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Protein

ABI gene family member 3

Gene

ABI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.By similarity1 Publication

GO - Biological processi

  • movement of cell or subcellular component Source: UniProtKB
  • regulation of cell migration Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ABI gene family member 3
Alternative name(s):
New molecule including SH3
Short name:
Nesh
Gene namesi
Name:ABI3
Synonyms:NESH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29859. ABI3.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Colocalizes with PAK2 at leading edge of cells.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • intracellular Source: MGI
  • lamellipodium Source: MGI
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51225.
OpenTargetsiENSG00000108798.
PharmGKBiPA134951642.

Polymorphism and mutation databases

BioMutaiABI3.
DMDMi296434384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917921 – 366ABI gene family member 3Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2A4.
MaxQBiQ9P2A4.
PaxDbiQ9P2A4.
PeptideAtlasiQ9P2A4.
PRIDEiQ9P2A4.

PTM databases

iPTMnetiQ9P2A4.
PhosphoSitePlusiQ9P2A4.

Expressioni

Tissue specificityi

Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000108798.
CleanExiHS_ABI3.
ExpressionAtlasiQ9P2A4. baseline and differential.
GenevisibleiQ9P2A4. HS.

Organism-specific databases

HPAiHPA017345.

Interactioni

Subunit structurei

May interact with PAK1 and PAK2. Probably interacts with TARSH.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R8Y43EBI-742038,EBI-10175581
ARMC7Q9H6L43EBI-742038,EBI-742909
CEP170P1Q96L143EBI-742038,EBI-743488
CEP44Q9C0F16EBI-742038,EBI-744115
DTNBO609413EBI-742038,EBI-740402
EIF3HO153723EBI-742038,EBI-709735
EIF3S3Q6IB983EBI-742038,EBI-10184995
EVLQ9UI083EBI-742038,EBI-346653
FARSAQ9Y2853EBI-742038,EBI-725361
FBF1Q8TES7-63EBI-742038,EBI-10244131
GRB2P629933EBI-742038,EBI-401755
HOMER1Q86YM75EBI-742038,EBI-746815
HOMER3Q9NSC54EBI-742038,EBI-748420
KANK2Q63ZY35EBI-742038,EBI-2556193
KLC3Q6P5973EBI-742038,EBI-1643885
KLC4Q9NSK03EBI-742038,EBI-949319
KRT13A1A4E93EBI-742038,EBI-10171552
MAGEA12Q6FHH83EBI-742038,EBI-10178394
MRFAP1L1Q96HT83EBI-742038,EBI-748896
NCK2O436395EBI-742038,EBI-713635
NUP58Q9BVL26EBI-742038,EBI-2811583
PSMA1P257863EBI-742038,EBI-359352
RUNX1T1Q06455-43EBI-742038,EBI-10224192
VASPP505525EBI-742038,EBI-748201
WASP427684EBI-742038,EBI-346375

Protein-protein interaction databases

BioGridi119389. 35 interactors.
IntActiQ9P2A4. 55 interactors.
MINTiMINT-235637.
STRINGi9606.ENSP00000225941.

Structurei

3D structure databases

ProteinModelPortaliQ9P2A4.
SMRiQ9P2A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 366SH3PROSITE-ProRule annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 61Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 306Pro-richAdd BLAST83

Sequence similaritiesi

Belongs to the ABI family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG2546. Eukaryota.
ENOG410Y0MH. LUCA.
GeneTreeiENSGT00390000003756.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
InParanoidiQ9P2A4.
OMAiFEIPMGR.
OrthoDBiEOG091G0AN8.
PhylomeDBiQ9P2A4.
TreeFamiTF314303.

Family and domain databases

InterProiIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF7. PTHR10460:SF7. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2A4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET
60 70 80 90 100
MAFTTQALAS VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH
110 120 130 140 150
MEKVARREIG TLATVQRLPP GQKVIAPENL PPLTPYCRRP LNFGCLDDIG
160 170 180 190 200
HGIKDLSTQL SRTGTLSRKS IKAPATPASA TLGRPPRIPE PVHLPVVPDG
210 220 230 240 250
RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS LDPPPPPAAV
260 270 280 290 300
EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD
310 320 330 340 350
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS
360
SEGTGFFPGN YVEPSC
Length:366
Mass (Da):39,035
Last modified:May 18, 2010 - v2
Checksum:i23EC3838E41D8ECD
GO
Isoform 2 (identifier: Q9P2A4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-95: Missing.

Show »
Length:360
Mass (Da):38,450
Checksum:i1DB04BD6FFA0ECF1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02203044R → Q.1 PublicationCorresponds to variant rs2233369dbSNPEnsembl.1
Natural variantiVAR_060243203S → F.Corresponds to variant rs616338dbSNPEnsembl.1
Natural variantiVAR_060993209F → S.Combined sources3 PublicationsCorresponds to variant rs616338dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04146790 – 95Missing in isoform 2. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037886 mRNA. Translation: BAA90667.1.
AL136709 mRNA. Translation: CAB66644.1.
AC004797 Genomic DNA. No translation available.
AC069454 Genomic DNA. No translation available.
BC007780 mRNA. Translation: AAH07780.1.
CCDSiCCDS11546.1. [Q9P2A4-1]
CCDS45725.1. [Q9P2A4-2]
RefSeqiNP_001128658.1. NM_001135186.1.
NP_057512.1. NM_016428.2.
UniGeneiHs.130719.

Genome annotation databases

EnsembliENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
GeneIDi51225.
KEGGihsa:51225.
UCSCiuc002iop.1. human. [Q9P2A4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037886 mRNA. Translation: BAA90667.1.
AL136709 mRNA. Translation: CAB66644.1.
AC004797 Genomic DNA. No translation available.
AC069454 Genomic DNA. No translation available.
BC007780 mRNA. Translation: AAH07780.1.
CCDSiCCDS11546.1. [Q9P2A4-1]
CCDS45725.1. [Q9P2A4-2]
RefSeqiNP_001128658.1. NM_001135186.1.
NP_057512.1. NM_016428.2.
UniGeneiHs.130719.

3D structure databases

ProteinModelPortaliQ9P2A4.
SMRiQ9P2A4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119389. 35 interactors.
IntActiQ9P2A4. 55 interactors.
MINTiMINT-235637.
STRINGi9606.ENSP00000225941.

PTM databases

iPTMnetiQ9P2A4.
PhosphoSitePlusiQ9P2A4.

Polymorphism and mutation databases

BioMutaiABI3.
DMDMi296434384.

Proteomic databases

EPDiQ9P2A4.
MaxQBiQ9P2A4.
PaxDbiQ9P2A4.
PeptideAtlasiQ9P2A4.
PRIDEiQ9P2A4.

Protocols and materials databases

DNASUi51225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
GeneIDi51225.
KEGGihsa:51225.
UCSCiuc002iop.1. human. [Q9P2A4-1]

Organism-specific databases

CTDi51225.
DisGeNETi51225.
GeneCardsiABI3.
HGNCiHGNC:29859. ABI3.
HPAiHPA017345.
MIMi606363. gene.
neXtProtiNX_Q9P2A4.
OpenTargetsiENSG00000108798.
PharmGKBiPA134951642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2546. Eukaryota.
ENOG410Y0MH. LUCA.
GeneTreeiENSGT00390000003756.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
InParanoidiQ9P2A4.
OMAiFEIPMGR.
OrthoDBiEOG091G0AN8.
PhylomeDBiQ9P2A4.
TreeFamiTF314303.

Miscellaneous databases

GeneWikiiABI3.
GenomeRNAii51225.
PROiQ9P2A4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108798.
CleanExiHS_ABI3.
ExpressionAtlasiQ9P2A4. baseline and differential.
GenevisibleiQ9P2A4. HS.

Family and domain databases

InterProiIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF7. PTHR10460:SF7. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABI3_HUMAN
AccessioniPrimary (citable) accession number: Q9P2A4
Secondary accession number(s): C9IZN8, Q9H0P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.