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Protein

Coatomer subunit zeta-2

Gene

COPZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit zeta-2
Alternative name(s):
Zeta-2-coat protein
Short name:
Zeta-2 COP
Gene namesi
Name:COPZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19356. COPZ2.

Subcellular locationi

GO - Cellular componenti

  • cis-Golgi network Source: UniProtKB
  • COPI vesicle coat Source: UniProtKB
  • cytosol Source: Reactome
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: Reactome
  • Golgi membrane Source: Reactome
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862698.

Polymorphism and mutation databases

BioMutaiCOPZ2.
DMDMi20532038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Coatomer subunit zeta-2PRO_0000193831Add
BLAST

Proteomic databases

EPDiQ9P299.
MaxQBiQ9P299.
PaxDbiQ9P299.
PeptideAtlasiQ9P299.
PRIDEiQ9P299.

PTM databases

iPTMnetiQ9P299.
PhosphoSiteiQ9P299.

Expressioni

Gene expression databases

BgeeiENSG00000005243.
CleanExiHS_COPZ2.
ExpressionAtlasiQ9P299. baseline and differential.
GenevisibleiQ9P299. HS.

Organism-specific databases

HPAiHPA055999.

Interactioni

Subunit structurei

Oligomeric complex.

Protein-protein interaction databases

BioGridi119390. 2 interactions.
STRINGi9606.ENSP00000006101.

Structurei

3D structure databases

ProteinModelPortaliQ9P299.
SMRiQ9P299. Positions 40-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3343. Eukaryota.
COG5541. LUCA.
GeneTreeiENSGT00390000004405.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiQ9P299.
OMAiHVLRRNI.
OrthoDBiEOG091G0TM0.
PhylomeDBiQ9P299.
TreeFamiTF300262.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRPEAWPRP HPGEGAAAAQ AGGPAPPARA GEPSGLRLQE PSLYTIKAVF
60 70 80 90 100
ILDNDGRRLL AKYYDDTFPS MKEQMVFEKN VFNKTSRTES EIAFFGGMTI
110 120 130 140 150
VYKNSIDLFL YVVGSSYENE LMLMSVLTCL FESLNHMLRK NVEKRWLLEN
160 170 180 190 200
MDGAFLVLDE IVDGGVILES DPQQVIQKVN FRADDGGLTE QSVAQVLQSA
210
KEQIKWSLLK
Length:210
Mass (Da):23,548
Last modified:October 1, 2000 - v1
Checksum:i2DD9D47E482C15DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047849 mRNA. Translation: BAB17660.1.
AB037938 mRNA. Translation: BAA90670.1.
BC015924 mRNA. Translation: AAH15924.1.
CCDSiCCDS74092.1.
RefSeqiNP_057513.1. NM_016429.3.
UniGeneiHs.408434.

Genome annotation databases

EnsembliENST00000621465; ENSP00000480707; ENSG00000005243.
GeneIDi51226.
KEGGihsa:51226.
UCSCiuc032flu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047849 mRNA. Translation: BAB17660.1.
AB037938 mRNA. Translation: BAA90670.1.
BC015924 mRNA. Translation: AAH15924.1.
CCDSiCCDS74092.1.
RefSeqiNP_057513.1. NM_016429.3.
UniGeneiHs.408434.

3D structure databases

ProteinModelPortaliQ9P299.
SMRiQ9P299. Positions 40-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119390. 2 interactions.
STRINGi9606.ENSP00000006101.

PTM databases

iPTMnetiQ9P299.
PhosphoSiteiQ9P299.

Polymorphism and mutation databases

BioMutaiCOPZ2.
DMDMi20532038.

Proteomic databases

EPDiQ9P299.
MaxQBiQ9P299.
PaxDbiQ9P299.
PeptideAtlasiQ9P299.
PRIDEiQ9P299.

Protocols and materials databases

DNASUi51226.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621465; ENSP00000480707; ENSG00000005243.
GeneIDi51226.
KEGGihsa:51226.
UCSCiuc032flu.2. human.

Organism-specific databases

CTDi51226.
GeneCardsiCOPZ2.
HGNCiHGNC:19356. COPZ2.
HPAiHPA055999.
MIMi615526. gene.
neXtProtiNX_Q9P299.
PharmGKBiPA134862698.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3343. Eukaryota.
COG5541. LUCA.
GeneTreeiENSGT00390000004405.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiQ9P299.
OMAiHVLRRNI.
OrthoDBiEOG091G0TM0.
PhylomeDBiQ9P299.
TreeFamiTF300262.

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

GenomeRNAii51226.
PROiQ9P299.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000005243.
CleanExiHS_COPZ2.
ExpressionAtlasiQ9P299. baseline and differential.
GenevisibleiQ9P299. HS.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOPZ2_HUMAN
AccessioniPrimary (citable) accession number: Q9P299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.