Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ABI gene family member 3

Gene

ABI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.By similarity1 Publication

GO - Biological processi

  1. movement of cell or subcellular component Source: UniProtKB
  2. regulation of cell migration Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ABI gene family member 3
Alternative name(s):
New molecule including SH3
Short name:
Nesh
Gene namesi
Name:ABI3
Synonyms:NESH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29859. ABI3.

Subcellular locationi

Cytoplasm 1 Publication
Note: Colocalizes with PAK2 at leading edge of cells.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. intracellular Source: MGI
  3. lamellipodium Source: MGI
  4. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366ABI gene family member 3PRO_0000191792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei213 – 2131Phosphoserine1 Publication
Modified residuei216 – 2161Phosphoserine1 Publication
Modified residuei342 – 3421Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P2A4.
PaxDbiQ9P2A4.
PRIDEiQ9P2A4.

PTM databases

PhosphoSiteiQ9P2A4.

Expressioni

Tissue specificityi

Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9P2A4.
CleanExiHS_ABI3.
GenevestigatoriQ9P2A4.

Organism-specific databases

HPAiHPA017345.

Interactioni

Subunit structurei

May interact with PAK1 and PAK2. Probably interacts with TARSH.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3HO153723EBI-742038,EBI-709735

Protein-protein interaction databases

BioGridi119389. 33 interactions.
IntActiQ9P2A4. 18 interactions.
MINTiMINT-235637.
STRINGi9606.ENSP00000225941.

Structurei

3D structure databases

ProteinModelPortaliQ9P2A4.
SMRiQ9P2A4. Positions 1-154, 301-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 36659SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili33 – 6129Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi224 – 30683Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the ABI family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG328966.
GeneTreeiENSGT00390000003756.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
InParanoidiQ9P2A4.
OMAiSWVPASY.
OrthoDBiEOG7673BC.
PhylomeDBiQ9P2A4.
TreeFamiTF314303.

Family and domain databases

InterProiIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF6. PTHR10460:SF6. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2A4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET
60 70 80 90 100
MAFTTQALAS VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH
110 120 130 140 150
MEKVARREIG TLATVQRLPP GQKVIAPENL PPLTPYCRRP LNFGCLDDIG
160 170 180 190 200
HGIKDLSTQL SRTGTLSRKS IKAPATPASA TLGRPPRIPE PVHLPVVPDG
210 220 230 240 250
RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS LDPPPPPAAV
260 270 280 290 300
EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD
310 320 330 340 350
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS
360
SEGTGFFPGN YVEPSC
Length:366
Mass (Da):39,035
Last modified:May 18, 2010 - v2
Checksum:i23EC3838E41D8ECD
GO
Isoform 2 (identifier: Q9P2A4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-95: Missing.

Show »
Length:360
Mass (Da):38,450
Checksum:i1DB04BD6FFA0ECF1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441R → Q.1 Publication
Corresponds to variant rs2233369 [ dbSNP | Ensembl ].
VAR_022030
Natural varianti203 – 2031S → F.
Corresponds to variant rs616338 [ dbSNP | Ensembl ].
VAR_060243
Natural varianti209 – 2091F → S.4 Publications
Corresponds to variant rs616338 [ dbSNP | Ensembl ].
VAR_060993

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 956Missing in isoform 2. CuratedVSP_041467

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037886 mRNA. Translation: BAA90667.1.
AL136709 mRNA. Translation: CAB66644.1.
AC004797 Genomic DNA. No translation available.
AC069454 Genomic DNA. No translation available.
BC007780 mRNA. Translation: AAH07780.1.
CCDSiCCDS11546.1. [Q9P2A4-1]
CCDS45725.1. [Q9P2A4-2]
RefSeqiNP_001128658.1. NM_001135186.1.
NP_057512.1. NM_016428.2.
UniGeneiHs.130719.

Genome annotation databases

EnsembliENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
GeneIDi51225.
KEGGihsa:51225.
UCSCiuc002iop.1. human. [Q9P2A4-1]
uc002ioq.1. human. [Q9P2A4-2]

Polymorphism databases

DMDMi296434384.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037886 mRNA. Translation: BAA90667.1.
AL136709 mRNA. Translation: CAB66644.1.
AC004797 Genomic DNA. No translation available.
AC069454 Genomic DNA. No translation available.
BC007780 mRNA. Translation: AAH07780.1.
CCDSiCCDS11546.1. [Q9P2A4-1]
CCDS45725.1. [Q9P2A4-2]
RefSeqiNP_001128658.1. NM_001135186.1.
NP_057512.1. NM_016428.2.
UniGeneiHs.130719.

3D structure databases

ProteinModelPortaliQ9P2A4.
SMRiQ9P2A4. Positions 1-154, 301-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119389. 33 interactions.
IntActiQ9P2A4. 18 interactions.
MINTiMINT-235637.
STRINGi9606.ENSP00000225941.

PTM databases

PhosphoSiteiQ9P2A4.

Polymorphism databases

DMDMi296434384.

Proteomic databases

MaxQBiQ9P2A4.
PaxDbiQ9P2A4.
PRIDEiQ9P2A4.

Protocols and materials databases

DNASUi51225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
GeneIDi51225.
KEGGihsa:51225.
UCSCiuc002iop.1. human. [Q9P2A4-1]
uc002ioq.1. human. [Q9P2A4-2]

Organism-specific databases

CTDi51225.
GeneCardsiGC17P047287.
HGNCiHGNC:29859. ABI3.
HPAiHPA017345.
MIMi606363. gene.
neXtProtiNX_Q9P2A4.
PharmGKBiPA134951642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG328966.
GeneTreeiENSGT00390000003756.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
InParanoidiQ9P2A4.
OMAiSWVPASY.
OrthoDBiEOG7673BC.
PhylomeDBiQ9P2A4.
TreeFamiTF314303.

Miscellaneous databases

GeneWikiiABI3.
GenomeRNAii51225.
NextBioi54310.
PROiQ9P2A4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2A4.
CleanExiHS_ABI3.
GenevestigatoriQ9P2A4.

Family and domain databases

InterProiIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF6. PTHR10460:SF6. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein."
    Miyazaki K., Matsuda S., Ichigotani Y., Takenouchi Y., Hayashi K., Fukuda Y., Nimura Y., Hamaguchi M.
    Biochim. Biophys. Acta 1493:237-241(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT SER-209.
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-44 AND SER-209.
    Tissue: Kidney.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-209.
    Tissue: B-cell.
  5. "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells."
    Ichigotani Y., Yokozaki S., Fukuda Y., Hamaguchi M., Matsuda S.
    Cancer Res. 62:2215-2219(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
  6. "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3."
    Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M.
    J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TARSH.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-216 AND SER-342, VARIANT [LARGE SCALE ANALYSIS] SER-209, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiABI3_HUMAN
AccessioniPrimary (citable) accession number: Q9P2A4
Secondary accession number(s): C9IZN8, Q9H0P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: March 4, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.