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Protein

Armadillo repeat-containing X-linked protein 1

Gene

ARMCX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 1
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 1
Short name:
Protein ALEX1
Gene namesi
Name:ARMCX1
Synonyms:ALEX1
ORF Names:AD032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000126947.11.
HGNCiHGNC:18073. ARMCX1.
MIMi300362. gene.
neXtProtiNX_Q9P291.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneBy similarity6
Transmembranei7 – 29Helical; Signal-anchorSequence analysisAdd BLAST23
Topological domaini30 – 453CytoplasmicBy similarityAdd BLAST424

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51309.
OpenTargetsiENSG00000126947.
PharmGKBiPA128394658.

Polymorphism and mutation databases

BioMutaiARMCX1.
DMDMi74761871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913601 – 453Armadillo repeat-containing X-linked protein 1Add BLAST453

Proteomic databases

EPDiQ9P291.
MaxQBiQ9P291.
PaxDbiQ9P291.
PeptideAtlasiQ9P291.
PRIDEiQ9P291.

PTM databases

iPTMnetiQ9P291.
PhosphoSitePlusiQ9P291.

Expressioni

Tissue specificityi

Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carcinomas.1 Publication

Gene expression databases

BgeeiENSG00000126947.
CleanExiHS_ARMCX1.
ExpressionAtlasiQ9P291. baseline and differential.
GenevisibleiQ9P291. HS.

Organism-specific databases

HPAiCAB020695.
HPA005685.

Interactioni

Subunit structurei

Interacts with MIRO1.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119460. 4 interactors.
IntActiQ9P291. 7 interactors.
MINTiMINT-4657543.
STRINGi9606.ENSP00000361917.

Structurei

3D structure databases

ProteinModelPortaliQ9P291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati195 – 235ARM 1Sequence analysisAdd BLAST41
Repeati237 – 276ARM 2Sequence analysisAdd BLAST40
Repeati358 – 398ARM 3Sequence analysisAdd BLAST41
Repeati415 – 453ARM 4Sequence analysisAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 6Mitochondrion outer membrane (MOM)-targeting sequenceCurated6
Regioni26 – 36Mitochondrion outer membrane (MOM)-targeting sequenceCuratedAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU7C. Eukaryota.
ENOG41116BC. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9P291.
OMAiCVYRLTW.
OrthoDBiEOG091G0PCU.
PhylomeDBiQ9P291.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.
SMARTiView protein in SMART
SM00185. ARM. 2 hits.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI
60 70 80 90 100
GVETVKGAKT NAGAGSGAKL QGDSEVKPEV SLGLEDCPGV KEKAHSGSHS
110 120 130 140 150
GGGLEAKAKA LFNTLKEQAS AKAGKGARVG TISGNRTLAP SLPCPGGRGG
160 170 180 190 200
GCHPTRSGSR AGGRASGKSK GKARSKSTRA PATTWPVRRG KFNFPYKIDD
210 220 230 240 250
ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ NAIRELGGVP
260 270 280 290 300
IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL
310 320 330 340 350
DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL
360 370 380 390 400
IINFTENPAM TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI
410 420 430 440 450
KNEGLASSRK EFSRSSLFFL FKESGVCVKK IKALANHNDL VVKVKVLKVL

TKL
Length:453
Mass (Da):49,180
Last modified:October 1, 2000 - v1
Checksum:i01BED98EC3F64672
GO

Sequence cautioni

The sequence AAG44561 differs from that shown. Reason: Frameshift at positions 357 and 370.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21C → R in BAD96298 (Ref. 4) Curated1
Sequence conflicti357N → Y in BAD96298 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039670 mRNA. Translation: BAA94603.1.
AF248963 mRNA. Translation: AAG44561.1. Frameshift.
AK074785 mRNA. Translation: BAC11208.1.
AK222578 mRNA. Translation: BAD96298.1.
Z73913 Genomic DNA. Translation: CAI41999.1.
BC002691 mRNA. Translation: AAH02691.1.
CCDSiCCDS14487.1.
PIRiJC7582.
RefSeqiNP_057692.1. NM_016608.1.
UniGeneiHs.9728.

Genome annotation databases

EnsembliENST00000372829; ENSP00000361917; ENSG00000126947.
GeneIDi51309.
KEGGihsa:51309.
UCSCiuc004ehv.4. human.

Similar proteinsi

Entry informationi

Entry nameiARMX1_HUMAN
AccessioniPrimary (citable) accession number: Q9P291
Secondary accession number(s): Q53HK2, Q9H2Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families