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Protein

Serine/threonine-protein kinase 26

Gene

STK26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediator of cell growth. Modulates apoptosis.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+By similarity

Enzyme regulationi

Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53ATPPROSITE-ProRule annotation1
Active sitei144Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 38ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cellular component disassembly involved in execution phase of apoptosis Source: Reactome
  • microvillus assembly Source: UniProtKB
  • mitotic cell cycle Source: GO_Central
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of cell differentiation Source: GO_Central
  • regulation of hydrogen peroxide-induced cell death Source: UniProtKB
  • response to hydrogen peroxide Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05894-MONOMER.
ReactomeiR-HSA-111465. Apoptotic cleavage of cellular proteins.
SignaLinkiQ9P289.
SIGNORiQ9P289.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 26Curated (EC:2.7.11.11 Publication)
Alternative name(s):
MST3 and SOK1-related kinase1 Publication
Mammalian STE20-like protein kinase 41 Publication
Short name:
MST-4Curated
Short name:
STE20-like kinase MST4Curated
Serine/threonine-protein kinase MASKCurated
Gene namesi
Name:STK26Imported
Synonyms:MASK1 Publication, MST41 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18174. STK26.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cell periphery Source: UniProtKB
  • centrosome Source: HPA
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi-associated vesicle Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • nucleus Source: HPA
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51765.
OpenTargetsiENSG00000134602.

Chemistry databases

ChEMBLiCHEMBL5941.
GuidetoPHARMACOLOGYi2287.

Polymorphism and mutation databases

BioMutaiMST4.
DMDMi73621232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000864042 – 416Serine/threonine-protein kinase 26Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei178Phosphothreonine; by autocatalysisCombined sources1 Publication1
Modified residuei300PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei309PhosphoserineBy similarity1
Modified residuei325PhosphoserineCombined sources1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei328PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9P289.
MaxQBiQ9P289.
PaxDbiQ9P289.
PeptideAtlasiQ9P289.
PRIDEiQ9P289.

PTM databases

iPTMnetiQ9P289.
PhosphoSitePlusiQ9P289.
SwissPalmiQ9P289.

Miscellaneous databases

PMAP-CutDBQ9P289.

Expressioni

Gene expression databases

BgeeiENSG00000134602.
ExpressionAtlasiQ9P289. baseline and differential.
GenevisibleiQ9P289. HS.

Organism-specific databases

HPAiHPA059921.

Interactioni

Subunit structurei

Homodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-618239,EBI-618239
CAB39Q9Y3766EBI-618239,EBI-306905
CTTNBP2NLQ9P2B44EBI-618239,EBI-1774273
PDCD10Q9BUL87EBI-618239,EBI-740195
STRIP1Q5VSL92EBI-618239,EBI-1773588

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi119722. 75 interactors.
DIPiDIP-34049N.
IntActiQ9P289. 33 interactors.
STRINGi9606.ENSP00000377867.

Chemistry databases

BindingDBiQ9P289.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 23Combined sources4
Beta strandi24 – 32Combined sources9
Beta strandi34 – 43Combined sources10
Turni44 – 46Combined sources3
Beta strandi49 – 56Combined sources8
Turni58 – 60Combined sources3
Helixi63 – 74Combined sources12
Beta strandi85 – 91Combined sources7
Beta strandi94 – 100Combined sources7
Beta strandi104 – 106Combined sources3
Helixi107 – 111Combined sources5
Helixi118 – 132Combined sources15
Beta strandi138 – 142Combined sources5
Helixi147 – 149Combined sources3
Beta strandi150 – 152Combined sources3
Beta strandi158 – 161Combined sources4
Turni162 – 164Combined sources3
Turni172 – 174Combined sources3
Turni176 – 178Combined sources3
Helixi188 – 191Combined sources4
Helixi199 – 214Combined sources16
Turni218 – 221Combined sources4
Helixi224 – 233Combined sources10
Beta strandi241 – 243Combined sources3
Helixi245 – 254Combined sources10
Helixi259 – 261Combined sources3
Helixi265 – 269Combined sources5
Helixi272 – 277Combined sources6
Helixi281 – 284Combined sources4
Helixi285 – 296Combined sources12
Helixi346 – 350Combined sources5
Helixi352 – 355Combined sources4
Helixi357 – 366Combined sources10
Turni367 – 370Combined sources4
Helixi372 – 391Combined sources20
Helixi395 – 409Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GGFX-ray2.35A/B1-300[»]
3W8IX-ray2.40B346-416[»]
4FZAX-ray3.15B18-297[»]
4FZDX-ray3.25B18-297[»]
C323-327[»]
4FZFX-ray3.64B18-297[»]
4GEHX-ray1.95B/D325-413[»]
ProteinModelPortaliQ9P289.
SMRiQ9P289.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P289.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 274Protein kinasePROSITE-ProRule annotationAdd BLAST251

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0201. Eukaryota.
ENOG410XP9G. LUCA.
GeneTreeiENSGT00810000125395.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiQ9P289.
KOiK08838.
PhylomeDBiQ9P289.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P289-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV
60 70 80 90 100
AIKIIDLEEA EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME
110 120 130 140 150
YLGGGSALDL LRAGPFDEFQ IATMLKEILK GLDYLHSEKK IHRDIKAANV
160 170 180 190 200
LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV GTPFWMAPEV IQQSAYDSKA
210 220 230 240 250
DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLV GDFTKSFKEF
260 270 280 290 300
IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS
310 320 330 340 350
DDESDSEGSD SESTSRENNT HPEWSFTTVR KKPDPKKVQN GAEQDLVQTL
360 370 380 390 400
SCLSMIITPA FAELKQQDEN NASRNQAIEE LEKSIAVAEA ACPGITDKMV
410
KKLIEKFQKC SADESP
Length:416
Mass (Da):46,529
Last modified:October 1, 2001 - v2
Checksum:i3E31B7E3CBDA5768
GO
Isoform 2 (identifier: Q9P289-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-91: Missing.

Show »
Length:339
Mass (Da):37,770
Checksum:iE80868882811C8DE
GO
Isoform 3 (identifier: Q9P289-3) [UniParc]FASTAAdd to basket
Also known as: MST4a

The sequence of this isoform differs from the canonical sequence as follows:
     200-261: Missing.

Show »
Length:354
Mass (Da):39,658
Checksum:i34BF60E79E9A42B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0408449Q → R.1 PublicationCorresponds to variant rs56035648dbSNPEnsembl.1
Natural variantiVAR_04084536G → W in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04084645R → C.1 PublicationCorresponds to variant rs56044451dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04146915 – 91Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_041470200 – 261Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231012 mRNA. Translation: AAK38484.1.
AF344882 mRNA. Translation: AAK29620.1.
AF344883 mRNA. Translation: AAK29621.1.
AB040057 mRNA. Translation: BAA92785.2.
BT020099 mRNA. Translation: AAV38902.1.
AK075107 mRNA. Translation: BAC11406.1.
AK314356 mRNA. Translation: BAG36989.1.
AL109749 Genomic DNA. Translation: CAI42079.1.
CH471107 Genomic DNA. Translation: EAX11786.1.
CH471107 Genomic DNA. Translation: EAX11787.1.
BC098315 mRNA. Translation: AAH98315.1.
BC103503 mRNA. Translation: AAI03504.1.
CCDSiCCDS14631.1. [Q9P289-1]
CCDS43995.1. [Q9P289-3]
CCDS48168.1. [Q9P289-2]
RefSeqiNP_001035917.1. NM_001042452.1. [Q9P289-3]
NP_001035918.1. NM_001042453.1. [Q9P289-2]
NP_057626.2. NM_016542.3. [Q9P289-1]
UniGeneiHs.444247.

Genome annotation databases

EnsembliENST00000394334; ENSP00000377867; ENSG00000134602. [Q9P289-1]
ENST00000394335; ENSP00000377868; ENSG00000134602. [Q9P289-2]
ENST00000496850; ENSP00000419702; ENSG00000134602. [Q9P289-3]
GeneIDi51765.
KEGGihsa:51765.
UCSCiuc004ewk.2. human. [Q9P289-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231012 mRNA. Translation: AAK38484.1.
AF344882 mRNA. Translation: AAK29620.1.
AF344883 mRNA. Translation: AAK29621.1.
AB040057 mRNA. Translation: BAA92785.2.
BT020099 mRNA. Translation: AAV38902.1.
AK075107 mRNA. Translation: BAC11406.1.
AK314356 mRNA. Translation: BAG36989.1.
AL109749 Genomic DNA. Translation: CAI42079.1.
CH471107 Genomic DNA. Translation: EAX11786.1.
CH471107 Genomic DNA. Translation: EAX11787.1.
BC098315 mRNA. Translation: AAH98315.1.
BC103503 mRNA. Translation: AAI03504.1.
CCDSiCCDS14631.1. [Q9P289-1]
CCDS43995.1. [Q9P289-3]
CCDS48168.1. [Q9P289-2]
RefSeqiNP_001035917.1. NM_001042452.1. [Q9P289-3]
NP_001035918.1. NM_001042453.1. [Q9P289-2]
NP_057626.2. NM_016542.3. [Q9P289-1]
UniGeneiHs.444247.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GGFX-ray2.35A/B1-300[»]
3W8IX-ray2.40B346-416[»]
4FZAX-ray3.15B18-297[»]
4FZDX-ray3.25B18-297[»]
C323-327[»]
4FZFX-ray3.64B18-297[»]
4GEHX-ray1.95B/D325-413[»]
ProteinModelPortaliQ9P289.
SMRiQ9P289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119722. 75 interactors.
DIPiDIP-34049N.
IntActiQ9P289. 33 interactors.
STRINGi9606.ENSP00000377867.

Chemistry databases

BindingDBiQ9P289.
ChEMBLiCHEMBL5941.
GuidetoPHARMACOLOGYi2287.

PTM databases

iPTMnetiQ9P289.
PhosphoSitePlusiQ9P289.
SwissPalmiQ9P289.

Polymorphism and mutation databases

BioMutaiMST4.
DMDMi73621232.

Proteomic databases

EPDiQ9P289.
MaxQBiQ9P289.
PaxDbiQ9P289.
PeptideAtlasiQ9P289.
PRIDEiQ9P289.

Protocols and materials databases

DNASUi51765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394334; ENSP00000377867; ENSG00000134602. [Q9P289-1]
ENST00000394335; ENSP00000377868; ENSG00000134602. [Q9P289-2]
ENST00000496850; ENSP00000419702; ENSG00000134602. [Q9P289-3]
GeneIDi51765.
KEGGihsa:51765.
UCSCiuc004ewk.2. human. [Q9P289-1]

Organism-specific databases

CTDi51765.
DisGeNETi51765.
GeneCardsiSTK26.
HGNCiHGNC:18174. STK26.
HPAiHPA059921.
MIMi300547. gene.
neXtProtiNX_Q9P289.
OpenTargetsiENSG00000134602.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0201. Eukaryota.
ENOG410XP9G. LUCA.
GeneTreeiENSGT00810000125395.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiQ9P289.
KOiK08838.
PhylomeDBiQ9P289.

Enzyme and pathway databases

BioCyciZFISH:HS05894-MONOMER.
ReactomeiR-HSA-111465. Apoptotic cleavage of cellular proteins.
SignaLinkiQ9P289.
SIGNORiQ9P289.

Miscellaneous databases

EvolutionaryTraceiQ9P289.
GeneWikiiMST4.
GenomeRNAii51765.
PMAP-CutDBQ9P289.
PROiQ9P289.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134602.
ExpressionAtlasiQ9P289. baseline and differential.
GenevisibleiQ9P289. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTK26_HUMAN
AccessioniPrimary (citable) accession number: Q9P289
Secondary accession number(s): B2RAU2
, Q3ZB77, Q8NC04, Q9BXC3, Q9BXC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.