Q9P2D3 (HTR5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HEAT repeat-containing protein 5B

Gene names

Name:	HEATR5B
Synonyms:	KIAA1414

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2071 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the HEATR5 family. Contains 3 HEAT repeats.
Sequence caution	The sequence BAA91733.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2D3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2D3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     763-768: RIPAGE → LLFLVH
     769-2071: Missing.

Isoform 3 (identifier: Q9P2D3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1684-1773: NEDDMEKEAC...DLPSLCSPAG → R

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2071	2071	HEAT repeat-containing protein 5B		PRO_0000311994
Regions
	Repeat	848 – 885	38	HEAT 1
	Repeat	1062 – 1099	38	HEAT 2
	Repeat	1290 – 1327	38	HEAT 3
Amino acid modifications
	Modified residue	1123	1	Phosphoserine Ref.5
	Modified residue	1737	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	763 – 768	6	RIPAGE → LLFLVH in isoform 2.		VSP_029690
	Alternative sequence	769 – 2071	1303	Missing in isoform 2.		VSP_029691
	Alternative sequence	1684 – 1773	90	NEDDM…CSPAG → R in isoform 3.		VSP_029692
	Natural variant	1601	1	S → P. Corresponds to variant rs2302657 [ dbSNP | Ensembl ].		VAR_037392
Experimental info
	Sequence conflict	324	1	E → G in CAD97959. Ref.2
	Sequence conflict	1640	1	E → G in BAA91733. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 5CAAD3A49BFC975E	FASTA	2,071	224,302
	10 20 30 40 50 60 MELAHSLLLN EEALAQITEA KRPVFIFEWL RFLDKVLVAA NKTDVKEKQK KLVEQLTGLI 70 80 90 100 110 120 SSSPGPPTRK LLAKNLAALY SIGDTFTVFQ TLDKCNDIIR NKDDTAAYLP TKLAAVACVG 130 140 150 160 170 180 AFYEKMGRML GSAFPETVNN LLKSLKSAES QGRSEILMSL QKVLSGLGGA AASSHRDIYK 190 200 210 220 230 240 NARSLLTDRS MAVRCAVAKC LLELQNEAVF MWTAELENIA TLCFKALENS NYGVRVAVSK 250 260 270 280 290 300 LLGTVMATAL MPKQATVMRQ NVKRATFDEV LELMATGFLR GGSGFLKSGG EMLKVGGSVN 310 320 330 340 350 360 REVRVGVTQA YVVFVTTLGG QWLERSFATF LSHVLDLVSH PRATQTHVEA VYSRRCVSFI 370 380 390 400 410 420 LRATVGSLLG EKAQIAAAKE ICQAIGKQMK AVEAVVNDTS GENKSGAADI AASQHVMVCA 430 440 450 460 470 480 LQELGSLVQS LNATASPLIQ EASIGLLEIV TSVLLHPSMA ARLAAAWCLR CVAVALPFQL 490 500 510 520 530 540 TPFLDRCAER LNNLKTSPEA VSGYSFAMAA LLGGVHQCPL GIPHAKGKMV VSIAEDLLRT 550 560 570 580 590 600 AAQNSRLSLQ RTQAGWLLLG ALMTLGPSVV RYHLPKMLLL WRNVFPRSLK ELEAEKARGD 610 620 630 640 650 660 SFTWQVTLEG RAGALCAMRS FVAHCPELLT EDVIRKLMTP IECAMTMMSH IPSVMKAHGA 670 680 690 700 710 720 HLKASAAMVR LRLYDILALL PPKTYEGSFN ALLRELVAEF TLTDNSANTT TSLLRSLCHY 730 740 750 760 770 780 DDSVLLGSWL QETDHKSIED QLQPNSASGS GALEHDPSSI YLRIPAGEAV PGPLPLGVSV 790 800 810 820 830 840 IDASVALFGV VFPHVSYKHR LQMLDHFAEC VKQAKGVRQQ AVQLNIFTAV LSALKGLAEN 850 860 870 880 890 900 KSTLGPEEVR KSALTLVMGP LDNPNPILRC AAGEALGRMA QVVGEATFIA RMAQYSFDKL 910 920 930 940 950 960 KSARDVVSRT GHSLALGCLH RYVGGIGSGQ HLKTSVSILL ALAQDGTSPE VQTWSLHSLA 970 980 990 1000 1010 1020 LIVDSSGPMY RGYVEPTLSL VLTLLLTVPP SHTEVHQCLG RCLGAIITTV GPELQGNGAT 1030 1040 1050 1060 1070 1080 TSTIRSSCLV GCAITQDHSD SLVQAAAISC LQQLHMFAPR HVNLSSLVPS LCVHLCSSHL 1090 1100 1110 1120 1130 1140 LLRRAAVACL RQLAQREAAE VCEYAMSLAK NTGDKESSSA NVSPFAPGVS SRTDIHCRHQ 1150 1160 1170 1180 1190 1200 GVNITETGLE GLLFGMLDRE TDRKLCSDIH DTLGHMLSSL AVEKLSHWLM LCKDVLAASS 1210 1220 1230 1240 1250 1260 DMSTATLLSS GKDEEAEKKD EMDDDTMFTT LGEEDKSKPF VAPRWATRVF AADCLCRIIN 1270 1280 1290 1300 1310 1320 LCENADQAHF DLALARSAKL RNPTNDLLVL HLSDLIRMAF MAATDHSNQL RMAGLQALED 1330 1340 1350 1360 1370 1380 IIKKFASVPE PEFPGHVILE QYQANVGAAL RPAFSQDTPS DIIAKACQVC STWIGSGVVS 1390 1400 1410 1420 1430 1440 DLNDLRRVHN LLVSSLDKVQ AGKGSSSQLY RESATTMEKL AVLKAWAEVY VVAMNIKKEA 1450 1460 1470 1480 1490 1500 ESKPKRAIKN TDDDDDDCGT IDELPPDSLI TLVQPELPTL SRLWLAALKD YALLTLPAEF 1510 1520 1530 1540 1550 1560 SSQLPPDGGA FYTPETIDTA RLHYRNSWAP ILHAVALWLN STGFTCSEST EAAAISGLQK 1570 1580 1590 1600 1610 1620 RSTSVNLNQA SGAVGSAKSL PEINKDRMHL ILGVSIQFLC SPRPEEPIEH VTACLQALHT 1630 1640 1650 1660 1670 1680 LLDSPYARVH IAEDQLIGVE LLSVLHRLLL TWNPSSVQLL VTGVVQQIVR AAQDYLQEKR 1690 1700 1710 1720 1730 1740 NTLNEDDMEK EACTVLGEGG DSGGLIPGKS LVFATMELLM FILVRHMPHL STKVSDSPSH 1750 1760 1770 1780 1790 1800 IATKTRLSEE SARLVAATVT ILSDLPSLCS PAGCMTILPT ILFLIARILK DTAIKSADNQ 1810 1820 1830 1840 1850 1860 VPPPVSAALQ GIKSIVTLSM AKTEAGVQKQ WTALIRSTLA CILEYSQPED SVPTPDEVSM 1870 1880 1890 1900 1910 1920 LTAIALFLWS ASNEIIGVQS LQNGCMNRFK NALNSCDPWV QAKCYQLLLS VFQHSNRALS 1930 1940 1950 1960 1970 1980 TPYIHSLAPI VVEKLKAVER NRPASNIELL AVQEGIKVLE TLVALGEEQN RVQLLALLVP 1990 2000 2010 2020 2030 2040 TLISYLLDEN SFASASSASK DLHEFALQNL MHIGPLYPHA FKTVMGAAPE LKVRLETAVR 2050 2060 2070 ASQASKAKAA ARQPAPAIHS APTIKLKTSF F
	Isoform 2 [UniParc]. Checksum: 138EBB6A1D0EE5D2	FASTA	768	83,487
	10 20 30 40 50 60 MELAHSLLLN EEALAQITEA KRPVFIFEWL RFLDKVLVAA NKTDVKEKQK KLVEQLTGLI 70 80 90 100 110 120 SSSPGPPTRK LLAKNLAALY SIGDTFTVFQ TLDKCNDIIR NKDDTAAYLP TKLAAVACVG 130 140 150 160 170 180 AFYEKMGRML GSAFPETVNN LLKSLKSAES QGRSEILMSL QKVLSGLGGA AASSHRDIYK 190 200 210 220 230 240 NARSLLTDRS MAVRCAVAKC LLELQNEAVF MWTAELENIA TLCFKALENS NYGVRVAVSK 250 260 270 280 290 300 LLGTVMATAL MPKQATVMRQ NVKRATFDEV LELMATGFLR GGSGFLKSGG EMLKVGGSVN 310 320 330 340 350 360 REVRVGVTQA YVVFVTTLGG QWLERSFATF LSHVLDLVSH PRATQTHVEA VYSRRCVSFI 370 380 390 400 410 420 LRATVGSLLG EKAQIAAAKE ICQAIGKQMK AVEAVVNDTS GENKSGAADI AASQHVMVCA 430 440 450 460 470 480 LQELGSLVQS LNATASPLIQ EASIGLLEIV TSVLLHPSMA ARLAAAWCLR CVAVALPFQL 490 500 510 520 530 540 TPFLDRCAER LNNLKTSPEA VSGYSFAMAA LLGGVHQCPL GIPHAKGKMV VSIAEDLLRT 550 560 570 580 590 600 AAQNSRLSLQ RTQAGWLLLG ALMTLGPSVV RYHLPKMLLL WRNVFPRSLK ELEAEKARGD 610 620 630 640 650 660 SFTWQVTLEG RAGALCAMRS FVAHCPELLT EDVIRKLMTP IECAMTMMSH IPSVMKAHGA 670 680 690 700 710 720 HLKASAAMVR LRLYDILALL PPKTYEGSFN ALLRELVAEF TLTDNSANTT TSLLRSLCHY 730 740 750 760 DDSVLLGSWL QETDHKSIED QLQPNSASGS GALEHDPSSI YLLLFLVH
	Isoform 3 [UniParc]. Checksum: 5E81D286D1D41D25	FASTA	1,982	214,994
	10 20 30 40 50 60 MELAHSLLLN EEALAQITEA KRPVFIFEWL RFLDKVLVAA NKTDVKEKQK KLVEQLTGLI 70 80 90 100 110 120 SSSPGPPTRK LLAKNLAALY SIGDTFTVFQ TLDKCNDIIR NKDDTAAYLP TKLAAVACVG 130 140 150 160 170 180 AFYEKMGRML GSAFPETVNN LLKSLKSAES QGRSEILMSL QKVLSGLGGA AASSHRDIYK 190 200 210 220 230 240 NARSLLTDRS MAVRCAVAKC LLELQNEAVF MWTAELENIA TLCFKALENS NYGVRVAVSK 250 260 270 280 290 300 LLGTVMATAL MPKQATVMRQ NVKRATFDEV LELMATGFLR GGSGFLKSGG EMLKVGGSVN 310 320 330 340 350 360 REVRVGVTQA YVVFVTTLGG QWLERSFATF LSHVLDLVSH PRATQTHVEA VYSRRCVSFI 370 380 390 400 410 420 LRATVGSLLG EKAQIAAAKE ICQAIGKQMK AVEAVVNDTS GENKSGAADI AASQHVMVCA 430 440 450 460 470 480 LQELGSLVQS LNATASPLIQ EASIGLLEIV TSVLLHPSMA ARLAAAWCLR CVAVALPFQL 490 500 510 520 530 540 TPFLDRCAER LNNLKTSPEA VSGYSFAMAA LLGGVHQCPL GIPHAKGKMV VSIAEDLLRT 550 560 570 580 590 600 AAQNSRLSLQ RTQAGWLLLG ALMTLGPSVV RYHLPKMLLL WRNVFPRSLK ELEAEKARGD 610 620 630 640 650 660 SFTWQVTLEG RAGALCAMRS FVAHCPELLT EDVIRKLMTP IECAMTMMSH IPSVMKAHGA 670 680 690 700 710 720 HLKASAAMVR LRLYDILALL PPKTYEGSFN ALLRELVAEF TLTDNSANTT TSLLRSLCHY 730 740 750 760 770 780 DDSVLLGSWL QETDHKSIED QLQPNSASGS GALEHDPSSI YLRIPAGEAV PGPLPLGVSV 790 800 810 820 830 840 IDASVALFGV VFPHVSYKHR LQMLDHFAEC VKQAKGVRQQ AVQLNIFTAV LSALKGLAEN 850 860 870 880 890 900 KSTLGPEEVR KSALTLVMGP LDNPNPILRC AAGEALGRMA QVVGEATFIA RMAQYSFDKL 910 920 930 940 950 960 KSARDVVSRT GHSLALGCLH RYVGGIGSGQ HLKTSVSILL ALAQDGTSPE VQTWSLHSLA 970 980 990 1000 1010 1020 LIVDSSGPMY RGYVEPTLSL VLTLLLTVPP SHTEVHQCLG RCLGAIITTV GPELQGNGAT 1030 1040 1050 1060 1070 1080 TSTIRSSCLV GCAITQDHSD SLVQAAAISC LQQLHMFAPR HVNLSSLVPS LCVHLCSSHL 1090 1100 1110 1120 1130 1140 LLRRAAVACL RQLAQREAAE VCEYAMSLAK NTGDKESSSA NVSPFAPGVS SRTDIHCRHQ 1150 1160 1170 1180 1190 1200 GVNITETGLE GLLFGMLDRE TDRKLCSDIH DTLGHMLSSL AVEKLSHWLM LCKDVLAASS 1210 1220 1230 1240 1250 1260 DMSTATLLSS GKDEEAEKKD EMDDDTMFTT LGEEDKSKPF VAPRWATRVF AADCLCRIIN 1270 1280 1290 1300 1310 1320 LCENADQAHF DLALARSAKL RNPTNDLLVL HLSDLIRMAF MAATDHSNQL RMAGLQALED 1330 1340 1350 1360 1370 1380 IIKKFASVPE PEFPGHVILE QYQANVGAAL RPAFSQDTPS DIIAKACQVC STWIGSGVVS 1390 1400 1410 1420 1430 1440 DLNDLRRVHN LLVSSLDKVQ AGKGSSSQLY RESATTMEKL AVLKAWAEVY VVAMNIKKEA 1450 1460 1470 1480 1490 1500 ESKPKRAIKN TDDDDDDCGT IDELPPDSLI TLVQPELPTL SRLWLAALKD YALLTLPAEF 1510 1520 1530 1540 1550 1560 SSQLPPDGGA FYTPETIDTA RLHYRNSWAP ILHAVALWLN STGFTCSEST EAAAISGLQK 1570 1580 1590 1600 1610 1620 RSTSVNLNQA SGAVGSAKSL PEINKDRMHL ILGVSIQFLC SPRPEEPIEH VTACLQALHT 1630 1640 1650 1660 1670 1680 LLDSPYARVH IAEDQLIGVE LLSVLHRLLL TWNPSSVQLL VTGVVQQIVR AAQDYLQEKR 1690 1700 1710 1720 1730 1740 NTLRCMTILP TILFLIARIL KDTAIKSADN QVPPPVSAAL QGIKSIVTLS MAKTEAGVQK 1750 1760 1770 1780 1790 1800 QWTALIRSTL ACILEYSQPE DSVPTPDEVS MLTAIALFLW SASNEIIGVQ SLQNGCMNRF 1810 1820 1830 1840 1850 1860 KNALNSCDPW VQAKCYQLLL SVFQHSNRAL STPYIHSLAP IVVEKLKAVE RNRPASNIEL 1870 1880 1890 1900 1910 1920 LAVQEGIKVL ETLVALGEEQ NRVQLLALLV PTLISYLLDE NSFASASSAS KDLHEFALQN 1930 1940 1950 1960 1970 1980 LMHIGPLYPH AFKTVMGAAP ELKVRLETAV RASQASKAKA AARQPAPAIH SAPTIKLKTS FF

References

[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-2071 (ISOFORM 2). Tissue: Amygdala.
[3]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-2071 (ISOFORM 1). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1399-2071 (ISOFORM 3). Tissue: Teratocarcinoma.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1737, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC007404 Genomic DNA. No translation available. AC007899 Genomic DNA. No translation available. BX538008 mRNA. Translation: CAD97959.1. AB037835 mRNA. Translation: BAA92652.1. AK001513 mRNA. Translation: BAA91733.1. Different initiation.
IPI	IPI00333696. IPI00479069. IPI00877102.
RefSeq	NP_061897.1. NM_019024.1.
UniGene	Hs.468186.
3D structure databases
ProteinModelPortal	Q9P2D3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2D3. 1 interaction.
PTM databases
PhosphoSite	Q9P2D3.
Polymorphism databases
DMDM	162416219.
Proteomic databases
PaxDb	Q9P2D3.
PeptideAtlas	Q7Z3B2.
PRIDE	Q9P2D3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000233099; ENSP00000233099; ENSG00000008869. ENST00000354531; ENSP00000346531; ENSG00000008869.
GeneID	54497.
KEGG	hsa:54497.
UCSC	uc002rpp.1. human.
Organism-specific databases
CTD	54497.
GeneCards	GC02M037195.
H-InvDB	HIX0001970. HIX0161853.
HGNC	HGNC:29273. HEATR5B.
HPA	HPA042025.
neXtProt	NX_Q9P2D3.
PharmGKB	PA162390697.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289817.
HOGENOM	HOG000021545.
HOVERGEN	HBG056837.
InParanoid	Q9P2D3.
OMA	WNPPSVQ.
OrthoDB	EOG4MPHP7.
Gene expression databases
ArrayExpress	Q9P2D3.
Bgee	Q9P2D3.
CleanEx	HS_HEATR5B.
Genevestigator	Q9P2D3.
Family and domain databases
Gene3D	1.25.10.10. 5 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 2 hits.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HEATR5B. human.
GenomeRNAi	54497.
NextBio	56832.

Entry information

Entry name

HTR5B_HUMAN

Accession

Primary (citable) accession number: Q9P2D3
Secondary accession number(s): B5MDU8, Q7Z3B2, Q9NVL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.