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Protein

Solute carrier family 22 member 17

Gene

Slc22a17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiR-RNO-917937. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Brain-type organic cation transporter
Lipocalin-2 receptor
Gene namesi
Name:Slc22a17
Synonyms:Boct, Boit
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi631405. Slc22a17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32220HelicalSequence analysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Transmembranei397 – 41721HelicalSequence analysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence analysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Solute carrier family 22 member 17PRO_0000220508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9P290.
PRIDEiQ9P290.

PTM databases

PhosphoSiteiQ9P290.

Expressioni

Tissue specificityi

Expressed in brain.

Gene expression databases

GenevisibleiQ9P290. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021851.

Structurei

3D structure databases

ProteinModelPortaliQ9P290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000015298.
HOVERGENiHBG031124.
InParanoidiQ9P290.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG7PP56J.
PhylomeDBiQ9P290.
TreeFamiTF335753.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASDPIFTLA PPLHCHYGAL PPNASGWEQP PNSSGVSVAG AALAASAASR
60 70 80 90 100
VVTSTDPSCS GFAPPDFNHC LKDWDYNGLP VLTTNAIGQW DLVCDLGWQV
110 120 130 140 150
ILEQILFILG FASGYLFLGY PADRFGRRGI VLLTLGLVGP CGVGGAAAGS
160 170 180 190 200
STGIMTLRFL LGFLLAGVDL GVYLMRLELC DPTQRLRVAL AGELVGVGGH
210 220 230 240 250
FLFLGLALVS KDWRFLQRMI TAPCILFLFY GWPGLFLESA RWLIVKRQIE
260 270 280 290 300
EAQSVLRILA ERNRPHGQML GEEAQEALQE LENTCPLPTT STFSFASLLN
310 320 330 340 350
YRNIWKNLLI LGFTNFIAHA IRHCYQPVGG GGSPSDFYLC SLLASGTAAL
360 370 380 390 400
ACVFLGVTVD RFGRRGILLL SMTLTGIASL VLLGLWDYLN DAAITTFSVL
410 420 430 440 450
GLFSSQASAI LSTLLAAEVI PTTVRGRGLG LIMALGALGG LSCPAQRLHM
460 470 480 490 500
GHGAFLQHVV LAACALLCIL SIMLLPETKR KLLPEVLRDG ELCRRPSLLR
510 520
QPPPNRCDHV PLLATPNPAL
Length:520
Mass (Da):55,801
Last modified:October 5, 2010 - v2
Checksum:i793C45649EFA3312
GO

Sequence cautioni

The sequence BAA94604.1 differs from that shown. Reason: Frameshift at position 515. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040056 mRNA. Translation: BAA94604.1. Frameshift.
BC099072 mRNA. Translation: AAH99072.1.
CH474049 Genomic DNA. Translation: EDM14202.1.
RefSeqiNP_803156.2. NM_177421.3.
XP_006252027.1. XM_006251965.1.
UniGeneiRn.7312.

Genome annotation databases

EnsembliENSRNOT00000021851; ENSRNOP00000021851; ENSRNOG00000016414.
GeneIDi305886.
KEGGirno:305886.
UCSCiRGD:631405. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040056 mRNA. Translation: BAA94604.1. Frameshift.
BC099072 mRNA. Translation: AAH99072.1.
CH474049 Genomic DNA. Translation: EDM14202.1.
RefSeqiNP_803156.2. NM_177421.3.
XP_006252027.1. XM_006251965.1.
UniGeneiRn.7312.

3D structure databases

ProteinModelPortaliQ9P290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021851.

PTM databases

PhosphoSiteiQ9P290.

Proteomic databases

PaxDbiQ9P290.
PRIDEiQ9P290.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021851; ENSRNOP00000021851; ENSRNOG00000016414.
GeneIDi305886.
KEGGirno:305886.
UCSCiRGD:631405. rat.

Organism-specific databases

CTDi51310.
RGDi631405. Slc22a17.

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000015298.
HOVERGENiHBG031124.
InParanoidiQ9P290.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG7PP56J.
PhylomeDBiQ9P290.
TreeFamiTF335753.

Enzyme and pathway databases

ReactomeiR-RNO-917937. Iron uptake and transport.

Miscellaneous databases

PROiQ9P290.

Gene expression databases

GenevisibleiQ9P290. RN.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human potent organic ion transporter exclusively expressed in brain."
    Yaoi T., Fushiki S.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiS22AH_RAT
AccessioniPrimary (citable) accession number: Q9P290
Secondary accession number(s): Q4KLP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: October 5, 2010
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (Ref. 1) thought to originate from human.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.