UniProtKB - Q9P298 (HIG1B_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
HIG1 domain family member 1B
Gene
HIGD1B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: HIG1 domain family member 1BAlternative name(s): Protein CLST 11240 |
Gene namesi | Name:HIGD1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000131097.6. |
HGNCi | HGNC:24318. HIGD1B. |
neXtProti | NX_Q9P298. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 47 | HelicalPROSITE-ProRule annotationAdd BLAST | 18 | |
Topological domaini | 48 – 61 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 62 – 84 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Topological domaini | 85 – 99 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000131097. |
PharmGKBi | PA142671682. |
Polymorphism and mutation databases
DMDMi | 74734852. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215774 | 1 – 99 | HIG1 domain family member 1BAdd BLAST | 99 |
Proteomic databases
PaxDbi | Q9P298. |
PeptideAtlasi | Q9P298. |
PRIDEi | Q9P298. |
PTM databases
iPTMneti | Q9P298. |
PhosphoSitePlusi | Q9P298. |
Expressioni
Gene expression databases
Bgeei | ENSG00000131097. |
CleanExi | HS_HIGD1B. |
ExpressionAtlasi | Q9P298. baseline and differential. |
Genevisiblei | Q9P298. HS. |
Interactioni
Protein-protein interaction databases
BioGridi | 119712. 1 interactor. |
IntActi | Q9P298. 1 interactor. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 11 – 14 | Combined sources | 4 | |
Helixi | 18 – 24 | Combined sources | 7 | |
Helixi | 30 – 49 | Combined sources | 20 | |
Helixi | 66 – 87 | Combined sources | 22 | |
Beta strandi | 89 – 92 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LON | NMR | - | A | 1-99 | [»] | |
ProteinModelPortali | Q9P298. | |||||
SMRi | Q9P298. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 94 | HIG1PROSITE-ProRule annotationAdd BLAST | 94 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4431. Eukaryota. ENOG41121ET. LUCA. |
GeneTreei | ENSGT00530000063398. |
HOGENOMi | HOG000234513. |
HOVERGENi | HBG054361. |
InParanoidi | Q9P298. |
OMAi | WAPPEGE. |
OrthoDBi | EOG091G166Q. |
PhylomeDBi | Q9P298. |
Family and domain databases
InterProi | View protein in InterPro IPR007667. Hypoxia_induced_domain. |
Pfami | View protein in Pfam PF04588. HIG_1_N. 1 hit. |
PROSITEi | View protein in PROSITE PS51503. HIG1. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9P298-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSANRRWWVP PDDEDCVSEK LLRKTRESPL VPIGLGGCLV VAAYRIYRLR
60 70 80 90
SRGSTKMSIH LIHTRVAAQA CAVGAIMLGA VYTMYSDYVK RMAQDAGEK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049354 | 86 | S → N1 PublicationCorresponds to variant dbSNP:rs1071682Ensembl. | 1 | |
Natural variantiVAR_049355 | 87 | D → N. Corresponds to variant dbSNP:rs2231650Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB038021 mRNA. Translation: BAA90725.1. AB038022 mRNA. Translation: BAA90726.1. CH471178 Genomic DNA. Translation: EAW51575.1. CH471178 Genomic DNA. Translation: EAW51576.1. BC020667 mRNA. Translation: AAH20667.1. |
CCDSi | CCDS11488.1. |
RefSeqi | NP_001258809.1. NM_001271880.1. NP_057522.1. NM_016438.3. XP_006722009.1. XM_006721946.2. XP_006722010.1. XM_006721947.3. XP_006722011.1. XM_006721948.3. XP_011523193.1. XM_011524891.2. XP_016880231.1. XM_017024742.1. XP_016880232.1. XM_017024743.1. |
UniGenei | Hs.151787. Hs.287963. |
Genome annotation databases
Ensembli | ENST00000253410; ENSP00000253410; ENSG00000131097. ENST00000591513; ENSP00000468511; ENSG00000131097. |
GeneIDi | 51751. |
KEGGi | hsa:51751. |
UCSCi | uc002ihm.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | HIG1B_HUMAN | |
Accessioni | Q9P298Primary (citable) accession number: Q9P298 Secondary accession number(s): D3DX57, Q9P297 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 28, 2018 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |