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Q9P2B2

- FPRP_HUMAN

UniProt

Q9P2B2 - FPRP_HUMAN

Protein

Prostaglandin F2 receptor negative regulator

Gene

PTGFRN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Feb 2003)
      Previous versions | rss
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    Functioni

    Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. lipid particle organization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin F2 receptor negative regulator
    Alternative name(s):
    CD9 partner 1
    Short name:
    CD9P-1
    Glu-Trp-Ile EWI motif-containing protein F
    Short name:
    EWI-F
    Prostaglandin F2-alpha receptor regulatory protein
    Prostaglandin F2-alpha receptor-associated protein
    CD_antigen: CD315
    Gene namesi
    Name:PTGFRN
    Synonyms:CD9P1, EWIF, FPRP, KIAA1436
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:9601. PTGFRN.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33950.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 879854Prostaglandin F2 receptor negative regulatorPRO_0000014762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 119PROSITE-ProRule annotation
    Glycosylationi44 – 441N-linked (GlcNAc...)1 Publication
    Disulfide bondi169 ↔ 247PROSITE-ProRule annotation
    Modified residuei271 – 2711PhosphothreonineBy similarity
    Glycosylationi286 – 2861N-linked (GlcNAc...)2 Publications
    Disulfide bondi299 ↔ 373PROSITE-ProRule annotation
    Glycosylationi300 – 3001N-linked (GlcNAc...)2 Publications
    Glycosylationi383 – 3831N-linked (GlcNAc...)1 Publication
    Glycosylationi413 – 4131N-linked (GlcNAc...)1 Publication
    Disulfide bondi429 ↔ 515PROSITE-ProRule annotation
    Glycosylationi525 – 5251N-linked (GlcNAc...)1 Publication
    Disulfide bondi571 ↔ 655PROSITE-ProRule annotation
    Glycosylationi600 – 6001N-linked (GlcNAc...)1 Publication
    Glycosylationi618 – 6181N-linked (GlcNAc...)1 Publication
    Glycosylationi691 – 6911N-linked (GlcNAc...)1 Publication
    Disulfide bondi711 ↔ 793PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9P2B2.
    PaxDbiQ9P2B2.
    PeptideAtlasiQ9P2B2.
    PRIDEiQ9P2B2.

    PTM databases

    PhosphoSiteiQ9P2B2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P2B2.
    BgeeiQ9P2B2.
    CleanExiHS_PTGFRN.
    GenevestigatoriQ9P2B2.

    Organism-specific databases

    HPAiHPA017074.

    Interactioni

    Subunit structurei

    Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.1 Publication

    Protein-protein interaction databases

    BioGridi111710. 7 interactions.
    IntActiQ9P2B2. 1 interaction.
    STRINGi9606.ENSP00000376899.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2B2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 832807ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini854 – 87926CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei833 – 85321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 129104Ig-like C2-type 1Add
    BLAST
    Domaini149 – 268120Ig-like C2-type 2Add
    BLAST
    Domaini276 – 394119Ig-like C2-type 3Add
    BLAST
    Domaini406 – 536131Ig-like C2-type 4Add
    BLAST
    Domaini544 – 662119Ig-like C2-type 5Add
    BLAST
    Domaini688 – 813126Ig-like C2-type 6Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi424 – 4274Endoplasmic reticulum retention signal
    Motifi703 – 7053Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39204.
    HOGENOMiHOG000112641.
    HOVERGENiHBG031554.
    InParanoidiQ9P2B2.
    KOiK06729.
    OMAiWKSDLSL.
    OrthoDBiEOG7RNJZG.
    PhylomeDBiQ9P2B2.
    TreeFamiTF332702.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 6 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P2B2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG    50
    PSEQNFDWSF SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND 100
    AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADSLHVGPS 150
    ARPPPSLSLR EGEPFELRCT AASASPLHTH LALLWEVHRG PARRSVLALT 200
    HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA DQGSYRCIVS 250
    EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN 300
    ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH 350
    VDARSYHLLV RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG 400
    VTWLEPDYQV YLNASKVPGF ADDPTELACR VVDTKSGEAN VRFTVSWYYR 450
    MNRRSDNVVT SELLAVMDGD WTLKYGERSK QRAQDGDFIF SKEHTDTFNF 500
    RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN IFWALEDSVL 550
    VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN 600
    ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA 650
    GLYRCMVTAW SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS 700
    VIRGDLIKLF CIITVEGAAL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD 750
    RKGIVTTSRR DWKSDLSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVK 800
    SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI 850
    GYCSSHWCCK KEVQETRRER RRLMSMEMD 879
    Length:879
    Mass (Da):98,556
    Last modified:February 1, 2003 - v2
    Checksum:i9712C398A74DF570
    GO

    Sequence cautioni

    The sequence BAA92674.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11104.1 differs from that shown. Reason: Erroneous termination at position 864. Translated as Gln.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091V → A in BAC11104. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti277 – 2771S → T.1 Publication
    Corresponds to variant rs4546904 [ dbSNP | Ensembl ].
    VAR_059388
    Natural varianti837 – 8371V → I.
    Corresponds to variant rs10801922 [ dbSNP | Ensembl ].
    VAR_024496

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037857 mRNA. Translation: BAA92674.1. Different initiation.
    AK074637 mRNA. Translation: BAC11104.1. Sequence problems.
    AL445231, AL157904 Genomic DNA. Translation: CAH71960.1.
    AL157904, AL445231 Genomic DNA. Translation: CAI22650.1.
    BC152454 mRNA. Translation: AAI52455.1.
    CCDSiCCDS890.1.
    RefSeqiNP_065173.2. NM_020440.2.
    UniGeneiHs.418093.

    Genome annotation databases

    EnsembliENST00000393203; ENSP00000376899; ENSG00000134247.
    GeneIDi5738.
    KEGGihsa:5738.
    UCSCiuc001egv.1. human.

    Polymorphism databases

    DMDMi28201801.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037857 mRNA. Translation: BAA92674.1 . Different initiation.
    AK074637 mRNA. Translation: BAC11104.1 . Sequence problems.
    AL445231 , AL157904 Genomic DNA. Translation: CAH71960.1 .
    AL157904 , AL445231 Genomic DNA. Translation: CAI22650.1 .
    BC152454 mRNA. Translation: AAI52455.1 .
    CCDSi CCDS890.1.
    RefSeqi NP_065173.2. NM_020440.2.
    UniGenei Hs.418093.

    3D structure databases

    ProteinModelPortali Q9P2B2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111710. 7 interactions.
    IntActi Q9P2B2. 1 interaction.
    STRINGi 9606.ENSP00000376899.

    PTM databases

    PhosphoSitei Q9P2B2.

    Polymorphism databases

    DMDMi 28201801.

    Proteomic databases

    MaxQBi Q9P2B2.
    PaxDbi Q9P2B2.
    PeptideAtlasi Q9P2B2.
    PRIDEi Q9P2B2.

    Protocols and materials databases

    DNASUi 5738.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393203 ; ENSP00000376899 ; ENSG00000134247 .
    GeneIDi 5738.
    KEGGi hsa:5738.
    UCSCi uc001egv.1. human.

    Organism-specific databases

    CTDi 5738.
    GeneCardsi GC01P117452.
    HGNCi HGNC:9601. PTGFRN.
    HPAi HPA017074.
    MIMi 601204. gene.
    neXtProti NX_Q9P2B2.
    PharmGKBi PA33950.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39204.
    HOGENOMi HOG000112641.
    HOVERGENi HBG031554.
    InParanoidi Q9P2B2.
    KOi K06729.
    OMAi WKSDLSL.
    OrthoDBi EOG7RNJZG.
    PhylomeDBi Q9P2B2.
    TreeFami TF332702.

    Miscellaneous databases

    GeneWikii PTGFRN.
    GenomeRNAii 5738.
    NextBioi 22336.
    PROi Q9P2B2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2B2.
    Bgeei Q9P2B2.
    CleanExi HS_PTGFRN.
    Genevestigatori Q9P2B2.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 6 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-277.
      Tissue: Embryo.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes."
      Charrin S., Le Naour F., Oualid M., Billard M., Faure G., Hanash S.M., Boucheix C., Rubinstein E.
      J. Biol. Chem. 276:14329-14337(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, INTERACTION WITH CD9; CD63; CD81; CD82 AND CD151.
    6. Cited for: GLYCOSYLATION AT ASN-44; ASN-286; ASN-300; ASN-383; ASN-413; ASN-525; ASN-600; ASN-618 AND ASN-691.
    7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-286 AND ASN-300.
      Tissue: Liver.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFPRP_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2B2
    Secondary accession number(s): Q5VVU9, Q8N2K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: February 1, 2003
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3