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Q9P2D0

- IBTK_HUMAN

UniProt

Q9P2D0 - IBTK_HUMAN

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Protein

Inhibitor of Bruton tyrosine kinase

Gene
IBTK, BTKI, KIAA1417
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.1 Publication

GO - Molecular functioni

  1. protein kinase binding Source: MGI
  2. protein tyrosine kinase inhibitor activity Source: MGI

GO - Biological processi

  1. negative regulation of protein phosphorylation Source: MGI
  2. negative regulation of protein tyrosine kinase activity Source: GOC
  3. release of sequestered calcium ion into cytosol Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of Bruton tyrosine kinase
Short name:
IBtk
Gene namesi
Name:IBTK
Synonyms:BTKI, KIAA1417
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17853. IBTK.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein
Note: Translocates to the plasma membrane upon IgM stimulation.2 Publications
Isoform 2 : Nucleus 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane Source: UniProtKB-SubCell
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898277.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13531353Inhibitor of Bruton tyrosine kinasePRO_0000280276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei990 – 9901Phosphoserine1 Publication
Modified residuei1004 – 10041Phosphoserine1 Publication
Modified residuei1045 – 10451Phosphoserine3 Publications
Modified residuei1054 – 10541Phosphoserine1 Publication
Modified residuei1113 – 11131Phosphoserine1 Publication
Modified residuei1116 – 11161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P2D0.
PaxDbiQ9P2D0.
PRIDEiQ9P2D0.

PTM databases

PhosphoSiteiQ9P2D0.

Expressioni

Tissue specificityi

Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.2 Publications

Gene expression databases

ArrayExpressiQ9P2D0.
BgeeiQ9P2D0.
GenevestigatoriQ9P2D0.

Organism-specific databases

HPAiHPA023826.

Interactioni

Subunit structurei

Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK.2 Publications

Protein-protein interaction databases

BioGridi117474. 17 interactions.
IntActiQ9P2D0. 4 interactions.
MINTiMINT-215747.

Structurei

3D structure databases

ProteinModelPortaliQ9P2D0.
SMRiQ9P2D0. Positions 21-466, 744-899.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 8030ANK 1Add
BLAST
Repeati85 – 11430ANK 2Add
BLAST
Repeati141 – 19454RCC1 1Add
BLAST
Repeati195 – 24652RCC1 2Add
BLAST
Repeati248 – 30154RCC1 3Add
BLAST
Domaini564 – 64481BTB 1Add
BLAST
Domaini768 – 83669BTB 2Add
BLAST
Repeati806 – 83530ANK 3Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.
Contains 2 BTB (POZ) domains.
Contains 3 RCC1 repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG5184.
HOVERGENiHBG081779.
InParanoidiQ9P2D0.
OMAiVSALHHK.
OrthoDBiEOG7K6PT6.
PhylomeDBiQ9P2D0.
TreeFamiTF323747.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.130.10.30. 1 hit.
3.30.710.10. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00651. BTB. 2 hits.
PF00415. RCC1. 3 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50097. BTB. 2 hits.
PS50012. RCC1_3. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P2D0-1) [UniParc]FASTAAdd to Basket

Also known as: IBtk-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV     50
FGRNALHLVS SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID 100
CVWSLLKHGV SLYIQDKEGL SALDLVMKDR PTHVVFKNTD PTDVYTWGDN 150
TNFTLGHGSQ NSKHHPELVD LFSRSGIYIK QVVLCKFHSV FLSQKGQVYT 200
CGHGPGGRLG HGDEQTCLVP RLVEGLNGHN CSQVAAAKDH TVVLTEDGCV 250
YTFGLNIFHQ LGIIPPPSSC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 300
REAVYTMGLN GGQLGCLLDP NGEKCVTAPR QVSALHHKDI ALSLVAASDG 350
ATVCVTTRGD IYLLADYQCK KMASKQLNLK KVLVSGGHME YKVDPEHLKE 400
NGGQKICILA MDGAGRVFCW RSVNSSLKQC RWAYPRQVFI SDIALNRNEI 450
LFVTQDGEGF RGRWFEEKRK SSEKKEILSN LHNSSSDVSY VSDINSVYER 500
IRLEKLTFAH RAVSVSTDPS GCNFAILQSD PKTSLYEIPA VSSSSFFEEF 550
GKLLREADEM DSIHDVTFQV GNRLFPAHKY ILAVHSDFFQ KLFLSDGNTS 600
EFTDIYQKDE DSAGCHLFVV EKVHPDMFEY LLQFIYTDTC DFLTHGFKPR 650
IHLNKNPEEY QGTLNSHLNK VNFHEDDNQK SAFEVYKSNQ AQTVSERQKS 700
KPKSCKKGKN IREDDPVRML QTVAKKFDFS NLSSRLDGVR FENEKINVIA 750
KNTGNKLKLS QKKCSFLCDV TMKSVDGKEF PCHKCVLCAR LEYFHSMLSS 800
SWIEASSCAA LEMPIHSDIL KVILDYLYTD EAVVIKESQN VDFICSVLVV 850
ADQLLITRLK EICEVALTEK LTLKNAAMLL EFAAMYSAKQ LKLSCLQFIG 900
LNMAALLEAR SLDVLSDGVL KDLSEFYRKM IPAMDRRVIT PYQDGPDISY 950
LEVEDGDIFL KEEINMEQNH SETMFKKAKT KAKKKPRKRS DSSGGYNLSD 1000
IIQSPSSTGL LKSGKTNSVE SLPELLTSDS EGSYAGVGSP RDLQSPDFTT 1050
GFHSDKIEAK VKPYVNGTSP VYSREDLKPW EKSPILKISA PQPIPSNRID 1100
TTSSASWVAG SFSPVSPPVV DLRTIMEIEE SRQKCGATPK SHLGKTVSHG 1150
VKLSQKQRKM IALTTKENNS GMNSMETVLF TPSKAPKPVN AWASSLHSVS 1200
SKSFRDFLLE EKKSVTSHSS GDHVKKVSFK GIENSQAPKI VRCSTHGTPG 1250
PEGNHISDLP LLDSPNPWLS SSVTAPSMVA PVTFASIVEE ELQQEAALIR 1300
SREKPLALIQ IEEHAIQDLL VFYEAFGNPE EFVIVERTPQ GPLAVPMWNK 1350
HGC 1353
Length:1,353
Mass (Da):150,528
Last modified:March 20, 2007 - v3
Checksum:i67B2D11E276A6AF1
GO
Isoform 2 (identifier: Q9P2D0-2) [UniParc]FASTAAdd to Basket

Also known as: IBtk-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1145-1196: KTVSHGVKLS...KPVNAWASSL → WVENITKDHF...GQFSLHNIIS
     1197-1353: Missing.

Note: Due to a partial intron retention.

Show »
Length:1,196
Mass (Da):133,859
Checksum:i7AEB0AF9F4B92805
GO
Isoform 3 (identifier: Q9P2D0-3) [UniParc]FASTAAdd to Basket

Also known as: IBtk-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-1113: Missing.
     1114-1144: PVSPPVVDLRTIMEIEESRQKCGATPKSHLG → MLIDIISSKMISHGIKLCQKKPLKLIGLISS

Note: Due to a partial intron retention.

Show »
Length:240
Mass (Da):26,314
Checksum:i55673D0FC6EE3FEB
GO

Sequence cautioni

The sequence AAG27170.1 differs from that shown. Reason: Aberrant splicing.
The sequence BAA92655.2 differs from that shown. Reason: Erroneous initiation.
The sequence CAI23414.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI23416.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1065 – 10651V → I.
Corresponds to variant rs12662902 [ dbSNP | Ensembl ].
VAR_031106
Natural varianti1185 – 11851A → V.2 Publications
Corresponds to variant rs9449444 [ dbSNP | Ensembl ].
VAR_031107

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11131113Missing in isoform 3. VSP_023600Add
BLAST
Alternative sequencei1114 – 114431PVSPP…KSHLG → MLIDIISSKMISHGIKLCQK KPLKLIGLISS in isoform 3. VSP_023601Add
BLAST
Alternative sequencei1145 – 119652KTVSH…WASSL → WVENITKDHFMLYFCPKNWT DLLHLSYYFSAFDVIVNYTS FSGQFSLHNIIS in isoform 2. VSP_023602Add
BLAST
Alternative sequencei1197 – 1353157Missing in isoform 2. VSP_023604Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti971 – 9711S → G in CAB43239. 1 Publication
Sequence conflicti1197 – 11971H → R in CAB43239. 1 Publication
Sequence conflicti1218 – 12181H → L in CAB43239. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ005633 mRNA. Translation: AAY55906.1.
DQ005634 mRNA. Translation: AAY55907.1.
DQ005635 mRNA. Translation: AAY55908.1.
AB037838 mRNA. Translation: BAA92655.2. Different initiation.
AL050333 Genomic DNA. Translation: CAI23414.1. Sequence problems.
AL050333 Genomic DNA. Translation: CAI23416.1. Sequence problems.
BC027490 mRNA. Translation: AAH27490.1.
BC038244 mRNA. Translation: AAH38244.2.
BC042171 mRNA. Translation: AAH42171.2.
BC113696 mRNA. Translation: AAI13697.1.
BC113698 mRNA. Translation: AAI13699.1.
AL050018 mRNA. Translation: CAB43239.1.
AF235049 mRNA. Translation: AAG27170.1. Sequence problems.
CCDSiCCDS34490.1. [Q9P2D0-1]
PIRiT08705.
RefSeqiNP_056340.2. NM_015525.2. [Q9P2D0-1]
UniGeneiHs.306425.

Genome annotation databases

EnsembliENST00000306270; ENSP00000305721; ENSG00000005700. [Q9P2D0-1]
GeneIDi25998.
KEGGihsa:25998.
UCSCiuc003pjl.1. human. [Q9P2D0-1]
uc003pjm.2. human. [Q9P2D0-2]

Polymorphism databases

DMDMi134034141.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ005633 mRNA. Translation: AAY55906.1 .
DQ005634 mRNA. Translation: AAY55907.1 .
DQ005635 mRNA. Translation: AAY55908.1 .
AB037838 mRNA. Translation: BAA92655.2 . Different initiation.
AL050333 Genomic DNA. Translation: CAI23414.1 . Sequence problems.
AL050333 Genomic DNA. Translation: CAI23416.1 . Sequence problems.
BC027490 mRNA. Translation: AAH27490.1 .
BC038244 mRNA. Translation: AAH38244.2 .
BC042171 mRNA. Translation: AAH42171.2 .
BC113696 mRNA. Translation: AAI13697.1 .
BC113698 mRNA. Translation: AAI13699.1 .
AL050018 mRNA. Translation: CAB43239.1 .
AF235049 mRNA. Translation: AAG27170.1 . Sequence problems.
CCDSi CCDS34490.1. [Q9P2D0-1 ]
PIRi T08705.
RefSeqi NP_056340.2. NM_015525.2. [Q9P2D0-1 ]
UniGenei Hs.306425.

3D structure databases

ProteinModelPortali Q9P2D0.
SMRi Q9P2D0. Positions 21-466, 744-899.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117474. 17 interactions.
IntActi Q9P2D0. 4 interactions.
MINTi MINT-215747.

PTM databases

PhosphoSitei Q9P2D0.

Polymorphism databases

DMDMi 134034141.

Proteomic databases

MaxQBi Q9P2D0.
PaxDbi Q9P2D0.
PRIDEi Q9P2D0.

Protocols and materials databases

DNASUi 25998.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306270 ; ENSP00000305721 ; ENSG00000005700 . [Q9P2D0-1 ]
GeneIDi 25998.
KEGGi hsa:25998.
UCSCi uc003pjl.1. human. [Q9P2D0-1 ]
uc003pjm.2. human. [Q9P2D0-2 ]

Organism-specific databases

CTDi 25998.
GeneCardsi GC06M082879.
HGNCi HGNC:17853. IBTK.
HPAi HPA023826.
MIMi 606457. gene.
neXtProti NX_Q9P2D0.
PharmGKBi PA134898277.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5184.
HOVERGENi HBG081779.
InParanoidi Q9P2D0.
OMAi VSALHHK.
OrthoDBi EOG7K6PT6.
PhylomeDBi Q9P2D0.
TreeFami TF323747.

Miscellaneous databases

ChiTaRSi IBTK. human.
GenomeRNAii 25998.
NextBioi 47714.
PROi Q9P2D0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9P2D0.
Bgeei Q9P2D0.
Genevestigatori Q9P2D0.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.130.10.30. 1 hit.
3.30.710.10. 3 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF00651. BTB. 2 hits.
PF00415. RCC1. 3 hits.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50097. BTB. 2 hits.
PS50012. RCC1_3. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk."
    Spatuzza C., Schiavone M., Di Salle E., Janda E., Sardiello M., Fiume G., Fierro O., Simonetta M., Argiriou N., Faraonio R., Capparelli R., Quinto I., Scala G.
    Nucleic Acids Res. 36:4402-4416(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING, INTERACTION WITH BTK, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-1185.
    Tissue: Brain and Skin.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 971-1353 (ISOFORM 1).
    Tissue: Brain.
  7. "Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein."
    Liu W., Quinto I., Chen X., Palmieri C., Rabin R.L., Schwartz O.M., Nelson D.L., Scala G.
    Nat. Immunol. 2:939-946(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1159-1353 (ISOFORMS 1/3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BTK, VARIANT VAL-1185.
    Tissue: B-cell.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-990; SER-1004; SER-1045 AND SER-1054, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045; SER-1113 AND SER-1116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIBTK_HUMAN
AccessioniPrimary (citable) accession number: Q9P2D0
Secondary accession number(s): Q2QKU2
, Q2QKU3, Q2QKU4, Q5TFD7, Q5TFD9, Q8IUQ9, Q8IUY7, Q8TAI4, Q9HBI8, Q9Y3T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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