Q9P291 (ARMX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Armadillo repeat-containing X-linked protein 1

Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 1
Short name=Protein ALEX1

Gene names

Name:	ARMCX1
Synonyms:	ALEX1
ORF Names:	AD032

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carcinomas. Ref.1
Sequence similarities	Contains 3 ARM repeats.
Sequence caution	The sequence AAG44561.1 differs from that shown. Reason: Frameshift at positions 357 and 370.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Armadillo repeat-containing X-linked protein 1		PRO_0000191360
Regions
	Transmembrane	7 – 29	23	Helical; Potential
	Repeat	195 – 235	41	ARM 1
	Repeat	237 – 276	40	ARM 2
	Repeat	358 – 398	41	ARM 3
Experimental info
	Sequence conflict	21	1	C → R in BAD96298. Ref.4
	Sequence conflict	357	1	N → Y in BAD96298. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9P291 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 01BED98EC3F64672	FASTA	453	49,180
	10 20 30 40 50 60 MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI GVETVKGAKT 70 80 90 100 110 120 NAGAGSGAKL QGDSEVKPEV SLGLEDCPGV KEKAHSGSHS GGGLEAKAKA LFNTLKEQAS 130 140 150 160 170 180 AKAGKGARVG TISGNRTLAP SLPCPGGRGG GCHPTRSGSR AGGRASGKSK GKARSKSTRA 190 200 210 220 230 240 PATTWPVRRG KFNFPYKIDD ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ 250 260 270 280 290 300 NAIRELGGVP IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL 310 320 330 340 350 360 DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL IINFTENPAM 370 380 390 400 410 420 TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI KNEGLASSRK EFSRSSLFFL 430 440 450 FKESGVCVKK IKALANHNDL VVKVKVLKVL TKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas." Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H. Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	Yang Y., Xu X., Gao G., Xiao H., Chen Z., Han Z. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Coronary artery.
[5]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB039670 mRNA. Translation: BAA94603.1. AF248963 mRNA. Translation: AAG44561.1. Frameshift. AK074785 mRNA. Translation: BAC11208.1. AK222578 mRNA. Translation: BAD96298.1. Z73913 Genomic DNA. Translation: CAI41999.1. BC002691 mRNA. Translation: AAH02691.1.
IPI	IPI00009908.
PIR	JC7582.
RefSeq	NP_057692.1. NM_016608.1.
UniGene	Hs.9728.
3D structure databases
ProteinModelPortal	Q9P291.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P291. 1 interaction.
STRING	9606.ENSP00000361917.
PTM databases
PhosphoSite	Q9P291.
Polymorphism databases
DMDM	74761871.
Proteomic databases
PaxDb	Q9P291.
PRIDE	Q9P291.
Protocols and materials databases
DNASU	51309.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372829; ENSP00000361917; ENSG00000126947. ENST00000601441; ENSP00000469745; ENSG00000269801.
GeneID	51309.
KEGG	hsa:51309.
UCSC	uc004ehv.3. human.
Organism-specific databases
CTD	51309.
GeneCards	GC0XP100805.
HGNC	HGNC:18073. ARMCX1.
HPA	CAB020695. HPA005685.
MIM	300362. gene.
neXtProt	NX_Q9P291.
PharmGKB	PA128394658.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45061.
HOGENOM	HOG000231611.
HOVERGEN	HBG080349.
InParanoid	Q9P291.
OMA	ALANHND.
OrthoDB	EOG4BRWKX.
PhylomeDB	Q9P291.
Gene expression databases
ArrayExpress	Q9P291.
Bgee	Q9P291.
CleanEx	HS_ARMCX1.
Genevestigator	Q9P291.
GermOnline	ENSG00000126947. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR006911. ARM-rpt_dom. IPR016024. ARM-type_fold. IPR000225. Armadillo. [Graphical view]
Pfam	PF04826. Arm_2. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51309.
NextBio	54637.
SOURCE	Search...

Entry information

Entry name

ARMX1_HUMAN

Accession

Primary (citable) accession number: Q9P291
Secondary accession number(s): Q53HK2, Q9H2Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.