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Q9P291

- ARMX1_HUMAN

UniProt

Q9P291 - ARMX1_HUMAN

Protein

Armadillo repeat-containing X-linked protein 1

Gene

ARMCX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo repeat-containing X-linked protein 1
    Alternative name(s):
    ARM protein lost in epithelial cancers on chromosome X 1
    Short name:
    Protein ALEX1
    Gene namesi
    Name:ARMCX1
    Synonyms:ALEX1
    ORF Names:AD032
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:18073. ARMCX1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394658.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Armadillo repeat-containing X-linked protein 1PRO_0000191360Add
    BLAST

    Proteomic databases

    MaxQBiQ9P291.
    PaxDbiQ9P291.
    PRIDEiQ9P291.

    PTM databases

    PhosphoSiteiQ9P291.

    Expressioni

    Tissue specificityi

    Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carcinomas.1 Publication

    Gene expression databases

    ArrayExpressiQ9P291.
    BgeeiQ9P291.
    CleanExiHS_ARMCX1.
    GenevestigatoriQ9P291.

    Organism-specific databases

    HPAiCAB020695.
    HPA005685.

    Interactioni

    Protein-protein interaction databases

    BioGridi119460. 1 interaction.
    IntActiQ9P291. 1 interaction.
    MINTiMINT-4657543.
    STRINGi9606.ENSP00000361917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P291.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati195 – 23541ARM 1Add
    BLAST
    Repeati237 – 27640ARM 2Add
    BLAST
    Repeati358 – 39841ARM 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45061.
    HOGENOMiHOG000231611.
    HOVERGENiHBG080349.
    InParanoidiQ9P291.
    OMAiKALANHN.
    OrthoDBiEOG70PBZ0.
    PhylomeDBiQ9P291.
    TreeFamiTF335652.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view]
    PfamiPF04826. Arm_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P291-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI    50
    GVETVKGAKT NAGAGSGAKL QGDSEVKPEV SLGLEDCPGV KEKAHSGSHS 100
    GGGLEAKAKA LFNTLKEQAS AKAGKGARVG TISGNRTLAP SLPCPGGRGG 150
    GCHPTRSGSR AGGRASGKSK GKARSKSTRA PATTWPVRRG KFNFPYKIDD 200
    ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ NAIRELGGVP 250
    IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL 300
    DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL 350
    IINFTENPAM TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI 400
    KNEGLASSRK EFSRSSLFFL FKESGVCVKK IKALANHNDL VVKVKVLKVL 450
    TKL 453
    Length:453
    Mass (Da):49,180
    Last modified:October 1, 2000 - v1
    Checksum:i01BED98EC3F64672
    GO

    Sequence cautioni

    The sequence AAG44561.1 differs from that shown. Reason: Frameshift at positions 357 and 370.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211C → R in BAD96298. 1 PublicationCurated
    Sequence conflicti357 – 3571N → Y in BAD96298. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039670 mRNA. Translation: BAA94603.1.
    AF248963 mRNA. Translation: AAG44561.1. Frameshift.
    AK074785 mRNA. Translation: BAC11208.1.
    AK222578 mRNA. Translation: BAD96298.1.
    Z73913 Genomic DNA. Translation: CAI41999.1.
    BC002691 mRNA. Translation: AAH02691.1.
    CCDSiCCDS14487.1.
    PIRiJC7582.
    RefSeqiNP_057692.1. NM_016608.1.
    UniGeneiHs.9728.

    Genome annotation databases

    EnsembliENST00000372829; ENSP00000361917; ENSG00000126947.
    GeneIDi51309.
    KEGGihsa:51309.
    UCSCiuc004ehv.3. human.

    Polymorphism databases

    DMDMi74761871.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039670 mRNA. Translation: BAA94603.1 .
    AF248963 mRNA. Translation: AAG44561.1 . Frameshift.
    AK074785 mRNA. Translation: BAC11208.1 .
    AK222578 mRNA. Translation: BAD96298.1 .
    Z73913 Genomic DNA. Translation: CAI41999.1 .
    BC002691 mRNA. Translation: AAH02691.1 .
    CCDSi CCDS14487.1.
    PIRi JC7582.
    RefSeqi NP_057692.1. NM_016608.1.
    UniGenei Hs.9728.

    3D structure databases

    ProteinModelPortali Q9P291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119460. 1 interaction.
    IntActi Q9P291. 1 interaction.
    MINTi MINT-4657543.
    STRINGi 9606.ENSP00000361917.

    PTM databases

    PhosphoSitei Q9P291.

    Polymorphism databases

    DMDMi 74761871.

    Proteomic databases

    MaxQBi Q9P291.
    PaxDbi Q9P291.
    PRIDEi Q9P291.

    Protocols and materials databases

    DNASUi 51309.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372829 ; ENSP00000361917 ; ENSG00000126947 .
    GeneIDi 51309.
    KEGGi hsa:51309.
    UCSCi uc004ehv.3. human.

    Organism-specific databases

    CTDi 51309.
    GeneCardsi GC0XP100805.
    HGNCi HGNC:18073. ARMCX1.
    HPAi CAB020695.
    HPA005685.
    MIMi 300362. gene.
    neXtProti NX_Q9P291.
    PharmGKBi PA128394658.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45061.
    HOGENOMi HOG000231611.
    HOVERGENi HBG080349.
    InParanoidi Q9P291.
    OMAi KALANHN.
    OrthoDBi EOG70PBZ0.
    PhylomeDBi Q9P291.
    TreeFami TF335652.

    Miscellaneous databases

    GeneWikii ARMCX1.
    GenomeRNAii 51309.
    NextBioi 54637.
    PROi Q9P291.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P291.
    Bgeei Q9P291.
    CleanExi HS_ARMCX1.
    Genevestigatori Q9P291.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view ]
    Pfami PF04826. Arm_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
      Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
      Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Yang Y., Xu X., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Coronary artery.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiARMX1_HUMAN
    AccessioniPrimary (citable) accession number: Q9P291
    Secondary accession number(s): Q53HK2, Q9H2Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3