Reviewed, UniProtKB/Swiss-Prot Q9P2A4 (ABI3_HUMAN)

Names and origin

Protein names

Recommended name:
    ABI gene family member 3
Alternative name(s):
    New molecule including SH3
      Short name=Nesh

Gene names

Name:	ABI3
Synonyms:	NESH

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May inhibit tumor metastasis By similarity. In vitro, reduces cell motility.
Subunit structure	May interact with PAK1 and PAK2. Probably interacts with TARSH. Ref.5
Subcellular location	Cytoplasm. Note: Colocalizes with PAK2 at leading edge of cells. Ref.4
Tissue specificity	Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle. Ref.1
Sequence similarities	Belongs to the ABI family. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Coiled coil SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell motion Ref.4 Non-traceable author statement. Source: UniProtKB regulation of cell migration Ref.4 Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Ref.4 Non-traceable author statement. Source: UniProtKB lamellipodium Inferred from direct assay. Source: MGI
Molecular function	protein binding Ref.5 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF3H	O15372	2	EBI-742038,EBI-709735

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	ABI gene family member 3		PRO_0000191792
Regions
	Domain	308 – 366	59	SH3
	Coiled coil	33 – 61	29	Potential
	Compositional bias	224 – 306	83	Pro-rich
Natural variations
	Natural variant	44	1	R → Q: dbSNP rs2233369. Ref.2		VAR_022030
	Natural variant	203	1	S → F: dbSNP rs616338.		VAR_060243

Sequences

	Sequence		Length	Mass (Da)
	Q9P2A4-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 1437482552CF1947	FASTA	366	38,975
	10 20 30 40 50 60 MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS 70 80 90 100 110 120 VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH MEKVARREIG TLATVQRLPP 130 140 150 160 170 180 GQKVIAPENL PPLTPYCRRP LNFGCLDDIG HGIKDLSTQL SRTGTLSRKS IKAPATPASA 190 200 210 220 230 240 TLGRPPRIPE PVHLPVVPDG RLSAASSASS LASAGSAEGV GGAPTPKGQA APPAPPLPSS 250 260 270 280 290 300 LDPPPPPAAV EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD 310 320 330 340 350 360 EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS SEGTGFFPGN YVEPSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein." Miyazaki K., Matsuda S., Ichigotani Y., Takenouchi Y., Hayashi K., Fukuda Y., Nimura Y., Hamaguchi M. Biochim. Biophys. Acta 1493:237-241(2000) [PubMed: 10978530] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-44. Tissue: Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
[4]	"Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells." Ichigotani Y., Yokozaki S., Fukuda Y., Hamaguchi M., Matsuda S. Cancer Res. 62:2215-2219(2002) [PubMed: 11956071] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
[5]	"Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3." Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M. J. Hum. Genet. 46:483-486(2001) [PubMed: 11501947] [Abstract] Cited for: INTERACTION WITH TARSH.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB037886 mRNA. Translation: BAA90667.1. AL136709 mRNA. Translation: CAB66644.1. BC007780 mRNA. Translation: AAH07780.1.
IPI	IPI00009273.
RefSeq	NP_001128658.1. NP_057512.1.
UniGene	Hs.130719
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2A4. 11 interactions.
STRING	Q9P2A4.
Proteomic databases
PRIDE	Q9P2A4.
Genome annotation databases
Ensembl	ENST00000225941; ENSP00000225941; ENSG00000108798; Homo sapiens. [Genome view]
GeneID	51225.
KEGG	hsa:51225.
UCSC	uc002iop.1. human.
Organism-specific databases
CTD	51225.
GeneCards	GC17P044642.
H-InvDB	HIX0019748.
HGNC	HGNC:29859. ABI3.
MIM	606363. gene.
PharmGKB	PA134951642.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9P2A4.
HOVERGEN	Q9P2A4.
Gene expression databases
ArrayExpress	Q9P2A4.
Bgee	Q9P2A4.
CleanEx	HS_ABI3.
Genevestigator	Q9P2A4.
GermOnline	ENSG00000108798. Homo sapiens.
Family and domain databases
InterPro	IPR012849. Abl-interactor_HHR. IPR001452. SH3_domain. IPR020473. SH3_region. [Graphical view]
Pfam	PF07815. Abi_HHR. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54310.
SOURCE	Search...

Entry information

Entry name

ABI3_HUMAN

Accession

Primary (citable) accession number: Q9P2A4
Secondary accession number(s): Q9H0P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 1, 2000
Last modified:	November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.