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Protein

Transmembrane protein 181

Gene

TMEM181

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.1 Publication

GO - Molecular functioni

  • toxic substance binding Source: UniProtKB

GO - Biological processi

  • pathogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 181
Gene namesi
Name:TMEM181
Synonyms:GPR178, KIAA1423
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20958. TMEM181.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence analysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence analysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence analysisAdd
BLAST
Transmembranei457 – 47721HelicalSequence analysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence analysisAdd
BLAST
Transmembranei538 – 55821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406036.

Polymorphism and mutation databases

BioMutaiTMEM181.
DMDMi108935999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Transmembrane protein 181PRO_0000239661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei580 – 5801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2C4.
MaxQBiQ9P2C4.
PaxDbiQ9P2C4.
PeptideAtlasiQ9P2C4.
PRIDEiQ9P2C4.

PTM databases

iPTMnetiQ9P2C4.
PhosphoSiteiQ9P2C4.
SwissPalmiQ9P2C4.

Expressioni

Gene expression databases

BgeeiENSG00000146433.
CleanExiHS_TMEM181.
GenevisibleiQ9P2C4. HS.

Organism-specific databases

HPAiHPA040189.

Interactioni

Subunit structurei

Interacts with cytolethal distending toxin.1 Publication

Protein-protein interaction databases

BioGridi121635. 3 interactions.
IntActiQ9P2C4. 2 interactions.
STRINGi9606.ENSP00000356057.

Structurei

3D structure databases

ProteinModelPortaliQ9P2C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFUP. Eukaryota.
ENOG410ZN8U. LUCA.
GeneTreeiENSGT00390000007183.
HOGENOMiHOG000047732.
HOVERGENiHBG057881.
InParanoidiQ9P2C4.
OMAiYSMHKRE.
OrthoDBiEOG091G06L2.
PhylomeDBiQ9P2C4.
TreeFamiTF324083.

Sequencei

Sequence statusi: Complete.

Q9P2C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAPSPTQA SSRGGGPGPP APTRAVSSSS RARGGALSAL GPSPARPLTT
60 70 80 90 100
SPAPAPPPRS RPARQQPDPQ CWEKRGGAGG DTKGGAAGPG PGRLRGMDAE
110 120 130 140 150
YPAFEPPLCS ELKHLCRRLR EAYRELKEDL TPFKDDRYYR LAPMRLYTLS
160 170 180 190 200
KRHFVLVFVV FFICFGLTIF VGIRGPKVIQ TSAANFSLNN SKKLKPIQIL
210 220 230 240 250
SNPLSTYNQQ LWLTCVVELD QSKETSIKTS FPMTVKVDGV AQDGTTMYIH
260 270 280 290 300
NKVHNRTRTL TCAGKCAEII VAHLGYLNYT QYTVIVGFEH LKLPIKGMNF
310 320 330 340 350
TWKTYNPAFS RLEIWFRFFF VVLTFIVTCL FAHSLRKFSM RDWGIEQKWM
360 370 380 390 400
SVLLPLLLLY NDPFFPLSFL VNSWLPGMLD DLFQSMFLCA LLLFWLCVYH
410 420 430 440 450
GIRVQGERKC LTFYLPKFFI VGLLWLASVT LGIWQTVNEL HDPMYQYRVD
460 470 480 490 500
TGNFQGMKVF FMVVAAVYIL YLLFLIVRAC SELRHMPYVD LRLKFLTALT
510 520 530 540 550
FVVLVISIAI LYLRFGAQVL QDNFVAELST HYQNSAEFLS FYGLLNFYLY
560 570 580 590 600
TLAFVYSPSK NALYESQLKD NPAFSMLNDS DDDVIYGSDY EEMPLQNGQA
610
IRAKYKEESD SD
Length:612
Mass (Da):69,325
Last modified:June 13, 2006 - v2
Checksum:i2104278D3F64F1CF
GO

Sequence cautioni

The sequence BAA92661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037844 mRNA. Translation: BAA92661.1. Different initiation.
AL591025 Genomic DNA. Translation: CAH70179.1.
CCDSiCCDS43520.1.
RefSeqiNP_065874.1. NM_020823.1.
UniGeneiHs.99145.

Genome annotation databases

EnsembliENST00000367090; ENSP00000356057; ENSG00000146433.
GeneIDi57583.
KEGGihsa:57583.
UCSCiuc003qrm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037844 mRNA. Translation: BAA92661.1. Different initiation.
AL591025 Genomic DNA. Translation: CAH70179.1.
CCDSiCCDS43520.1.
RefSeqiNP_065874.1. NM_020823.1.
UniGeneiHs.99145.

3D structure databases

ProteinModelPortaliQ9P2C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121635. 3 interactions.
IntActiQ9P2C4. 2 interactions.
STRINGi9606.ENSP00000356057.

PTM databases

iPTMnetiQ9P2C4.
PhosphoSiteiQ9P2C4.
SwissPalmiQ9P2C4.

Polymorphism and mutation databases

BioMutaiTMEM181.
DMDMi108935999.

Proteomic databases

EPDiQ9P2C4.
MaxQBiQ9P2C4.
PaxDbiQ9P2C4.
PeptideAtlasiQ9P2C4.
PRIDEiQ9P2C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367090; ENSP00000356057; ENSG00000146433.
GeneIDi57583.
KEGGihsa:57583.
UCSCiuc003qrm.5. human.

Organism-specific databases

CTDi57583.
GeneCardsiTMEM181.
H-InvDBHIX0165000.
HGNCiHGNC:20958. TMEM181.
HPAiHPA040189.
MIMi613209. gene.
neXtProtiNX_Q9P2C4.
PharmGKBiPA162406036.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFUP. Eukaryota.
ENOG410ZN8U. LUCA.
GeneTreeiENSGT00390000007183.
HOGENOMiHOG000047732.
HOVERGENiHBG057881.
InParanoidiQ9P2C4.
OMAiYSMHKRE.
OrthoDBiEOG091G06L2.
PhylomeDBiQ9P2C4.
TreeFamiTF324083.

Miscellaneous databases

ChiTaRSiTMEM181. human.
GenomeRNAii57583.
PROiQ9P2C4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146433.
CleanExiHS_TMEM181.
GenevisibleiQ9P2C4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTM181_HUMAN
AccessioniPrimary (citable) accession number: Q9P2C4
Secondary accession number(s): Q5VTU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.