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Protein

ABI gene family member 3

Gene

ABI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.By similarity1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • regulation of cell migration Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
ABI gene family member 3
Alternative name(s):
New molecule including SH3
Short name:
Nesh
Gene namesi
Name:ABI3
Synonyms:NESH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108798.8
HGNCiHGNC:29859 ABI3
MIMi606363 gene
neXtProtiNX_Q9P2A4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51225
OpenTargetsiENSG00000108798
PharmGKBiPA134951642

Polymorphism and mutation databases

BioMutaiABI3
DMDMi296434384

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917921 – 366ABI gene family member 3Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2A4
MaxQBiQ9P2A4
PaxDbiQ9P2A4
PeptideAtlasiQ9P2A4
PRIDEiQ9P2A4

PTM databases

iPTMnetiQ9P2A4
PhosphoSitePlusiQ9P2A4

Expressioni

Tissue specificityi

Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000108798
CleanExiHS_ABI3
ExpressionAtlasiQ9P2A4 baseline and differential
GenevisibleiQ9P2A4 HS

Organism-specific databases

HPAiHPA017345

Interactioni

Subunit structurei

May interact with PAK1 and PAK2. Probably interacts with TARSH.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi119389, 35 interactors
IntActiQ9P2A4, 70 interactors
MINTiQ9P2A4
STRINGi9606.ENSP00000225941

Structurei

3D structure databases

ProteinModelPortaliQ9P2A4
SMRiQ9P2A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 366SH3PROSITE-ProRule annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 61Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 306Pro-richAdd BLAST83

Sequence similaritiesi

Belongs to the ABI family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG2546 Eukaryota
ENOG410Y0MH LUCA
GeneTreeiENSGT00390000003756
HOGENOMiHOG000293213
HOVERGENiHBG050446
InParanoidiQ9P2A4
OMAiSWVPASY
OrthoDBiEOG091G0AN8
PhylomeDBiQ9P2A4
TreeFamiTF314303

Family and domain databases

InterProiView protein in InterPro
IPR028457 ABI
IPR028455 ABI3
IPR012849 Abl-interactor_HHR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10460 PTHR10460, 1 hit
PTHR10460:SF7 PTHR10460:SF7, 1 hit
PfamiView protein in Pfam
PF07815 Abi_HHR, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2A4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET
60 70 80 90 100
MAFTTQALAS VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH
110 120 130 140 150
MEKVARREIG TLATVQRLPP GQKVIAPENL PPLTPYCRRP LNFGCLDDIG
160 170 180 190 200
HGIKDLSTQL SRTGTLSRKS IKAPATPASA TLGRPPRIPE PVHLPVVPDG
210 220 230 240 250
RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS LDPPPPPAAV
260 270 280 290 300
EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD
310 320 330 340 350
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS
360
SEGTGFFPGN YVEPSC
Length:366
Mass (Da):39,035
Last modified:May 18, 2010 - v2
Checksum:i23EC3838E41D8ECD
GO
Isoform 2 (identifier: Q9P2A4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-95: Missing.

Show »
Length:360
Mass (Da):38,450
Checksum:i1DB04BD6FFA0ECF1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02203044R → Q1 PublicationCorresponds to variant dbSNP:rs2233369Ensembl.1
Natural variantiVAR_060243203S → F. Corresponds to variant dbSNP:rs616338Ensembl.1
Natural variantiVAR_060993209F → SCombined sources3 PublicationsCorresponds to variant dbSNP:rs616338Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04146790 – 95Missing in isoform 2. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037886 mRNA Translation: BAA90667.1
AL136709 mRNA Translation: CAB66644.1
AC004797 Genomic DNA No translation available.
AC069454 Genomic DNA No translation available.
BC007780 mRNA Translation: AAH07780.1
CCDSiCCDS11546.1 [Q9P2A4-1]
CCDS45725.1 [Q9P2A4-2]
RefSeqiNP_001128658.1, NM_001135186.1
NP_057512.1, NM_016428.2
UniGeneiHs.130719

Genome annotation databases

EnsembliENST00000225941; ENSP00000225941; ENSG00000108798 [Q9P2A4-1]
ENST00000419580; ENSP00000406651; ENSG00000108798 [Q9P2A4-2]
GeneIDi51225
KEGGihsa:51225
UCSCiuc002iop.1 human [Q9P2A4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABI3_HUMAN
AccessioniPrimary (citable) accession number: Q9P2A4
Secondary accession number(s): C9IZN8, Q9H0P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health