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Q9P2E2

- KIF17_HUMAN

UniProt

Q9P2E2 - KIF17_HUMAN

Protein

Kinesin-like protein KIF17

Gene

KIF17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi91 – 988ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: Ensembl

    GO - Biological processi

    1. microtubule-based movement Source: InterPro
    2. protein complex localization Source: Ensembl
    3. protein transport Source: UniProtKB-KW
    4. vesicle-mediated transport Source: Ensembl

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF17
    Alternative name(s):
    KIF3-related motor protein
    Gene namesi
    Name:KIF17
    Synonyms:KIAA1405, KIF3X
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19167. KIF17.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. kinesin complex Source: Ensembl
    3. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38809.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10291029Kinesin-like protein KIF17PRO_0000125450Add
    BLAST

    Proteomic databases

    MaxQBiQ9P2E2.
    PaxDbiQ9P2E2.
    PRIDEiQ9P2E2.

    PTM databases

    PhosphoSiteiQ9P2E2.

    Expressioni

    Gene expression databases

    BgeeiQ9P2E2.
    CleanExiHS_KIF17.
    GenevestigatoriQ9P2E2.

    Organism-specific databases

    HPAiHPA032085.

    Interactioni

    Subunit structurei

    Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 By similarity. Interacts with TBATA By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121629. 4 interactions.
    IntActiQ9P2E2. 3 interactions.
    MINTiMINT-2875280.
    STRINGi9606.ENSP00000247986.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2E2.
    SMRiQ9P2E2. Positions 3-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 335331Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili346 – 462117Sequence AnalysisAdd
    BLAST
    Coiled coili739 – 846108Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOVERGENiHBG052255.
    InParanoidiQ9P2E2.
    KOiK10394.
    OMAiFWKIPEP.
    OrthoDBiEOG7WX086.
    PhylomeDBiQ9P2E2.
    TreeFamiTF105223.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2E2-1) [UniParc]FASTAAdd to Basket

    Also known as: KIF17b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MASEAVKVVV RCRPMNQRER ELRCQPVVTV DCARAQCCIQ NPGAADEPPK     50
    QFTFDGAYHV DHVTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT 100
    MQGLPDPPSQ RGIIPRAFEH VFESVQCAEN TKFLVRASYL EIYNEDVRDL 150
    LGADTKQKLE LKEHPEKGVY VKGLSMHTVH SVAQCEHIME TGWKNRSVGY 200
    TLMNKDSSRS HSIFTISIEM SAVDERGKDH LRAGKLNLVD LAGSERQSKT 250
    GATGERLKEA TKINLSLSAL GNVISALVDG RCKHVPYRDS KLTRLLQDSL 300
    GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIRNKPR INEDPKDALL 350
    REYQEEIKKL KAILTQQMSP SSLSALLSRQ VPPDPVQVEE KLLPQPVIQH 400
    DVEAEKQLIR EEYEERLARL KADYKAEQES RARLEEDITA MRNSYDVRLS 450
    TLEENLRKET EAVLQVGVLY KAEVMSRAEF ASSAEYPPAF QYETVVKPKV 500
    FSTTDTLPSD DVSKTQVSSR FAELPKVEPS KSEISLGSSE SSSLEETSVS 550
    EAFPGPEEPS NVEVSMPTEE SRSRYFLDEC LGQEAAGHLL GEQNYLPQEE 600
    PQEVPLQGLL GLQDPFAEVE AKLARLSSTV ARTDAPQADV PKVPVQVPAP 650
    TDLLEPSDAR PEAEAADDFP PRPEVDLASE VALEVVRTAE PGVWLEAQAP 700
    VALVAQPEPL PATAGVKRES VGMEVAVLTD DPLPVVDQQQ VLARLQLLEQ 750
    QVVGGEQAKN KDLKEKHKRR KRYADERRKQ LVAALQNSDE DSGDWVLLNV 800
    YDSIQEEVRA KSKLLEKMQR KLRAAEVEIK DLQSEFQLEK IDYLATIRRQ 850
    ERDSMLLQQL LEQVQPLIRR DCNYSNLEKI LRESCWDEDN GFWKIPHPVI 900
    TKTSLPVAVS TGPQNKPARK TSAADNGEPN MEDDRYRLML SRSNSENIAS 950
    NYFRSKRASQ ILSTDARKSL THHNSPPGLS CPLSNNSAIP PTQAPEMPQP 1000
    RPFRLESLDI PFTKAKRKKS KSNFGSEPL 1029
    Length:1,029
    Mass (Da):115,068
    Last modified:January 11, 2011 - v3
    Checksum:iED1B7F9806CC9AF6
    GO
    Isoform 2 (identifier: Q9P2E2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         908-908: Missing.

    Show »
    Length:1,028
    Mass (Da):114,997
    Checksum:i7827B2E000AD80C1
    GO

    Sequence cautioni

    The sequence AAD01428.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
    The sequence AAH36871.1 differs from that shown. Reason: Cloning artifact.
    The sequence BAA92643.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
    The sequence AAD01428.1 differs from that shown. Reason: Frameshift at positions 970 and 990.
    The sequence CAH73471.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI23390.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti925 – 9251D → Y in AAD01428. 1 PublicationCurated
    Sequence conflicti957 – 9571R → W in AAR33039. (PubMed:14673085)Curated
    Sequence conflicti957 – 9571R → W in BAA92643. (PubMed:10718198)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti341 – 3411I → V.
    Corresponds to variant rs2296225 [ dbSNP | Ensembl ].
    VAR_055983
    Natural varianti369 – 3691S → R.
    Corresponds to variant rs56750936 [ dbSNP | Ensembl ].
    VAR_061282
    Natural varianti402 – 4021V → M.3 Publications
    Corresponds to variant rs522496 [ dbSNP | Ensembl ].
    VAR_023527
    Natural varianti675 – 6751V → I.
    Corresponds to variant rs558760 [ dbSNP | Ensembl ].
    VAR_055984
    Natural varianti735 – 7351V → I.
    Corresponds to variant rs13375609 [ dbSNP | Ensembl ].
    VAR_055985
    Natural varianti933 – 9331D → E.4 Publications
    Corresponds to variant rs631357 [ dbSNP | Ensembl ].
    VAR_023528

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei908 – 9081Missing in isoform 2. 1 PublicationVSP_040346

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY484427 mRNA. Translation: AAR33039.1.
    AL391357, AL663074 Genomic DNA. Translation: CAH73471.1. Sequence problems.
    AL663074, AL391357 Genomic DNA. Translation: CAI23390.1. Sequence problems.
    AL391357, AL663074 Genomic DNA. Translation: CAM12849.1.
    AL663074, AL391357 Genomic DNA. Translation: CAM12853.1.
    AL391357, AL663074 Genomic DNA. Translation: CAM12850.1.
    AL663074, AL391357 Genomic DNA. Translation: CAM12852.1.
    BC036871 mRNA. Translation: AAH36871.1. Sequence problems.
    BC065927 mRNA. Translation: AAH65927.1.
    AB037826 mRNA. Translation: BAA92643.2. Sequence problems.
    AF009624 mRNA. Translation: AAD01428.1. Sequence problems.
    CCDSiCCDS213.1. [Q9P2E2-1]
    CCDS44079.1. [Q9P2E2-3]
    RefSeqiNP_001116291.1. NM_001122819.2. [Q9P2E2-3]
    NP_001274141.1. NM_001287212.1.
    NP_065867.2. NM_020816.3. [Q9P2E2-1]
    UniGeneiHs.130411.

    Genome annotation databases

    EnsembliENST00000247986; ENSP00000247986; ENSG00000117245. [Q9P2E2-1]
    ENST00000400463; ENSP00000383311; ENSG00000117245. [Q9P2E2-3]
    GeneIDi57576.
    KEGGihsa:57576.
    UCSCiuc001bdr.4. human. [Q9P2E2-1]
    uc001bds.4. human. [Q9P2E2-3]

    Polymorphism databases

    DMDMi317373436.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY484427 mRNA. Translation: AAR33039.1 .
    AL391357 , AL663074 Genomic DNA. Translation: CAH73471.1 . Sequence problems.
    AL663074 , AL391357 Genomic DNA. Translation: CAI23390.1 . Sequence problems.
    AL391357 , AL663074 Genomic DNA. Translation: CAM12849.1 .
    AL663074 , AL391357 Genomic DNA. Translation: CAM12853.1 .
    AL391357 , AL663074 Genomic DNA. Translation: CAM12850.1 .
    AL663074 , AL391357 Genomic DNA. Translation: CAM12852.1 .
    BC036871 mRNA. Translation: AAH36871.1 . Sequence problems.
    BC065927 mRNA. Translation: AAH65927.1 .
    AB037826 mRNA. Translation: BAA92643.2 . Sequence problems.
    AF009624 mRNA. Translation: AAD01428.1 . Sequence problems.
    CCDSi CCDS213.1. [Q9P2E2-1 ]
    CCDS44079.1. [Q9P2E2-3 ]
    RefSeqi NP_001116291.1. NM_001122819.2. [Q9P2E2-3 ]
    NP_001274141.1. NM_001287212.1.
    NP_065867.2. NM_020816.3. [Q9P2E2-1 ]
    UniGenei Hs.130411.

    3D structure databases

    ProteinModelPortali Q9P2E2.
    SMRi Q9P2E2. Positions 3-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121629. 4 interactions.
    IntActi Q9P2E2. 3 interactions.
    MINTi MINT-2875280.
    STRINGi 9606.ENSP00000247986.

    PTM databases

    PhosphoSitei Q9P2E2.

    Polymorphism databases

    DMDMi 317373436.

    Proteomic databases

    MaxQBi Q9P2E2.
    PaxDbi Q9P2E2.
    PRIDEi Q9P2E2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247986 ; ENSP00000247986 ; ENSG00000117245 . [Q9P2E2-1 ]
    ENST00000400463 ; ENSP00000383311 ; ENSG00000117245 . [Q9P2E2-3 ]
    GeneIDi 57576.
    KEGGi hsa:57576.
    UCSCi uc001bdr.4. human. [Q9P2E2-1 ]
    uc001bds.4. human. [Q9P2E2-3 ]

    Organism-specific databases

    CTDi 57576.
    GeneCardsi GC01M020990.
    H-InvDB HIX0000220.
    HGNCi HGNC:19167. KIF17.
    HPAi HPA032085.
    MIMi 605037. gene.
    neXtProti NX_Q9P2E2.
    PharmGKBi PA38809.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOVERGENi HBG052255.
    InParanoidi Q9P2E2.
    KOi K10394.
    OMAi FWKIPEP.
    OrthoDBi EOG7WX086.
    PhylomeDBi Q9P2E2.
    TreeFami TF105223.

    Miscellaneous databases

    GeneWikii KIF17.
    GenomeRNAii 57576.
    NextBioi 64119.
    PROi Q9P2E2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P2E2.
    CleanExi HS_KIF17.
    Genevestigatori Q9P2E2.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells."
      Chennathukuzhi V., Morales C.R., El-Alfy M., Hecht N.B.
      Proc. Natl. Acad. Sci. U.S.A. 100:15566-15571(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-402 AND GLU-933.
      Tissue: Eye.
    4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-1029 (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
      Tissue: Brain.
    5. Ohara O., Nagase T., Kikuno R.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    6. "The MAP kinase kinase kinases MLK2 and MLK3 are targets for RAC/Cdc42 and components of microtubule motor complexes."
      Nagata K., Puls A., Futter C., Aspenstroem P., Hall A.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 793-1029, VARIANT GLU-933.

    Entry informationi

    Entry nameiKIF17_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2E2
    Secondary accession number(s): A2A3Q7
    , A2A3Q8, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3