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Q9P2A4

- ABI3_HUMAN

UniProt

Q9P2A4 - ABI3_HUMAN

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Protein
ABI gene family member 3
Gene
ABI3, NESH
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May inhibit tumor metastasis By similarity. In vitro, reduces cell motility.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cellular component movement Source: UniProtKB
  2. regulation of cell migration Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ABI gene family member 3
Alternative name(s):
New molecule including SH3
Short name:
Nesh
Gene namesi
Name:ABI3
Synonyms:NESH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29859. ABI3.

Subcellular locationi

Cytoplasm
Note: Colocalizes with PAK2 at leading edge of cells.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. intracellular Source: MGI
  3. lamellipodium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366ABI gene family member 3
PRO_0000191792Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P2A4.
PaxDbiQ9P2A4.
PRIDEiQ9P2A4.

PTM databases

PhosphoSiteiQ9P2A4.

Expressioni

Tissue specificityi

Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9P2A4.
CleanExiHS_ABI3.
GenevestigatoriQ9P2A4.

Organism-specific databases

HPAiHPA017345.

Interactioni

Subunit structurei

May interact with PAK1 and PAK2. Probably interacts with TARSH.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3HO153723EBI-742038,EBI-709735

Protein-protein interaction databases

BioGridi119389. 14 interactions.
IntActiQ9P2A4. 18 interactions.
MINTiMINT-235637.
STRINGi9606.ENSP00000225941.

Structurei

3D structure databases

ProteinModelPortaliQ9P2A4.
SMRiQ9P2A4. Positions 1-154, 301-363.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 36659SH3
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili33 – 6129 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi224 – 30683Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the ABI family.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG328966.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
InParanoidiQ9P2A4.
OMAiSWVPASY.
OrthoDBiEOG7673BC.
PhylomeDBiQ9P2A4.
TreeFamiTF314303.

Family and domain databases

InterProiIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF6. PTHR10460:SF6. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P2A4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET    50
MAFTTQALAS VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH 100
MEKVARREIG TLATVQRLPP GQKVIAPENL PPLTPYCRRP LNFGCLDDIG 150
HGIKDLSTQL SRTGTLSRKS IKAPATPASA TLGRPPRIPE PVHLPVVPDG 200
RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS LDPPPPPAAV 250
EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD 300
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS 350
SEGTGFFPGN YVEPSC 366
Length:366
Mass (Da):39,035
Last modified:May 18, 2010 - v2
Checksum:i23EC3838E41D8ECD
GO
Isoform 2 (identifier: Q9P2A4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-95: Missing.

Show »
Length:360
Mass (Da):38,450
Checksum:i1DB04BD6FFA0ECF1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441R → Q.1 Publication
Corresponds to variant rs2233369 [ dbSNP | Ensembl ].
VAR_022030
Natural varianti203 – 2031S → F.
Corresponds to variant rs616338 [ dbSNP | Ensembl ].
VAR_060243
Natural varianti209 – 2091F → S.3 Publications
Corresponds to variant rs616338 [ dbSNP | Ensembl ].
VAR_060993

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 956Missing in isoform 2.
VSP_041467

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037886 mRNA. Translation: BAA90667.1.
AL136709 mRNA. Translation: CAB66644.1.
AC004797 Genomic DNA. No translation available.
AC069454 Genomic DNA. No translation available.
BC007780 mRNA. Translation: AAH07780.1.
CCDSiCCDS11546.1. [Q9P2A4-1]
CCDS45725.1. [Q9P2A4-2]
RefSeqiNP_001128658.1. NM_001135186.1.
NP_057512.1. NM_016428.2.
UniGeneiHs.130719.

Genome annotation databases

EnsembliENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
GeneIDi51225.
KEGGihsa:51225.
UCSCiuc002iop.1. human. [Q9P2A4-1]
uc002ioq.1. human. [Q9P2A4-2]

Polymorphism databases

DMDMi296434384.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037886 mRNA. Translation: BAA90667.1 .
AL136709 mRNA. Translation: CAB66644.1 .
AC004797 Genomic DNA. No translation available.
AC069454 Genomic DNA. No translation available.
BC007780 mRNA. Translation: AAH07780.1 .
CCDSi CCDS11546.1. [Q9P2A4-1 ]
CCDS45725.1. [Q9P2A4-2 ]
RefSeqi NP_001128658.1. NM_001135186.1.
NP_057512.1. NM_016428.2.
UniGenei Hs.130719.

3D structure databases

ProteinModelPortali Q9P2A4.
SMRi Q9P2A4. Positions 1-154, 301-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119389. 14 interactions.
IntActi Q9P2A4. 18 interactions.
MINTi MINT-235637.
STRINGi 9606.ENSP00000225941.

PTM databases

PhosphoSitei Q9P2A4.

Polymorphism databases

DMDMi 296434384.

Proteomic databases

MaxQBi Q9P2A4.
PaxDbi Q9P2A4.
PRIDEi Q9P2A4.

Protocols and materials databases

DNASUi 51225.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225941 ; ENSP00000225941 ; ENSG00000108798 . [Q9P2A4-1 ]
ENST00000419580 ; ENSP00000406651 ; ENSG00000108798 . [Q9P2A4-2 ]
GeneIDi 51225.
KEGGi hsa:51225.
UCSCi uc002iop.1. human. [Q9P2A4-1 ]
uc002ioq.1. human. [Q9P2A4-2 ]

Organism-specific databases

CTDi 51225.
GeneCardsi GC17P047287.
HGNCi HGNC:29859. ABI3.
HPAi HPA017345.
MIMi 606363. gene.
neXtProti NX_Q9P2A4.
PharmGKBi PA134951642.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328966.
HOGENOMi HOG000293213.
HOVERGENi HBG050446.
InParanoidi Q9P2A4.
OMAi SWVPASY.
OrthoDBi EOG7673BC.
PhylomeDBi Q9P2A4.
TreeFami TF314303.

Miscellaneous databases

GeneWikii ABI3.
GenomeRNAii 51225.
NextBioi 54310.
PROi Q9P2A4.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2A4.
CleanExi HS_ABI3.
Genevestigatori Q9P2A4.

Family and domain databases

InterProi IPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR10460. PTHR10460. 1 hit.
PTHR10460:SF6. PTHR10460:SF6. 1 hit.
Pfami PF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein."
    Miyazaki K., Matsuda S., Ichigotani Y., Takenouchi Y., Hayashi K., Fukuda Y., Nimura Y., Hamaguchi M.
    Biochim. Biophys. Acta 1493:237-241(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT SER-209.
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-44 AND SER-209.
    Tissue: Kidney.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-209.
    Tissue: B-cell.
  5. "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells."
    Ichigotani Y., Yokozaki S., Fukuda Y., Hamaguchi M., Matsuda S.
    Cancer Res. 62:2215-2219(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
  6. "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3."
    Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M.
    J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TARSH.

Entry informationi

Entry nameiABI3_HUMAN
AccessioniPrimary (citable) accession number: Q9P2A4
Secondary accession number(s): C9IZN8, Q9H0P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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