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Protein

Armadillo repeat-containing X-linked protein 1

Gene

ARMCX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 1
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 1
Short name:
Protein ALEX1
Gene namesi
Name:ARMCX1
Synonyms:ALEX1
ORF Names:AD032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18073. ARMCX1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Armadillo repeat-containing X-linked protein 1PRO_0000191360Add
BLAST

Proteomic databases

MaxQBiQ9P291.
PaxDbiQ9P291.
PRIDEiQ9P291.

PTM databases

PhosphoSiteiQ9P291.

Expressioni

Tissue specificityi

Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carcinomas.1 Publication

Gene expression databases

BgeeiQ9P291.
CleanExiHS_ARMCX1.
ExpressionAtlasiQ9P291. baseline and differential.
GenevestigatoriQ9P291.

Organism-specific databases

HPAiCAB020695.
HPA005685.

Interactioni

Protein-protein interaction databases

BioGridi119460. 4 interactions.
IntActiQ9P291. 1 interaction.
MINTiMINT-4657543.
STRINGi9606.ENSP00000361917.

Structurei

3D structure databases

ProteinModelPortaliQ9P291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati195 – 23541ARM 1Add
BLAST
Repeati237 – 27640ARM 2Add
BLAST
Repeati358 – 39841ARM 3Add
BLAST

Sequence similaritiesi

Contains 3 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45061.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9P291.
OMAiKALANHN.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ9P291.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI
60 70 80 90 100
GVETVKGAKT NAGAGSGAKL QGDSEVKPEV SLGLEDCPGV KEKAHSGSHS
110 120 130 140 150
GGGLEAKAKA LFNTLKEQAS AKAGKGARVG TISGNRTLAP SLPCPGGRGG
160 170 180 190 200
GCHPTRSGSR AGGRASGKSK GKARSKSTRA PATTWPVRRG KFNFPYKIDD
210 220 230 240 250
ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ NAIRELGGVP
260 270 280 290 300
IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL
310 320 330 340 350
DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL
360 370 380 390 400
IINFTENPAM TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI
410 420 430 440 450
KNEGLASSRK EFSRSSLFFL FKESGVCVKK IKALANHNDL VVKVKVLKVL

TKL
Length:453
Mass (Da):49,180
Last modified:October 1, 2000 - v1
Checksum:i01BED98EC3F64672
GO

Sequence cautioni

The sequence AAG44561.1 differs from that shown. Reason: Frameshift at positions 357 and 370. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211C → R in BAD96298 (Ref. 4) Curated
Sequence conflicti357 – 3571N → Y in BAD96298 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039670 mRNA. Translation: BAA94603.1.
AF248963 mRNA. Translation: AAG44561.1. Frameshift.
AK074785 mRNA. Translation: BAC11208.1.
AK222578 mRNA. Translation: BAD96298.1.
Z73913 Genomic DNA. Translation: CAI41999.1.
BC002691 mRNA. Translation: AAH02691.1.
CCDSiCCDS14487.1.
PIRiJC7582.
RefSeqiNP_057692.1. NM_016608.1.
UniGeneiHs.9728.

Genome annotation databases

EnsembliENST00000372829; ENSP00000361917; ENSG00000126947.
GeneIDi51309.
KEGGihsa:51309.
UCSCiuc004ehv.3. human.

Polymorphism databases

DMDMi74761871.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039670 mRNA. Translation: BAA94603.1.
AF248963 mRNA. Translation: AAG44561.1. Frameshift.
AK074785 mRNA. Translation: BAC11208.1.
AK222578 mRNA. Translation: BAD96298.1.
Z73913 Genomic DNA. Translation: CAI41999.1.
BC002691 mRNA. Translation: AAH02691.1.
CCDSiCCDS14487.1.
PIRiJC7582.
RefSeqiNP_057692.1. NM_016608.1.
UniGeneiHs.9728.

3D structure databases

ProteinModelPortaliQ9P291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119460. 4 interactions.
IntActiQ9P291. 1 interaction.
MINTiMINT-4657543.
STRINGi9606.ENSP00000361917.

PTM databases

PhosphoSiteiQ9P291.

Polymorphism databases

DMDMi74761871.

Proteomic databases

MaxQBiQ9P291.
PaxDbiQ9P291.
PRIDEiQ9P291.

Protocols and materials databases

DNASUi51309.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372829; ENSP00000361917; ENSG00000126947.
GeneIDi51309.
KEGGihsa:51309.
UCSCiuc004ehv.3. human.

Organism-specific databases

CTDi51309.
GeneCardsiGC0XP100805.
HGNCiHGNC:18073. ARMCX1.
HPAiCAB020695.
HPA005685.
MIMi300362. gene.
neXtProtiNX_Q9P291.
PharmGKBiPA128394658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45061.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9P291.
OMAiKALANHN.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ9P291.
TreeFamiTF335652.

Miscellaneous databases

GeneWikiiARMCX1.
GenomeRNAii51309.
NextBioi54637.
PROiQ9P291.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P291.
CleanExiHS_ARMCX1.
ExpressionAtlasiQ9P291. baseline and differential.
GenevestigatoriQ9P291.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
    Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
    Biochem. Biophys. Res. Commun. 280:340-347(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Yang Y., Xu X., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Coronary artery.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiARMX1_HUMAN
AccessioniPrimary (citable) accession number: Q9P291
Secondary accession number(s): Q53HK2, Q9H2Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.