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Protein

Protein FAM135A

Gene

FAM135A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082269-MONOMER.

Protein family/group databases

ESTHERihuman-FAM135A. Duf_676.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM135A
Gene namesi
Name:FAM135A
Synonyms:KIAA1411
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21084. FAM135A.

Pathology & Biotechi

Organism-specific databases

DisGeNETi57579.
OpenTargetsiENSG00000082269.
PharmGKBiPA162386230.

Polymorphism and mutation databases

BioMutaiFAM135A.
DMDMi166233529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141681 – 1515Protein FAM135AAdd BLAST1515

Proteomic databases

EPDiQ9P2D6.
MaxQBiQ9P2D6.
PaxDbiQ9P2D6.
PeptideAtlasiQ9P2D6.
PRIDEiQ9P2D6.

PTM databases

iPTMnetiQ9P2D6.
PhosphoSitePlusiQ9P2D6.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000082269.
CleanExiHS_FAM135A.
ExpressionAtlasiQ9P2D6. baseline and differential.
GenevisibleiQ9P2D6. HS.

Organism-specific databases

HPAiHPA031743.
HPA031744.

Interactioni

Protein-protein interaction databases

IntActiQ9P2D6. 3 interactors.
MINTiMINT-4717076.
STRINGi9606.ENSP00000410768.

Structurei

3D structure databases

ProteinModelPortaliQ9P2D6.
SMRiQ9P2D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM135 family.Curated

Phylogenomic databases

eggNOGiKOG2205. Eukaryota.
ENOG410XQFK. LUCA.
GeneTreeiENSGT00390000007885.
HOVERGENiHBG106788.
InParanoidiQ9P2D6.
OMAiQAMVEFS.
OrthoDBiEOG091G0KFW.
PhylomeDBiQ9P2D6.
TreeFamiTF314837.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022122. DUF3657.
IPR007751. DUF676_lipase-like.
[Graphical view]
PfamiPF12394. DUF3657. 1 hit.
PF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2D6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEVQAMVEF SVELNKFYNV DLFQRGFYQI RASMKIPSRI PHRVEASLLH
60 70 80 90 100
ATGMTLAFPA SVHDSLICSK TFQILYKNEE VVLNDVMIFK VKMLLDERKI
110 120 130 140 150
EETLEEMNFL LSLDLHFTDG DYSADDLNAL QLISSRTLKL HFSPHRGLHH
160 170 180 190 200
HVNVMFDYFH LSVVSVTVHA SLVALHQPLI SFPRPVKTTW LNRNAPAQNK
210 220 230 240 250
DSVIPTLESV VFGINYTKQL SPDGCSFIIA DSFLHHAYRF HYTLCATLLL
260 270 280 290 300
AFKGLHSYFI TVTEEIPSCQ KLELEEMDVE ARLTELCEEV KKIENPDELA
310 320 330 340 350
ELINMNLAQL CSLLMALWGQ FLEVITLHEE LRILLAQEHH TLRVRRFSEA
360 370 380 390 400
FFCFEHPREA AIAYQELHAQ SHLQMCTAIK NTSFCSSLPP LPIECSELDG
410 420 430 440 450
DLNSLPIIFE DRYLDSVTED LDAPWMGIQN LQRSESSKMD KYETEESSVA
460 470 480 490 500
GLSSPELKVR PAGASSIWYT EGEKQLTKSL KGKNEESNKS KVKVTKLMKT
510 520 530 540 550
MKSENTKKLI KQNSKDSVVL VGYKCLKSTA SNDLIKCFEG NPSHSQKEGL
560 570 580 590 600
DPTICGYNFD PKTYMRQTSQ KEASCLPTNT ERTEQKSPDI ENVQPDQFDP
610 620 630 640 650
LNSGNLNLCA NLSISGKLDI SQDDSEITQM EHNLASRRSS DDCHDHQTTP
660 670 680 690 700
SLGVRTIEIK PSNKDPFSGE NITVKLGPWT ELRQEEILVD NLLPNFESLE
710 720 730 740 750
SNGKSKSIEI TFEKEALQEA KCLSIGESLT KLRSNLPAPS TKEYHVVVSG
760 770 780 790 800
DTIKLPDISA TYASSRFSDS GVESEPSSFA THPNTDLVFE TVQGQGPCNS
810 820 830 840 850
ERLFPQLLMK PDYNVKFSLG NHCTESTSAI SEIQSSLTSI NSLPSDDELS
860 870 880 890 900
PDENSKKSVV PECHLNDSKT VLNLGTTDLP KCDDTKKSSI TLQQQSVVFS
910 920 930 940 950
GNLDNETVAI HSLNSSIKDP LQFVFSDEET SSDVKSSCSS KPNLDTMCKG
960 970 980 990 1000
FQSPDKSNNS TGTAITLNSK LICLGTPCVI SGSISSNTDV SEDRTMKKNS
1010 1020 1030 1040 1050
DVLNLTQMYS EIPTVESETH LGTSDPFSAS TDIVKQGLVE NYFGSQSSTD
1060 1070 1080 1090 1100
ISDTCAVSYS NALSPQKETS EKEISNLQQE QDKEDEEEEQ DQQMVQNGYY
1110 1120 1130 1140 1150
EETDYSALDG TINAHYTSRD ELMEERLTKS EKINSDYLRD GINMPTVCTS
1160 1170 1180 1190 1200
GCLSFPSAPR ESPCNVKYSS KSKFDAITKQ PSSTSYNFTS SISWYESSPK
1210 1220 1230 1240 1250
PQIQAFLQAK EELKLLKLPG FMYSEVPLLA SSVPYFSVEE EDGSEDGVHL
1260 1270 1280 1290 1300
IVCVHGLDGN SADLRLVKTY IELGLPGGRI DFLMSERNQN DTFADFDSMT
1310 1320 1330 1340 1350
DRLLDEIIQY IQIYSLTVSK ISFIGHSLGN LIIRSVLTRP RFKYYLNKLH
1360 1370 1380 1390 1400
TFLSLSGPHL GTLYNSSALV NTGLWFMQKW KKSGSLLQLT CRDHSDPRQT
1410 1420 1430 1440 1450
FLYKLSNKAG LHYFKNVVLV GSLQDRYVPY HSARIEMCKT ALKDKQSGQI
1460 1470 1480 1490 1500
YSEMIHNLLR PVLQSKDCNL VRYNVINALP NTADSLIGRA AHIAVLDSEI
1510
FLEKFFLVAA LKYFQ
Length:1,515
Mass (Da):169,840
Last modified:January 15, 2008 - v2
Checksum:i43DB6301DE0F907F
GO
Isoform 2 (identifier: Q9P2D6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-615: Missing.

Show »
Length:1,319
Mass (Da):148,065
Checksum:iDEA7ED3DC0993467
GO
Isoform 3 (identifier: Q9P2D6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-69: Missing.
     273-273: E → ELAKANMQLLYERLLRRKQLRTQKDNH
     420-615: Missing.

Show »
Length:1,302
Mass (Da):146,549
Checksum:iEAD715D6E55E0B48
GO
Isoform 4 (identifier: Q9P2D6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1449-1515: QIYSEMIHNL...FLVAALKYFQ → NGIKLFQRVIGINELFPKFFL

Note: No experimental confirmation available.
Show »
Length:1,469
Mass (Da):164,684
Checksum:i43057A50D33D6B94
GO

Sequence cautioni

The sequence AAH65767 differs from that shown. Intron retention.Curated
The sequence BAA90995 differs from that shown. Intron retention.Curated
The sequence BAA92649 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66754 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI42417 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti738A → T in CAH18110 (PubMed:17974005).Curated1
Sequence conflicti1330N → D in CAH18110 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037854725I → V.Corresponds to variant rs9455142dbSNPEnsembl.1
Natural variantiVAR_037855954P → S.Corresponds to variant rs16869301dbSNPEnsembl.1
Natural variantiVAR_0378561242D → G.3 PublicationsCorresponds to variant rs2747701dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03022527 – 69Missing in isoform 3. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_030226273E → ELAKANMQLLYERLLRRKQL RTQKDNH in isoform 3. 2 Publications1
Alternative sequenceiVSP_030227420 – 615Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST196
Alternative sequenceiVSP_0302301449 – 1515QIYSE…LKYFQ → NGIKLFQRVIGINELFPKFF L in isoform 4. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037832 mRNA. Translation: BAA92649.1. Different initiation.
CR749254 mRNA. Translation: CAH18110.1.
AL078591 Genomic DNA. Translation: CAB89265.1.
AL078591 Genomic DNA. Translation: CAI42417.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48820.1.
BC065767 mRNA. Translation: AAH65767.1. Sequence problems.
BC131782 mRNA. Translation: AAI31783.1.
AK000183 mRNA. Translation: BAA90995.1. Sequence problems.
AK002067 mRNA. Translation: BAA92066.1.
AK023639 mRNA. No translation available.
AL136820 mRNA. Translation: CAB66754.1. Different initiation.
CCDSiCCDS34481.1. [Q9P2D6-3]
CCDS47448.1. [Q9P2D6-2]
CCDS55028.1. [Q9P2D6-1]
RefSeqiNP_001099001.1. NM_001105531.2. [Q9P2D6-2]
NP_001156001.1. NM_001162529.2. [Q9P2D6-1]
NP_001317926.1. NM_001330997.1.
NP_001317930.1. NM_001331001.1.
NP_001317931.1. NM_001331002.1.
NP_065870.3. NM_020819.4. [Q9P2D6-3]
XP_016866614.1. XM_017011125.1. [Q9P2D6-1]
XP_016866615.1. XM_017011126.1. [Q9P2D6-1]
XP_016866616.1. XM_017011127.1. [Q9P2D6-1]
UniGeneiHs.211700.

Genome annotation databases

EnsembliENST00000361499; ENSP00000354913; ENSG00000082269. [Q9P2D6-2]
ENST00000370479; ENSP00000359510; ENSG00000082269. [Q9P2D6-1]
ENST00000418814; ENSP00000410768; ENSG00000082269. [Q9P2D6-1]
ENST00000457062; ENSP00000409201; ENSG00000082269. [Q9P2D6-3]
ENST00000505868; ENSP00000423307; ENSG00000082269. [Q9P2D6-4]
GeneIDi57579.
KEGGihsa:57579.
UCSCiuc003pfh.4. human. [Q9P2D6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037832 mRNA. Translation: BAA92649.1. Different initiation.
CR749254 mRNA. Translation: CAH18110.1.
AL078591 Genomic DNA. Translation: CAB89265.1.
AL078591 Genomic DNA. Translation: CAI42417.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48820.1.
BC065767 mRNA. Translation: AAH65767.1. Sequence problems.
BC131782 mRNA. Translation: AAI31783.1.
AK000183 mRNA. Translation: BAA90995.1. Sequence problems.
AK002067 mRNA. Translation: BAA92066.1.
AK023639 mRNA. No translation available.
AL136820 mRNA. Translation: CAB66754.1. Different initiation.
CCDSiCCDS34481.1. [Q9P2D6-3]
CCDS47448.1. [Q9P2D6-2]
CCDS55028.1. [Q9P2D6-1]
RefSeqiNP_001099001.1. NM_001105531.2. [Q9P2D6-2]
NP_001156001.1. NM_001162529.2. [Q9P2D6-1]
NP_001317926.1. NM_001330997.1.
NP_001317930.1. NM_001331001.1.
NP_001317931.1. NM_001331002.1.
NP_065870.3. NM_020819.4. [Q9P2D6-3]
XP_016866614.1. XM_017011125.1. [Q9P2D6-1]
XP_016866615.1. XM_017011126.1. [Q9P2D6-1]
XP_016866616.1. XM_017011127.1. [Q9P2D6-1]
UniGeneiHs.211700.

3D structure databases

ProteinModelPortaliQ9P2D6.
SMRiQ9P2D6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9P2D6. 3 interactors.
MINTiMINT-4717076.
STRINGi9606.ENSP00000410768.

Protein family/group databases

ESTHERihuman-FAM135A. Duf_676.

PTM databases

iPTMnetiQ9P2D6.
PhosphoSitePlusiQ9P2D6.

Polymorphism and mutation databases

BioMutaiFAM135A.
DMDMi166233529.

Proteomic databases

EPDiQ9P2D6.
MaxQBiQ9P2D6.
PaxDbiQ9P2D6.
PeptideAtlasiQ9P2D6.
PRIDEiQ9P2D6.

Protocols and materials databases

DNASUi57579.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361499; ENSP00000354913; ENSG00000082269. [Q9P2D6-2]
ENST00000370479; ENSP00000359510; ENSG00000082269. [Q9P2D6-1]
ENST00000418814; ENSP00000410768; ENSG00000082269. [Q9P2D6-1]
ENST00000457062; ENSP00000409201; ENSG00000082269. [Q9P2D6-3]
ENST00000505868; ENSP00000423307; ENSG00000082269. [Q9P2D6-4]
GeneIDi57579.
KEGGihsa:57579.
UCSCiuc003pfh.4. human. [Q9P2D6-1]

Organism-specific databases

CTDi57579.
DisGeNETi57579.
GeneCardsiFAM135A.
H-InvDBHIX0005996.
HGNCiHGNC:21084. FAM135A.
HPAiHPA031743.
HPA031744.
neXtProtiNX_Q9P2D6.
OpenTargetsiENSG00000082269.
PharmGKBiPA162386230.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2205. Eukaryota.
ENOG410XQFK. LUCA.
GeneTreeiENSGT00390000007885.
HOVERGENiHBG106788.
InParanoidiQ9P2D6.
OMAiQAMVEFS.
OrthoDBiEOG091G0KFW.
PhylomeDBiQ9P2D6.
TreeFamiTF314837.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082269-MONOMER.

Miscellaneous databases

ChiTaRSiFAM135A. human.
GeneWikiiFAM135A.
GenomeRNAii57579.
PROiQ9P2D6.

Gene expression databases

BgeeiENSG00000082269.
CleanExiHS_FAM135A.
ExpressionAtlasiQ9P2D6. baseline and differential.
GenevisibleiQ9P2D6. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022122. DUF3657.
IPR007751. DUF676_lipase-like.
[Graphical view]
PfamiPF12394. DUF3657. 1 hit.
PF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF135A_HUMAN
AccessioniPrimary (citable) accession number: Q9P2D6
Secondary accession number(s): A2RRQ5
, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.