Reviewed, UniProtKB/Swiss-Prot Q9P2D0 (IBTK_HUMAN)

Names and origin

Protein names

Recommended name:
    Inhibitor of Bruton tyrosine kinase
      Short name=IBtk

Gene names

Name:	IBTK
Synonyms:	BTKI, KIAA1417

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. Ref.7
Subunit structure	Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK. Ref.7
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein. Note: Translocates to the plasma membrane upon IgM stimulation. Ref.7 Isoform 2: Nucleus.
Tissue specificity	Expressed in DeFew, 293T, Hela and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.
Sequence similarities	Contains 3 ANK repeats. Contains 2 BTB (POZ) domains. Contains 3 RCC1 repeats.
Sequence caution	The sequence AAG27170.1 differs from that shown. Reason: Miscellaneous discrepancy. Aberrant splicing. The sequence CAI23414.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23416.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	negative regulation of protein amino acid phosphorylation Ref.7 Inferred from direct assay. Source: MGI release of sequestered calcium ion into cytosol Ref.7 Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Ref.7 Inferred from direct assay. Source: MGI extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein kinase binding Ref.7 Inferred from direct assay. Source: MGI protein tyrosine kinase inhibitor activity Ref.7 Inferred from direct assay. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BTK	Q06187	1	EBI-1052017,EBI-624835
BTK	Q06187	3	EBI-1521221,EBI-624835
RGS2	P41220	1	EBI-1052017,EBI-712388
SNRPN	P63162	1	EBI-1052017,EBI-712493

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2D0-1)

Also known as: IBtk-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2D0-2)

Also known as: IBtk-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1145-1196: KTVSHGVKLS...KPVNAWASSL → WVENITKDHF...GQFSLHNIIS
     1197-1353: Missing.

Note: Due to a partial intron retention.

Isoform 3 (identifier: Q9P2D0-3)

Also known as: IBtk-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1113: Missing.
     1114-1144: PVSPPVVDLRTIMEIEESRQKCGATPKSHLG → MLIDIISSKMISHGIKLCQKKPLKLIGLISS

Note: Due to a partial intron retention.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1353	1353	Inhibitor of Bruton tyrosine kinase		PRO_0000280276
Regions
	Repeat	51 – 80	30	ANK 1
	Repeat	85 – 114	30	ANK 2
	Repeat	141 – 194	54	RCC1 1
	Repeat	195 – 246	52	RCC1 2
	Repeat	248 – 301	54	RCC1 3
	Domain	564 – 644	81	BTB 1
	Domain	768 – 836	69	BTB 2
	Repeat	806 – 835	30	ANK 3
Amino acid modifications
	Modified residue	630	1	Phosphotyrosine Ref.9
	Modified residue	990	1	Phosphoserine Ref.10
	Modified residue	992	1	Phosphoserine Ref.10
	Modified residue	993	1	Phosphoserine Ref.10
	Modified residue	1004	1	Phosphoserine Ref.10
	Modified residue	1045	1	Phosphoserine Ref.10 Ref.8
	Modified residue	1054	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 1113	1113	Missing in isoform 3.		VSP_023600
	Alternative sequence	1114 – 1144	31	PVSPP…KSHLG → MLIDIISSKMISHGIKLCQK KPLKLIGLISS in isoform 3.		VSP_023601
	Alternative sequence	1145 – 1196	52	KTVSH…WASSL → WVENITKDHFMLYFCPKNWT DLLHLSYYFSAFDVIVNYTS FSGQFSLHNIIS in isoform 2.		VSP_023602
	Alternative sequence	1197 – 1353	157	Missing in isoform 2.		VSP_023604
	Natural variant	1065	1	V → I: dbSNP rs12662902.		VAR_031106
	Natural variant	1185	1	A → V: dbSNP rs9449444. Ref.7 Ref.5		VAR_031107
Experimental info
	Sequence conflict	971	1	S → G in CAB43239. Ref.6
	Sequence conflict	1197	1	H → R in CAB43239. Ref.6
	Sequence conflict	1218	1	H → L in CAB43239. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (IBtk-alpha) [UniParc]. Last modified March 20, 2007. Version 3. Checksum: 67B2D11E276A6AF1	FASTA	1,353	150,528
	10 20 30 40 50 60 MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV FGRNALHLVS 70 80 90 100 110 120 SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID CVWSLLKHGV SLYIQDKEGL 130 140 150 160 170 180 SALDLVMKDR PTHVVFKNTD PTDVYTWGDN TNFTLGHGSQ NSKHHPELVD LFSRSGIYIK 190 200 210 220 230 240 QVVLCKFHSV FLSQKGQVYT CGHGPGGRLG HGDEQTCLVP RLVEGLNGHN CSQVAAAKDH 250 260 270 280 290 300 TVVLTEDGCV YTFGLNIFHQ LGIIPPPSSC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 310 320 330 340 350 360 REAVYTMGLN GGQLGCLLDP NGEKCVTAPR QVSALHHKDI ALSLVAASDG ATVCVTTRGD 370 380 390 400 410 420 IYLLADYQCK KMASKQLNLK KVLVSGGHME YKVDPEHLKE NGGQKICILA MDGAGRVFCW 430 440 450 460 470 480 RSVNSSLKQC RWAYPRQVFI SDIALNRNEI LFVTQDGEGF RGRWFEEKRK SSEKKEILSN 490 500 510 520 530 540 LHNSSSDVSY VSDINSVYER IRLEKLTFAH RAVSVSTDPS GCNFAILQSD PKTSLYEIPA 550 560 570 580 590 600 VSSSSFFEEF GKLLREADEM DSIHDVTFQV GNRLFPAHKY ILAVHSDFFQ KLFLSDGNTS 610 620 630 640 650 660 EFTDIYQKDE DSAGCHLFVV EKVHPDMFEY LLQFIYTDTC DFLTHGFKPR IHLNKNPEEY 670 680 690 700 710 720 QGTLNSHLNK VNFHEDDNQK SAFEVYKSNQ AQTVSERQKS KPKSCKKGKN IREDDPVRML 730 740 750 760 770 780 QTVAKKFDFS NLSSRLDGVR FENEKINVIA KNTGNKLKLS QKKCSFLCDV TMKSVDGKEF 790 800 810 820 830 840 PCHKCVLCAR LEYFHSMLSS SWIEASSCAA LEMPIHSDIL KVILDYLYTD EAVVIKESQN 850 860 870 880 890 900 VDFICSVLVV ADQLLITRLK EICEVALTEK LTLKNAAMLL EFAAMYSAKQ LKLSCLQFIG 910 920 930 940 950 960 LNMAALLEAR SLDVLSDGVL KDLSEFYRKM IPAMDRRVIT PYQDGPDISY LEVEDGDIFL 970 980 990 1000 1010 1020 KEEINMEQNH SETMFKKAKT KAKKKPRKRS DSSGGYNLSD IIQSPSSTGL LKSGKTNSVE 1030 1040 1050 1060 1070 1080 SLPELLTSDS EGSYAGVGSP RDLQSPDFTT GFHSDKIEAK VKPYVNGTSP VYSREDLKPW 1090 1100 1110 1120 1130 1140 EKSPILKISA PQPIPSNRID TTSSASWVAG SFSPVSPPVV DLRTIMEIEE SRQKCGATPK 1150 1160 1170 1180 1190 1200 SHLGKTVSHG VKLSQKQRKM IALTTKENNS GMNSMETVLF TPSKAPKPVN AWASSLHSVS 1210 1220 1230 1240 1250 1260 SKSFRDFLLE EKKSVTSHSS GDHVKKVSFK GIENSQAPKI VRCSTHGTPG PEGNHISDLP 1270 1280 1290 1300 1310 1320 LLDSPNPWLS SSVTAPSMVA PVTFASIVEE ELQQEAALIR SREKPLALIQ IEEHAIQDLL 1330 1340 1350 VFYEAFGNPE EFVIVERTPQ GPLAVPMWNK HGC
	Isoform 2 (IBtk-beta). Checksum: 7AEB0AF9F4B92805	FASTA	1,196	133,859
	10 20 30 40 50 60 MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV FGRNALHLVS 70 80 90 100 110 120 SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID CVWSLLKHGV SLYIQDKEGL 130 140 150 160 170 180 SALDLVMKDR PTHVVFKNTD PTDVYTWGDN TNFTLGHGSQ NSKHHPELVD LFSRSGIYIK 190 200 210 220 230 240 QVVLCKFHSV FLSQKGQVYT CGHGPGGRLG HGDEQTCLVP RLVEGLNGHN CSQVAAAKDH 250 260 270 280 290 300 TVVLTEDGCV YTFGLNIFHQ LGIIPPPSSC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 310 320 330 340 350 360 REAVYTMGLN GGQLGCLLDP NGEKCVTAPR QVSALHHKDI ALSLVAASDG ATVCVTTRGD 370 380 390 400 410 420 IYLLADYQCK KMASKQLNLK KVLVSGGHME YKVDPEHLKE NGGQKICILA MDGAGRVFCW 430 440 450 460 470 480 RSVNSSLKQC RWAYPRQVFI SDIALNRNEI LFVTQDGEGF RGRWFEEKRK SSEKKEILSN 490 500 510 520 530 540 LHNSSSDVSY VSDINSVYER IRLEKLTFAH RAVSVSTDPS GCNFAILQSD PKTSLYEIPA 550 560 570 580 590 600 VSSSSFFEEF GKLLREADEM DSIHDVTFQV GNRLFPAHKY ILAVHSDFFQ KLFLSDGNTS 610 620 630 640 650 660 EFTDIYQKDE DSAGCHLFVV EKVHPDMFEY LLQFIYTDTC DFLTHGFKPR IHLNKNPEEY 670 680 690 700 710 720 QGTLNSHLNK VNFHEDDNQK SAFEVYKSNQ AQTVSERQKS KPKSCKKGKN IREDDPVRML 730 740 750 760 770 780 QTVAKKFDFS NLSSRLDGVR FENEKINVIA KNTGNKLKLS QKKCSFLCDV TMKSVDGKEF 790 800 810 820 830 840 PCHKCVLCAR LEYFHSMLSS SWIEASSCAA LEMPIHSDIL KVILDYLYTD EAVVIKESQN 850 860 870 880 890 900 VDFICSVLVV ADQLLITRLK EICEVALTEK LTLKNAAMLL EFAAMYSAKQ LKLSCLQFIG 910 920 930 940 950 960 LNMAALLEAR SLDVLSDGVL KDLSEFYRKM IPAMDRRVIT PYQDGPDISY LEVEDGDIFL 970 980 990 1000 1010 1020 KEEINMEQNH SETMFKKAKT KAKKKPRKRS DSSGGYNLSD IIQSPSSTGL LKSGKTNSVE 1030 1040 1050 1060 1070 1080 SLPELLTSDS EGSYAGVGSP RDLQSPDFTT GFHSDKIEAK VKPYVNGTSP VYSREDLKPW 1090 1100 1110 1120 1130 1140 EKSPILKISA PQPIPSNRID TTSSASWVAG SFSPVSPPVV DLRTIMEIEE SRQKCGATPK 1150 1160 1170 1180 1190 SHLGWVENIT KDHFMLYFCP KNWTDLLHLS YYFSAFDVIV NYTSFSGQFS LHNIIS
	Isoform 3 (IBtk-gamma). Checksum: 55673D0FC6EE3FEB	FASTA	240	26,314
	10 20 30 40 50 60 MLIDIISSKM ISHGIKLCQK KPLKLIGLIS SKTVSHGVKL SQKQRKMIAL TTKENNSGMN 70 80 90 100 110 120 SMETVLFTPS KAPKPVNAWA SSLHSVSSKS FRDFLLEEKK SVTSHSSGDH VKKVSFKGIE 130 140 150 160 170 180 NSQAPKIVRC STHGTPGPEG NHISDLPLLD SPNPWLSSSV TAPSMVAPVT FASIVEEELQ 190 200 210 220 230 240 QEAALIRSRE KPLALIQIEE HAIQDLLVFY EAFGNPEEFV IVERTPQGPL AVPMWNKHGC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk." Spatuzza C., Schiavone M., Di Salle E., Janda E., Sardiello M., Fiume G., Fierro O., Simonetta M., Argiriou N., Faraonio R., Capparelli R., Quinto I., Scala G. Nucleic Acids Res. 36:4402-4416(2008) [PubMed: 18596081] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING, INTERACTION WITH BTK, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-1185. Tissue: Brain and Skin.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 971-1353 (ISOFORM 1). Tissue: Brain.
[7]	"Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein." Liu W., Quinto I., Chen X., Palmieri C., Rabin R.L., Schwartz O.M., Nelson D.L., Scala G. Nat. Immunol. 2:939-946(2001) [PubMed: 11577348] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1159-1353 (ISOFORMS 1/3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BTK, VARIANT VAL-1185. Tissue: B-cell.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling." Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A., Lottspeich F., Chen Z. EMBO J. 25:5058-5070(2006) [PubMed: 17053785] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-630, MASS SPECTROMETRY.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-990; SER-992; SER-993; SER-1004; SER-1045 AND SER-1054, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ005633 mRNA. Translation: AAY55906.1. DQ005634 mRNA. Translation: AAY55907.1. DQ005635 mRNA. Translation: AAY55908.1. AB037838 mRNA. Translation: BAA92655.2. Different initiation. AL050333 Genomic DNA. Translation: CAI23414.1. Sequence problems. AL050333 Genomic DNA. Translation: CAI23416.1. Sequence problems. BC027490 mRNA. Translation: AAH27490.1. BC038244 mRNA. Translation: AAH38244.2. BC042171 mRNA. Translation: AAH42171.2. BC113696 mRNA. Translation: AAI13697.1. BC113698 mRNA. Translation: AAI13699.1. AL050018 mRNA. Translation: CAB43239.1. AF235049 mRNA. Translation: AAG27170.1. Sequence problems.
IPI	IPI00792333. IPI00829736. IPI00829860. IPI00910313.
PIR	T08705.
RefSeq	NP_056340.2.
UniGene	Hs.306425
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2D0. 6 interactions.
STRING	Q9P2D0.
PTM databases
PhosphoSite	Q9P2D0.
Genome annotation databases
Ensembl	ENST00000306270; ENSP00000305721; ENSG00000005700; Homo sapiens. [Genome view]
GeneID	25998.
KEGG	hsa:25998.
UCSC	uc003pjj.1. human. uc003pjl.1. human. uc003pjm.1. human.
Organism-specific databases
CTD	25998.
GeneCards	GC06M082936.
HGNC	HGNC:17853. IBTK.
HPA	HPA023826.
MIM	606457. gene.
PharmGKB	PA134898277.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9P2D0.
OMA	KGQVYTC
OrthoDB	EOG9D81RK
Enzyme and pathway databases
Pathway_Interaction_DB	bcr_5pathway. BCR signaling pathway.
Gene expression databases
ArrayExpress	Q9P2D0.
Bgee	Q9P2D0.
Genevestigator	Q9P2D0.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR000408. Reg_chr_condens. IPR009091. Reg_csome_cond/b-lactamase_inh. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:3.30.710.10. BTB/POZ_fold. 2 hits. G3DSA:2.130.10.30. Reg_csome_cond/b-lactamase_inh. 1 hit.
Pfam	PF00023. Ank. 2 hits. PF00651. BTB. 2 hits. PF00415. RCC1. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. SM00225. BTB. 2 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50097. BTB. 2 hits. PS00625. RCC1_1. False negative. PS00626. RCC1_2. False negative. PS50012. RCC1_3. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47714.
SOURCE	Search...

Entry information

Entry name

IBTK_HUMAN

Accession

Primary (citable) accession number: Q9P2D0
Secondary accession number(s): Q2QKU2 , Q2QKU3, Q2QKU4, Q5TFD7, Q5TFD9, Q8IUQ9, Q8IUY7, Q8TAI4, Q9HBI8, Q9Y3T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	November 24, 2009
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.