribosome-binding protein 1

Gene

RRBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • receptor activity Source: ProtInc

GO - Biological processi

  • osteoblast differentiation Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • translation Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125844-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-binding protein 1
Alternative name(s):
180 kDa ribosome receptor homolog
Short name:
RRp
ES/130-related protein
Ribosome receptor protein
Gene namesi
Name:RRBP1
Synonyms:KIAA1398
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:10448. RRBP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7LumenalSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 1410CytoplasmicSequence analysisAdd BLAST1382

GO - Cellular componenti

  • endoplasmic reticulum Source: HPA
  • integral component of endoplasmic reticulum membrane Source: GO_Central
  • membrane Source: UniProtKB
  • ribosome Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6238.
OpenTargetsiENSG00000125844.
PharmGKBiPA34863.

Polymorphism and mutation databases

BioMutaiRRBP1.
DMDMi23822112.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974411 – 1410Ribosome-binding protein 1Add BLAST1410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei225PhosphothreonineCombined sources1
Modified residuei235PhosphothreonineCombined sources1
Modified residuei245PhosphothreonineCombined sources1
Modified residuei255PhosphothreonineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei615PhosphoserineCombined sources1
Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei900PhosphoserineCombined sources1
Modified residuei932N6-acetyllysineBy similarity1
Modified residuei959PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1
Modified residuei1276PhosphoserineCombined sources1
Modified residuei1277PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9P2E9.
MaxQBiQ9P2E9.
PaxDbiQ9P2E9.
PeptideAtlasiQ9P2E9.
PRIDEiQ9P2E9.

PTM databases

iPTMnetiQ9P2E9.
PhosphoSitePlusiQ9P2E9.
SwissPalmiQ9P2E9.

Expressioni

Gene expression databases

BgeeiENSG00000125844.
ExpressionAtlasiQ9P2E9. baseline and differential.
GenevisibleiQ9P2E9. HS.

Organism-specific databases

HPAiHPA009026.
HPA011924.

Interactioni

Protein-protein interaction databases

BioGridi112152. 49 interactors.
IntActiQ9P2E9. 21 interactors.
MINTiMINT-5006662.
STRINGi9606.ENSP00000354045.

Structurei

3D structure databases

ProteinModelPortaliQ9P2E9.
SMRiQ9P2E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati197 – 206110
Repeati207 – 216210
Repeati217 – 226310
Repeati227 – 236410
Repeati237 – 246510
Repeati247 – 256610
Repeati257 – 266710
Repeati267 – 276810
Repeati277 – 286910
Repeati287 – 2961010
Repeati297 – 3061110
Repeati307 – 3161210
Repeati317 – 3261310
Repeati327 – 3361410
Repeati337 – 3461510
Repeati347 – 3561610
Repeati357 – 3661710
Repeati367 – 3761810
Repeati377 – 3861910
Repeati387 – 3962010
Repeati397 – 4062110
Repeati407 – 4162210
Repeati417 – 4262310
Repeati427 – 4362410
Repeati437 – 4462510
Repeati447 – 4562610
Repeati457 – 4662710
Repeati467 – 4762810
Repeati477 – 4862910
Repeati487 – 4963010
Repeati497 – 5063110
Repeati507 – 5163210
Repeati517 – 5263310
Repeati527 – 53434; approximate8
Repeati535 – 5443510
Repeati545 – 55436; approximate10
Repeati555 – 5643710
Repeati565 – 5743810
Repeati575 – 58439; approximate10
Repeati585 – 5944010
Repeati595 – 6044110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 60441 X 10 AA approximate tandem repeats of [TN]-Q-[GSA]-[KRQT]-K-[ATGSV]-[ED]-[GTAS]-[ATIS]-[PQTAS]Add BLAST408

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFNK. Eukaryota.
ENOG410XY8H. LUCA.
GeneTreeiENSGT00530000063895.
HOVERGENiHBG061483.
InParanoidiQ9P2E9.
KOiK14000.
PhylomeDBiQ9P2E9.
TreeFamiTF333579.

Family and domain databases

InterProiIPR007794. Rib_rcpt_KP.
[Graphical view]
PfamiPF05104. Rib_recp_KP_reg. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Additional isoforms are probable deriving from alternative splicing in the repeat region.
Isoform 3 (identifier: Q9P2E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA
60 70 80 90 100
KTHHQKVEKK KKEKTVEKKG KTKKKEEKPN GKIPDHDPAP NVTVLLREPV
110 120 130 140 150
RAPAVAVAPT PVQPPIIVAP VATVPAMPQE KLASSPKDKK KKEKKVAKVE
160 170 180 190 200
PAVSSVVNSI QVLTSKAAIL ETAPKEVPMV VVPPVGAKGN TPATGTTQGK
210 220 230 240 250
KAEGTQNQSK KAEGAPNQGR KAEGTPNQGK KTEGTPNQGK KAEGTPNQGK
260 270 280 290 300
KAEGTPNQGK KAEGAQNQGK KVDTTPNQGK KVEGAPTQGR KAEGAQNQAK
310 320 330 340 350
KVEGAQNQGK KAEGAQNQGK KGEGAQNQGK KAEGAQNQGK KAEGAQNQGK
360 370 380 390 400
KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KSEGAQNQGK KVEGAQNQGK
410 420 430 440 450
KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK
460 470 480 490 500
KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK KAEGAQNQGK KAEGAQNQGK
510 520 530 540 550
KAEGAQNQGQ KGEGAQNQGK KTEGAQGKKA ERSPNQGKKG EGAPIQGKKA
560 570 580 590 600
DSVANQGTKV EGITNQGKKA EGSPSEGKKA EGSPNQGKKA DAAANQGKKT
610 620 630 640 650
ESASVQGRNT DVAQSPEAPK QEAPAKKKSG SKKKGEPGPP DADGPLYLPY
660 670 680 690 700
KTLVSTVGSM VFNEGEAQRL IEILSEKAGI IQDTWHKATQ KGDPVAILKR
710 720 730 740 750
QLEEKEKLLA TEQEDAAVAK SKLRELNKEM AAEKAKAAAG EAKVKKQLVA
760 770 780 790 800
REQEITAVQA RMQASYREHV KEVQQLQGKI RTLQEQLENG PNTQLARLQQ
810 820 830 840 850
ENSILRDALN QATSQVESKQ NAELAKLRQE LSKVSKELVE KSEAVRQDEQ
860 870 880 890 900
QRKALEAKAA AFEKQVLQLQ ASHRESEEAL QKRLDEVSRE LCHTQSSHAS
910 920 930 940 950
LRADAEKAQE QQQQMAELHS KLQSSEAEVR SKCEELSGLH GQLQEARAEN
960 970 980 990 1000
SQLTERIRSI EALLEAGQAR DAQDVQASQA EADQQQTRLK ELESQVSGLE
1010 1020 1030 1040 1050
KEAIELREAV EQQKVKNNDL REKNWKAMEA LATAEQACKE KLLSLTQAKE
1060 1070 1080 1090 1100
ESEKQLCLIE AQTMEALLAL LPELSVLAQQ NYTEWLQDLK EKGPTLLKHP
1110 1120 1130 1140 1150
PAPAEPSSDL ASKLREAEET QSTLQAECDQ YRSILAETEG MLRDLQKSVE
1160 1170 1180 1190 1200
EEEQVWRAKV GAAEEELQKS RVTVKHLEEI VEKLKGELES SDQVREHTSH
1210 1220 1230 1240 1250
LEAELEKHMA AASAECQNYA KEVAGLRQLL LESQSQLDAA KSEAQKQSDE
1260 1270 1280 1290 1300
LALVRQQLSE MKSHVEDGDI AGAPASSPEA PPAEQDPVQL KTQLEWTEAI
1310 1320 1330 1340 1350
LEDEQTQRQK LTAEFEEAQT SACRLQEELE KLRTAGPLES SETEEASQLK
1360 1370 1380 1390 1400
ERLEKEKKLT SDLGRAATRL QELLKTTQEQ LAREKDTVKK LQEQLEKAED
1410
GSSSKEGTSV
Length:1,410
Mass (Da):152,472
Last modified:October 10, 2002 - v4
Checksum:iB83FD15D002D366C
GO
Isoform 1 (identifier: Q9P2E9-2) [UniParc]FASTAAdd to basket
Also known as: p180

The sequence of this isoform differs from the canonical sequence as follows:
     635-637: Missing.

Show »
Length:1,407
Mass (Da):152,189
Checksum:i7A0FEF5AD86EF0E4
GO
Isoform 2 (identifier: Q9P2E9-3) [UniParc]FASTAAdd to basket
Also known as: ES130

The sequence of this isoform differs from the canonical sequence as follows:
     177-606: Missing.
     635-637: Missing.

Show »
Length:977
Mass (Da):108,632
Checksum:i63B7644AAA334537
GO

Sequence cautioni

The sequence BAA92636 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti322G → A in AAC25978 (PubMed:9628588).Curated1
Sequence conflicti345A → G in AAC25978 (PubMed:9628588).Curated1
Sequence conflicti350K → KKTEEAQKQGKKAEGAQIQG KKNEGAQTQGKKAEGAQNQG KKNEGAQTQGKKAEGAQTQG KKADGAQNQGKKAEGAQNQG KKAEGAQNQGKKAEGAQNQG KKADGAQNQGKKAEGAQNQG KKAEGAQNQGT in AAC25978 (PubMed:9628588).Curated1
Sequence conflicti382S → A in AAC25978 (PubMed:9628588).Curated1
Sequence conflicti382S → A in BAA92636 (PubMed:10718198).Curated1
Sequence conflicti392V → A in AAC25978 (PubMed:9628588).Curated1
Sequence conflicti448Q → QDKKAEGAQNQGRKAEGAQN QGRKAEGAQNQGKKAEGAPN QGKKAEGAPNQGKKAEGTPN QGKKAEGTPNQGKKAEGTPN QGKKAEGAQNQGKKAEGAQN QGKKAEGTPNQGKKAEGAQN QGKKAEGAQNQGKKAEGAQN QGKKAEGAQNQ (PubMed:10718198).Curated1
Sequence conflicti1043L → H in AAC25977 (PubMed:9628588).Curated1
Sequence conflicti1043L → H (PubMed:10718198).Curated1
Sequence conflicti1043L → H (PubMed:17974005).Curated1
Sequence conflicti1043L → H in AAH00099 (PubMed:15489334).Curated1
Sequence conflicti1199S → L (PubMed:10718198).Curated1
Sequence conflicti1199S → L (PubMed:17974005).Curated1
Sequence conflicti1199S → L in AAH00099 (PubMed:15489334).Curated1
Sequence conflicti1312T → M in AAC25977 (PubMed:9628588).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0569821324R → L.Corresponds to variant rs1132274dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003949177 – 606Missing in isoform 2. 1 PublicationAdd BLAST430
Alternative sequenceiVSP_003950635 – 637Missing in isoform 1 and isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006751 mRNA. Translation: AAC25977.1.
AF007575 mRNA. Translation: AAC25978.1.
AB037819 mRNA. Translation: BAA92636.2. Different initiation.
AL132765 Genomic DNA. Translation: CAC10587.1.
AL132765 Genomic DNA. Translation: CAH74034.1.
AL833822 mRNA. Translation: CAD38684.1.
BC000099 mRNA. Translation: AAH00099.4.
CCDSiCCDS13128.1. [Q9P2E9-3]
RefSeqiNP_001036041.1. NM_001042576.1.
NP_004578.2. NM_004587.2.
UniGeneiHs.472213.

Genome annotation databases

EnsembliENST00000360807; ENSP00000354045; ENSG00000125844. [Q9P2E9-3]
ENST00000377807; ENSP00000367038; ENSG00000125844. [Q9P2E9-3]
GeneIDi6238.
KEGGihsa:6238.
UCSCiuc002wpv.1. human. [Q9P2E9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006751 mRNA. Translation: AAC25977.1.
AF007575 mRNA. Translation: AAC25978.1.
AB037819 mRNA. Translation: BAA92636.2. Different initiation.
AL132765 Genomic DNA. Translation: CAC10587.1.
AL132765 Genomic DNA. Translation: CAH74034.1.
AL833822 mRNA. Translation: CAD38684.1.
BC000099 mRNA. Translation: AAH00099.4.
CCDSiCCDS13128.1. [Q9P2E9-3]
RefSeqiNP_001036041.1. NM_001042576.1.
NP_004578.2. NM_004587.2.
UniGeneiHs.472213.

3D structure databases

ProteinModelPortaliQ9P2E9.
SMRiQ9P2E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112152. 49 interactors.
IntActiQ9P2E9. 21 interactors.
MINTiMINT-5006662.
STRINGi9606.ENSP00000354045.

PTM databases

iPTMnetiQ9P2E9.
PhosphoSitePlusiQ9P2E9.
SwissPalmiQ9P2E9.

Polymorphism and mutation databases

BioMutaiRRBP1.
DMDMi23822112.

Proteomic databases

EPDiQ9P2E9.
MaxQBiQ9P2E9.
PaxDbiQ9P2E9.
PeptideAtlasiQ9P2E9.
PRIDEiQ9P2E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360807; ENSP00000354045; ENSG00000125844. [Q9P2E9-3]
ENST00000377807; ENSP00000367038; ENSG00000125844. [Q9P2E9-3]
GeneIDi6238.
KEGGihsa:6238.
UCSCiuc002wpv.1. human. [Q9P2E9-1]

Organism-specific databases

CTDi6238.
DisGeNETi6238.
GeneCardsiRRBP1.
HGNCiHGNC:10448. RRBP1.
HPAiHPA009026.
HPA011924.
MIMi601418. gene.
neXtProtiNX_Q9P2E9.
OpenTargetsiENSG00000125844.
PharmGKBiPA34863.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFNK. Eukaryota.
ENOG410XY8H. LUCA.
GeneTreeiENSGT00530000063895.
HOVERGENiHBG061483.
InParanoidiQ9P2E9.
KOiK14000.
PhylomeDBiQ9P2E9.
TreeFamiTF333579.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125844-MONOMER.

Miscellaneous databases

ChiTaRSiRRBP1. human.
GeneWikiiRRBP1.
GenomeRNAii6238.
PROiQ9P2E9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125844.
ExpressionAtlasiQ9P2E9. baseline and differential.
GenevisibleiQ9P2E9. HS.

Family and domain databases

InterProiIPR007794. Rib_rcpt_KP.
[Graphical view]
PfamiPF05104. Rib_recp_KP_reg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2E9
Secondary accession number(s): A2A2S6
, A6NCN6, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 2, 2016
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.