HIGD1B

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HIG1 domain family member 1B Alternative name(s): Protein CLST 11240
Gene namesⁱ	Name:HIGD1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24318. HIGD1B.

HGNCⁱ

HGNC:24318. HIGD1B.

Subcellular locationⁱ

Membrane
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00836
; Multi-pass membrane protein
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00836

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 29	CytoplasmicSequence analysisAdd BLAST	29
Transmembraneⁱ	30 – 47	HelicalPROSITE-ProRule annotationAdd BLAST	18
Topological domainⁱ	48 – 61	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	62 – 84	HelicalPROSITE-ProRule annotationAdd BLAST	23
Topological domainⁱ	85 – 99	CytoplasmicSequence analysisAdd BLAST	15

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000131097.
PharmGKBⁱ	PA142671682.

Polymorphism and mutation databases

DMDMⁱ	74734852.

DMDMⁱ

74734852.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215774	1 – 99	HIG1 domain family member 1BAdd BLAST		99

Proteomic databases

PaxDbⁱ	Q9P298.
PeptideAtlas More...PeptideAtlasⁱ	Q9P298.
PRIDEⁱ	Q9P298.

PTM databases

iPTMnetⁱ	Q9P298.
PhosphoSitePlusⁱ	Q9P298.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000131097.
CleanExⁱ	HS_HIGD1B.
ExpressionAtlasⁱ	Q9P298. baseline and differential.
Genevisibleⁱ	Q9P298. HS.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119712. 1 interactor.
IntActⁱ	Q9P298. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-1420253.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	11 – 14	Combined sources	4
Helixⁱ	18 – 24	Combined sources	7
Helixⁱ	30 – 49	Combined sources	20
Helixⁱ	66 – 87	Combined sources	22
Beta strandⁱ	89 – 92	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LON	NMR	-	A	1-99	[»]
ProteinModelPortalⁱ	Q9P298.
SMRⁱ	Q9P298.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 94	HIG1PROSITE-ProRule annotationAdd BLAST		94

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4431. Eukaryota. ENOG41121ET. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063398.
HOGENOMⁱ	HOG000234513.
HOVERGENⁱ	HBG054361.
InParanoidⁱ	Q9P298.
OMAⁱ	WAPPEGE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G166Q.
PhylomeDBⁱ	Q9P298.

Family and domain databases

InterProⁱ	View protein in InterPro IPR007667. Hypoxia_induced_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04588. HIG_1_N. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51503. HIG1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9P298-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSANRRWWVP PDDEDCVSEK LLRKTRESPL VPIGLGGCLV VAAYRIYRLR 
        60         70         80         90 
SRGSTKMSIH LIHTRVAAQA CAVGAIMLGA VYTMYSDYVK RMAQDAGEK

Length:99

Mass (Da):11,058

Last modified:October 1, 2000 - v1

Checksum:ⁱ2B5AF9EE5F27FB05

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049354	86	S → N1 PublicationCorresponds to variant dbSNP:rs1071682Ensembl.		1
Natural variantⁱVAR_049355	87	D → N. Corresponds to variant dbSNP:rs2231650Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB038021 mRNA. Translation: BAA90725.1. AB038022 mRNA. Translation: BAA90726.1. CH471178 Genomic DNA. Translation: EAW51575.1. CH471178 Genomic DNA. Translation: EAW51576.1. BC020667 mRNA. Translation: AAH20667.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11488.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001258809.1. NM_001271880.1. NP_057522.1. NM_016438.3. XP_006722009.1. XM_006721946.2. XP_006722010.1. XM_006721947.3. XP_006722011.1. XM_006721948.3. XP_011523193.1. XM_011524891.2. XP_016880231.1. XM_017024742.1. XP_016880232.1. XM_017024743.1.
UniGeneⁱ	Hs.151787. Hs.287963.

Genome annotation databases

Ensemblⁱ	ENST00000253410; ENSP00000253410; ENSG00000131097. ENST00000591513; ENSP00000468511; ENSG00000131097.
GeneIDⁱ	51751.
KEGGⁱ	hsa:51751.
UCSC genome browser More...UCSCⁱ	uc002ihm.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB038021 mRNA. Translation: BAA90725.1. AB038022 mRNA. Translation: BAA90726.1. CH471178 Genomic DNA. Translation: EAW51575.1. CH471178 Genomic DNA. Translation: EAW51576.1. BC020667 mRNA. Translation: AAH20667.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11488.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001258809.1. NM_001271880.1. NP_057522.1. NM_016438.3. XP_006722009.1. XM_006721946.2. XP_006722010.1. XM_006721947.3. XP_006722011.1. XM_006721948.3. XP_011523193.1. XM_011524891.2. XP_016880231.1. XM_017024742.1. XP_016880232.1. XM_017024743.1.
UniGeneⁱ	Hs.151787. Hs.287963.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LON	NMR	-	A	1-99	[»]
ProteinModelPortalⁱ	Q9P298.
SMRⁱ	Q9P298.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119712. 1 interactor.
IntActⁱ	Q9P298. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-1420253.

PTM databases

iPTMnetⁱ	Q9P298.
PhosphoSitePlusⁱ	Q9P298.

Polymorphism and mutation databases

DMDMⁱ	74734852.

DMDMⁱ

74734852.

Proteomic databases

PaxDbⁱ	Q9P298.
PeptideAtlas More...PeptideAtlasⁱ	Q9P298.
PRIDEⁱ	Q9P298.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000253410; ENSP00000253410; ENSG00000131097. ENST00000591513; ENSP00000468511; ENSG00000131097.
GeneIDⁱ	51751.
KEGGⁱ	hsa:51751.
UCSC genome browser More...UCSCⁱ	uc002ihm.4. human.

Organism-specific databases

CTDⁱ	51751.
GeneCardsⁱ	HIGD1B.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24318. HIGD1B.
neXtProtⁱ	NX_Q9P298.
Open Targets More...OpenTargetsⁱ	ENSG00000131097.
PharmGKBⁱ	PA142671682.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4431. Eukaryota. ENOG41121ET. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063398.
HOGENOMⁱ	HOG000234513.
HOVERGENⁱ	HBG054361.
InParanoidⁱ	Q9P298.
OMAⁱ	WAPPEGE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G166Q.
PhylomeDBⁱ	Q9P298.

Miscellaneous databases

GenomeRNAiⁱ	51751.
Protein Ontology More...PROⁱ	PR:Q9P298.

Gene expression databases

Bgeeⁱ	ENSG00000131097.
CleanExⁱ	HS_HIGD1B.
ExpressionAtlasⁱ	Q9P298. baseline and differential.
Genevisibleⁱ	Q9P298. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR007667. Hypoxia_induced_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04588. HIG_1_N. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51503. HIG1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HIG1B_HUMAN
Accessionⁱ	Q9P298Primary (citable) accession number: Q9P298 Secondary accession number(s): D3DX57, Q9P297
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	October 1, 2000
	Last modified:	July 5, 2017
	This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9P298 (HIG1B_HUMAN)

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HIG1 domain family member 1B

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ