ID   SEM5B_HUMAN             Reviewed;        1151 AA.
AC   Q9P283; A8K5U2; B7Z393; F8W9U8; Q6DD89; Q6UY12; Q9NW17;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 4.
DT   27-MAR-2024, entry version 183.
DE   RecName: Full=Semaphorin-5B;
GN   Name=SEMA5B; Synonyms=KIAA1445, SEMAG; ORFNames=UNQ5867/PRO34001;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS THR-220;
RP   ASP-840 AND GLY-1028.
RC   TISSUE=Brain;
RX   PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:143-150(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 935-1151 (ISOFORM 3), AND VARIANTS THR-220;
RP   THR-742; ASP-840 AND GLY-1028.
RC   TISSUE=Brain, and Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ASP-840
RP   AND GLY-1028.
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   VARIANTS [LARGE SCALE ANALYSIS] SER-42 AND MET-223.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May act as a positive axonal guidance cue.
CC       {ECO:0000250|UniProtKB:Q60519}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type III
CC       membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q9P283-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9P283-2; Sequence=VSP_029462, VSP_029464, VSP_029465;
CC       Name=3;
CC         IsoId=Q9P283-3; Sequence=VSP_029463;
CC       Name=4;
CC         IsoId=Q9P283-4; Sequence=VSP_044748;
CC   -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-59 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA91570.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA95969.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB040878; BAA95969.1; ALT_INIT; mRNA.
DR   EMBL; AY358124; AAQ88491.1; -; mRNA.
DR   EMBL; AK001234; BAA91570.1; ALT_INIT; mRNA.
DR   EMBL; AK291407; BAF84096.1; -; mRNA.
DR   EMBL; AK295619; BAH12129.1; -; mRNA.
DR   EMBL; AC078794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471052; EAW79457.1; -; Genomic_DNA.
DR   EMBL; BC077726; AAH77726.1; -; mRNA.
DR   CCDS; CCDS35491.1; -. [Q9P283-1]
DR   CCDS; CCDS58848.1; -. [Q9P283-4]
DR   RefSeq; NP_001026872.2; NM_001031702.3. [Q9P283-1]
DR   RefSeq; NP_001243275.1; NM_001256346.1. [Q9P283-1]
DR   RefSeq; NP_001243276.1; NM_001256347.1. [Q9P283-4]
DR   AlphaFoldDB; Q9P283; -.
DR   SMR; Q9P283; -.
DR   BioGRID; 119953; 10.
DR   IntAct; Q9P283; 8.
DR   MINT; Q9P283; -.
DR   STRING; 9606.ENSP00000389588; -.
DR   GlyCosmos; Q9P283; 5 sites, No reported glycans.
DR   GlyGen; Q9P283; 5 sites.
DR   iPTMnet; Q9P283; -.
DR   PhosphoSitePlus; Q9P283; -.
DR   BioMuta; SEMA5B; -.
DR   DMDM; 212276522; -.
DR   EPD; Q9P283; -.
DR   jPOST; Q9P283; -.
DR   MassIVE; Q9P283; -.
DR   MaxQB; Q9P283; -.
DR   PaxDb; 9606-ENSP00000389588; -.
DR   PeptideAtlas; Q9P283; -.
DR   ProteomicsDB; 30384; -.
DR   ProteomicsDB; 83748; -. [Q9P283-1]
DR   ProteomicsDB; 83749; -. [Q9P283-2]
DR   ProteomicsDB; 83750; -. [Q9P283-3]
DR   Antibodypedia; 2250; 143 antibodies from 14 providers.
DR   DNASU; 54437; -.
DR   Ensembl; ENST00000357599.8; ENSP00000350215.3; ENSG00000082684.16. [Q9P283-1]
DR   Ensembl; ENST00000451055.6; ENSP00000389588.2; ENSG00000082684.16. [Q9P283-4]
DR   Ensembl; ENST00000616742.4; ENSP00000479602.1; ENSG00000082684.16. [Q9P283-1]
DR   GeneID; 54437; -.
DR   KEGG; hsa:54437; -.
DR   MANE-Select; ENST00000357599.8; ENSP00000350215.3; NM_001031702.4; NP_001026872.2.
DR   UCSC; uc003efz.3; human. [Q9P283-1]
DR   AGR; HGNC:10737; -.
DR   CTD; 54437; -.
DR   DisGeNET; 54437; -.
DR   GeneCards; SEMA5B; -.
DR   HGNC; HGNC:10737; SEMA5B.
DR   HPA; ENSG00000082684; Tissue enhanced (brain).
DR   MIM; 609298; gene.
DR   neXtProt; NX_Q9P283; -.
DR   OpenTargets; ENSG00000082684; -.
DR   PharmGKB; PA35659; -.
DR   VEuPathDB; HostDB:ENSG00000082684; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   GeneTree; ENSGT00940000156712; -.
DR   InParanoid; Q9P283; -.
DR   OMA; KRNSHGQ; -.
DR   OrthoDB; 5399685at2759; -.
DR   PhylomeDB; Q9P283; -.
DR   TreeFam; TF329951; -.
DR   PathwayCommons; Q9P283; -.
DR   Reactome; R-HSA-5083635; Defective B3GALTL causes PpS.
DR   Reactome; R-HSA-5173214; O-glycosylation of TSR domain-containing proteins.
DR   SignaLink; Q9P283; -.
DR   SIGNOR; Q9P283; -.
DR   BioGRID-ORCS; 54437; 14 hits in 1137 CRISPR screens.
DR   ChiTaRS; SEMA5B; human.
DR   GenomeRNAi; 54437; -.
DR   Pharos; Q9P283; Tbio.
DR   PRO; PR:Q9P283; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9P283; Protein.
DR   Bgee; ENSG00000082684; Expressed in ventricular zone and 136 other cell types or tissues.
DR   ExpressionAtlas; Q9P283; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR   GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR   GO; GO:0048675; P:axon extension; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
DR   GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR   GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR   GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR   CDD; cd11264; Sema_5B; 1.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF39; SEMAPHORIN-5B; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR   PROSITE; PS51004; SEMA; 1.
DR   PROSITE; PS50092; TSP1; 5.
DR   Genevisible; Q9P283; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; Differentiation;
KW   Disulfide bond; Glycoprotein; Membrane; Neurogenesis; Reference proteome;
KW   Repeat; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1151
FT                   /note="Semaphorin-5B"
FT                   /id="PRO_0000032337"
FT   TOPO_DOM        1..1036
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1037..1057
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1058..1151
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          103..553
FT                   /note="Sema"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DOMAIN          555..602
FT                   /note="PSI"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          664..720
FT                   /note="TSP type-1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          722..771
FT                   /note="TSP type-1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          853..908
FT                   /note="TSP type-1 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          910..965
FT                   /note="TSP type-1 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          966..1010
FT                   /note="TSP type-1 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   CARBOHYD        153
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        236
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        345
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        436
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        788
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        172..182
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        199..208
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        322..425
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        346..388
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        676..713
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        680..719
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        691..703
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        734..765
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        738..770
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        749..755
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        865..902
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        869..907
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        880..892
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        922..959
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        926..964
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        937..949
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   VAR_SEQ         1
FT                   /note="M -> MLHLSAEEAIGCVRVRRSFIDELAFGRGHSTGTGKQKRRDRVSGSSW
FT                   CLACVSWM (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044748"
FT   VAR_SEQ         760
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_029462"
FT   VAR_SEQ         944..964
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029463"
FT   VAR_SEQ         966
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_029464"
FT   VAR_SEQ         1032..1151
FT                   /note="FNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYK
FT                   GGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPEAS
FT                   PGQRCFPNS -> KRNRTYLMLRSSQPSSTPLQSLDSFHILLQTAKLCWGPHCFEMGSI
FT                   SSTWWPRASPASWALGS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_029465"
FT   VARIANT         42
FT                   /note="G -> S (in a breast cancer sample; somatic mutation;
FT                   dbSNP:rs148102705)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_037196"
FT   VARIANT         220
FT                   /note="I -> T (in dbSNP:rs2276774)"
FT                   /evidence="ECO:0000269|PubMed:10819331,
FT                   ECO:0000269|PubMed:14702039"
FT                   /id="VAR_037197"
FT   VARIANT         223
FT                   /note="I -> M (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_037198"
FT   VARIANT         742
FT                   /note="M -> T (in dbSNP:rs2276781)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_037199"
FT   VARIANT         840
FT                   /note="V -> D (in dbSNP:rs2276782)"
FT                   /evidence="ECO:0000269|PubMed:10819331,
FT                   ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037200"
FT   VARIANT         996
FT                   /note="S -> P (in dbSNP:rs35306342)"
FT                   /id="VAR_037201"
FT   VARIANT         1028
FT                   /note="D -> G (in dbSNP:rs2303983)"
FT                   /evidence="ECO:0000269|PubMed:10819331,
FT                   ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037202"
FT   CONFLICT        703
FT                   /note="C -> F (in Ref. 2; AAQ88491)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        Q9P283-4:14
FT                   /note="R -> K (in Ref. 3; BAH12129)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1151 AA;  125913 MW;  96B1D4BC2A1E36C9 CRC64;
     MPCGFSPSPV AHHLVPGPPD TPAQQLRCGW TVGGWLLSLV RGLLPCLPPG ARTAEGPIMV
     LAGPLAVSLL LPSLTLLVSH LSSSQDVSSE PSSEQQLCAL SKHPTVAFED LQPWVSNFTY
     PGARDFSQLA LDPSGNQLIV GARNYLFRLS LANVSLLQAT EWASSEDTRR SCQSKGKTEE
     ECQNYVRVLI VAGRKVFMCG TNAFSPMCTS RQVGNLSRTI EKINGVARCP YDPRHNSTAV
     ISSQGELYAA TVIDFSGRDP AIYRSLGSGP PLRTAQYNSK WLNEPNFVAA YDIGLFAYFF
     LRENAVEHDC GRTVYSRVAR VCKNDVGGRF LLEDTWTTFM KARLNCSRPG EVPFYYNELQ
     SAFHLPEQDL IYGVFTTNVN SIAASAVCAF NLSAISQAFN GPFRYQENPR AAWLPIANPI
     PNFQCGTLPE TGPNENLTER SLQDAQRLFL MSEAVQPVTP EPCVTQDSVR FSHLVVDLVQ
     AKDTLYHVLY IGTESGTILK ALSTASRSLH GCYLEELHVL PPGRREPLRS LRILHSARAL
     FVGLRDGVLR VPLERCAAYR SQGACLGARD PYCGWDGKQQ RCSTLEDSSN MSLWTQNITA
     CPVRNVTRDG GFGPWSPWQP CEHLDGDNSG SCLCRARSCD SPRPRCGGLD CLGPAIHIAN
     CSRNGAWTPW SSWALCSTSC GIGFQVRQRS CSNPAPRHGG RICVGKSREE RFCNENTPCP
     VPIFWASWGS WSKCSSNCGG GMQSRRRACE NGNSCLGCGV EFKTCNPEGC PEVRRNTPWT
     PWLPVNVTQG GARQEQRFRF TCRAPLADPH GLQFGRRRTE TRTCPADGSG SCDTDALVEV
     LLRSGSTSPH TVSGGWAAWG PWSSCSRDCE LGFRVRKRTC TNPEPRNGGL PCVGDAAEYQ
     DCNPQACPVR GAWSCWTSWS PCSASCGGGH YQRTRSCTSP APSPGEDICL GLHTEEALCA
     TQACPEGWSP WSEWSKCTDD GAQSRSRHCE ELLPGSSACA GNSSQSRPCP YSEIPVILPA
     SSMEEATDCA GFNLIHLVAT GISCFLGSGL LTLAVYLSCQ HCQRQSQEST LVHPATPNHL
     HYKGGGTPKN EKYTPMEFKT LNKNNLIPDD RANFYPLQQT NVYTTTYYPS PLNKHSFRPE
     ASPGQRCFPN S
//