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Protein

Kinesin-like protein KIF17

Gene

KIF17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi91 – 988ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central

GO - Biological processi

  1. cell projection organization Source: GO_Central
  2. metabolic process Source: GOC
  3. microtubule-based movement Source: GO_Central
  4. neurogenesis Source: GO_Central
  5. organelle organization Source: Reactome
  6. protein complex localization Source: Ensembl
  7. protein transport Source: UniProtKB-KW
  8. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_268024. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF17
Alternative name(s):
KIF3-related motor protein
Gene namesi
Name:KIF17
Synonyms:KIAA1405, KIF3X
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19167. KIF17.

Subcellular locationi

GO - Cellular componenti

  1. axoneme Source: Ensembl
  2. ciliary basal body Source: Ensembl
  3. cytosol Source: Reactome
  4. intraciliary transport particle B Source: Ensembl
  5. kinesin complex Source: GO_Central
  6. microtubule Source: UniProtKB-KW
  7. periciliary membrane compartment Source: Ensembl
  8. photoreceptor connecting cilium Source: Ensembl
  9. primary cilium Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10291029Kinesin-like protein KIF17PRO_0000125450Add
BLAST

Proteomic databases

MaxQBiQ9P2E2.
PaxDbiQ9P2E2.
PRIDEiQ9P2E2.

PTM databases

PhosphoSiteiQ9P2E2.

Expressioni

Gene expression databases

BgeeiQ9P2E2.
CleanExiHS_KIF17.
GenevestigatoriQ9P2E2.

Organism-specific databases

HPAiCAB037185.
HPA032085.

Interactioni

Subunit structurei

Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By similarity).By similarity

Protein-protein interaction databases

BioGridi121629. 4 interactions.
IntActiQ9P2E2. 3 interactions.
MINTiMINT-2875280.
STRINGi9606.ENSP00000247986.

Structurei

3D structure databases

ProteinModelPortaliQ9P2E2.
SMRiQ9P2E2. Positions 2-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 335331Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili346 – 462117Sequence AnalysisAdd
BLAST
Coiled coili739 – 846108Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOVERGENiHBG052255.
InParanoidiQ9P2E2.
KOiK10394.
OMAiFWKIPEP.
OrthoDBiEOG7WX086.
PhylomeDBiQ9P2E2.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2E2-1) [UniParc]FASTAAdd to basket

Also known as: KIF17b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEAVKVVV RCRPMNQRER ELRCQPVVTV DCARAQCCIQ NPGAADEPPK
60 70 80 90 100
QFTFDGAYHV DHVTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT
110 120 130 140 150
MQGLPDPPSQ RGIIPRAFEH VFESVQCAEN TKFLVRASYL EIYNEDVRDL
160 170 180 190 200
LGADTKQKLE LKEHPEKGVY VKGLSMHTVH SVAQCEHIME TGWKNRSVGY
210 220 230 240 250
TLMNKDSSRS HSIFTISIEM SAVDERGKDH LRAGKLNLVD LAGSERQSKT
260 270 280 290 300
GATGERLKEA TKINLSLSAL GNVISALVDG RCKHVPYRDS KLTRLLQDSL
310 320 330 340 350
GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIRNKPR INEDPKDALL
360 370 380 390 400
REYQEEIKKL KAILTQQMSP SSLSALLSRQ VPPDPVQVEE KLLPQPVIQH
410 420 430 440 450
DVEAEKQLIR EEYEERLARL KADYKAEQES RARLEEDITA MRNSYDVRLS
460 470 480 490 500
TLEENLRKET EAVLQVGVLY KAEVMSRAEF ASSAEYPPAF QYETVVKPKV
510 520 530 540 550
FSTTDTLPSD DVSKTQVSSR FAELPKVEPS KSEISLGSSE SSSLEETSVS
560 570 580 590 600
EAFPGPEEPS NVEVSMPTEE SRSRYFLDEC LGQEAAGHLL GEQNYLPQEE
610 620 630 640 650
PQEVPLQGLL GLQDPFAEVE AKLARLSSTV ARTDAPQADV PKVPVQVPAP
660 670 680 690 700
TDLLEPSDAR PEAEAADDFP PRPEVDLASE VALEVVRTAE PGVWLEAQAP
710 720 730 740 750
VALVAQPEPL PATAGVKRES VGMEVAVLTD DPLPVVDQQQ VLARLQLLEQ
760 770 780 790 800
QVVGGEQAKN KDLKEKHKRR KRYADERRKQ LVAALQNSDE DSGDWVLLNV
810 820 830 840 850
YDSIQEEVRA KSKLLEKMQR KLRAAEVEIK DLQSEFQLEK IDYLATIRRQ
860 870 880 890 900
ERDSMLLQQL LEQVQPLIRR DCNYSNLEKI LRESCWDEDN GFWKIPHPVI
910 920 930 940 950
TKTSLPVAVS TGPQNKPARK TSAADNGEPN MEDDRYRLML SRSNSENIAS
960 970 980 990 1000
NYFRSKRASQ ILSTDARKSL THHNSPPGLS CPLSNNSAIP PTQAPEMPQP
1010 1020
RPFRLESLDI PFTKAKRKKS KSNFGSEPL
Length:1,029
Mass (Da):115,068
Last modified:January 11, 2011 - v3
Checksum:iED1B7F9806CC9AF6
GO
Isoform 2 (identifier: Q9P2E2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     908-908: Missing.

Show »
Length:1,028
Mass (Da):114,997
Checksum:i7827B2E000AD80C1
GO

Sequence cautioni

The sequence AAD01428.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAD01428.1 differs from that shown. Reason: Frameshift at positions 970 and 990. Curated
The sequence AAH36871.1 differs from that shown.Cloning artifact.Curated
The sequence BAA92643.2 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence CAH73471.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI23390.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti925 – 9251D → Y in AAD01428 (Ref. 6) Curated
Sequence conflicti957 – 9571R → W in AAR33039 (PubMed:14673085).Curated
Sequence conflicti957 – 9571R → W in BAA92643 (PubMed:10718198).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti341 – 3411I → V.
Corresponds to variant rs2296225 [ dbSNP | Ensembl ].
VAR_055983
Natural varianti369 – 3691S → R.
Corresponds to variant rs56750936 [ dbSNP | Ensembl ].
VAR_061282
Natural varianti402 – 4021V → M.3 Publications
Corresponds to variant rs522496 [ dbSNP | Ensembl ].
VAR_023527
Natural varianti675 – 6751V → I.
Corresponds to variant rs558760 [ dbSNP | Ensembl ].
VAR_055984
Natural varianti735 – 7351V → I.
Corresponds to variant rs13375609 [ dbSNP | Ensembl ].
VAR_055985
Natural varianti933 – 9331D → E.4 Publications
Corresponds to variant rs631357 [ dbSNP | Ensembl ].
VAR_023528

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei908 – 9081Missing in isoform 2. 1 PublicationVSP_040346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484427 mRNA. Translation: AAR33039.1.
AL391357, AL663074 Genomic DNA. Translation: CAH73471.1. Sequence problems.
AL663074, AL391357 Genomic DNA. Translation: CAI23390.1. Sequence problems.
AL391357, AL663074 Genomic DNA. Translation: CAM12849.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12853.1.
AL391357, AL663074 Genomic DNA. Translation: CAM12850.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12852.1.
BC036871 mRNA. Translation: AAH36871.1. Sequence problems.
BC065927 mRNA. Translation: AAH65927.1.
AB037826 mRNA. Translation: BAA92643.2. Sequence problems.
AF009624 mRNA. Translation: AAD01428.1. Sequence problems.
CCDSiCCDS213.1. [Q9P2E2-1]
CCDS44079.1. [Q9P2E2-3]
RefSeqiNP_001116291.1. NM_001122819.2. [Q9P2E2-3]
NP_001274141.1. NM_001287212.1.
NP_065867.2. NM_020816.3. [Q9P2E2-1]
UniGeneiHs.130411.

Genome annotation databases

EnsembliENST00000247986; ENSP00000247986; ENSG00000117245. [Q9P2E2-1]
ENST00000400463; ENSP00000383311; ENSG00000117245. [Q9P2E2-3]
GeneIDi57576.
KEGGihsa:57576.
UCSCiuc001bdr.4. human. [Q9P2E2-1]
uc001bds.4. human. [Q9P2E2-3]

Polymorphism databases

DMDMi317373436.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484427 mRNA. Translation: AAR33039.1.
AL391357, AL663074 Genomic DNA. Translation: CAH73471.1. Sequence problems.
AL663074, AL391357 Genomic DNA. Translation: CAI23390.1. Sequence problems.
AL391357, AL663074 Genomic DNA. Translation: CAM12849.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12853.1.
AL391357, AL663074 Genomic DNA. Translation: CAM12850.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12852.1.
BC036871 mRNA. Translation: AAH36871.1. Sequence problems.
BC065927 mRNA. Translation: AAH65927.1.
AB037826 mRNA. Translation: BAA92643.2. Sequence problems.
AF009624 mRNA. Translation: AAD01428.1. Sequence problems.
CCDSiCCDS213.1. [Q9P2E2-1]
CCDS44079.1. [Q9P2E2-3]
RefSeqiNP_001116291.1. NM_001122819.2. [Q9P2E2-3]
NP_001274141.1. NM_001287212.1.
NP_065867.2. NM_020816.3. [Q9P2E2-1]
UniGeneiHs.130411.

3D structure databases

ProteinModelPortaliQ9P2E2.
SMRiQ9P2E2. Positions 2-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121629. 4 interactions.
IntActiQ9P2E2. 3 interactions.
MINTiMINT-2875280.
STRINGi9606.ENSP00000247986.

PTM databases

PhosphoSiteiQ9P2E2.

Polymorphism databases

DMDMi317373436.

Proteomic databases

MaxQBiQ9P2E2.
PaxDbiQ9P2E2.
PRIDEiQ9P2E2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247986; ENSP00000247986; ENSG00000117245. [Q9P2E2-1]
ENST00000400463; ENSP00000383311; ENSG00000117245. [Q9P2E2-3]
GeneIDi57576.
KEGGihsa:57576.
UCSCiuc001bdr.4. human. [Q9P2E2-1]
uc001bds.4. human. [Q9P2E2-3]

Organism-specific databases

CTDi57576.
GeneCardsiGC01M020990.
H-InvDBHIX0000220.
HGNCiHGNC:19167. KIF17.
HPAiCAB037185.
HPA032085.
MIMi605037. gene.
neXtProtiNX_Q9P2E2.
PharmGKBiPA38809.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOVERGENiHBG052255.
InParanoidiQ9P2E2.
KOiK10394.
OMAiFWKIPEP.
OrthoDBiEOG7WX086.
PhylomeDBiQ9P2E2.
TreeFamiTF105223.

Enzyme and pathway databases

ReactomeiREACT_268024. Intraflagellar transport.

Miscellaneous databases

GeneWikiiKIF17.
GenomeRNAii57576.
NextBioi64119.
PROiQ9P2E2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2E2.
CleanExiHS_KIF17.
GenevestigatoriQ9P2E2.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells."
    Chennathukuzhi V., Morales C.R., El-Alfy M., Hecht N.B.
    Proc. Natl. Acad. Sci. U.S.A. 100:15566-15571(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-402 AND GLU-933.
    Tissue: Eye.
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-1029 (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
    Tissue: Brain.
  5. Ohara O., Nagase T., Kikuno R.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "The MAP kinase kinase kinases MLK2 and MLK3 are targets for RAC/Cdc42 and components of microtubule motor complexes."
    Nagata K., Puls A., Futter C., Aspenstroem P., Hall A.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 793-1029, VARIANT GLU-933.

Entry informationi

Entry nameiKIF17_HUMAN
AccessioniPrimary (citable) accession number: Q9P2E2
Secondary accession number(s): A2A3Q7
, A2A3Q8, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 11, 2011
Last modified: April 1, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.