Q9P2D0 (IBTK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inhibitor of Bruton tyrosine kinase
Short name=IBtk

Gene names

Name:	IBTK
Synonyms:	BTKI, KIAA1417

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1353 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. Ref.7
Subunit structure	Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK. Ref.1 Ref.7
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein. Note: Translocates to the plasma membrane upon IgM stimulation. Ref.1 Ref.7 Isoform 2: Nucleus Ref.1 Ref.7.
Tissue specificity	Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. Ref.1 Ref.7
Sequence similarities	Contains 3 ANK repeats. Contains 2 BTB (POZ) domains. Contains 3 RCC1 repeats.
Sequence caution	The sequence AAG27170.1 differs from that shown. Reason: Aberrant splicing. The sequence BAA92655.2 differs from that shown. Reason: Erroneous initiation. The sequence CAI23414.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23416.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	release of sequestered calcium ion into cytosol Inferred from direct assay Ref.7. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay Ref.7. Source: MGI membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA
Molecular_function	protein kinase binding Inferred from direct assay Ref.7. Source: MGI protein tyrosine kinase inhibitor activity Inferred from direct assay Ref.7. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2D0-1)

Also known as: IBtk-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2D0-2)

Also known as: IBtk-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1145-1196: KTVSHGVKLS...KPVNAWASSL → WVENITKDHF...GQFSLHNIIS
     1197-1353: Missing.

Note: Due to a partial intron retention.

Isoform 3 (identifier: Q9P2D0-3)

Also known as: IBtk-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1113: Missing.
     1114-1144: PVSPPVVDLRTIMEIEESRQKCGATPKSHLG → MLIDIISSKMISHGIKLCQKKPLKLIGLISS

Note: Due to a partial intron retention.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1353	1353	Inhibitor of Bruton tyrosine kinase		PRO_0000280276
Regions
	Repeat	51 – 80	30	ANK 1
	Repeat	85 – 114	30	ANK 2
	Repeat	141 – 194	54	RCC1 1
	Repeat	195 – 246	52	RCC1 2
	Repeat	248 – 301	54	RCC1 3
	Domain	564 – 644	81	BTB 1
	Domain	768 – 836	69	BTB 2
	Repeat	806 – 835	30	ANK 3
Amino acid modifications
	Modified residue	990	1	Phosphoserine Ref.8
	Modified residue	1004	1	Phosphoserine Ref.8
	Modified residue	1045	1	Phosphoserine Ref.8 Ref.10 Ref.11
	Modified residue	1054	1	Phosphoserine Ref.8
	Modified residue	1113	1	Phosphoserine Ref.10
	Modified residue	1116	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 1113	1113	Missing in isoform 3.		VSP_023600
	Alternative sequence	1114 – 1144	31	PVSPP…KSHLG → MLIDIISSKMISHGIKLCQK KPLKLIGLISS in isoform 3.		VSP_023601
	Alternative sequence	1145 – 1196	52	KTVSH…WASSL → WVENITKDHFMLYFCPKNWT DLLHLSYYFSAFDVIVNYTS FSGQFSLHNIIS in isoform 2.		VSP_023602
	Alternative sequence	1197 – 1353	157	Missing in isoform 2.		VSP_023604
	Natural variant	1065	1	V → I. Corresponds to variant rs12662902 [ dbSNP | Ensembl ].		VAR_031106
	Natural variant	1185	1	A → V. Ref.5 Ref.7 Corresponds to variant rs9449444 [ dbSNP | Ensembl ].		VAR_031107
Experimental info
	Sequence conflict	971	1	S → G in CAB43239. Ref.6
	Sequence conflict	1197	1	H → R in CAB43239. Ref.6
	Sequence conflict	1218	1	H → L in CAB43239. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (IBtk-alpha) [UniParc]. Last modified March 20, 2007. Version 3. Checksum: 67B2D11E276A6AF1	FASTA	1,353	150,528
	10 20 30 40 50 60 MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV FGRNALHLVS 70 80 90 100 110 120 SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID CVWSLLKHGV SLYIQDKEGL 130 140 150 160 170 180 SALDLVMKDR PTHVVFKNTD PTDVYTWGDN TNFTLGHGSQ NSKHHPELVD LFSRSGIYIK 190 200 210 220 230 240 QVVLCKFHSV FLSQKGQVYT CGHGPGGRLG HGDEQTCLVP RLVEGLNGHN CSQVAAAKDH 250 260 270 280 290 300 TVVLTEDGCV YTFGLNIFHQ LGIIPPPSSC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 310 320 330 340 350 360 REAVYTMGLN GGQLGCLLDP NGEKCVTAPR QVSALHHKDI ALSLVAASDG ATVCVTTRGD 370 380 390 400 410 420 IYLLADYQCK KMASKQLNLK KVLVSGGHME YKVDPEHLKE NGGQKICILA MDGAGRVFCW 430 440 450 460 470 480 RSVNSSLKQC RWAYPRQVFI SDIALNRNEI LFVTQDGEGF RGRWFEEKRK SSEKKEILSN 490 500 510 520 530 540 LHNSSSDVSY VSDINSVYER IRLEKLTFAH RAVSVSTDPS GCNFAILQSD PKTSLYEIPA 550 560 570 580 590 600 VSSSSFFEEF GKLLREADEM DSIHDVTFQV GNRLFPAHKY ILAVHSDFFQ KLFLSDGNTS 610 620 630 640 650 660 EFTDIYQKDE DSAGCHLFVV EKVHPDMFEY LLQFIYTDTC DFLTHGFKPR IHLNKNPEEY 670 680 690 700 710 720 QGTLNSHLNK VNFHEDDNQK SAFEVYKSNQ AQTVSERQKS KPKSCKKGKN IREDDPVRML 730 740 750 760 770 780 QTVAKKFDFS NLSSRLDGVR FENEKINVIA KNTGNKLKLS QKKCSFLCDV TMKSVDGKEF 790 800 810 820 830 840 PCHKCVLCAR LEYFHSMLSS SWIEASSCAA LEMPIHSDIL KVILDYLYTD EAVVIKESQN 850 860 870 880 890 900 VDFICSVLVV ADQLLITRLK EICEVALTEK LTLKNAAMLL EFAAMYSAKQ LKLSCLQFIG 910 920 930 940 950 960 LNMAALLEAR SLDVLSDGVL KDLSEFYRKM IPAMDRRVIT PYQDGPDISY LEVEDGDIFL 970 980 990 1000 1010 1020 KEEINMEQNH SETMFKKAKT KAKKKPRKRS DSSGGYNLSD IIQSPSSTGL LKSGKTNSVE 1030 1040 1050 1060 1070 1080 SLPELLTSDS EGSYAGVGSP RDLQSPDFTT GFHSDKIEAK VKPYVNGTSP VYSREDLKPW 1090 1100 1110 1120 1130 1140 EKSPILKISA PQPIPSNRID TTSSASWVAG SFSPVSPPVV DLRTIMEIEE SRQKCGATPK 1150 1160 1170 1180 1190 1200 SHLGKTVSHG VKLSQKQRKM IALTTKENNS GMNSMETVLF TPSKAPKPVN AWASSLHSVS 1210 1220 1230 1240 1250 1260 SKSFRDFLLE EKKSVTSHSS GDHVKKVSFK GIENSQAPKI VRCSTHGTPG PEGNHISDLP 1270 1280 1290 1300 1310 1320 LLDSPNPWLS SSVTAPSMVA PVTFASIVEE ELQQEAALIR SREKPLALIQ IEEHAIQDLL 1330 1340 1350 VFYEAFGNPE EFVIVERTPQ GPLAVPMWNK HGC
	Isoform 2 (IBtk-beta) [UniParc]. Checksum: 7AEB0AF9F4B92805	FASTA	1,196	133,859
	10 20 30 40 50 60 MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV FGRNALHLVS 70 80 90 100 110 120 SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID CVWSLLKHGV SLYIQDKEGL 130 140 150 160 170 180 SALDLVMKDR PTHVVFKNTD PTDVYTWGDN TNFTLGHGSQ NSKHHPELVD LFSRSGIYIK 190 200 210 220 230 240 QVVLCKFHSV FLSQKGQVYT CGHGPGGRLG HGDEQTCLVP RLVEGLNGHN CSQVAAAKDH 250 260 270 280 290 300 TVVLTEDGCV YTFGLNIFHQ LGIIPPPSSC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 310 320 330 340 350 360 REAVYTMGLN GGQLGCLLDP NGEKCVTAPR QVSALHHKDI ALSLVAASDG ATVCVTTRGD 370 380 390 400 410 420 IYLLADYQCK KMASKQLNLK KVLVSGGHME YKVDPEHLKE NGGQKICILA MDGAGRVFCW 430 440 450 460 470 480 RSVNSSLKQC RWAYPRQVFI SDIALNRNEI LFVTQDGEGF RGRWFEEKRK SSEKKEILSN 490 500 510 520 530 540 LHNSSSDVSY VSDINSVYER IRLEKLTFAH RAVSVSTDPS GCNFAILQSD PKTSLYEIPA 550 560 570 580 590 600 VSSSSFFEEF GKLLREADEM DSIHDVTFQV GNRLFPAHKY ILAVHSDFFQ KLFLSDGNTS 610 620 630 640 650 660 EFTDIYQKDE DSAGCHLFVV EKVHPDMFEY LLQFIYTDTC DFLTHGFKPR IHLNKNPEEY 670 680 690 700 710 720 QGTLNSHLNK VNFHEDDNQK SAFEVYKSNQ AQTVSERQKS KPKSCKKGKN IREDDPVRML 730 740 750 760 770 780 QTVAKKFDFS NLSSRLDGVR FENEKINVIA KNTGNKLKLS QKKCSFLCDV TMKSVDGKEF 790 800 810 820 830 840 PCHKCVLCAR LEYFHSMLSS SWIEASSCAA LEMPIHSDIL KVILDYLYTD EAVVIKESQN 850 860 870 880 890 900 VDFICSVLVV ADQLLITRLK EICEVALTEK LTLKNAAMLL EFAAMYSAKQ LKLSCLQFIG 910 920 930 940 950 960 LNMAALLEAR SLDVLSDGVL KDLSEFYRKM IPAMDRRVIT PYQDGPDISY LEVEDGDIFL 970 980 990 1000 1010 1020 KEEINMEQNH SETMFKKAKT KAKKKPRKRS DSSGGYNLSD IIQSPSSTGL LKSGKTNSVE 1030 1040 1050 1060 1070 1080 SLPELLTSDS EGSYAGVGSP RDLQSPDFTT GFHSDKIEAK VKPYVNGTSP VYSREDLKPW 1090 1100 1110 1120 1130 1140 EKSPILKISA PQPIPSNRID TTSSASWVAG SFSPVSPPVV DLRTIMEIEE SRQKCGATPK 1150 1160 1170 1180 1190 SHLGWVENIT KDHFMLYFCP KNWTDLLHLS YYFSAFDVIV NYTSFSGQFS LHNIIS
	Isoform 3 (IBtk-gamma) [UniParc]. Checksum: 55673D0FC6EE3FEB	FASTA	240	26,314
	10 20 30 40 50 60 MLIDIISSKM ISHGIKLCQK KPLKLIGLIS SKTVSHGVKL SQKQRKMIAL TTKENNSGMN 70 80 90 100 110 120 SMETVLFTPS KAPKPVNAWA SSLHSVSSKS FRDFLLEEKK SVTSHSSGDH VKKVSFKGIE 130 140 150 160 170 180 NSQAPKIVRC STHGTPGPEG NHISDLPLLD SPNPWLSSSV TAPSMVAPVT FASIVEEELQ 190 200 210 220 230 240 QEAALIRSRE KPLALIQIEE HAIQDLLVFY EAFGNPEEFV IVERTPQGPL AVPMWNKHGC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk." Spatuzza C., Schiavone M., Di Salle E., Janda E., Sardiello M., Fiume G., Fierro O., Simonetta M., Argiriou N., Faraonio R., Capparelli R., Quinto I., Scala G. Nucleic Acids Res. 36:4402-4416(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING, INTERACTION WITH BTK, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-1185. Tissue: Brain and Skin.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 971-1353 (ISOFORM 1). Tissue: Brain.
[7]	"Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein." Liu W., Quinto I., Chen X., Palmieri C., Rabin R.L., Schwartz O.M., Nelson D.L., Scala G. Nat. Immunol. 2:939-946(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1159-1353 (ISOFORMS 1/3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BTK, VARIANT VAL-1185. Tissue: B-cell.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-990; SER-1004; SER-1045 AND SER-1054, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045; SER-1113 AND SER-1116, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ005633 mRNA. Translation: AAY55906.1. DQ005634 mRNA. Translation: AAY55907.1. DQ005635 mRNA. Translation: AAY55908.1. AB037838 mRNA. Translation: BAA92655.2. Different initiation. AL050333 Genomic DNA. Translation: CAI23414.1. Sequence problems. AL050333 Genomic DNA. Translation: CAI23416.1. Sequence problems. BC027490 mRNA. Translation: AAH27490.1. BC038244 mRNA. Translation: AAH38244.2. BC042171 mRNA. Translation: AAH42171.2. BC113696 mRNA. Translation: AAI13697.1. BC113698 mRNA. Translation: AAI13699.1. AL050018 mRNA. Translation: CAB43239.1. AF235049 mRNA. Translation: AAG27170.1. Sequence problems.
IPI	IPI00792333. IPI00829736. IPI00910313.
PIR	T08705.
RefSeq	NP_056340.2. NM_015525.2.
UniGene	Hs.306425.
3D structure databases
ProteinModelPortal	Q9P2D0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2D0. 4 interactions.
MINT	MINT-215747.
PTM databases
PhosphoSite	Q9P2D0.
Polymorphism databases
DMDM	134034141.
Proteomic databases
PaxDb	Q9P2D0.
PRIDE	Q9P2D0.
Protocols and materials databases
DNASU	25998.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306270; ENSP00000305721; ENSG00000005700.
GeneID	25998.
KEGG	hsa:25998.
UCSC	uc003pjl.1. human. uc003pjm.2. human.
Organism-specific databases
CTD	25998.
GeneCards	GC06M082879.
HGNC	HGNC:17853. IBTK.
HPA	HPA023826.
MIM	606457. gene.
neXtProt	NX_Q9P2D0.
PharmGKB	PA134898277.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5184.
HOVERGEN	HBG081779.
InParanoid	Q9P2D0.
OMA	VSALHHK.
OrthoDB	EOG4J6RQ1.
Enzyme and pathway databases
Pathway_Interaction_DB	bcr_5pathway. BCR signaling pathway.
Gene expression databases
ArrayExpress	Q9P2D0.
Bgee	Q9P2D0.
Genevestigator	Q9P2D0.
Family and domain databases
Gene3D	1.25.40.20. 1 hit. 2.130.10.30. 1 hit. 3.30.710.10. 3 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR009091. RCC1/BLIP-II. IPR000408. Reg_chr_condens. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. PF00651. BTB. 2 hits. PF00415. RCC1. 3 hits. [Graphical view]
SMART	SM00248. ANK. 2 hits. SM00225. BTB. 2 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF54695. BTB/POZ_fold. 2 hits. SSF50985. RCC1/BLIP-II. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50097. BTB. 2 hits. PS00625. RCC1_1. False negative. PS00626. RCC1_2. False negative. PS50012. RCC1_3. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IBTK. human.
GenomeRNAi	25998.
NextBio	47714.
SOURCE	Search...

Entry information

Entry name

IBTK_HUMAN

Accession

Primary (citable) accession number: Q9P2D0
Secondary accession number(s): Q2QKU2 , Q2QKU3, Q2QKU4, Q5TFD7, Q5TFD9, Q8IUQ9, Q8IUY7, Q8TAI4, Q9HBI8, Q9Y3T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	May 1, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.