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Protein

HEAT repeat-containing protein 5B

Gene

HEATR5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 5B
Gene namesi
Name:HEATR5B
Synonyms:KIAA1414
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29273. HEATR5B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20712071HEAT repeat-containing protein 5BPRO_0000311994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1123 – 11231Phosphoserine1 Publication
Modified residuei1737 – 17371Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P2D3.
PaxDbiQ9P2D3.
PeptideAtlasiQ7Z3B2.
PRIDEiQ9P2D3.

PTM databases

PhosphoSiteiQ9P2D3.

Expressioni

Gene expression databases

BgeeiQ9P2D3.
CleanExiHS_HEATR5B.
ExpressionAtlasiQ9P2D3. baseline and differential.
GenevestigatoriQ9P2D3.

Organism-specific databases

HPAiHPA042025.
HPA055639.

Interactioni

Protein-protein interaction databases

BioGridi119993. 7 interactions.
IntActiQ9P2D3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9P2D3.
SMRiQ9P2D3. Positions 447-473, 855-880, 1038-1097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati848 – 88538HEAT 1Add
BLAST
Repeati1062 – 109938HEAT 2Add
BLAST
Repeati1290 – 132738HEAT 3Add
BLAST

Sequence similaritiesi

Belongs to the HEATR5 family.Curated
Contains 3 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG289817.
GeneTreeiENSGT00390000006205.
HOGENOMiHOG000021545.
HOVERGENiHBG056837.
InParanoidiQ9P2D3.
OMAiFRGYVEP.
OrthoDBiEOG7T4MJB.
PhylomeDBiQ9P2D3.
TreeFamiTF300706.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 8 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELAHSLLLN EEALAQITEA KRPVFIFEWL RFLDKVLVAA NKTDVKEKQK
60 70 80 90 100
KLVEQLTGLI SSSPGPPTRK LLAKNLAALY SIGDTFTVFQ TLDKCNDIIR
110 120 130 140 150
NKDDTAAYLP TKLAAVACVG AFYEKMGRML GSAFPETVNN LLKSLKSAES
160 170 180 190 200
QGRSEILMSL QKVLSGLGGA AASSHRDIYK NARSLLTDRS MAVRCAVAKC
210 220 230 240 250
LLELQNEAVF MWTAELENIA TLCFKALENS NYGVRVAVSK LLGTVMATAL
260 270 280 290 300
MPKQATVMRQ NVKRATFDEV LELMATGFLR GGSGFLKSGG EMLKVGGSVN
310 320 330 340 350
REVRVGVTQA YVVFVTTLGG QWLERSFATF LSHVLDLVSH PRATQTHVEA
360 370 380 390 400
VYSRRCVSFI LRATVGSLLG EKAQIAAAKE ICQAIGKQMK AVEAVVNDTS
410 420 430 440 450
GENKSGAADI AASQHVMVCA LQELGSLVQS LNATASPLIQ EASIGLLEIV
460 470 480 490 500
TSVLLHPSMA ARLAAAWCLR CVAVALPFQL TPFLDRCAER LNNLKTSPEA
510 520 530 540 550
VSGYSFAMAA LLGGVHQCPL GIPHAKGKMV VSIAEDLLRT AAQNSRLSLQ
560 570 580 590 600
RTQAGWLLLG ALMTLGPSVV RYHLPKMLLL WRNVFPRSLK ELEAEKARGD
610 620 630 640 650
SFTWQVTLEG RAGALCAMRS FVAHCPELLT EDVIRKLMTP IECAMTMMSH
660 670 680 690 700
IPSVMKAHGA HLKASAAMVR LRLYDILALL PPKTYEGSFN ALLRELVAEF
710 720 730 740 750
TLTDNSANTT TSLLRSLCHY DDSVLLGSWL QETDHKSIED QLQPNSASGS
760 770 780 790 800
GALEHDPSSI YLRIPAGEAV PGPLPLGVSV IDASVALFGV VFPHVSYKHR
810 820 830 840 850
LQMLDHFAEC VKQAKGVRQQ AVQLNIFTAV LSALKGLAEN KSTLGPEEVR
860 870 880 890 900
KSALTLVMGP LDNPNPILRC AAGEALGRMA QVVGEATFIA RMAQYSFDKL
910 920 930 940 950
KSARDVVSRT GHSLALGCLH RYVGGIGSGQ HLKTSVSILL ALAQDGTSPE
960 970 980 990 1000
VQTWSLHSLA LIVDSSGPMY RGYVEPTLSL VLTLLLTVPP SHTEVHQCLG
1010 1020 1030 1040 1050
RCLGAIITTV GPELQGNGAT TSTIRSSCLV GCAITQDHSD SLVQAAAISC
1060 1070 1080 1090 1100
LQQLHMFAPR HVNLSSLVPS LCVHLCSSHL LLRRAAVACL RQLAQREAAE
1110 1120 1130 1140 1150
VCEYAMSLAK NTGDKESSSA NVSPFAPGVS SRTDIHCRHQ GVNITETGLE
1160 1170 1180 1190 1200
GLLFGMLDRE TDRKLCSDIH DTLGHMLSSL AVEKLSHWLM LCKDVLAASS
1210 1220 1230 1240 1250
DMSTATLLSS GKDEEAEKKD EMDDDTMFTT LGEEDKSKPF VAPRWATRVF
1260 1270 1280 1290 1300
AADCLCRIIN LCENADQAHF DLALARSAKL RNPTNDLLVL HLSDLIRMAF
1310 1320 1330 1340 1350
MAATDHSNQL RMAGLQALED IIKKFASVPE PEFPGHVILE QYQANVGAAL
1360 1370 1380 1390 1400
RPAFSQDTPS DIIAKACQVC STWIGSGVVS DLNDLRRVHN LLVSSLDKVQ
1410 1420 1430 1440 1450
AGKGSSSQLY RESATTMEKL AVLKAWAEVY VVAMNIKKEA ESKPKRAIKN
1460 1470 1480 1490 1500
TDDDDDDCGT IDELPPDSLI TLVQPELPTL SRLWLAALKD YALLTLPAEF
1510 1520 1530 1540 1550
SSQLPPDGGA FYTPETIDTA RLHYRNSWAP ILHAVALWLN STGFTCSEST
1560 1570 1580 1590 1600
EAAAISGLQK RSTSVNLNQA SGAVGSAKSL PEINKDRMHL ILGVSIQFLC
1610 1620 1630 1640 1650
SPRPEEPIEH VTACLQALHT LLDSPYARVH IAEDQLIGVE LLSVLHRLLL
1660 1670 1680 1690 1700
TWNPSSVQLL VTGVVQQIVR AAQDYLQEKR NTLNEDDMEK EACTVLGEGG
1710 1720 1730 1740 1750
DSGGLIPGKS LVFATMELLM FILVRHMPHL STKVSDSPSH IATKTRLSEE
1760 1770 1780 1790 1800
SARLVAATVT ILSDLPSLCS PAGCMTILPT ILFLIARILK DTAIKSADNQ
1810 1820 1830 1840 1850
VPPPVSAALQ GIKSIVTLSM AKTEAGVQKQ WTALIRSTLA CILEYSQPED
1860 1870 1880 1890 1900
SVPTPDEVSM LTAIALFLWS ASNEIIGVQS LQNGCMNRFK NALNSCDPWV
1910 1920 1930 1940 1950
QAKCYQLLLS VFQHSNRALS TPYIHSLAPI VVEKLKAVER NRPASNIELL
1960 1970 1980 1990 2000
AVQEGIKVLE TLVALGEEQN RVQLLALLVP TLISYLLDEN SFASASSASK
2010 2020 2030 2040 2050
DLHEFALQNL MHIGPLYPHA FKTVMGAAPE LKVRLETAVR ASQASKAKAA
2060 2070
ARQPAPAIHS APTIKLKTSF F
Length:2,071
Mass (Da):224,302
Last modified:December 4, 2007 - v2
Checksum:i5CAAD3A49BFC975E
GO
Isoform 2 (identifier: Q9P2D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-768: RIPAGE → LLFLVH
     769-2071: Missing.

Show »
Length:768
Mass (Da):83,487
Checksum:i138EBB6A1D0EE5D2
GO
Isoform 3 (identifier: Q9P2D3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1684-1773: NEDDMEKEAC...DLPSLCSPAG → R

Show »
Length:1,982
Mass (Da):214,994
Checksum:i5E81D286D1D41D25
GO

Sequence cautioni

The sequence BAA91733.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241E → G in CAD97959 (PubMed:17974005).Curated
Sequence conflicti1640 – 16401E → G in BAA91733 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1601 – 16011S → P.
Corresponds to variant rs2302657 [ dbSNP | Ensembl ].
VAR_037392

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei763 – 7686RIPAGE → LLFLVH in isoform 2. 1 PublicationVSP_029690
Alternative sequencei769 – 20711303Missing in isoform 2. 1 PublicationVSP_029691Add
BLAST
Alternative sequencei1684 – 177390NEDDM…CSPAG → R in isoform 3. 1 PublicationVSP_029692Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007404 Genomic DNA. No translation available.
AC007899 Genomic DNA. No translation available.
BX538008 mRNA. Translation: CAD97959.1.
AB037835 mRNA. Translation: BAA92652.1.
AK001513 mRNA. Translation: BAA91733.1. Different initiation.
CCDSiCCDS33181.1. [Q9P2D3-1]
RefSeqiNP_061897.1. NM_019024.2. [Q9P2D3-1]
UniGeneiHs.744084.

Genome annotation databases

EnsembliENST00000233099; ENSP00000233099; ENSG00000008869. [Q9P2D3-1]
GeneIDi54497.
KEGGihsa:54497.
UCSCiuc002rpp.1. human. [Q9P2D3-1]

Polymorphism databases

DMDMi162416219.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007404 Genomic DNA. No translation available.
AC007899 Genomic DNA. No translation available.
BX538008 mRNA. Translation: CAD97959.1.
AB037835 mRNA. Translation: BAA92652.1.
AK001513 mRNA. Translation: BAA91733.1. Different initiation.
CCDSiCCDS33181.1. [Q9P2D3-1]
RefSeqiNP_061897.1. NM_019024.2. [Q9P2D3-1]
UniGeneiHs.744084.

3D structure databases

ProteinModelPortaliQ9P2D3.
SMRiQ9P2D3. Positions 447-473, 855-880, 1038-1097.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119993. 7 interactions.
IntActiQ9P2D3. 1 interaction.

PTM databases

PhosphoSiteiQ9P2D3.

Polymorphism databases

DMDMi162416219.

Proteomic databases

MaxQBiQ9P2D3.
PaxDbiQ9P2D3.
PeptideAtlasiQ7Z3B2.
PRIDEiQ9P2D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233099; ENSP00000233099; ENSG00000008869. [Q9P2D3-1]
GeneIDi54497.
KEGGihsa:54497.
UCSCiuc002rpp.1. human. [Q9P2D3-1]

Organism-specific databases

CTDi54497.
GeneCardsiGC02M037195.
H-InvDBHIX0001970.
HIX0161853.
HGNCiHGNC:29273. HEATR5B.
HPAiHPA042025.
HPA055639.
neXtProtiNX_Q9P2D3.
PharmGKBiPA162390697.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG289817.
GeneTreeiENSGT00390000006205.
HOGENOMiHOG000021545.
HOVERGENiHBG056837.
InParanoidiQ9P2D3.
OMAiFRGYVEP.
OrthoDBiEOG7T4MJB.
PhylomeDBiQ9P2D3.
TreeFamiTF300706.

Miscellaneous databases

ChiTaRSiHEATR5B. human.
GenomeRNAii54497.
NextBioi56832.
PROiQ9P2D3.

Gene expression databases

BgeeiQ9P2D3.
CleanExiHS_HEATR5B.
ExpressionAtlasiQ9P2D3. baseline and differential.
GenevestigatoriQ9P2D3.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 8 hits.
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-2071 (ISOFORM 2).
    Tissue: Amygdala.
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-2071 (ISOFORM 1).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1399-2071 (ISOFORM 3).
    Tissue: Teratocarcinoma.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHTR5B_HUMAN
AccessioniPrimary (citable) accession number: Q9P2D3
Secondary accession number(s): B5MDU8, Q7Z3B2, Q9NVL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 4, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.