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Q9P2A4 (ABI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABI gene family member 3
Alternative name(s):
New molecule including SH3
Short name=Nesh
Gene names
Name:ABI3
Synonyms:NESH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May inhibit tumor metastasis By similarity. In vitro, reduces cell motility. Ref.5

Subunit structure

May interact with PAK1 and PAK2. Probably interacts with TARSH. Ref.6

Subcellular location

Cytoplasm. Note: Colocalizes with PAK2 at leading edge of cells. Ref.5

Tissue specificity

Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle. Ref.1

Sequence similarities

Belongs to the ABI family.

Contains 1 SH3 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EIF3HO153723EBI-742038,EBI-709735

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P2A4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P2A4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     90-95: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366ABI gene family member 3
PRO_0000191792

Regions

Domain308 – 36659SH3
Coiled coil33 – 6129 Potential
Compositional bias224 – 30683Pro-rich

Natural variations

Alternative sequence90 – 956Missing in isoform 2.
VSP_041467
Natural variant441R → Q. Ref.2
Corresponds to variant rs2233369 [ dbSNP | Ensembl ].
VAR_022030
Natural variant2031S → F.
Corresponds to variant rs616338 [ dbSNP | Ensembl ].
VAR_060243
Natural variant2091F → S. Ref.1 Ref.2 Ref.4
Corresponds to variant rs616338 [ dbSNP | Ensembl ].
VAR_060993

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 23EC3838E41D8ECD

FASTA36639,035
        10         20         30         40         50         60 
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS 

        70         80         90        100        110        120 
VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH MEKVARREIG TLATVQRLPP 

       130        140        150        160        170        180 
GQKVIAPENL PPLTPYCRRP LNFGCLDDIG HGIKDLSTQL SRTGTLSRKS IKAPATPASA 

       190        200        210        220        230        240 
TLGRPPRIPE PVHLPVVPDG RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS 

       250        260        270        280        290        300 
LDPPPPPAAV EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD 

       310        320        330        340        350        360 
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS SEGTGFFPGN 


YVEPSC 

« Hide

Isoform 2 [UniParc].

Checksum: 1DB04BD6FFA0ECF1
Show »

FASTA36038,450

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein."
Miyazaki K., Matsuda S., Ichigotani Y., Takenouchi Y., Hayashi K., Fukuda Y., Nimura Y., Hamaguchi M.
Biochim. Biophys. Acta 1493:237-241(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT SER-209.
Tissue: Placenta.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-44 AND SER-209.
Tissue: Kidney.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-209.
Tissue: B-cell.
[5]"Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells."
Ichigotani Y., Yokozaki S., Fukuda Y., Hamaguchi M., Matsuda S.
Cancer Res. 62:2215-2219(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
[6]"Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3."
Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M.
J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TARSH.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB037886 mRNA. Translation: BAA90667.1.
AL136709 mRNA. Translation: CAB66644.1.
AC004797 Genomic DNA. No translation available.
AC069454 Genomic DNA. No translation available.
BC007780 mRNA. Translation: AAH07780.1.
CCDSCCDS11546.1. [Q9P2A4-1]
CCDS45725.1. [Q9P2A4-2]
RefSeqNP_001128658.1. NM_001135186.1.
NP_057512.1. NM_016428.2.
UniGeneHs.130719.

3D structure databases

ProteinModelPortalQ9P2A4.
SMRQ9P2A4. Positions 1-154, 301-363.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119389. 14 interactions.
IntActQ9P2A4. 18 interactions.
MINTMINT-235637.
STRING9606.ENSP00000225941.

PTM databases

PhosphoSiteQ9P2A4.

Polymorphism databases

DMDM296434384.

Proteomic databases

MaxQBQ9P2A4.
PaxDbQ9P2A4.
PRIDEQ9P2A4.

Protocols and materials databases

DNASU51225.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
GeneID51225.
KEGGhsa:51225.
UCSCuc002iop.1. human. [Q9P2A4-1]
uc002ioq.1. human. [Q9P2A4-2]

Organism-specific databases

CTD51225.
GeneCardsGC17P047287.
HGNCHGNC:29859. ABI3.
HPAHPA017345.
MIM606363. gene.
neXtProtNX_Q9P2A4.
PharmGKBPA134951642.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG328966.
HOGENOMHOG000293213.
HOVERGENHBG050446.
InParanoidQ9P2A4.
OMASWVPASY.
OrthoDBEOG7673BC.
PhylomeDBQ9P2A4.
TreeFamTF314303.

Gene expression databases

BgeeQ9P2A4.
CleanExHS_ABI3.
GenevestigatorQ9P2A4.

Family and domain databases

InterProIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF6. PTHR10460:SF6. 1 hit.
PfamPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiABI3.
GenomeRNAi51225.
NextBio54310.
PROQ9P2A4.
SOURCESearch...

Entry information

Entry nameABI3_HUMAN
AccessionPrimary (citable) accession number: Q9P2A4
Secondary accession number(s): C9IZN8, Q9H0P6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM