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Q9P2A4

- ABI3_HUMAN

UniProt

Q9P2A4 - ABI3_HUMAN

Protein

ABI gene family member 3

Gene

ABI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May inhibit tumor metastasis By similarity. In vitro, reduces cell motility.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cellular component movement Source: UniProtKB
    2. regulation of cell migration Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ABI gene family member 3
    Alternative name(s):
    New molecule including SH3
    Short name:
    Nesh
    Gene namesi
    Name:ABI3
    Synonyms:NESH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29859. ABI3.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Colocalizes with PAK2 at leading edge of cells.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. intracellular Source: MGI
    3. lamellipodium Source: MGI
    4. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134951642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366ABI gene family member 3PRO_0000191792Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9P2A4.
    PaxDbiQ9P2A4.
    PRIDEiQ9P2A4.

    PTM databases

    PhosphoSiteiQ9P2A4.

    Expressioni

    Tissue specificityi

    Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ9P2A4.
    CleanExiHS_ABI3.
    GenevestigatoriQ9P2A4.

    Organism-specific databases

    HPAiHPA017345.

    Interactioni

    Subunit structurei

    May interact with PAK1 and PAK2. Probably interacts with TARSH.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF3HO153723EBI-742038,EBI-709735

    Protein-protein interaction databases

    BioGridi119389. 14 interactions.
    IntActiQ9P2A4. 18 interactions.
    MINTiMINT-235637.
    STRINGi9606.ENSP00000225941.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2A4.
    SMRiQ9P2A4. Positions 1-154, 301-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini308 – 36659SH3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili33 – 6129Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi224 – 30683Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABI family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG328966.
    HOGENOMiHOG000293213.
    HOVERGENiHBG050446.
    InParanoidiQ9P2A4.
    OMAiSWVPASY.
    OrthoDBiEOG7673BC.
    PhylomeDBiQ9P2A4.
    TreeFamiTF314303.

    Family and domain databases

    InterProiIPR028457. ABI.
    IPR028455. ABI3.
    IPR012849. Abl-interactor_HHR_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10460. PTHR10460. 1 hit.
    PTHR10460:SF6. PTHR10460:SF6. 1 hit.
    PfamiPF07815. Abi_HHR. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2A4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET    50
    MAFTTQALAS VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH 100
    MEKVARREIG TLATVQRLPP GQKVIAPENL PPLTPYCRRP LNFGCLDDIG 150
    HGIKDLSTQL SRTGTLSRKS IKAPATPASA TLGRPPRIPE PVHLPVVPDG 200
    RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS LDPPPPPAAV 250
    EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD 300
    EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS 350
    SEGTGFFPGN YVEPSC 366
    Length:366
    Mass (Da):39,035
    Last modified:May 18, 2010 - v2
    Checksum:i23EC3838E41D8ECD
    GO
    Isoform 2 (identifier: Q9P2A4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         90-95: Missing.

    Show »
    Length:360
    Mass (Da):38,450
    Checksum:i1DB04BD6FFA0ECF1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441R → Q.1 Publication
    Corresponds to variant rs2233369 [ dbSNP | Ensembl ].
    VAR_022030
    Natural varianti203 – 2031S → F.
    Corresponds to variant rs616338 [ dbSNP | Ensembl ].
    VAR_060243
    Natural varianti209 – 2091F → S.3 Publications
    Corresponds to variant rs616338 [ dbSNP | Ensembl ].
    VAR_060993

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei90 – 956Missing in isoform 2. CuratedVSP_041467

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037886 mRNA. Translation: BAA90667.1.
    AL136709 mRNA. Translation: CAB66644.1.
    AC004797 Genomic DNA. No translation available.
    AC069454 Genomic DNA. No translation available.
    BC007780 mRNA. Translation: AAH07780.1.
    CCDSiCCDS11546.1. [Q9P2A4-1]
    CCDS45725.1. [Q9P2A4-2]
    RefSeqiNP_001128658.1. NM_001135186.1.
    NP_057512.1. NM_016428.2.
    UniGeneiHs.130719.

    Genome annotation databases

    EnsembliENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
    ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
    GeneIDi51225.
    KEGGihsa:51225.
    UCSCiuc002iop.1. human. [Q9P2A4-1]
    uc002ioq.1. human. [Q9P2A4-2]

    Polymorphism databases

    DMDMi296434384.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037886 mRNA. Translation: BAA90667.1 .
    AL136709 mRNA. Translation: CAB66644.1 .
    AC004797 Genomic DNA. No translation available.
    AC069454 Genomic DNA. No translation available.
    BC007780 mRNA. Translation: AAH07780.1 .
    CCDSi CCDS11546.1. [Q9P2A4-1 ]
    CCDS45725.1. [Q9P2A4-2 ]
    RefSeqi NP_001128658.1. NM_001135186.1.
    NP_057512.1. NM_016428.2.
    UniGenei Hs.130719.

    3D structure databases

    ProteinModelPortali Q9P2A4.
    SMRi Q9P2A4. Positions 1-154, 301-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119389. 14 interactions.
    IntActi Q9P2A4. 18 interactions.
    MINTi MINT-235637.
    STRINGi 9606.ENSP00000225941.

    PTM databases

    PhosphoSitei Q9P2A4.

    Polymorphism databases

    DMDMi 296434384.

    Proteomic databases

    MaxQBi Q9P2A4.
    PaxDbi Q9P2A4.
    PRIDEi Q9P2A4.

    Protocols and materials databases

    DNASUi 51225.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225941 ; ENSP00000225941 ; ENSG00000108798 . [Q9P2A4-1 ]
    ENST00000419580 ; ENSP00000406651 ; ENSG00000108798 . [Q9P2A4-2 ]
    GeneIDi 51225.
    KEGGi hsa:51225.
    UCSCi uc002iop.1. human. [Q9P2A4-1 ]
    uc002ioq.1. human. [Q9P2A4-2 ]

    Organism-specific databases

    CTDi 51225.
    GeneCardsi GC17P047287.
    HGNCi HGNC:29859. ABI3.
    HPAi HPA017345.
    MIMi 606363. gene.
    neXtProti NX_Q9P2A4.
    PharmGKBi PA134951642.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328966.
    HOGENOMi HOG000293213.
    HOVERGENi HBG050446.
    InParanoidi Q9P2A4.
    OMAi SWVPASY.
    OrthoDBi EOG7673BC.
    PhylomeDBi Q9P2A4.
    TreeFami TF314303.

    Miscellaneous databases

    GeneWikii ABI3.
    GenomeRNAii 51225.
    NextBioi 54310.
    PROi Q9P2A4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P2A4.
    CleanExi HS_ABI3.
    Genevestigatori Q9P2A4.

    Family and domain databases

    InterProi IPR028457. ABI.
    IPR028455. ABI3.
    IPR012849. Abl-interactor_HHR_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10460. PTHR10460. 1 hit.
    PTHR10460:SF6. PTHR10460:SF6. 1 hit.
    Pfami PF07815. Abi_HHR. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein."
      Miyazaki K., Matsuda S., Ichigotani Y., Takenouchi Y., Hayashi K., Fukuda Y., Nimura Y., Hamaguchi M.
      Biochim. Biophys. Acta 1493:237-241(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT SER-209.
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-44 AND SER-209.
      Tissue: Kidney.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-209.
      Tissue: B-cell.
    5. "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells."
      Ichigotani Y., Yokozaki S., Fukuda Y., Hamaguchi M., Matsuda S.
      Cancer Res. 62:2215-2219(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
    6. "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3."
      Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M.
      J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TARSH.

    Entry informationi

    Entry nameiABI3_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2A4
    Secondary accession number(s): C9IZN8, Q9H0P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3