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Protein

Semaphorin-5B

Gene

SEMA5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as positive axonal guidance cues.By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_264269. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-5B
Gene namesi
Name:SEMA5B
Synonyms:KIAA1445, SEMAG
ORF Names:UNQ5867/PRO34001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:10737. SEMA5B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 10361036ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1037 – 105721Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
BLAST
Topological domaini1058 – 115194CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35659.

Polymorphism and mutation databases

BioMutaiSEMA5B.
DMDMi212276522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11511151Semaphorin-5BPRO_0000032337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi172 ↔ 182By similarity
Disulfide bondi199 ↔ 208By similarity
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi322 ↔ 425By similarity
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi346 ↔ 388By similarity
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi556 ↔ 573By similarity
Disulfide bondi565 ↔ 582By similarity
Disulfide bondi676 ↔ 713By similarity
Disulfide bondi680 ↔ 719By similarity
Disulfide bondi691 ↔ 703By similarity
Disulfide bondi734 ↔ 765By similarity
Disulfide bondi738 ↔ 770By similarity
Disulfide bondi749 ↔ 755By similarity
Glycosylationi788 – 7881O-linked (GalNAc...)Sequence Analysis
Disulfide bondi865 ↔ 902By similarity
Disulfide bondi869 ↔ 907By similarity
Disulfide bondi880 ↔ 892By similarity
Disulfide bondi922 ↔ 959By similarity
Disulfide bondi926 ↔ 964By similarity
Disulfide bondi937 ↔ 949By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9P283.
PaxDbiQ9P283.
PRIDEiQ9P283.

PTM databases

PhosphoSiteiQ9P283.

Expressioni

Gene expression databases

BgeeiQ9P283.
CleanExiHS_SEMA5B.
ExpressionAtlasiQ9P283. baseline and differential.
GenevestigatoriQ9P283.

Organism-specific databases

HPAiHPA017084.

Interactioni

Protein-protein interaction databases

BioGridi119953. 8 interactions.
IntActiQ9P283. 8 interactions.
MINTiMINT-8247359.

Structurei

3D structure databases

SMRiQ9P283. Positions 104-592, 608-720, 725-774, 779-907, 911-1015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 553451SemaPROSITE-ProRule annotationAdd
BLAST
Domaini664 – 72057TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini722 – 77150TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini853 – 90856TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini910 – 96556TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini966 – 101045TSP type-1 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation
Contains 5 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316291.
GeneTreeiENSGT00760000119134.
HOGENOMiHOG000047106.
HOVERGENiHBG062356.
InParanoidiQ9P283.
KOiK06841.
OMAiSRSRHCE.
OrthoDBiEOG7SN8C0.
PhylomeDBiQ9P283.
TreeFamiTF329951.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR000884. Thrombospondin_1_rpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF82895. SSF82895. 5 hits.
PROSITEiPS51004. SEMA. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCGFSPSPV AHHLVPGPPD TPAQQLRCGW TVGGWLLSLV RGLLPCLPPG
60 70 80 90 100
ARTAEGPIMV LAGPLAVSLL LPSLTLLVSH LSSSQDVSSE PSSEQQLCAL
110 120 130 140 150
SKHPTVAFED LQPWVSNFTY PGARDFSQLA LDPSGNQLIV GARNYLFRLS
160 170 180 190 200
LANVSLLQAT EWASSEDTRR SCQSKGKTEE ECQNYVRVLI VAGRKVFMCG
210 220 230 240 250
TNAFSPMCTS RQVGNLSRTI EKINGVARCP YDPRHNSTAV ISSQGELYAA
260 270 280 290 300
TVIDFSGRDP AIYRSLGSGP PLRTAQYNSK WLNEPNFVAA YDIGLFAYFF
310 320 330 340 350
LRENAVEHDC GRTVYSRVAR VCKNDVGGRF LLEDTWTTFM KARLNCSRPG
360 370 380 390 400
EVPFYYNELQ SAFHLPEQDL IYGVFTTNVN SIAASAVCAF NLSAISQAFN
410 420 430 440 450
GPFRYQENPR AAWLPIANPI PNFQCGTLPE TGPNENLTER SLQDAQRLFL
460 470 480 490 500
MSEAVQPVTP EPCVTQDSVR FSHLVVDLVQ AKDTLYHVLY IGTESGTILK
510 520 530 540 550
ALSTASRSLH GCYLEELHVL PPGRREPLRS LRILHSARAL FVGLRDGVLR
560 570 580 590 600
VPLERCAAYR SQGACLGARD PYCGWDGKQQ RCSTLEDSSN MSLWTQNITA
610 620 630 640 650
CPVRNVTRDG GFGPWSPWQP CEHLDGDNSG SCLCRARSCD SPRPRCGGLD
660 670 680 690 700
CLGPAIHIAN CSRNGAWTPW SSWALCSTSC GIGFQVRQRS CSNPAPRHGG
710 720 730 740 750
RICVGKSREE RFCNENTPCP VPIFWASWGS WSKCSSNCGG GMQSRRRACE
760 770 780 790 800
NGNSCLGCGV EFKTCNPEGC PEVRRNTPWT PWLPVNVTQG GARQEQRFRF
810 820 830 840 850
TCRAPLADPH GLQFGRRRTE TRTCPADGSG SCDTDALVEV LLRSGSTSPH
860 870 880 890 900
TVSGGWAAWG PWSSCSRDCE LGFRVRKRTC TNPEPRNGGL PCVGDAAEYQ
910 920 930 940 950
DCNPQACPVR GAWSCWTSWS PCSASCGGGH YQRTRSCTSP APSPGEDICL
960 970 980 990 1000
GLHTEEALCA TQACPEGWSP WSEWSKCTDD GAQSRSRHCE ELLPGSSACA
1010 1020 1030 1040 1050
GNSSQSRPCP YSEIPVILPA SSMEEATDCA GFNLIHLVAT GISCFLGSGL
1060 1070 1080 1090 1100
LTLAVYLSCQ HCQRQSQEST LVHPATPNHL HYKGGGTPKN EKYTPMEFKT
1110 1120 1130 1140 1150
LNKNNLIPDD RANFYPLQQT NVYTTTYYPS PLNKHSFRPE ASPGQRCFPN

S
Length:1,151
Mass (Da):125,913
Last modified:November 4, 2008 - v4
Checksum:i96B1D4BC2A1E36C9
GO
Isoform 2 (identifier: Q9P283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-760: Missing.
     966-966: Missing.
     1032-1151: FNLIHLVATG...SPGQRCFPNS → KRNRTYLMLR...ASPASWALGS

Note: No experimental confirmation available.

Show »
Length:1,092
Mass (Da):119,280
Checksum:i3F9AF6108E99CD23
GO
Isoform 3 (identifier: Q9P283-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     944-964: Missing.

Note: No experimental confirmation available.

Show »
Length:1,130
Mass (Da):123,757
Checksum:i20ECAB8D936AE0FA
GO
Isoform 4 (identifier: Q9P283-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLHLSAEEAIGCVRVRRSFIDELAFGRGHSTGTGKQKRRDRVSGSSWCLACVSWM

Note: No experimental confirmation available.Curated

Show »
Length:1,205
Mass (Da):131,904
Checksum:i9EA9AB44CC93588D
GO

Sequence cautioni

The sequence BAA91570.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA95969.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti703 – 7031C → F in AAQ88491 (PubMed:12975309).Curated
Isoform 4 (identifier: Q9P283-4)
Sequence conflicti14 – 141R → K in BAH12129 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_037196
Natural varianti220 – 2201I → T.2 Publications
Corresponds to variant rs2276774 [ dbSNP | Ensembl ].
VAR_037197
Natural varianti223 – 2231I → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_037198
Natural varianti742 – 7421M → T.1 Publication
Corresponds to variant rs2276781 [ dbSNP | Ensembl ].
VAR_037199
Natural varianti840 – 8401V → D.3 Publications
Corresponds to variant rs2276782 [ dbSNP | Ensembl ].
VAR_037200
Natural varianti996 – 9961S → P.
Corresponds to variant rs35306342 [ dbSNP | Ensembl ].
VAR_037201
Natural varianti1028 – 10281D → G.3 Publications
Corresponds to variant rs2303983 [ dbSNP | Ensembl ].
VAR_037202

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MLHLSAEEAIGCVRVRRSFI DELAFGRGHSTGTGKQKRRD RVSGSSWCLACVSWM in isoform 4. 1 PublicationVSP_044748
Alternative sequencei760 – 7601Missing in isoform 2. 1 PublicationVSP_029462
Alternative sequencei944 – 96421Missing in isoform 3. 1 PublicationVSP_029463Add
BLAST
Alternative sequencei966 – 9661Missing in isoform 2. 1 PublicationVSP_029464
Alternative sequencei1032 – 1151120FNLIH…CFPNS → KRNRTYLMLRSSQPSSTPLQ SLDSFHILLQTAKLCWGPHC FEMGSISSTWWPRASPASWA LGS in isoform 2. 1 PublicationVSP_029465Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040878 mRNA. Translation: BAA95969.1. Different initiation.
AY358124 mRNA. Translation: AAQ88491.1.
AK001234 mRNA. Translation: BAA91570.1. Different initiation.
AK291407 mRNA. Translation: BAF84096.1.
AK295619 mRNA. Translation: BAH12129.1.
AC078794 Genomic DNA. No translation available.
AC083797 Genomic DNA. No translation available.
AC109130 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79457.1.
BC077726 mRNA. Translation: AAH77726.1.
CCDSiCCDS35491.1. [Q9P283-1]
CCDS58848.1. [Q9P283-4]
RefSeqiNP_001026872.2. NM_001031702.3. [Q9P283-1]
NP_001243275.1. NM_001256346.1. [Q9P283-1]
NP_001243276.1. NM_001256347.1. [Q9P283-4]
UniGeneiHs.210870.

Genome annotation databases

EnsembliENST00000357599; ENSP00000350215; ENSG00000082684. [Q9P283-1]
ENST00000451055; ENSP00000389588; ENSG00000082684. [Q9P283-4]
ENST00000616742; ENSP00000479602; ENSG00000082684. [Q9P283-1]
GeneIDi54437.
KEGGihsa:54437.
UCSCiuc003efz.2. human. [Q9P283-1]

Polymorphism and mutation databases

BioMutaiSEMA5B.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040878 mRNA. Translation: BAA95969.1. Different initiation.
AY358124 mRNA. Translation: AAQ88491.1.
AK001234 mRNA. Translation: BAA91570.1. Different initiation.
AK291407 mRNA. Translation: BAF84096.1.
AK295619 mRNA. Translation: BAH12129.1.
AC078794 Genomic DNA. No translation available.
AC083797 Genomic DNA. No translation available.
AC109130 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79457.1.
BC077726 mRNA. Translation: AAH77726.1.
CCDSiCCDS35491.1. [Q9P283-1]
CCDS58848.1. [Q9P283-4]
RefSeqiNP_001026872.2. NM_001031702.3. [Q9P283-1]
NP_001243275.1. NM_001256346.1. [Q9P283-1]
NP_001243276.1. NM_001256347.1. [Q9P283-4]
UniGeneiHs.210870.

3D structure databases

SMRiQ9P283. Positions 104-592, 608-720, 725-774, 779-907, 911-1015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119953. 8 interactions.
IntActiQ9P283. 8 interactions.
MINTiMINT-8247359.

PTM databases

PhosphoSiteiQ9P283.

Polymorphism and mutation databases

BioMutaiSEMA5B.
DMDMi212276522.

Proteomic databases

MaxQBiQ9P283.
PaxDbiQ9P283.
PRIDEiQ9P283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357599; ENSP00000350215; ENSG00000082684. [Q9P283-1]
ENST00000451055; ENSP00000389588; ENSG00000082684. [Q9P283-4]
ENST00000616742; ENSP00000479602; ENSG00000082684. [Q9P283-1]
GeneIDi54437.
KEGGihsa:54437.
UCSCiuc003efz.2. human. [Q9P283-1]

Organism-specific databases

CTDi54437.
GeneCardsiGC03M122628.
H-InvDBHIX0020193.
HGNCiHGNC:10737. SEMA5B.
HPAiHPA017084.
MIMi609298. gene.
neXtProtiNX_Q9P283.
PharmGKBiPA35659.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG316291.
GeneTreeiENSGT00760000119134.
HOGENOMiHOG000047106.
HOVERGENiHBG062356.
InParanoidiQ9P283.
KOiK06841.
OMAiSRSRHCE.
OrthoDBiEOG7SN8C0.
PhylomeDBiQ9P283.
TreeFamiTF329951.

Enzyme and pathway databases

ReactomeiREACT_264269. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

ChiTaRSiSEMA5B. human.
GenomeRNAii54437.
NextBioi56654.
PROiQ9P283.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P283.
CleanExiHS_SEMA5B.
ExpressionAtlasiQ9P283. baseline and differential.
GenevestigatoriQ9P283.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR000884. Thrombospondin_1_rpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF82895. SSF82895. 5 hits.
PROSITEiPS51004. SEMA. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-220; ASP-840 AND GLY-1028.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 935-1151 (ISOFORM 3), VARIANTS THR-220; THR-742; ASP-840 AND GLY-1028.
    Tissue: Brain and Hippocampus.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-840 AND GLY-1028.
    Tissue: Ovary.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-42 AND MET-223.

Entry informationi

Entry nameiSEM5B_HUMAN
AccessioniPrimary (citable) accession number: Q9P283
Secondary accession number(s): A8K5U2
, B7Z393, F8W9U8, Q6DD89, Q6UY12, Q9NW17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: April 29, 2015
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-59 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.