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Q9P2B2 (FPRP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin F2 receptor negative regulator
Alternative name(s):
CD9 partner 1
Short name=CD9P-1
Glu-Trp-Ile EWI motif-containing protein F
Short name=EWI-F
Prostaglandin F2-alpha receptor regulatory protein
Prostaglandin F2-alpha receptor-associated protein
CD_antigen=CD315
Gene names
Name:PTGFRN
Synonyms:CD9P1, EWIF, FPRP, KIAA1436
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length879 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur By similarity.

Subunit structure

Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Sequence caution

The sequence BAA92674.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC11104.1 differs from that shown. Reason: Erroneous termination at position 864. Translated as Gln.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 879854Prostaglandin F2 receptor negative regulator
PRO_0000014762

Regions

Topological domain26 – 832807Extracellular Potential
Transmembrane833 – 85321Helical; Potential
Topological domain854 – 87926Cytoplasmic Potential
Domain26 – 129104Ig-like C2-type 1
Domain149 – 268120Ig-like C2-type 2
Domain276 – 394119Ig-like C2-type 3
Domain406 – 536131Ig-like C2-type 4
Domain544 – 662119Ig-like C2-type 5
Domain688 – 813126Ig-like C2-type 6
Motif424 – 4274Endoplasmic reticulum retention signal
Motif703 – 7053Cell attachment site Potential

Amino acid modifications

Modified residue2711Phosphothreonine By similarity
Glycosylation441N-linked (GlcNAc...) Ref.6
Glycosylation2861N-linked (GlcNAc...) Ref.6 Ref.7
Glycosylation3001N-linked (GlcNAc...) Ref.6 Ref.7
Glycosylation3831N-linked (GlcNAc...) Ref.6
Glycosylation4131N-linked (GlcNAc...) Ref.6
Glycosylation5251N-linked (GlcNAc...) Ref.6
Glycosylation6001N-linked (GlcNAc...) Ref.6
Glycosylation6181N-linked (GlcNAc...) Ref.6
Glycosylation6911N-linked (GlcNAc...) Ref.6
Disulfide bond43 ↔ 119 By similarity
Disulfide bond169 ↔ 247 By similarity
Disulfide bond299 ↔ 373 By similarity
Disulfide bond429 ↔ 515 By similarity
Disulfide bond571 ↔ 655 By similarity
Disulfide bond711 ↔ 793 By similarity

Natural variations

Natural variant2771S → T. Ref.2
Corresponds to variant rs4546904 [ dbSNP | Ensembl ].
VAR_059388
Natural variant8371V → I.
Corresponds to variant rs10801922 [ dbSNP | Ensembl ].
VAR_024496

Experimental info

Sequence conflict1091V → A in BAC11104. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9P2B2 [UniParc].

Last modified February 1, 2003. Version 2.
Checksum: 9712C398A74DF570

FASTA87998,556
        10         20         30         40         50         60 
MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG PSEQNFDWSF 

        70         80         90        100        110        120 
SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND AVELHIKNVQ PSDQGHYKCS 

       130        140        150        160        170        180 
TPSTDATVQG NYEDTVQVKV LADSLHVGPS ARPPPSLSLR EGEPFELRCT AASASPLHTH 

       190        200        210        220        230        240 
LALLWEVHRG PARRSVLALT HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA 

       250        260        270        280        290        300 
DQGSYRCIVS EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN 

       310        320        330        340        350        360 
ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH VDARSYHLLV 

       370        380        390        400        410        420 
RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG VTWLEPDYQV YLNASKVPGF 

       430        440        450        460        470        480 
ADDPTELACR VVDTKSGEAN VRFTVSWYYR MNRRSDNVVT SELLAVMDGD WTLKYGERSK 

       490        500        510        520        530        540 
QRAQDGDFIF SKEHTDTFNF RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN 

       550        560        570        580        590        600 
IFWALEDSVL VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN 

       610        620        630        640        650        660 
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA GLYRCMVTAW 

       670        680        690        700        710        720 
SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS VIRGDLIKLF CIITVEGAAL 

       730        740        750        760        770        780 
DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD RKGIVTTSRR DWKSDLSLER VSVLEFLLQV 

       790        800        810        820        830        840 
HGSEDQDFGN YYCSVTPWVK SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS 

       850        860        870 
TVIGLLSCLI GYCSSHWCCK KEVQETRRER RRLMSMEMD 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-277.
Tissue: Embryo.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The major CD9 and CD81 molecular partner. Identification and characterization of the complexes."
Charrin S., Le Naour F., Oualid M., Billard M., Faure G., Hanash S.M., Boucheix C., Rubinstein E.
J. Biol. Chem. 276:14329-14337(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, INTERACTION WITH CD9; CD63; CD81; CD82 AND CD151.
[6]"Glycosylation status of the membrane protein CD9P-1."
Andre M., Morelle W., Planchon S., Milhiet P.E., Rubinstein E., Mollicone R., Chamot-Rooke J., Le Naour F.
Proteomics 7:3880-3895(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-44; ASN-286; ASN-300; ASN-383; ASN-413; ASN-525; ASN-600; ASN-618 AND ASN-691.
[7]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-286 AND ASN-300.
Tissue: Liver.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB037857 mRNA. Translation: BAA92674.1. Different initiation.
AK074637 mRNA. Translation: BAC11104.1. Sequence problems.
AL445231, AL157904 Genomic DNA. Translation: CAH71960.1.
AL157904, AL445231 Genomic DNA. Translation: CAI22650.1.
BC152454 mRNA. Translation: AAI52455.1.
CCDSCCDS890.1.
RefSeqNP_065173.2. NM_020440.2.
UniGeneHs.418093.

3D structure databases

ProteinModelPortalQ9P2B2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111710. 7 interactions.
IntActQ9P2B2. 1 interaction.
STRING9606.ENSP00000376899.

PTM databases

PhosphoSiteQ9P2B2.

Polymorphism databases

DMDM28201801.

Proteomic databases

MaxQBQ9P2B2.
PaxDbQ9P2B2.
PeptideAtlasQ9P2B2.
PRIDEQ9P2B2.

Protocols and materials databases

DNASU5738.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000393203; ENSP00000376899; ENSG00000134247.
GeneID5738.
KEGGhsa:5738.
UCSCuc001egv.1. human.

Organism-specific databases

CTD5738.
GeneCardsGC01P117452.
HGNCHGNC:9601. PTGFRN.
HPAHPA017074.
MIM601204. gene.
neXtProtNX_Q9P2B2.
PharmGKBPA33950.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39204.
HOGENOMHOG000112641.
HOVERGENHBG031554.
InParanoidQ9P2B2.
KOK06729.
OMAWKSDLSL.
OrthoDBEOG7RNJZG.
PhylomeDBQ9P2B2.
TreeFamTF332702.

Gene expression databases

ArrayExpressQ9P2B2.
BgeeQ9P2B2.
CleanExHS_PTGFRN.
GenevestigatorQ9P2B2.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 2 hits.
[Graphical view]
SMARTSM00409. IG. 6 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPTGFRN.
GenomeRNAi5738.
NextBio22336.
PROQ9P2B2.
SOURCESearch...

Entry information

Entry nameFPRP_HUMAN
AccessionPrimary (citable) accession number: Q9P2B2
Secondary accession number(s): Q5VVU9, Q8N2K6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries