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Protein

HIG1 domain family member 1B

Gene

HIGD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HIG1 domain family member 1B
Alternative name(s):
Protein CLST 11240
Gene namesi
Name:HIGD1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24318. HIGD1B.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 47HelicalPROSITE-ProRule annotationAdd BLAST18
Topological domaini48 – 61ExtracellularSequence analysisAdd BLAST14
Transmembranei62 – 84HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini85 – 99CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131097.
PharmGKBiPA142671682.

Polymorphism and mutation databases

DMDMi74734852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002157741 – 99HIG1 domain family member 1BAdd BLAST99

Proteomic databases

PaxDbiQ9P298.
PRIDEiQ9P298.

PTM databases

iPTMnetiQ9P298.
PhosphoSitePlusiQ9P298.

Expressioni

Gene expression databases

BgeeiENSG00000131097.
CleanExiHS_HIGD1B.
ExpressionAtlasiQ9P298. baseline and differential.
GenevisibleiQ9P298. HS.

Organism-specific databases

HPAiHPA053212.

Interactioni

Protein-protein interaction databases

BioGridi119712. 1 interactor.
IntActiQ9P298. 1 interactor.
MINTiMINT-1420253.
STRINGi9606.ENSP00000253410.

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 14Combined sources4
Helixi18 – 24Combined sources7
Helixi30 – 49Combined sources20
Helixi66 – 87Combined sources22
Beta strandi89 – 92Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LONNMR-A1-99[»]
ProteinModelPortaliQ9P298.
SMRiQ9P298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94HIG1PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Contains 1 HIG1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4431. Eukaryota.
ENOG41121ET. LUCA.
GeneTreeiENSGT00530000063398.
HOGENOMiHOG000234513.
HOVERGENiHBG054361.
InParanoidiQ9P298.
OMAiWAPPEGE.
OrthoDBiEOG091G166Q.
PhylomeDBiQ9P298.

Family and domain databases

InterProiIPR007667. Hypoxia_induced_domain.
[Graphical view]
PfamiPF04588. HIG_1_N. 1 hit.
[Graphical view]
PROSITEiPS51503. HIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANRRWWVP PDDEDCVSEK LLRKTRESPL VPIGLGGCLV VAAYRIYRLR
60 70 80 90
SRGSTKMSIH LIHTRVAAQA CAVGAIMLGA VYTMYSDYVK RMAQDAGEK
Length:99
Mass (Da):11,058
Last modified:October 1, 2000 - v1
Checksum:i2B5AF9EE5F27FB05
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04935486S → N.1 PublicationCorresponds to variant rs1071682dbSNPEnsembl.1
Natural variantiVAR_04935587D → N.Corresponds to variant rs2231650dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038021 mRNA. Translation: BAA90725.1.
AB038022 mRNA. Translation: BAA90726.1.
CH471178 Genomic DNA. Translation: EAW51575.1.
CH471178 Genomic DNA. Translation: EAW51576.1.
BC020667 mRNA. Translation: AAH20667.1.
CCDSiCCDS11488.1.
RefSeqiNP_001258809.1. NM_001271880.1.
NP_057522.1. NM_016438.3.
XP_006722009.1. XM_006721946.2.
XP_006722010.1. XM_006721947.3.
XP_006722011.1. XM_006721948.3.
XP_011523193.1. XM_011524891.2.
XP_016880231.1. XM_017024742.1.
XP_016880232.1. XM_017024743.1.
UniGeneiHs.151787.
Hs.287963.

Genome annotation databases

EnsembliENST00000253410; ENSP00000253410; ENSG00000131097.
ENST00000591513; ENSP00000468511; ENSG00000131097.
GeneIDi51751.
KEGGihsa:51751.
UCSCiuc002ihm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038021 mRNA. Translation: BAA90725.1.
AB038022 mRNA. Translation: BAA90726.1.
CH471178 Genomic DNA. Translation: EAW51575.1.
CH471178 Genomic DNA. Translation: EAW51576.1.
BC020667 mRNA. Translation: AAH20667.1.
CCDSiCCDS11488.1.
RefSeqiNP_001258809.1. NM_001271880.1.
NP_057522.1. NM_016438.3.
XP_006722009.1. XM_006721946.2.
XP_006722010.1. XM_006721947.3.
XP_006722011.1. XM_006721948.3.
XP_011523193.1. XM_011524891.2.
XP_016880231.1. XM_017024742.1.
XP_016880232.1. XM_017024743.1.
UniGeneiHs.151787.
Hs.287963.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LONNMR-A1-99[»]
ProteinModelPortaliQ9P298.
SMRiQ9P298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119712. 1 interactor.
IntActiQ9P298. 1 interactor.
MINTiMINT-1420253.
STRINGi9606.ENSP00000253410.

PTM databases

iPTMnetiQ9P298.
PhosphoSitePlusiQ9P298.

Polymorphism and mutation databases

DMDMi74734852.

Proteomic databases

PaxDbiQ9P298.
PRIDEiQ9P298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253410; ENSP00000253410; ENSG00000131097.
ENST00000591513; ENSP00000468511; ENSG00000131097.
GeneIDi51751.
KEGGihsa:51751.
UCSCiuc002ihm.4. human.

Organism-specific databases

CTDi51751.
GeneCardsiHIGD1B.
HGNCiHGNC:24318. HIGD1B.
HPAiHPA053212.
neXtProtiNX_Q9P298.
OpenTargetsiENSG00000131097.
PharmGKBiPA142671682.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4431. Eukaryota.
ENOG41121ET. LUCA.
GeneTreeiENSGT00530000063398.
HOGENOMiHOG000234513.
HOVERGENiHBG054361.
InParanoidiQ9P298.
OMAiWAPPEGE.
OrthoDBiEOG091G166Q.
PhylomeDBiQ9P298.

Miscellaneous databases

GenomeRNAii51751.
PROiQ9P298.

Gene expression databases

BgeeiENSG00000131097.
CleanExiHS_HIGD1B.
ExpressionAtlasiQ9P298. baseline and differential.
GenevisibleiQ9P298. HS.

Family and domain databases

InterProiIPR007667. Hypoxia_induced_domain.
[Graphical view]
PfamiPF04588. HIG_1_N. 1 hit.
[Graphical view]
PROSITEiPS51503. HIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIG1B_HUMAN
AccessioniPrimary (citable) accession number: Q9P298
Secondary accession number(s): D3DX57, Q9P297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.