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Q9P2E7

- PCD10_HUMAN

UniProt

Q9P2E7 - PCD10_HUMAN

Protein

Protocadherin-10

Gene

PCDH10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin-10
    Gene namesi
    Name:PCDH10
    Synonyms:KIAA1400
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:13404. PCDH10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32995.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 10401022Protocadherin-10PRO_0000003995Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9P2E7.
    PRIDEiQ9P2E7.

    PTM databases

    PhosphoSiteiQ9P2E7.

    Expressioni

    Tissue specificityi

    Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.1 Publication

    Gene expression databases

    ArrayExpressiQ9P2E7.
    BgeeiQ9P2E7.
    CleanExiHS_PCDH10.
    GenevestigatoriQ9P2E7.

    Organism-specific databases

    HPAiHPA011220.

    Interactioni

    Protein-protein interaction databases

    BioGridi121628. 3 interactions.
    IntActiQ9P2E7. 6 interactions.
    STRINGi9606.ENSP00000264360.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2E7.
    SMRiQ9P2E7. Positions 18-680.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 715697ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini737 – 1040304CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei716 – 73621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 122104Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini123 – 250128Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini251 – 358108Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini359 – 463105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini464 – 574111Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini582 – 690109Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi751 – 77121Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274463.
    HOGENOMiHOG000220893.
    HOVERGENiHBG054878.
    KOiK16499.
    OMAiYKPPYLS.
    OrthoDBiEOG7J445X.
    PhylomeDBiQ9P2E7.
    TreeFamiTF352008.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 4 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2E7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIVLLLFALL WMVEGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA     50
    RGFQTVPNSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE 100
    NPLELFQVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD 150
    VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV 200
    LTAVDGGGGG GVGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF 250
    DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL 300
    FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD 350
    ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD 400
    VPFRLKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ 450
    VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAQLAY 500
    SILECQIQGM SVFTYVSINS ENGYLYALRS FDYEQLKDFS FQVEARDAGS 550
    PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL 600
    TRVAAVDADD GENARLTYSI VRGNEMNLFR MDWRTGELRT ARRVPAKRDP 650
    QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG SGGGGSGEHQ 700
    RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT 750
    CLASDCCLCC CCCGGGGSTC CGRQARARKK KLSKSDIMLV QSSNVPSNPA 800
    QVPIEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDTEH 850
    NPCGAIVTGY TDQQPDIISN GSILSNETKH QRAELSYLVD RPRRVNSSAF 900
    QEADIVSSKD SGHGDSEQGD SDHDATNRAQ SAGMDLFSNC TEECKALGHS 950
    DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFETP EAQPGAERSF 1000
    STFGKEKALH STLERKELDG LLTNTRAPYK PPYLTRKRIC 1040
    Length:1,040
    Mass (Da):112,936
    Last modified:January 16, 2004 - v2
    Checksum:iDE53F8B1A7198F85
    GO
    Isoform 2 (identifier: Q9P2E7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         878-896: TKHQRAELSYLVDRPRRVN → VRLKRKDHHLSSPPSESLL
         897-1040: Missing.

    Show »
    Length:896
    Mass (Da):97,002
    Checksum:i2FB57D0B9C754C65
    GO

    Sequence cautioni

    The sequence BAA92638.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei878 – 89619TKHQR…PRRVN → VRLKRKDHHLSSPPSESLL in isoform 2. 2 PublicationsVSP_054404Add
    BLAST
    Alternative sequencei897 – 1040144Missing in isoform 2. 2 PublicationsVSP_054405Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY013874 mRNA. Translation: AAK21987.1.
    AB037821 mRNA. Translation: BAA92638.1. Different initiation.
    AK314377 mRNA. Translation: BAG37004.1.
    AC105383 Genomic DNA. Translation: AAY41018.1.
    CH471056 Genomic DNA. Translation: EAX05151.1.
    CH471056 Genomic DNA. Translation: EAX05152.1.
    CCDSiCCDS34063.1. [Q9P2E7-1]
    RefSeqiNP_065866.1. NM_020815.1. [Q9P2E7-2]
    NP_116586.1. NM_032961.1. [Q9P2E7-1]
    UniGeneiHs.192859.

    Genome annotation databases

    EnsembliENST00000264360; ENSP00000264360; ENSG00000138650. [Q9P2E7-1]
    GeneIDi57575.
    KEGGihsa:57575.
    UCSCiuc003igz.3. human.
    uc003iha.3. human. [Q9P2E7-1]

    Polymorphism databases

    DMDMi41017507.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY013874 mRNA. Translation: AAK21987.1 .
    AB037821 mRNA. Translation: BAA92638.1 . Different initiation.
    AK314377 mRNA. Translation: BAG37004.1 .
    AC105383 Genomic DNA. Translation: AAY41018.1 .
    CH471056 Genomic DNA. Translation: EAX05151.1 .
    CH471056 Genomic DNA. Translation: EAX05152.1 .
    CCDSi CCDS34063.1. [Q9P2E7-1 ]
    RefSeqi NP_065866.1. NM_020815.1. [Q9P2E7-2 ]
    NP_116586.1. NM_032961.1. [Q9P2E7-1 ]
    UniGenei Hs.192859.

    3D structure databases

    ProteinModelPortali Q9P2E7.
    SMRi Q9P2E7. Positions 18-680.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121628. 3 interactions.
    IntActi Q9P2E7. 6 interactions.
    STRINGi 9606.ENSP00000264360.

    PTM databases

    PhosphoSitei Q9P2E7.

    Polymorphism databases

    DMDMi 41017507.

    Proteomic databases

    PaxDbi Q9P2E7.
    PRIDEi Q9P2E7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264360 ; ENSP00000264360 ; ENSG00000138650 . [Q9P2E7-1 ]
    GeneIDi 57575.
    KEGGi hsa:57575.
    UCSCi uc003igz.3. human.
    uc003iha.3. human. [Q9P2E7-1 ]

    Organism-specific databases

    CTDi 57575.
    GeneCardsi GC04P134070.
    HGNCi HGNC:13404. PCDH10.
    HPAi HPA011220.
    MIMi 608286. gene.
    neXtProti NX_Q9P2E7.
    PharmGKBi PA32995.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274463.
    HOGENOMi HOG000220893.
    HOVERGENi HBG054878.
    KOi K16499.
    OMAi YKPPYLS.
    OrthoDBi EOG7J445X.
    PhylomeDBi Q9P2E7.
    TreeFami TF352008.

    Miscellaneous databases

    ChiTaRSi PCDH10. human.
    GeneWikii PCDH10.
    GenomeRNAii 57575.
    NextBioi 64113.
    PROi Q9P2E7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2E7.
    Bgeei Q9P2E7.
    CleanExi HS_PCDH10.
    Genevestigatori Q9P2E7.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 4 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
      Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
      Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hippocampus.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Identification and characterization of three members of a novel subclass of protocadherins."
      Wolverton T., Lalande M.
      Genomics 76:66-72(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE STRUCTURE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPCD10_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2E7
    Secondary accession number(s): Q4W5F6, Q96SF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3