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Q9P2E7

- PCD10_HUMAN

UniProt

Q9P2E7 - PCD10_HUMAN

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Protein

Protocadherin-10

Gene

PCDH10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-10
Gene namesi
Name:PCDH10
Synonyms:KIAA1400
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:13404. PCDH10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 715697ExtracellularSequence AnalysisAdd
BLAST
Transmembranei716 – 73621HelicalSequence AnalysisAdd
BLAST
Topological domaini737 – 1040304CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 10401022Protocadherin-10PRO_0000003995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9P2E7.
PRIDEiQ9P2E7.

PTM databases

PhosphoSiteiQ9P2E7.

Expressioni

Tissue specificityi

Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.1 Publication

Gene expression databases

BgeeiQ9P2E7.
CleanExiHS_PCDH10.
ExpressionAtlasiQ9P2E7. baseline and differential.
GenevestigatoriQ9P2E7.

Organism-specific databases

HPAiHPA011220.

Interactioni

Protein-protein interaction databases

BioGridi121628. 3 interactions.
IntActiQ9P2E7. 6 interactions.
STRINGi9606.ENSP00000264360.

Structurei

3D structure databases

ProteinModelPortaliQ9P2E7.
SMRiQ9P2E7. Positions 18-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 122104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini123 – 250128Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini251 – 358108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini359 – 463105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini464 – 574111Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini582 – 690109Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi751 – 77121Cys-richAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274463.
GeneTreeiENSGT00760000118847.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ9P2E7.
KOiK16499.
OMAiYKPPYLS.
OrthoDBiEOG7J445X.
PhylomeDBiQ9P2E7.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P2E7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIVLLLFALL WMVEGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA
60 70 80 90 100
RGFQTVPNSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE
110 120 130 140 150
NPLELFQVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD
160 170 180 190 200
VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV
210 220 230 240 250
LTAVDGGGGG GVGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF
260 270 280 290 300
DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL
310 320 330 340 350
FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD
360 370 380 390 400
ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD
410 420 430 440 450
VPFRLKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ
460 470 480 490 500
VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAQLAY
510 520 530 540 550
SILECQIQGM SVFTYVSINS ENGYLYALRS FDYEQLKDFS FQVEARDAGS
560 570 580 590 600
PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL
610 620 630 640 650
TRVAAVDADD GENARLTYSI VRGNEMNLFR MDWRTGELRT ARRVPAKRDP
660 670 680 690 700
QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG SGGGGSGEHQ
710 720 730 740 750
RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT
760 770 780 790 800
CLASDCCLCC CCCGGGGSTC CGRQARARKK KLSKSDIMLV QSSNVPSNPA
810 820 830 840 850
QVPIEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDTEH
860 870 880 890 900
NPCGAIVTGY TDQQPDIISN GSILSNETKH QRAELSYLVD RPRRVNSSAF
910 920 930 940 950
QEADIVSSKD SGHGDSEQGD SDHDATNRAQ SAGMDLFSNC TEECKALGHS
960 970 980 990 1000
DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFETP EAQPGAERSF
1010 1020 1030 1040
STFGKEKALH STLERKELDG LLTNTRAPYK PPYLTRKRIC
Length:1,040
Mass (Da):112,936
Last modified:January 16, 2004 - v2
Checksum:iDE53F8B1A7198F85
GO
Isoform 2 (identifier: Q9P2E7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     878-896: TKHQRAELSYLVDRPRRVN → VRLKRKDHHLSSPPSESLL
     897-1040: Missing.

Show »
Length:896
Mass (Da):97,002
Checksum:i2FB57D0B9C754C65
GO

Sequence cautioni

The sequence BAA92638.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei878 – 89619TKHQR…PRRVN → VRLKRKDHHLSSPPSESLL in isoform 2. 2 PublicationsVSP_054404Add
BLAST
Alternative sequencei897 – 1040144Missing in isoform 2. 2 PublicationsVSP_054405Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013874 mRNA. Translation: AAK21987.1.
AB037821 mRNA. Translation: BAA92638.1. Different initiation.
AK314377 mRNA. Translation: BAG37004.1.
AC105383 Genomic DNA. Translation: AAY41018.1.
CH471056 Genomic DNA. Translation: EAX05151.1.
CH471056 Genomic DNA. Translation: EAX05152.1.
CCDSiCCDS34063.1. [Q9P2E7-1]
CCDS75192.1. [Q9P2E7-2]
RefSeqiNP_065866.1. NM_020815.1. [Q9P2E7-2]
NP_116586.1. NM_032961.1. [Q9P2E7-1]
UniGeneiHs.192859.

Genome annotation databases

EnsembliENST00000264360; ENSP00000264360; ENSG00000138650. [Q9P2E7-1]
ENST00000618019; ENSP00000480512; ENSG00000138650. [Q9P2E7-2]
GeneIDi57575.
KEGGihsa:57575.
UCSCiuc003igz.3. human.
uc003iha.3. human. [Q9P2E7-1]

Polymorphism databases

DMDMi41017507.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013874 mRNA. Translation: AAK21987.1 .
AB037821 mRNA. Translation: BAA92638.1 . Different initiation.
AK314377 mRNA. Translation: BAG37004.1 .
AC105383 Genomic DNA. Translation: AAY41018.1 .
CH471056 Genomic DNA. Translation: EAX05151.1 .
CH471056 Genomic DNA. Translation: EAX05152.1 .
CCDSi CCDS34063.1. [Q9P2E7-1 ]
CCDS75192.1. [Q9P2E7-2 ]
RefSeqi NP_065866.1. NM_020815.1. [Q9P2E7-2 ]
NP_116586.1. NM_032961.1. [Q9P2E7-1 ]
UniGenei Hs.192859.

3D structure databases

ProteinModelPortali Q9P2E7.
SMRi Q9P2E7. Positions 18-680.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121628. 3 interactions.
IntActi Q9P2E7. 6 interactions.
STRINGi 9606.ENSP00000264360.

PTM databases

PhosphoSitei Q9P2E7.

Polymorphism databases

DMDMi 41017507.

Proteomic databases

PaxDbi Q9P2E7.
PRIDEi Q9P2E7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264360 ; ENSP00000264360 ; ENSG00000138650 . [Q9P2E7-1 ]
ENST00000618019 ; ENSP00000480512 ; ENSG00000138650 . [Q9P2E7-2 ]
GeneIDi 57575.
KEGGi hsa:57575.
UCSCi uc003igz.3. human.
uc003iha.3. human. [Q9P2E7-1 ]

Organism-specific databases

CTDi 57575.
GeneCardsi GC04P134070.
HGNCi HGNC:13404. PCDH10.
HPAi HPA011220.
MIMi 608286. gene.
neXtProti NX_Q9P2E7.
PharmGKBi PA32995.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274463.
GeneTreei ENSGT00760000118847.
HOGENOMi HOG000220893.
HOVERGENi HBG054878.
InParanoidi Q9P2E7.
KOi K16499.
OMAi YKPPYLS.
OrthoDBi EOG7J445X.
PhylomeDBi Q9P2E7.
TreeFami TF352008.

Miscellaneous databases

ChiTaRSi PCDH10. human.
GeneWikii PCDH10.
GenomeRNAii 57575.
NextBioi 64113.
PROi Q9P2E7.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2E7.
CleanExi HS_PCDH10.
ExpressionAtlasi Q9P2E7. baseline and differential.
Genevestigatori Q9P2E7.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
    Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
    Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Identification and characterization of three members of a novel subclass of protocadherins."
    Wolverton T., Lalande M.
    Genomics 76:66-72(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPCD10_HUMAN
AccessioniPrimary (citable) accession number: Q9P2E7
Secondary accession number(s): Q4W5F6, Q96SF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 26, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3