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Q9P2E2

- KIF17_HUMAN

UniProt

Q9P2E2 - KIF17_HUMAN

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Protein
Kinesin-like protein KIF17
Gene
KIF17, KIAA1405, KIF3X
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi91 – 988ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: Ensembl

GO - Biological processi

  1. microtubule-based movement Source: InterPro
  2. protein complex localization Source: Ensembl
  3. protein transport Source: UniProtKB-KW
  4. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF17
Alternative name(s):
KIF3-related motor protein
Gene namesi
Name:KIF17
Synonyms:KIAA1405, KIF3X
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19167. KIF17.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: Ensembl
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10291029Kinesin-like protein KIF17
PRO_0000125450Add
BLAST

Proteomic databases

MaxQBiQ9P2E2.
PaxDbiQ9P2E2.
PRIDEiQ9P2E2.

PTM databases

PhosphoSiteiQ9P2E2.

Expressioni

Gene expression databases

BgeeiQ9P2E2.
CleanExiHS_KIF17.
GenevestigatoriQ9P2E2.

Organism-specific databases

HPAiHPA032085.

Interactioni

Subunit structurei

Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 By similarity. Interacts with TBATA By similarity.

Protein-protein interaction databases

BioGridi121629. 3 interactions.
IntActiQ9P2E2. 3 interactions.
MINTiMINT-2875280.
STRINGi9606.ENSP00000247986.

Structurei

3D structure databases

ProteinModelPortaliQ9P2E2.
SMRiQ9P2E2. Positions 3-353.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 335331Kinesin motor
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili346 – 462117 Reviewed prediction
Add
BLAST
Coiled coili739 – 846108 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOVERGENiHBG052255.
InParanoidiQ9P2E2.
KOiK10394.
OMAiFWKIPEP.
OrthoDBiEOG7WX086.
PhylomeDBiQ9P2E2.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P2E2-1) [UniParc]FASTAAdd to Basket

Also known as: KIF17b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASEAVKVVV RCRPMNQRER ELRCQPVVTV DCARAQCCIQ NPGAADEPPK     50
QFTFDGAYHV DHVTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT 100
MQGLPDPPSQ RGIIPRAFEH VFESVQCAEN TKFLVRASYL EIYNEDVRDL 150
LGADTKQKLE LKEHPEKGVY VKGLSMHTVH SVAQCEHIME TGWKNRSVGY 200
TLMNKDSSRS HSIFTISIEM SAVDERGKDH LRAGKLNLVD LAGSERQSKT 250
GATGERLKEA TKINLSLSAL GNVISALVDG RCKHVPYRDS KLTRLLQDSL 300
GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIRNKPR INEDPKDALL 350
REYQEEIKKL KAILTQQMSP SSLSALLSRQ VPPDPVQVEE KLLPQPVIQH 400
DVEAEKQLIR EEYEERLARL KADYKAEQES RARLEEDITA MRNSYDVRLS 450
TLEENLRKET EAVLQVGVLY KAEVMSRAEF ASSAEYPPAF QYETVVKPKV 500
FSTTDTLPSD DVSKTQVSSR FAELPKVEPS KSEISLGSSE SSSLEETSVS 550
EAFPGPEEPS NVEVSMPTEE SRSRYFLDEC LGQEAAGHLL GEQNYLPQEE 600
PQEVPLQGLL GLQDPFAEVE AKLARLSSTV ARTDAPQADV PKVPVQVPAP 650
TDLLEPSDAR PEAEAADDFP PRPEVDLASE VALEVVRTAE PGVWLEAQAP 700
VALVAQPEPL PATAGVKRES VGMEVAVLTD DPLPVVDQQQ VLARLQLLEQ 750
QVVGGEQAKN KDLKEKHKRR KRYADERRKQ LVAALQNSDE DSGDWVLLNV 800
YDSIQEEVRA KSKLLEKMQR KLRAAEVEIK DLQSEFQLEK IDYLATIRRQ 850
ERDSMLLQQL LEQVQPLIRR DCNYSNLEKI LRESCWDEDN GFWKIPHPVI 900
TKTSLPVAVS TGPQNKPARK TSAADNGEPN MEDDRYRLML SRSNSENIAS 950
NYFRSKRASQ ILSTDARKSL THHNSPPGLS CPLSNNSAIP PTQAPEMPQP 1000
RPFRLESLDI PFTKAKRKKS KSNFGSEPL 1029
Length:1,029
Mass (Da):115,068
Last modified:January 11, 2011 - v3
Checksum:iED1B7F9806CC9AF6
GO
Isoform 2 (identifier: Q9P2E2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     908-908: Missing.

Show »
Length:1,028
Mass (Da):114,997
Checksum:i7827B2E000AD80C1
GO

Sequence cautioni

The sequence AAD01428.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
The sequence AAH36871.1 differs from that shown. Reason: Cloning artifact.
The sequence BAA92643.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
The sequence AAD01428.1 differs from that shown. Reason: Frameshift at positions 970 and 990.
The sequence CAH73471.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI23390.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti341 – 3411I → V.
Corresponds to variant rs2296225 [ dbSNP | Ensembl ].
VAR_055983
Natural varianti369 – 3691S → R.
Corresponds to variant rs56750936 [ dbSNP | Ensembl ].
VAR_061282
Natural varianti402 – 4021V → M.3 Publications
Corresponds to variant rs522496 [ dbSNP | Ensembl ].
VAR_023527
Natural varianti675 – 6751V → I.
Corresponds to variant rs558760 [ dbSNP | Ensembl ].
VAR_055984
Natural varianti735 – 7351V → I.
Corresponds to variant rs13375609 [ dbSNP | Ensembl ].
VAR_055985
Natural varianti933 – 9331D → E.4 Publications
Corresponds to variant rs631357 [ dbSNP | Ensembl ].
VAR_023528

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei908 – 9081Missing in isoform 2.
VSP_040346

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti925 – 9251D → Y in AAD01428. 1 Publication
Sequence conflicti957 – 9571R → W in AAR33039. 1 Publication
Sequence conflicti957 – 9571R → W in BAA92643. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY484427 mRNA. Translation: AAR33039.1.
AL391357, AL663074 Genomic DNA. Translation: CAH73471.1. Sequence problems.
AL663074, AL391357 Genomic DNA. Translation: CAI23390.1. Sequence problems.
AL391357, AL663074 Genomic DNA. Translation: CAM12849.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12853.1.
AL391357, AL663074 Genomic DNA. Translation: CAM12850.1.
AL663074, AL391357 Genomic DNA. Translation: CAM12852.1.
BC036871 mRNA. Translation: AAH36871.1. Sequence problems.
BC065927 mRNA. Translation: AAH65927.1.
AB037826 mRNA. Translation: BAA92643.2. Sequence problems.
AF009624 mRNA. Translation: AAD01428.1. Sequence problems.
CCDSiCCDS213.1. [Q9P2E2-1]
CCDS44079.1. [Q9P2E2-3]
RefSeqiNP_001116291.1. NM_001122819.2. [Q9P2E2-3]
NP_001274141.1. NM_001287212.1.
NP_065867.2. NM_020816.3. [Q9P2E2-1]
UniGeneiHs.130411.

Genome annotation databases

EnsembliENST00000247986; ENSP00000247986; ENSG00000117245. [Q9P2E2-1]
ENST00000400463; ENSP00000383311; ENSG00000117245. [Q9P2E2-3]
GeneIDi57576.
KEGGihsa:57576.
UCSCiuc001bdr.4. human. [Q9P2E2-1]
uc001bds.4. human. [Q9P2E2-3]

Polymorphism databases

DMDMi317373436.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY484427 mRNA. Translation: AAR33039.1 .
AL391357 , AL663074 Genomic DNA. Translation: CAH73471.1 . Sequence problems.
AL663074 , AL391357 Genomic DNA. Translation: CAI23390.1 . Sequence problems.
AL391357 , AL663074 Genomic DNA. Translation: CAM12849.1 .
AL663074 , AL391357 Genomic DNA. Translation: CAM12853.1 .
AL391357 , AL663074 Genomic DNA. Translation: CAM12850.1 .
AL663074 , AL391357 Genomic DNA. Translation: CAM12852.1 .
BC036871 mRNA. Translation: AAH36871.1 . Sequence problems.
BC065927 mRNA. Translation: AAH65927.1 .
AB037826 mRNA. Translation: BAA92643.2 . Sequence problems.
AF009624 mRNA. Translation: AAD01428.1 . Sequence problems.
CCDSi CCDS213.1. [Q9P2E2-1 ]
CCDS44079.1. [Q9P2E2-3 ]
RefSeqi NP_001116291.1. NM_001122819.2. [Q9P2E2-3 ]
NP_001274141.1. NM_001287212.1.
NP_065867.2. NM_020816.3. [Q9P2E2-1 ]
UniGenei Hs.130411.

3D structure databases

ProteinModelPortali Q9P2E2.
SMRi Q9P2E2. Positions 3-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121629. 3 interactions.
IntActi Q9P2E2. 3 interactions.
MINTi MINT-2875280.
STRINGi 9606.ENSP00000247986.

PTM databases

PhosphoSitei Q9P2E2.

Polymorphism databases

DMDMi 317373436.

Proteomic databases

MaxQBi Q9P2E2.
PaxDbi Q9P2E2.
PRIDEi Q9P2E2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247986 ; ENSP00000247986 ; ENSG00000117245 . [Q9P2E2-1 ]
ENST00000400463 ; ENSP00000383311 ; ENSG00000117245 . [Q9P2E2-3 ]
GeneIDi 57576.
KEGGi hsa:57576.
UCSCi uc001bdr.4. human. [Q9P2E2-1 ]
uc001bds.4. human. [Q9P2E2-3 ]

Organism-specific databases

CTDi 57576.
GeneCardsi GC01M020990.
H-InvDB HIX0000220.
HGNCi HGNC:19167. KIF17.
HPAi HPA032085.
MIMi 605037. gene.
neXtProti NX_Q9P2E2.
PharmGKBi PA38809.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOVERGENi HBG052255.
InParanoidi Q9P2E2.
KOi K10394.
OMAi FWKIPEP.
OrthoDBi EOG7WX086.
PhylomeDBi Q9P2E2.
TreeFami TF105223.

Miscellaneous databases

GeneWikii KIF17.
GenomeRNAii 57576.
NextBioi 64119.
PROi Q9P2E2.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2E2.
CleanExi HS_KIF17.
Genevestigatori Q9P2E2.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells."
    Chennathukuzhi V., Morales C.R., El-Alfy M., Hecht N.B.
    Proc. Natl. Acad. Sci. U.S.A. 100:15566-15571(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-402 AND GLU-933.
    Tissue: Eye.
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-1029 (ISOFORM 1), VARIANTS MET-402 AND GLU-933.
    Tissue: Brain.
  5. Ohara O., Nagase T., Kikuno R.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "The MAP kinase kinase kinases MLK2 and MLK3 are targets for RAC/Cdc42 and components of microtubule motor complexes."
    Nagata K., Puls A., Futter C., Aspenstroem P., Hall A.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 793-1029, VARIANT GLU-933.

Entry informationi

Entry nameiKIF17_HUMAN
AccessioniPrimary (citable) accession number: Q9P2E2
Secondary accession number(s): A2A3Q7
, A2A3Q8, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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