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Protein

CTTNBP2 N-terminal-like protein

Gene

CTTNBP2NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein phosphatase 2A binding Source: MGI

GO - Biological processi

  • negative regulation of transmembrane transport Source: MGI
  • negative regulation of transporter activity Source: MGI
  • protein dephosphorylation Source: MGI
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143079-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CTTNBP2 N-terminal-like protein
Gene namesi
Name:CTTNBP2NL
Synonyms:KIAA1433
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25330. CTTNBP2NL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143079.
PharmGKBiPA142672062.

Polymorphism and mutation databases

BioMutaiCTTNBP2NL.
DMDMi92087169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269971 – 639CTTNBP2 N-terminal-like proteinAdd BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei570PhosphothreonineCombined sources1
Modified residuei590PhosphothreonineCombined sources1
Modified residuei592PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2B4.
MaxQBiQ9P2B4.
PaxDbiQ9P2B4.
PeptideAtlasiQ9P2B4.
PRIDEiQ9P2B4.

PTM databases

iPTMnetiQ9P2B4.
PhosphoSitePlusiQ9P2B4.

Expressioni

Gene expression databases

BgeeiENSG00000143079.
CleanExiHS_CTTNBP2NL.
ExpressionAtlasiQ9P2B4. baseline and differential.
GenevisibleiQ9P2B4. HS.

Organism-specific databases

HPAiHPA007301.

Interactioni

Subunit structurei

Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers (By similarity). May form homomers. May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HGSO149643EBI-1774273,EBI-740220
MOB4Q9Y3A36EBI-1774273,EBI-713935
STK24Q9Y6E04EBI-1774273,EBI-740175
STK26Q9P2894EBI-1774273,EBI-618239
STRIP1Q5VSL94EBI-1774273,EBI-1773588
STRNO438156EBI-1774273,EBI-1046642
STRN3Q130338EBI-1774273,EBI-1053857
USHBP1Q8N6Y03EBI-1774273,EBI-739895

GO - Molecular functioni

  • protein phosphatase 2A binding Source: MGI

Protein-protein interaction databases

BioGridi121000. 41 interactors.
IntActiQ9P2B4. 34 interactors.
MINTiMINT-4725988.
STRINGi9606.ENSP00000271277.

Structurei

3D structure databases

ProteinModelPortaliQ9P2B4.
SMRiQ9P2B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 285Sequence analysisAdd BLAST199

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1103. Eukaryota.
ENOG410YR8R. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112036.
HOVERGENiHBG081371.
InParanoidiQ9P2B4.
OMAiSSPGYQS.
OrthoDBiEOG091G0CSA.
PhylomeDBiQ9P2B4.
TreeFamiTF325130.

Family and domain databases

InterProiIPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF09727. CortBP2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEKLSKPE LLTLFSILEG ELEARDLVIE ALKAQHRDTF IEERYGKYNI
60 70 80 90 100
SDPLMALQRD FETLKEKNDG EKQPVCTNPL SILKVVMKQC KNMQERMLSQ
110 120 130 140 150
LAAAESRHRK VILDLEEERQ RHAQDTAEGD DVTYMLEKER ERLTQQLEFE
160 170 180 190 200
KSQVKKFEKE QKKLSSQLEE ERSRHKQLSS MLVLECKKAT NKAAEEGQKA
210 220 230 240 250
GELSLKLEKE KSRVSKLEEE LAAERKRGLQ TEAQVEKQLS EFDIEREQLR
260 270 280 290 300
AKLNREENRT KTLKEEMESL KKIVKDLEAS HQHSSPNEQL KKPVTVSKGT
310 320 330 340 350
ATEPLMLMSV FCQTESFPAE RTHGSNIAKM TNTGLPGPAT PAYSYAKTNG
360 370 380 390 400
HCDPEIQTTR ELTAGNNVEN QVPPREKSVA LAQEKPVENG GCPVGIETPV
410 420 430 440 450
PMPSPLSSSG SSLSPSSTAS SSLTSSPCSS PVLTKRLLGS SASSPGYQSS
460 470 480 490 500
YQVGINQRFH AARHKFQSQA DQDQQASGLQ SPPSRDLSPT LIDNSAAKQL
510 520 530 540 550
ARNTVTQVLS RFTSQQGPIK PVSPNSSPFG TDYRNLANTA NPRGDTSHSP
560 570 580 590 600
TPGKVSSPLS PLSPGIKSPT IPRAERGNPP PIPPKKPGLT PSPSATTPLT
610 620 630
KTHSQAASLT TAEDLASSCS SNTVVANGKD VELLLPTSS
Length:639
Mass (Da):70,158
Last modified:March 7, 2006 - v2
Checksum:i63F1D27C50623564
GO

Sequence cautioni

The sequence BAA92671 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38D → V in BAG51087 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050925296V → M.Corresponds to variant rs1175640dbSNPEnsembl.1
Natural variantiVAR_050926409S → G.Corresponds to variant rs12137578dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037854 mRNA. Translation: BAA92671.1. Different initiation.
AK022544 mRNA. Translation: BAG51087.1.
AL354760 Genomic DNA. Translation: CAI22308.1.
BC016029 mRNA. Translation: AAH16029.1.
CCDSiCCDS845.1.
RefSeqiNP_061174.1. NM_018704.2.
XP_011540083.1. XM_011541781.2.
XP_016857295.1. XM_017001806.1.
UniGeneiHs.744100.

Genome annotation databases

EnsembliENST00000271277; ENSP00000271277; ENSG00000143079.
GeneIDi55917.
KEGGihsa:55917.
UCSCiuc001ebx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037854 mRNA. Translation: BAA92671.1. Different initiation.
AK022544 mRNA. Translation: BAG51087.1.
AL354760 Genomic DNA. Translation: CAI22308.1.
BC016029 mRNA. Translation: AAH16029.1.
CCDSiCCDS845.1.
RefSeqiNP_061174.1. NM_018704.2.
XP_011540083.1. XM_011541781.2.
XP_016857295.1. XM_017001806.1.
UniGeneiHs.744100.

3D structure databases

ProteinModelPortaliQ9P2B4.
SMRiQ9P2B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121000. 41 interactors.
IntActiQ9P2B4. 34 interactors.
MINTiMINT-4725988.
STRINGi9606.ENSP00000271277.

PTM databases

iPTMnetiQ9P2B4.
PhosphoSitePlusiQ9P2B4.

Polymorphism and mutation databases

BioMutaiCTTNBP2NL.
DMDMi92087169.

Proteomic databases

EPDiQ9P2B4.
MaxQBiQ9P2B4.
PaxDbiQ9P2B4.
PeptideAtlasiQ9P2B4.
PRIDEiQ9P2B4.

Protocols and materials databases

DNASUi55917.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271277; ENSP00000271277; ENSG00000143079.
GeneIDi55917.
KEGGihsa:55917.
UCSCiuc001ebx.4. human.

Organism-specific databases

CTDi55917.
GeneCardsiCTTNBP2NL.
HGNCiHGNC:25330. CTTNBP2NL.
HPAiHPA007301.
MIMi615100. gene.
neXtProtiNX_Q9P2B4.
OpenTargetsiENSG00000143079.
PharmGKBiPA142672062.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1103. Eukaryota.
ENOG410YR8R. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112036.
HOVERGENiHBG081371.
InParanoidiQ9P2B4.
OMAiSSPGYQS.
OrthoDBiEOG091G0CSA.
PhylomeDBiQ9P2B4.
TreeFamiTF325130.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143079-MONOMER.

Miscellaneous databases

ChiTaRSiCTTNBP2NL. human.
GeneWikiiCTTNBP2NL.
GenomeRNAii55917.
PROiQ9P2B4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143079.
CleanExiHS_CTTNBP2NL.
ExpressionAtlasiQ9P2B4. baseline and differential.
GenevisibleiQ9P2B4. HS.

Family and domain databases

InterProiIPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF09727. CortBP2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCT2NL_HUMAN
AccessioniPrimary (citable) accession number: Q9P2B4
Secondary accession number(s): B3KMS5, Q96B40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.