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Protein

NFX1-type zinc finger-containing protein 1

Gene

ZNFX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1298 – 1320NF-X1-type 1Add BLAST23
Zinc fingeri1330 – 1346NF-X1-type 2Add BLAST17
Zinc fingeri1382 – 1400NF-X1-type 3Add BLAST19
Zinc fingeri1441 – 1463NF-X1-type 4Add BLAST23
Zinc fingeri1471 – 1488NF-X1-type 5Add BLAST18
Zinc fingeri1546 – 1564NF-X1-type 6Add BLAST19

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NFX1-type zinc finger-containing protein 1
Gene namesi
Name:ZNFX1
Synonyms:KIAA1404
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:29271. ZNFX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi57169.
OpenTargetsiENSG00000124201.
PharmGKBiPA143485687.

Polymorphism and mutation databases

BioMutaiZNFX1.
DMDMi23821814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507951 – 1918NFX1-type zinc finger-containing protein 1Add BLAST1918

Proteomic databases

EPDiQ9P2E3.
MaxQBiQ9P2E3.
PaxDbiQ9P2E3.
PeptideAtlasiQ9P2E3.
PRIDEiQ9P2E3.

PTM databases

iPTMnetiQ9P2E3.
PhosphoSitePlusiQ9P2E3.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000124201.
CleanExiHS_ZNFX1.
ExpressionAtlasiQ9P2E3. baseline and differential.
GenevisibleiQ9P2E3. HS.

Organism-specific databases

HPAiHPA046629.

Interactioni

Protein-protein interaction databases

BioGridi121422. 27 interactors.
IntActiQ9P2E3. 28 interactors.
STRINGi9606.ENSP00000360817.

Structurei

3D structure databases

ProteinModelPortaliQ9P2E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili286 – 313Sequence analysisAdd BLAST28
Coiled coili886 – 967Sequence analysisAdd BLAST82
Coiled coili1741 – 1820Sequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi812 – 819Poly-Glu8
Compositional biasi839 – 842Poly-Glu4

Sequence similaritiesi

Contains 6 NF-X1-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1298 – 1320NF-X1-type 1Add BLAST23
Zinc fingeri1330 – 1346NF-X1-type 2Add BLAST17
Zinc fingeri1382 – 1400NF-X1-type 3Add BLAST19
Zinc fingeri1441 – 1463NF-X1-type 4Add BLAST23
Zinc fingeri1471 – 1488NF-X1-type 5Add BLAST18
Zinc fingeri1546 – 1564NF-X1-type 6Add BLAST19

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1807. Eukaryota.
COG1112. LUCA.
GeneTreeiENSGT00810000125415.
HOVERGENiHBG052201.
InParanoidiQ9P2E3.
OMAiCVRLCSE.
OrthoDBiEOG091G04KI.
PhylomeDBiQ9P2E3.
TreeFamiTF323611.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR027417. P-loop_NTPase.
IPR000967. Znf_NFX1.
[Graphical view]
SMARTiSM00438. ZnF_NFX. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF52540. SSF52540. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2E3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEERRPHLDA RPRNSHTNHR GPVDGELPPR ARNQANNPPA NALRGGASHP
60 70 80 90 100
GRHPRANNHP AAYWQREERF RAMGRNPHQG RRNQEGHASD EARDQRHDQE
110 120 130 140 150
NDTRWRNGNQ DCRNRRPPWS NDNFQQWRTP HQKPTEQPQQ AKKLGYKFLE
160 170 180 190 200
SLLQKDPSEV VITLATSLGL KELLSHSSMK SNFLELICQV LRKACSSKMD
210 220 230 240 250
RQSVLHVLGI LKNSKFLKVC LPAYVVGMIT EPIPDIRNQY PEHISNIISL
260 270 280 290 300
LQDLVSVFPA SSVQETSMLV SLLPTSLNAL RASGVDIEEE TEKNLEKVQT
310 320 330 340 350
IIEHLQEKRR EGTLRVDTYT LVQPEAEDHV ESYRTMPIYP TYNEVHLDER
360 370 380 390 400
PFLRPNIISG KYDSTAIYLD THFRLLREDF VRPLREGILE LLQSFEDQGL
410 420 430 440 450
RKRKFDDIRI YFDTRIITPM CSSSGIVYKV QFDTKPLKFV RWQNSKRLLY
460 470 480 490 500
GSLVCMSKDN FETFLFATVS NREQEDLCRG IVQLCFNEQS QQLLAEVQPS
510 520 530 540 550
DSFLMVETTA YFEAYRHVLE GLQEVQEEDV PFQRNIVECN SHVKEPRYLL
560 570 580 590 600
MGGRYDFTPL IENPSATGEF LRNVEGLRHP RINVLDPGQW PSKEALKLDD
610 620 630 640 650
SQMEALQFAL TRELAIIQGP PGTGKTYVGL KIVQALLTNE SVWQISLQKF
660 670 680 690 700
PILVVCYTNH ALDQFLEGIY NCQKTSIVRV GGRSNSEILK QFTLRELRNK
710 720 730 740 750
REFRRNLPMH LRRAYMSIMT QMKESEQELH EGAKTLECTM RGVLREQYLQ
760 770 780 790 800
KYISPQHWES LMNGPVQDSE WICFQHWKHS MMLEWLGLGV GSFTQSVSPA
810 820 830 840 850
GPENTAQAEG DEEEEGEEES SLIEIAEEAD LIQADRVIEE EEVVRPQRRK
860 870 880 890 900
KEESGADQEL AKMLLAMRLD HCGTGTAAGQ EQATGEWQTQ RNQKKKMKKR
910 920 930 940 950
VKDELRKLNT MTAAEANEIE DVWQLDLSSR WQLYRLWLQL YQADTRRKIL
960 970 980 990 1000
SYERQYRTSA ERMAELRLQE DLHILKDAQV VGMTTTGAAK YRQILQKVEP
1010 1020 1030 1040 1050
RIVIVEEAAE VLEAHTIATL SKACQHLILI GDHQQLRPSA NVYDLAKNFN
1060 1070 1080 1090 1100
LEVSLFERLV KVNIPFVRLN YQHRMCPEIA RLLTPHIYQD LENHPSVLKY
1110 1120 1130 1140 1150
EKIKGVSSNL FFVEHNFPEQ EIQEGKSHQN QHEAHFVVEL CKYFLCQEYL
1160 1170 1180 1190 1200
PSQITILTTY TGQLFCLRKL MPAKTFAGVR VHVVDKYQGE ENDIILLSLV
1210 1220 1230 1240 1250
RSNQEGKVGF LQISNRICVA LSRAKKGMYC IGNMQMLAKV PLWSKIIHTL
1260 1270 1280 1290 1300
RENNQIGPML RLCCQNHPET HTLVSKASDF QKVPEGGCSL PCEFRLGCGH
1310 1320 1330 1340 1350
VCTRACHPYD SSHKEFQCMK PCQKVICQEG HRCPLVCFQE CQPCQVKVPK
1360 1370 1380 1390 1400
TIPRCGHEQM VPCSVPESDF CCQEPCSKSL RCGHRCSHPC GEDCVQLCSE
1410 1420 1430 1440 1450
MVTIKLKCGH SQPVKCGHVE GLLYGGLLVK CTTKCGTILD CGHPCPGSCH
1460 1470 1480 1490 1500
SCFEGRFHER CQQPCKRLLI CSHKCQEPCI GECPPCQRTC QNRCVHSQCK
1510 1520 1530 1540 1550
KKCGELCSPC VEPCVWRCQH YQCTKLCSEP CNRPPCYVPC TKLLVCGHPC
1560 1570 1580 1590 1600
IGLCGEPCPK KCRICHMDEV TQIFFGFEDE PDARFVQLED CSHIFEVQAL
1610 1620 1630 1640 1650
DRYMNEQKDD EVAIRLKVCP ICQVPIRKNL RYGTSIKQRL EEIEIIKEKI
1660 1670 1680 1690 1700
QGSAGEIATS QERLKALLER KSLLHQLLPE DFLMLKEKLA QKNLSVKDLG
1710 1720 1730 1740 1750
LVENYISFYD HLASLWDSLK KMHVLEEKRV RTRLEQVHEW LAKKRLSFTS
1760 1770 1780 1790 1800
QELSDLRSEI QRLTYLVNLL TRYKIAEKKV KDSIAVEVYS VQNILEKTCK
1810 1820 1830 1840 1850
FTQEDEQLVQ EKMEALKATL PCSGLGISEE ERVQIVSAIG YPRGHWFKCR
1860 1870 1880 1890 1900
NGHIYVIGDC GGAMERGTCP DCKEVIGGTN HTLERSNQLA SEMDGAQHAA
1910
WSDTANNLMN FEEIQGMM
Length:1,918
Mass (Da):220,227
Last modified:October 10, 2002 - v2
Checksum:i4E6F2C193BC313CE
GO
Isoform 2 (identifier: Q9P2E3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-903: QRNQKKKMKKRVKD → VPCLVLMSADPAQP
     904-1918: Missing.

Show »
Length:903
Mass (Da):103,846
Checksum:i354E3DBA164492BB
GO

Sequence cautioni

The sequence BAA91264 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92642 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14149 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14696 differs from that shown. Reason: Erroneous termination at position 1846. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti738C → S in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti755P → L in BAA92102 (PubMed:14702039).Curated1
Sequence conflicti891R → H in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti1715L → P in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti1743K → Q in BAA91264 (PubMed:14702039).Curated1
Sequence conflicti1773Y → N in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti1856V → E in BAB14696 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014078864L → V.Corresponds to variant rs2664578dbSNPEnsembl.1
Natural variantiVAR_014079910T → A.Corresponds to variant rs2273148dbSNPEnsembl.1
Natural variantiVAR_014080924Q → H.2 PublicationsCorresponds to variant rs238221dbSNPEnsembl.1
Natural variantiVAR_0244871259M → I.Corresponds to variant rs6512577dbSNPEnsembl.1
Natural variantiVAR_0515041297G → S.Corresponds to variant rs36068952dbSNPEnsembl.1
Natural variantiVAR_0140811351T → I.1 PublicationCorresponds to variant rs238209dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002434890 – 903QRNQK…KRVKD → VPCLVLMSADPAQP in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_002435904 – 1918Missing in isoform 2. 1 PublicationAdd BLAST1015

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037825 mRNA. Translation: BAA92642.1. Different initiation.
AK000573 mRNA. Translation: BAA91264.1. Different initiation.
AK002139 mRNA. Translation: BAA92102.1.
AK022641 mRNA. Translation: BAB14149.1. Different initiation.
AK023836 mRNA. Translation: BAB14696.1. Sequence problems.
AL049766 Genomic DNA. Translation: CAC33877.1.
CCDSiCCDS13417.1. [Q9P2E3-1]
RefSeqiNP_066363.1. NM_021035.2. [Q9P2E3-1]
XP_006723899.1. XM_006723836.1. [Q9P2E3-1]
UniGeneiHs.371794.

Genome annotation databases

EnsembliENST00000371752; ENSP00000360817; ENSG00000124201. [Q9P2E3-1]
ENST00000396105; ENSP00000379412; ENSG00000124201. [Q9P2E3-1]
GeneIDi57169.
KEGGihsa:57169.
UCSCiuc002xui.5. human. [Q9P2E3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037825 mRNA. Translation: BAA92642.1. Different initiation.
AK000573 mRNA. Translation: BAA91264.1. Different initiation.
AK002139 mRNA. Translation: BAA92102.1.
AK022641 mRNA. Translation: BAB14149.1. Different initiation.
AK023836 mRNA. Translation: BAB14696.1. Sequence problems.
AL049766 Genomic DNA. Translation: CAC33877.1.
CCDSiCCDS13417.1. [Q9P2E3-1]
RefSeqiNP_066363.1. NM_021035.2. [Q9P2E3-1]
XP_006723899.1. XM_006723836.1. [Q9P2E3-1]
UniGeneiHs.371794.

3D structure databases

ProteinModelPortaliQ9P2E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121422. 27 interactors.
IntActiQ9P2E3. 28 interactors.
STRINGi9606.ENSP00000360817.

PTM databases

iPTMnetiQ9P2E3.
PhosphoSitePlusiQ9P2E3.

Polymorphism and mutation databases

BioMutaiZNFX1.
DMDMi23821814.

Proteomic databases

EPDiQ9P2E3.
MaxQBiQ9P2E3.
PaxDbiQ9P2E3.
PeptideAtlasiQ9P2E3.
PRIDEiQ9P2E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371752; ENSP00000360817; ENSG00000124201. [Q9P2E3-1]
ENST00000396105; ENSP00000379412; ENSG00000124201. [Q9P2E3-1]
GeneIDi57169.
KEGGihsa:57169.
UCSCiuc002xui.5. human. [Q9P2E3-1]

Organism-specific databases

CTDi57169.
DisGeNETi57169.
GeneCardsiZNFX1.
HGNCiHGNC:29271. ZNFX1.
HPAiHPA046629.
neXtProtiNX_Q9P2E3.
OpenTargetsiENSG00000124201.
PharmGKBiPA143485687.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1807. Eukaryota.
COG1112. LUCA.
GeneTreeiENSGT00810000125415.
HOVERGENiHBG052201.
InParanoidiQ9P2E3.
OMAiCVRLCSE.
OrthoDBiEOG091G04KI.
PhylomeDBiQ9P2E3.
TreeFamiTF323611.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124201-MONOMER.

Miscellaneous databases

ChiTaRSiZNFX1. human.
GenomeRNAii57169.
PROiQ9P2E3.

Gene expression databases

BgeeiENSG00000124201.
CleanExiHS_ZNFX1.
ExpressionAtlasiQ9P2E3. baseline and differential.
GenevisibleiQ9P2E3. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR027417. P-loop_NTPase.
IPR000967. Znf_NFX1.
[Graphical view]
SMARTiSM00438. ZnF_NFX. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZNFX1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2E3
Secondary accession number(s): Q9BQM7
, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.