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Q9P296

- C5AR2_HUMAN

UniProt

Q9P296 - C5AR2_HUMAN

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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5AR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.3 Publications

GO - Molecular functioni

  1. C5a anaphylatoxin receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. inflammatory response Source: InterPro
  3. negative regulation of interleukin-6 secretion Source: UniProtKB
  4. negative regulation of neutrophil chemotaxis Source: UniProtKB
  5. negative regulation of tumor necrosis factor production Source: UniProtKB
  6. positive regulation of epithelial cell proliferation Source: InterPro
  7. positive regulation of ERK1 and ERK2 cascade Source: InterPro
  8. regulation of interleukin-8 secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5AR2
Synonyms:C5L2, GPR77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4527. C5AR2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6123Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 7211CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei73 – 9523Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 11419ExtracellularSequence AnalysisAdd
BLAST
Transmembranei115 – 13723Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 14912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17223Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 20230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 23712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei275 – 29420Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini295 – 33743CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: UniProtKB
  2. basal plasma membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337C5a anaphylatoxin chemotactic receptor 2PRO_0000069216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9P296.

PTM databases

PhosphoSiteiQ9P296.

Expressioni

Tissue specificityi

Frontal cortex, hippocampus, hypothalamus, pons and liver.2 Publications

Gene expression databases

BgeeiQ9P296.
CleanExiHS_GPR77.
GenevestigatoriQ9P296.

Organism-specific databases

HPAiHPA016629.

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.1 Publication

Protein-protein interaction databases

IntActiQ9P296. 1 interaction.
STRINGi9606.ENSP00000257267.

Structurei

3D structure databases

ProteinModelPortaliQ9P296.
SMRiQ9P296. Positions 34-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151055.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
InParanoidiQ9P296.
KOiK04171.
OMAiAACHWAL.
OrthoDBiEOG7G1V6M.
PhylomeDBiQ9P296.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P296-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNDSVSYEY GDYSDLSDRP VDCLDGACLA IDPLRVAPLP LYAAIFLVGV
60 70 80 90 100
PGNAMVAWVA GKVARRRVGA TWLLHLAVAD LLCCLSLPIL AVPIARGGHW
110 120 130 140 150
PYGAVGCRAL PSIILLTMYA SVLLLAALSA DLCFLALGPA WWSTVQRACG
160 170 180 190 200
VQVACGAAWT LALLLTVPSA IYRRLHQEHF PARLQCVVDY GGSSSTENAV
210 220 230 240 250
TAIRFLFGFL GPLVAVASCH SALLCWAARR CRPLGTAIVV GFFVCWAPYH
260 270 280 290 300
LLGLVLTVAA PNSALLARAL RAEPLIVGLA LAHSCLNPML FLYFGRAQLR
310 320 330
RSLPAACHWA LRESQGQDES VDSKKSTSHD LVSEMEV
Length:337
Mass (Da):36,080
Last modified:October 1, 2000 - v1
Checksum:i53AF41B129FE8FE6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti233 – 2331P → L.1 Publication
Corresponds to variant rs149572881 [ dbSNP | Ensembl ].
VAR_068748
Natural varianti323 – 3231S → I Rare polymorphism found in a family with familial combined hyperlipemia; associated with increased plasma triglyceride, plasma cholesterol, low-density lipoprotein cholesterol, apolipoprotein B and ASP. 1 Publication
Corresponds to variant rs150599989 [ dbSNP | Ensembl ].
VAR_068749

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038237 mRNA. Translation: BAA95414.1.
AF317655 Genomic DNA. Translation: AAK12640.1.
AY268430 Genomic DNA. Translation: AAP23197.1.
AK313994 mRNA. Translation: BAG36706.1.
AC008754 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57472.1.
BC067478 mRNA. Translation: AAH67478.1.
CCDSiCCDS12699.1.
RefSeqiNP_001258678.1. NM_001271749.1.
NP_001258679.1. NM_001271750.1.
NP_060955.1. NM_018485.2.
UniGeneiHs.534412.

Genome annotation databases

EnsembliENST00000595464; ENSP00000472620; ENSG00000134830.
ENST00000600626; ENSP00000471184; ENSG00000134830.
GeneIDi27202.
KEGGihsa:27202.
UCSCiuc002pgk.2. human.

Polymorphism databases

DMDMi20137533.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038237 mRNA. Translation: BAA95414.1 .
AF317655 Genomic DNA. Translation: AAK12640.1 .
AY268430 Genomic DNA. Translation: AAP23197.1 .
AK313994 mRNA. Translation: BAG36706.1 .
AC008754 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57472.1 .
BC067478 mRNA. Translation: AAH67478.1 .
CCDSi CCDS12699.1.
RefSeqi NP_001258678.1. NM_001271749.1.
NP_001258679.1. NM_001271750.1.
NP_060955.1. NM_018485.2.
UniGenei Hs.534412.

3D structure databases

ProteinModelPortali Q9P296.
SMRi Q9P296. Positions 34-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9P296. 1 interaction.
STRINGi 9606.ENSP00000257267.

Chemistry

GuidetoPHARMACOLOGYi 33.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9P296.

Polymorphism databases

DMDMi 20137533.

Proteomic databases

PRIDEi Q9P296.

Protocols and materials databases

DNASUi 27202.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000595464 ; ENSP00000472620 ; ENSG00000134830 .
ENST00000600626 ; ENSP00000471184 ; ENSG00000134830 .
GeneIDi 27202.
KEGGi hsa:27202.
UCSCi uc002pgk.2. human.

Organism-specific databases

CTDi 27202.
GeneCardsi GC19P047841.
HGNCi HGNC:4527. C5AR2.
HPAi HPA016629.
MIMi 609949. gene.
neXtProti NX_Q9P296.
PharmGKBi PA28920.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG151055.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000234122.
HOVERGENi HBG107547.
InParanoidi Q9P296.
KOi K04171.
OMAi AACHWAL.
OrthoDBi EOG7G1V6M.
PhylomeDBi Q9P296.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.

Miscellaneous databases

GeneWikii GPR77.
GenomeRNAii 27202.
NextBioi 50076.
PROi Q9P296.
SOURCEi Search...

Gene expression databases

Bgeei Q9P296.
CleanExi HS_GPR77.
Genevestigatori Q9P296.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001274. Anaphtx_C5AR1/C5AR2.
IPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells."
    Ohno M., Hirata T., Enomoto M., Araki T., Ishimaru H., Takahashi T.A.
    Mol. Immunol. 37:407-412(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Identification of four novel human G protein-coupled receptors expressed in the brain."
    Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R., O'Dowd B.F.
    Brain Res. Mol. Brain Res. 86:13-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74)."
    Cain S.A., Monk P.N.
    J. Biol. Chem. 277:7165-7169(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Tissue: Brain.
  9. "The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein."
    Kalant D., Cain S.A., Maslowska M., Sniderman A.D., Cianflone K., Monk P.N.
    J. Biol. Chem. 278:11123-11129(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH C3 ADIOPOGENIC PEPTIDE ASP.
  10. "C5L2 is a functional receptor for acylation-stimulating protein."
    Kalant D., MacLaren R., Cui W., Samanta R., Monk P.N., Laporte S.A., Cianflone K.
    J. Biol. Chem. 280:23936-23944(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RECEPTOR FOR THE C3 ADIOPOGENIC PEPTIDE ASP.
  11. "C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation."
    Cui W., Simaan M., Laporte S., Lodge R., Cianflone K.
    Mol. Immunol. 46:3086-3098(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, CHARACTERIZATION OF VARIANT ILE-323.
  12. "Identification of a novel C5L2 variant (S323I) in a French Canadian family with familial combined hyperlipemia."
    Marcil M., Vu H., Cui W., Dastani Z., Engert J.C., Gaudet D., Castro-Cabezas M., Sniderman A.D., Genest J. Jr., Cianflone K.
    Arterioscler. Thromb. Vasc. Biol. 26:1619-1625(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ILE-323.
  13. "Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease."
    Zheng Y.Y., Xie X., Ma Y.T., Yang Y.N., Fu Z.Y., Li X.M., Ma X., Chen B.D., Liu F.
    PLoS ONE 6:E20984-E20984(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-233.

Entry informationi

Entry nameiC5AR2_HUMAN
AccessioniPrimary (citable) accession number: Q9P296
Secondary accession number(s): B2RA09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3