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Q9P2E2 (KIF17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF17
Alternative name(s):
KIF3-related motor protein
Gene names
Name:KIF17
Synonyms:KIAA1405, KIF3X
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1029 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules By similarity.

Subunit structure

Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 By similarity. Interacts with TBATA By similarity.

Subcellular location

Cytoplasmcytoskeleton Probable.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Contains 1 kinesin motor domain.

Sequence caution

The sequence AAD01428.1 differs from that shown. Reason: Frameshift at positions 970 and 990.

The sequence AAD01428.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

The sequence AAH36871.1 differs from that shown. Reason: Cloning artifact.

The sequence BAA92643.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

The sequence CAH73471.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI23390.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P2E2-1)

Also known as: KIF17b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P2E2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     908-908: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10291029Kinesin-like protein KIF17
PRO_0000125450

Regions

Domain5 – 335331Kinesin motor
Nucleotide binding91 – 988ATP By similarity
Coiled coil346 – 462117 Potential
Coiled coil739 – 846108 Potential

Natural variations

Alternative sequence9081Missing in isoform 2.
VSP_040346
Natural variant3411I → V.
Corresponds to variant rs2296225 [ dbSNP | Ensembl ].
VAR_055983
Natural variant3691S → R.
Corresponds to variant rs56750936 [ dbSNP | Ensembl ].
VAR_061282
Natural variant4021V → M. Ref.1 Ref.3 Ref.4
Corresponds to variant rs522496 [ dbSNP | Ensembl ].
VAR_023527
Natural variant6751V → I.
Corresponds to variant rs558760 [ dbSNP | Ensembl ].
VAR_055984
Natural variant7351V → I.
Corresponds to variant rs13375609 [ dbSNP | Ensembl ].
VAR_055985
Natural variant9331D → E. Ref.1 Ref.3 Ref.4 Ref.6
Corresponds to variant rs631357 [ dbSNP | Ensembl ].
VAR_023528

Experimental info

Sequence conflict9251D → Y in AAD01428. Ref.6
Sequence conflict9571R → W in AAR33039. Ref.1
Sequence conflict9571R → W in BAA92643. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (KIF17b) [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: ED1B7F9806CC9AF6

FASTA1,029115,068
        10         20         30         40         50         60 
MASEAVKVVV RCRPMNQRER ELRCQPVVTV DCARAQCCIQ NPGAADEPPK QFTFDGAYHV 

        70         80         90        100        110        120 
DHVTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT MQGLPDPPSQ RGIIPRAFEH 

       130        140        150        160        170        180 
VFESVQCAEN TKFLVRASYL EIYNEDVRDL LGADTKQKLE LKEHPEKGVY VKGLSMHTVH 

       190        200        210        220        230        240 
SVAQCEHIME TGWKNRSVGY TLMNKDSSRS HSIFTISIEM SAVDERGKDH LRAGKLNLVD 

       250        260        270        280        290        300 
LAGSERQSKT GATGERLKEA TKINLSLSAL GNVISALVDG RCKHVPYRDS KLTRLLQDSL 

       310        320        330        340        350        360 
GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIRNKPR INEDPKDALL REYQEEIKKL 

       370        380        390        400        410        420 
KAILTQQMSP SSLSALLSRQ VPPDPVQVEE KLLPQPVIQH DVEAEKQLIR EEYEERLARL 

       430        440        450        460        470        480 
KADYKAEQES RARLEEDITA MRNSYDVRLS TLEENLRKET EAVLQVGVLY KAEVMSRAEF 

       490        500        510        520        530        540 
ASSAEYPPAF QYETVVKPKV FSTTDTLPSD DVSKTQVSSR FAELPKVEPS KSEISLGSSE 

       550        560        570        580        590        600 
SSSLEETSVS EAFPGPEEPS NVEVSMPTEE SRSRYFLDEC LGQEAAGHLL GEQNYLPQEE 

       610        620        630        640        650        660 
PQEVPLQGLL GLQDPFAEVE AKLARLSSTV ARTDAPQADV PKVPVQVPAP TDLLEPSDAR 

       670        680        690        700        710        720 
PEAEAADDFP PRPEVDLASE VALEVVRTAE PGVWLEAQAP VALVAQPEPL PATAGVKRES 

       730        740        750        760        770        780 
VGMEVAVLTD DPLPVVDQQQ VLARLQLLEQ QVVGGEQAKN KDLKEKHKRR KRYADERRKQ 

       790        800        810        820        830        840 
LVAALQNSDE DSGDWVLLNV YDSIQEEVRA KSKLLEKMQR KLRAAEVEIK DLQSEFQLEK 

       850        860        870        880        890        900 
IDYLATIRRQ ERDSMLLQQL LEQVQPLIRR DCNYSNLEKI LRESCWDEDN GFWKIPHPVI 

       910        920        930        940        950        960 
TKTSLPVAVS TGPQNKPARK TSAADNGEPN MEDDRYRLML SRSNSENIAS NYFRSKRASQ 

       970        980        990       1000       1010       1020 
ILSTDARKSL THHNSPPGLS CPLSNNSAIP PTQAPEMPQP RPFRLESLDI PFTKAKRKKS 


KSNFGSEPL 

« Hide

Isoform 2 [UniParc].

Checksum: 7827B2E000AD80C1
Show »

FASTA1,028114,997

References

« Hide 'large scale' references
[1]"The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells."
Chennathukuzhi V., Morales C.R., El-Alfy M., Hecht N.B.
Proc. Natl. Acad. Sci. U.S.A. 100:15566-15571(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-402 AND GLU-933.
Tissue: Eye.
[4]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-1029 (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
Tissue: Brain.
[5]Ohara O., Nagase T., Kikuno R.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[6]"The MAP kinase kinase kinases MLK2 and MLK3 are targets for RAC/Cdc42 and components of microtubule motor complexes."
Nagata K., Puls A., Futter C., Aspenstroem P., Hall A.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 793-1029, VARIANT GLU-933.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY484427 mRNA. Translation: AAR33039.1.
AL391357, AL663074 Genomic DNA. Translation: CAH73471.1. Sequence problems.
AL663074, AL391357 Genomic DNA. Translation: CAI23390.1. Sequence problems.
AL391357, AL663074 Genomic DNA. Translation: CAM12849.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12853.1.
AL391357, AL663074 Genomic DNA. Translation: CAM12850.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12852.1.
BC036871 mRNA. Translation: AAH36871.1. Sequence problems.
BC065927 mRNA. Translation: AAH65927.1.
AB037826 mRNA. Translation: BAA92643.2. Sequence problems.
AF009624 mRNA. Translation: AAD01428.1. Sequence problems.
CCDSCCDS213.1. [Q9P2E2-1]
CCDS44079.1. [Q9P2E2-3]
RefSeqNP_001116291.1. NM_001122819.2. [Q9P2E2-3]
NP_001274141.1. NM_001287212.1.
NP_065867.2. NM_020816.3. [Q9P2E2-1]
UniGeneHs.130411.

3D structure databases

ProteinModelPortalQ9P2E2.
SMRQ9P2E2. Positions 3-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121629. 3 interactions.
IntActQ9P2E2. 3 interactions.
MINTMINT-2875280.
STRING9606.ENSP00000247986.

PTM databases

PhosphoSiteQ9P2E2.

Polymorphism databases

DMDM317373436.

Proteomic databases

MaxQBQ9P2E2.
PaxDbQ9P2E2.
PRIDEQ9P2E2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000247986; ENSP00000247986; ENSG00000117245. [Q9P2E2-1]
ENST00000400463; ENSP00000383311; ENSG00000117245. [Q9P2E2-3]
GeneID57576.
KEGGhsa:57576.
UCSCuc001bdr.4. human. [Q9P2E2-1]
uc001bds.4. human. [Q9P2E2-3]

Organism-specific databases

CTD57576.
GeneCardsGC01M020990.
H-InvDBHIX0000220.
HGNCHGNC:19167. KIF17.
HPAHPA032085.
MIM605037. gene.
neXtProtNX_Q9P2E2.
PharmGKBPA38809.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOVERGENHBG052255.
InParanoidQ9P2E2.
KOK10394.
OMAFWKIPEP.
OrthoDBEOG7WX086.
PhylomeDBQ9P2E2.
TreeFamTF105223.

Gene expression databases

BgeeQ9P2E2.
CleanExHS_KIF17.
GenevestigatorQ9P2E2.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKIF17.
GenomeRNAi57576.
NextBio64119.
PROQ9P2E2.
SOURCESearch...

Entry information

Entry nameKIF17_HUMAN
AccessionPrimary (citable) accession number: Q9P2E2
Secondary accession number(s): A2A3Q7 expand/collapse secondary AC list , A2A3Q8, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM