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Protein

Serine/threonine-protein kinase 26

Gene

STK26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediator of cell growth. Modulates apoptosis.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+By similarity

Enzyme regulationi

Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531ATPPROSITE-ProRule annotation
Active sitei144 – 1441Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 389ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • magnesium ion binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cellular component disassembly involved in execution phase of apoptosis Source: Reactome
  • microvillus assembly Source: UniProtKB
  • mitotic cell cycle Source: GO_Central
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of cell differentiation Source: GO_Central
  • regulation of hydrogen peroxide-induced cell death Source: UniProtKB
  • response to hydrogen peroxide Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-111465. Apoptotic cleavage of cellular proteins.
SignaLinkiQ9P289.
SIGNORiQ9P289.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 26Curated (EC:2.7.11.11 Publication)
Alternative name(s):
MST3 and SOK1-related kinase1 Publication
Mammalian STE20-like protein kinase 41 Publication
Short name:
MST-4Curated
Short name:
STE20-like kinase MST4Curated
Serine/threonine-protein kinase MASKCurated
Gene namesi
Name:STK26Imported
Synonyms:MASK1 Publication, MST41 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18174. STK26.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cell periphery Source: UniProtKB
  • centrosome Source: HPA
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi-associated vesicle Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • nucleus Source: HPA
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5941.
GuidetoPHARMACOLOGYi2287.

Polymorphism and mutation databases

BioMutaiMST4.
DMDMi73621232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 416415Serine/threonine-protein kinase 26PRO_0000086404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei4 – 41PhosphoserineCombined sources
Modified residuei178 – 1781Phosphothreonine; by autocatalysisCombined sources1 Publication
Modified residuei300 – 3001PhosphoserineCombined sources
Modified residuei304 – 3041PhosphoserineCombined sources
Modified residuei306 – 3061PhosphoserineCombined sources
Modified residuei309 – 3091PhosphoserineBy similarity
Modified residuei325 – 3251PhosphoserineCombined sources
Modified residuei327 – 3271PhosphothreonineCombined sources
Modified residuei328 – 3281PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9P289.
MaxQBiQ9P289.
PaxDbiQ9P289.
PeptideAtlasiQ9P289.
PRIDEiQ9P289.

PTM databases

iPTMnetiQ9P289.
PhosphoSiteiQ9P289.
SwissPalmiQ9P289.

Miscellaneous databases

PMAP-CutDBQ9P289.

Expressioni

Gene expression databases

BgeeiENSG00000134602.
ExpressionAtlasiQ9P289. baseline and differential.
GenevisibleiQ9P289. HS.

Organism-specific databases

HPAiHPA059921.

Interactioni

Subunit structurei

Homodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-618239,EBI-618239
CAB39Q9Y3766EBI-618239,EBI-306905
CTTNBP2NLQ9P2B44EBI-618239,EBI-1774273
STRIP1Q5VSL92EBI-618239,EBI-1773588

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi119722. 75 interactions.
DIPiDIP-34049N.
IntActiQ9P289. 32 interactions.
STRINGi9606.ENSP00000377867.

Chemistry

BindingDBiQ9P289.

Structurei

Secondary structure

1
416
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 234Combined sources
Beta strandi24 – 329Combined sources
Beta strandi34 – 4310Combined sources
Turni44 – 463Combined sources
Beta strandi49 – 568Combined sources
Turni58 – 603Combined sources
Helixi63 – 7412Combined sources
Beta strandi85 – 917Combined sources
Beta strandi94 – 1007Combined sources
Beta strandi104 – 1063Combined sources
Helixi107 – 1115Combined sources
Helixi118 – 13215Combined sources
Beta strandi138 – 1425Combined sources
Helixi147 – 1493Combined sources
Beta strandi150 – 1523Combined sources
Beta strandi158 – 1614Combined sources
Turni162 – 1643Combined sources
Turni172 – 1743Combined sources
Turni176 – 1783Combined sources
Helixi188 – 1914Combined sources
Helixi199 – 21416Combined sources
Turni218 – 2214Combined sources
Helixi224 – 23310Combined sources
Beta strandi241 – 2433Combined sources
Helixi245 – 25410Combined sources
Helixi259 – 2613Combined sources
Helixi265 – 2695Combined sources
Helixi272 – 2776Combined sources
Helixi281 – 2844Combined sources
Helixi285 – 29612Combined sources
Helixi346 – 3505Combined sources
Helixi352 – 3554Combined sources
Helixi357 – 36610Combined sources
Turni367 – 3704Combined sources
Helixi372 – 39120Combined sources
Helixi395 – 40915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GGFX-ray2.35A/B1-300[»]
3W8IX-ray2.40B346-416[»]
4FZAX-ray3.15B18-297[»]
4FZDX-ray3.25B18-297[»]
C323-327[»]
4FZFX-ray3.64B18-297[»]
4GEHX-ray1.95B/D325-413[»]
ProteinModelPortaliQ9P289.
SMRiQ9P289. Positions 17-297, 344-412.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P289.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 274251Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0201. Eukaryota.
ENOG410XP9G. LUCA.
GeneTreeiENSGT00810000125395.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiQ9P289.
KOiK08838.
PhylomeDBiQ9P289.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P289-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV
60 70 80 90 100
AIKIIDLEEA EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME
110 120 130 140 150
YLGGGSALDL LRAGPFDEFQ IATMLKEILK GLDYLHSEKK IHRDIKAANV
160 170 180 190 200
LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV GTPFWMAPEV IQQSAYDSKA
210 220 230 240 250
DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLV GDFTKSFKEF
260 270 280 290 300
IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS
310 320 330 340 350
DDESDSEGSD SESTSRENNT HPEWSFTTVR KKPDPKKVQN GAEQDLVQTL
360 370 380 390 400
SCLSMIITPA FAELKQQDEN NASRNQAIEE LEKSIAVAEA ACPGITDKMV
410
KKLIEKFQKC SADESP
Length:416
Mass (Da):46,529
Last modified:October 1, 2001 - v2
Checksum:i3E31B7E3CBDA5768
GO
Isoform 2 (identifier: Q9P289-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-91: Missing.

Show »
Length:339
Mass (Da):37,770
Checksum:iE80868882811C8DE
GO
Isoform 3 (identifier: Q9P289-3) [UniParc]FASTAAdd to basket
Also known as: MST4a

The sequence of this isoform differs from the canonical sequence as follows:
     200-261: Missing.

Show »
Length:354
Mass (Da):39,658
Checksum:i34BF60E79E9A42B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91Q → R.1 Publication
Corresponds to variant rs56035648 [ dbSNP | Ensembl ].
VAR_040844
Natural varianti36 – 361G → W in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040845
Natural varianti45 – 451R → C.1 Publication
Corresponds to variant rs56044451 [ dbSNP | Ensembl ].
VAR_040846

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 9177Missing in isoform 2. 1 PublicationVSP_041469Add
BLAST
Alternative sequencei200 – 26162Missing in isoform 3. 1 PublicationVSP_041470Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231012 mRNA. Translation: AAK38484.1.
AF344882 mRNA. Translation: AAK29620.1.
AF344883 mRNA. Translation: AAK29621.1.
AB040057 mRNA. Translation: BAA92785.2.
BT020099 mRNA. Translation: AAV38902.1.
AK075107 mRNA. Translation: BAC11406.1.
AK314356 mRNA. Translation: BAG36989.1.
AL109749 Genomic DNA. Translation: CAI42079.1.
CH471107 Genomic DNA. Translation: EAX11786.1.
CH471107 Genomic DNA. Translation: EAX11787.1.
BC098315 mRNA. Translation: AAH98315.1.
BC103503 mRNA. Translation: AAI03504.1.
CCDSiCCDS14631.1. [Q9P289-1]
CCDS43995.1. [Q9P289-3]
CCDS48168.1. [Q9P289-2]
RefSeqiNP_001035917.1. NM_001042452.1. [Q9P289-3]
NP_001035918.1. NM_001042453.1. [Q9P289-2]
NP_057626.2. NM_016542.3. [Q9P289-1]
UniGeneiHs.444247.

Genome annotation databases

EnsembliENST00000394334; ENSP00000377867; ENSG00000134602. [Q9P289-1]
ENST00000394335; ENSP00000377868; ENSG00000134602. [Q9P289-2]
ENST00000496850; ENSP00000419702; ENSG00000134602. [Q9P289-3]
GeneIDi51765.
KEGGihsa:51765.
UCSCiuc004ewk.2. human. [Q9P289-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231012 mRNA. Translation: AAK38484.1.
AF344882 mRNA. Translation: AAK29620.1.
AF344883 mRNA. Translation: AAK29621.1.
AB040057 mRNA. Translation: BAA92785.2.
BT020099 mRNA. Translation: AAV38902.1.
AK075107 mRNA. Translation: BAC11406.1.
AK314356 mRNA. Translation: BAG36989.1.
AL109749 Genomic DNA. Translation: CAI42079.1.
CH471107 Genomic DNA. Translation: EAX11786.1.
CH471107 Genomic DNA. Translation: EAX11787.1.
BC098315 mRNA. Translation: AAH98315.1.
BC103503 mRNA. Translation: AAI03504.1.
CCDSiCCDS14631.1. [Q9P289-1]
CCDS43995.1. [Q9P289-3]
CCDS48168.1. [Q9P289-2]
RefSeqiNP_001035917.1. NM_001042452.1. [Q9P289-3]
NP_001035918.1. NM_001042453.1. [Q9P289-2]
NP_057626.2. NM_016542.3. [Q9P289-1]
UniGeneiHs.444247.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GGFX-ray2.35A/B1-300[»]
3W8IX-ray2.40B346-416[»]
4FZAX-ray3.15B18-297[»]
4FZDX-ray3.25B18-297[»]
C323-327[»]
4FZFX-ray3.64B18-297[»]
4GEHX-ray1.95B/D325-413[»]
ProteinModelPortaliQ9P289.
SMRiQ9P289. Positions 17-297, 344-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119722. 75 interactions.
DIPiDIP-34049N.
IntActiQ9P289. 32 interactions.
STRINGi9606.ENSP00000377867.

Chemistry

BindingDBiQ9P289.
ChEMBLiCHEMBL5941.
GuidetoPHARMACOLOGYi2287.

PTM databases

iPTMnetiQ9P289.
PhosphoSiteiQ9P289.
SwissPalmiQ9P289.

Polymorphism and mutation databases

BioMutaiMST4.
DMDMi73621232.

Proteomic databases

EPDiQ9P289.
MaxQBiQ9P289.
PaxDbiQ9P289.
PeptideAtlasiQ9P289.
PRIDEiQ9P289.

Protocols and materials databases

DNASUi51765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394334; ENSP00000377867; ENSG00000134602. [Q9P289-1]
ENST00000394335; ENSP00000377868; ENSG00000134602. [Q9P289-2]
ENST00000496850; ENSP00000419702; ENSG00000134602. [Q9P289-3]
GeneIDi51765.
KEGGihsa:51765.
UCSCiuc004ewk.2. human. [Q9P289-1]

Organism-specific databases

CTDi51765.
GeneCardsiSTK26.
HGNCiHGNC:18174. STK26.
HPAiHPA059921.
MIMi300547. gene.
neXtProtiNX_Q9P289.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0201. Eukaryota.
ENOG410XP9G. LUCA.
GeneTreeiENSGT00810000125395.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiQ9P289.
KOiK08838.
PhylomeDBiQ9P289.

Enzyme and pathway databases

ReactomeiR-HSA-111465. Apoptotic cleavage of cellular proteins.
SignaLinkiQ9P289.
SIGNORiQ9P289.

Miscellaneous databases

EvolutionaryTraceiQ9P289.
GeneWikiiMST4.
GenomeRNAii51765.
PMAP-CutDBQ9P289.
PROiQ9P289.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134602.
ExpressionAtlasiQ9P289. baseline and differential.
GenevisibleiQ9P289. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTK26_HUMAN
AccessioniPrimary (citable) accession number: Q9P289
Secondary accession number(s): B2RAU2
, Q3ZB77, Q8NC04, Q9BXC3, Q9BXC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2001
Last modified: September 7, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.