Reviewed,
UniProtKB/Swiss-Prot Q9P291 (ARMX1_HUMAN)
Last modified
November 3, 2009.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Armadillo repeat-containing X-linked protein 1 Short name=Protein ALEX1 Alternative name(s): ARM protein lost in epithelial cancers on chromosome X 1 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 453 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Tissue specificity | Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carcinomas. Ref.1 |
| Sequence similarities | Contains 3 ARM repeats. |
| Sequence caution | The sequence AAG44561.1 differs from that shown. Reason: Frameshift at positions 357 and 370. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Repeat Transmembrane |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 453 | 453 | Armadillo repeat-containing X-linked protein 1 | PRO_0000191360 | |||||
Regions | |||||||||
| Transmembrane | 7 – 29 | 23 | Potential | ||||||
| Repeat | 195 – 235 | 41 | ARM 1 | ||||||
| Repeat | 237 – 276 | 40 | ARM 2 | ||||||
| Repeat | 358 – 398 | 41 | ARM 3 | ||||||
Experimental info | |||||||||
| Sequence conflict | 21 | 1 | C → R in BAD96298. Ref.4 | ||||||
| Sequence conflict | 357 | 1 | N → Y in BAD96298. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas." Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H. Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed: 11162520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | Yang Y., Xu X., Gao G., Xiao H., Chen Z., Han Z. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Coronary artery. |
| [5] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
Cross-references
Sequence databases | |
|---|---|
| AB039670 mRNA. Translation: BAA94603.1. AF248963 mRNA. Translation: AAG44561.1. Frameshift. AK074785 mRNA. Translation: BAC11208.1. AK222578 mRNA. Translation: BAD96298.1. Z73913 Genomic DNA. Translation: CAI41999.1. BC002691 mRNA. Translation: AAH02691.1. | |
| IPI | IPI00009908. |
| PIR | JC7582. |
| RefSeq | NP_057692.1. |
| UniGene | Hs.9728 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9P291. |
Genome annotation databases | |
| Ensembl | ENST00000372829; ENSP00000361917; ENSG00000126947; Homo sapiens. [Genome view] |
| GeneID | 51309. |
| KEGG | hsa:51309. |
| UCSC | uc004ehv.1. human. |
Organism-specific databases | |
| CTD | 51309. |
| GeneCards | GC0XP100692. |
| HGNC | HGNC:18073. ARMCX1. |
| MIM | 300362. gene. |
| PharmGKB | PA128394658. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9P291. |
| HOVERGEN | Q9P291. |
| OMA | FTKIQIM. |
Gene expression databases | |
| ArrayExpress | Q9P291. |
| Bgee | Q9P291. |
| CleanEx | HS_ARMCX1. |
| Genevestigator | Q9P291. |
| GermOnline | ENSG00000126947. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011989. ARM-like. IPR000225. Armadillo. IPR006911. DUF634. [Graphical view] |
| Gene3D | G3DSA:1.25.10.10. ARM-like. 1 hit. |
| Pfam | PF04826. DUF634. 1 hit. [Graphical view] |
| PROSITE | PS50176. ARM_REPEAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 54637. |
| SOURCE | Search... |
Entry information
| Entry name | ARMX1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9P291 Secondary accession number(s): Q53HK2, Q9H2Q0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


