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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5AR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.3 Publications

GO - Molecular functioni

GO - Biological processi

  • chemotaxis Source: InterPro
  • inflammatory response Source: GO_Central
  • negative regulation of interleukin-6 secretion Source: UniProtKB
  • negative regulation of neutrophil chemotaxis Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: UniProtKB
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • positive regulation of epithelial cell proliferation Source: InterPro
  • positive regulation of ERK1 and ERK2 cascade Source: InterPro
  • regulation of complement activation Source: Reactome
  • regulation of interleukin-8 secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134830-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-977606. Regulation of Complement cascade.
SIGNORiQ9P296.

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5AR2
Synonyms:C5L2, GPR77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4527. C5AR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 61Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini62 – 72CytoplasmicSequence analysisAdd BLAST11
Transmembranei73 – 95Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini96 – 114ExtracellularSequence analysisAdd BLAST19
Transmembranei115 – 137Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 202ExtracellularSequence analysisAdd BLAST30
Transmembranei203 – 225Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini226 – 237CytoplasmicSequence analysisAdd BLAST12
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 274ExtracellularSequence analysisAdd BLAST14
Transmembranei275 – 294Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini295 – 337CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • apical part of cell Source: UniProtKB
  • basal plasma membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27202.
OpenTargetsiENSG00000134830.
PharmGKBiPA28920.

Chemistry databases

GuidetoPHARMACOLOGYi33.

Polymorphism and mutation databases

DMDMi20137533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692161 – 337C5a anaphylatoxin chemotactic receptor 2Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation
Modified residuei320PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9P296.
PeptideAtlasiQ9P296.
PRIDEiQ9P296.

PTM databases

iPTMnetiQ9P296.
PhosphoSitePlusiQ9P296.

Expressioni

Tissue specificityi

Frontal cortex, hippocampus, hypothalamus, pons and liver.2 Publications

Gene expression databases

BgeeiENSG00000134830.
CleanExiHS_GPR77.
GenevisibleiQ9P296. HS.

Organism-specific databases

HPAiHPA016629.

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.1 Publication

Protein-protein interaction databases

BioGridi118077. 56 interactors.
IntActiQ9P296. 1 interactor.
STRINGi9606.ENSP00000257267.

Structurei

3D structure databases

ProteinModelPortaliQ9P296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiQ9P296.
KOiK04171.
OMAiAACHWAL.
OrthoDBiEOG091G0FUR.
PhylomeDBiQ9P296.
TreeFamiTF330976.

Family and domain databases

InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNDSVSYEY GDYSDLSDRP VDCLDGACLA IDPLRVAPLP LYAAIFLVGV
60 70 80 90 100
PGNAMVAWVA GKVARRRVGA TWLLHLAVAD LLCCLSLPIL AVPIARGGHW
110 120 130 140 150
PYGAVGCRAL PSIILLTMYA SVLLLAALSA DLCFLALGPA WWSTVQRACG
160 170 180 190 200
VQVACGAAWT LALLLTVPSA IYRRLHQEHF PARLQCVVDY GGSSSTENAV
210 220 230 240 250
TAIRFLFGFL GPLVAVASCH SALLCWAARR CRPLGTAIVV GFFVCWAPYH
260 270 280 290 300
LLGLVLTVAA PNSALLARAL RAEPLIVGLA LAHSCLNPML FLYFGRAQLR
310 320 330
RSLPAACHWA LRESQGQDES VDSKKSTSHD LVSEMEV
Length:337
Mass (Da):36,080
Last modified:October 1, 2000 - v1
Checksum:i53AF41B129FE8FE6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068748233P → L.1 PublicationCorresponds to variant rs149572881dbSNPEnsembl.1
Natural variantiVAR_068749323S → I Rare polymorphism found in a family with familial combined hyperlipemia; associated with increased plasma triglyceride, plasma cholesterol, low-density lipoprotein cholesterol, apolipoprotein B and ASP. 2 PublicationsCorresponds to variant rs150599989dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038237 mRNA. Translation: BAA95414.1.
AF317655 Genomic DNA. Translation: AAK12640.1.
AY268430 Genomic DNA. Translation: AAP23197.1.
AK313994 mRNA. Translation: BAG36706.1.
AC008754 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57472.1.
BC067478 mRNA. Translation: AAH67478.1.
CCDSiCCDS12699.1.
RefSeqiNP_001258678.1. NM_001271749.1.
NP_001258679.1. NM_001271750.1.
NP_060955.1. NM_018485.2.
XP_011525038.1. XM_011526736.2.
UniGeneiHs.534412.

Genome annotation databases

EnsembliENST00000595464; ENSP00000472620; ENSG00000134830.
ENST00000600626; ENSP00000471184; ENSG00000134830.
GeneIDi27202.
KEGGihsa:27202.
UCSCiuc002pgk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038237 mRNA. Translation: BAA95414.1.
AF317655 Genomic DNA. Translation: AAK12640.1.
AY268430 Genomic DNA. Translation: AAP23197.1.
AK313994 mRNA. Translation: BAG36706.1.
AC008754 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57472.1.
BC067478 mRNA. Translation: AAH67478.1.
CCDSiCCDS12699.1.
RefSeqiNP_001258678.1. NM_001271749.1.
NP_001258679.1. NM_001271750.1.
NP_060955.1. NM_018485.2.
XP_011525038.1. XM_011526736.2.
UniGeneiHs.534412.

3D structure databases

ProteinModelPortaliQ9P296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118077. 56 interactors.
IntActiQ9P296. 1 interactor.
STRINGi9606.ENSP00000257267.

Chemistry databases

GuidetoPHARMACOLOGYi33.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9P296.
PhosphoSitePlusiQ9P296.

Polymorphism and mutation databases

DMDMi20137533.

Proteomic databases

PaxDbiQ9P296.
PeptideAtlasiQ9P296.
PRIDEiQ9P296.

Protocols and materials databases

DNASUi27202.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595464; ENSP00000472620; ENSG00000134830.
ENST00000600626; ENSP00000471184; ENSG00000134830.
GeneIDi27202.
KEGGihsa:27202.
UCSCiuc002pgk.3. human.

Organism-specific databases

CTDi27202.
DisGeNETi27202.
GeneCardsiC5AR2.
HGNCiHGNC:4527. C5AR2.
HPAiHPA016629.
MIMi609949. gene.
neXtProtiNX_Q9P296.
OpenTargetsiENSG00000134830.
PharmGKBiPA28920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiQ9P296.
KOiK04171.
OMAiAACHWAL.
OrthoDBiEOG091G0FUR.
PhylomeDBiQ9P296.
TreeFamiTF330976.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134830-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-977606. Regulation of Complement cascade.
SIGNORiQ9P296.

Miscellaneous databases

GeneWikiiGPR77.
GenomeRNAii27202.
PROiQ9P296.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134830.
CleanExiHS_GPR77.
GenevisibleiQ9P296. HS.

Family and domain databases

InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC5AR2_HUMAN
AccessioniPrimary (citable) accession number: Q9P296
Secondary accession number(s): B2RA09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.