Q9P283 (SEM5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Semaphorin-5B

Gene names

Name:	SEMA5B
Synonyms:	KIAA1445, SEMAG
ORF Names:	UNQ5867/PRO34001

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1151 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as positive axonal guidance cues By similarity.
Subcellular location	Membrane; Single-pass type III membrane protein.
Sequence similarities	Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. Contains 5 TSP type-1 domains.
Caution	It is uncertain whether Met-1 or Met-59 is the initiator.
Sequence caution	The sequence BAA91570.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA95969.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal-anchor Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P283-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P283-2)

The sequence of this isoform differs from the canonical sequence as follows:
     760-760: Missing.
     966-966: Missing.
     1032-1151: FNLIHLVATG...SPGQRCFPNS → KRNRTYLMLR...ASPASWALGS

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9P283-3)

The sequence of this isoform differs from the canonical sequence as follows:
     944-964: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9P283-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLHLSAEEAIGCVRVRRSFIDELAFGRGHSTGTGKQKRRDRVSGSSWCLACVSWM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1151	1151	Semaphorin-5B		PRO_0000032337
Regions
	Topological domain	1 – 1036	1036	Extracellular Potential
	Transmembrane	1037 – 1057	21	Helical; Signal-anchor for type III membrane protein; Potential
	Topological domain	1058 – 1151	94	Cytoplasmic Potential
	Domain	103 – 553	451	Sema
	Domain	664 – 720	57	TSP type-1 1
	Domain	722 – 771	50	TSP type-1 2
	Domain	853 – 908	56	TSP type-1 3
	Domain	910 – 965	56	TSP type-1 4
	Domain	966 – 1010	45	TSP type-1 5
Amino acid modifications
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Glycosylation	236	1	N-linked (GlcNAc...) Potential
	Glycosylation	345	1	N-linked (GlcNAc...) Potential
	Glycosylation	436	1	N-linked (GlcNAc...) Potential
	Glycosylation	788	1	O-linked (GalNAc...) Potential
	Disulfide bond	172 ↔ 182		By similarity
	Disulfide bond	199 ↔ 208		By similarity
	Disulfide bond	322 ↔ 425		By similarity
	Disulfide bond	346 ↔ 388		By similarity
	Disulfide bond	556 ↔ 573		By similarity
	Disulfide bond	565 ↔ 582		By similarity
	Disulfide bond	676 ↔ 713		By similarity
	Disulfide bond	680 ↔ 719		By similarity
	Disulfide bond	691 ↔ 703		By similarity
	Disulfide bond	734 ↔ 765		By similarity
	Disulfide bond	738 ↔ 770		By similarity
	Disulfide bond	749 ↔ 755		By similarity
	Disulfide bond	865 ↔ 902		By similarity
	Disulfide bond	869 ↔ 907		By similarity
	Disulfide bond	880 ↔ 892		By similarity
	Disulfide bond	922 ↔ 959		By similarity
	Disulfide bond	926 ↔ 964		By similarity
	Disulfide bond	937 ↔ 949		By similarity
Natural variations
	Alternative sequence	1	1	M → MLHLSAEEAIGCVRVRRSFI DELAFGRGHSTGTGKQKRRD RVSGSSWCLACVSWM in isoform 4.		VSP_044748
	Alternative sequence	760	1	Missing in isoform 2.		VSP_029462
	Alternative sequence	944 – 964	21	Missing in isoform 3.		VSP_029463
	Alternative sequence	966	1	Missing in isoform 2.		VSP_029464
	Alternative sequence	1032 – 1151	120	FNLIH…CFPNS → KRNRTYLMLRSSQPSSTPLQ SLDSFHILLQTAKLCWGPHC FEMGSISSTWWPRASPASWA LGS in isoform 2.		VSP_029465
	Natural variant	42	1	G → S in a breast cancer sample; somatic mutation. Ref.7		VAR_037196
	Natural variant	220	1	I → T. Ref.1 Ref.3 Corresponds to variant rs2276774 [ dbSNP | Ensembl ].		VAR_037197
	Natural variant	223	1	I → M in a breast cancer sample; somatic mutation. Ref.7		VAR_037198
	Natural variant	742	1	M → T. Ref.3 Corresponds to variant rs2276781 [ dbSNP | Ensembl ].		VAR_037199
	Natural variant	840	1	V → D. Ref.1 Ref.3 Ref.6 Corresponds to variant rs2276782 [ dbSNP | Ensembl ].		VAR_037200
	Natural variant	996	1	S → P. Corresponds to variant rs35306342 [ dbSNP | Ensembl ].		VAR_037201
	Natural variant	1028	1	D → G. Ref.1 Ref.3 Ref.6 Corresponds to variant rs2303983 [ dbSNP | Ensembl ].		VAR_037202
Experimental info
	Sequence conflict	703	1	C → F in AAQ88491. Ref.2
Isoform 4:
	Sequence conflict	14	1	R → K in BAH12129. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 4, 2008. Version 4. Checksum: 96B1D4BC2A1E36C9	FASTA	1,151	125,913
	10 20 30 40 50 60 MPCGFSPSPV AHHLVPGPPD TPAQQLRCGW TVGGWLLSLV RGLLPCLPPG ARTAEGPIMV 70 80 90 100 110 120 LAGPLAVSLL LPSLTLLVSH LSSSQDVSSE PSSEQQLCAL SKHPTVAFED LQPWVSNFTY 130 140 150 160 170 180 PGARDFSQLA LDPSGNQLIV GARNYLFRLS LANVSLLQAT EWASSEDTRR SCQSKGKTEE 190 200 210 220 230 240 ECQNYVRVLI VAGRKVFMCG TNAFSPMCTS RQVGNLSRTI EKINGVARCP YDPRHNSTAV 250 260 270 280 290 300 ISSQGELYAA TVIDFSGRDP AIYRSLGSGP PLRTAQYNSK WLNEPNFVAA YDIGLFAYFF 310 320 330 340 350 360 LRENAVEHDC GRTVYSRVAR VCKNDVGGRF LLEDTWTTFM KARLNCSRPG EVPFYYNELQ 370 380 390 400 410 420 SAFHLPEQDL IYGVFTTNVN SIAASAVCAF NLSAISQAFN GPFRYQENPR AAWLPIANPI 430 440 450 460 470 480 PNFQCGTLPE TGPNENLTER SLQDAQRLFL MSEAVQPVTP EPCVTQDSVR FSHLVVDLVQ 490 500 510 520 530 540 AKDTLYHVLY IGTESGTILK ALSTASRSLH GCYLEELHVL PPGRREPLRS LRILHSARAL 550 560 570 580 590 600 FVGLRDGVLR VPLERCAAYR SQGACLGARD PYCGWDGKQQ RCSTLEDSSN MSLWTQNITA 610 620 630 640 650 660 CPVRNVTRDG GFGPWSPWQP CEHLDGDNSG SCLCRARSCD SPRPRCGGLD CLGPAIHIAN 670 680 690 700 710 720 CSRNGAWTPW SSWALCSTSC GIGFQVRQRS CSNPAPRHGG RICVGKSREE RFCNENTPCP 730 740 750 760 770 780 VPIFWASWGS WSKCSSNCGG GMQSRRRACE NGNSCLGCGV EFKTCNPEGC PEVRRNTPWT 790 800 810 820 830 840 PWLPVNVTQG GARQEQRFRF TCRAPLADPH GLQFGRRRTE TRTCPADGSG SCDTDALVEV 850 860 870 880 890 900 LLRSGSTSPH TVSGGWAAWG PWSSCSRDCE LGFRVRKRTC TNPEPRNGGL PCVGDAAEYQ 910 920 930 940 950 960 DCNPQACPVR GAWSCWTSWS PCSASCGGGH YQRTRSCTSP APSPGEDICL GLHTEEALCA 970 980 990 1000 1010 1020 TQACPEGWSP WSEWSKCTDD GAQSRSRHCE ELLPGSSACA GNSSQSRPCP YSEIPVILPA 1030 1040 1050 1060 1070 1080 SSMEEATDCA GFNLIHLVAT GISCFLGSGL LTLAVYLSCQ HCQRQSQEST LVHPATPNHL 1090 1100 1110 1120 1130 1140 HYKGGGTPKN EKYTPMEFKT LNKNNLIPDD RANFYPLQQT NVYTTTYYPS PLNKHSFRPE 1150 ASPGQRCFPN S
	Isoform 2 [UniParc]. Checksum: 3F9AF6108E99CD23	FASTA	1,092	119,280
	10 20 30 40 50 60 MPCGFSPSPV AHHLVPGPPD TPAQQLRCGW TVGGWLLSLV RGLLPCLPPG ARTAEGPIMV 70 80 90 100 110 120 LAGPLAVSLL LPSLTLLVSH LSSSQDVSSE PSSEQQLCAL SKHPTVAFED LQPWVSNFTY 130 140 150 160 170 180 PGARDFSQLA LDPSGNQLIV GARNYLFRLS LANVSLLQAT EWASSEDTRR SCQSKGKTEE 190 200 210 220 230 240 ECQNYVRVLI VAGRKVFMCG TNAFSPMCTS RQVGNLSRTI EKINGVARCP YDPRHNSTAV 250 260 270 280 290 300 ISSQGELYAA TVIDFSGRDP AIYRSLGSGP PLRTAQYNSK WLNEPNFVAA YDIGLFAYFF 310 320 330 340 350 360 LRENAVEHDC GRTVYSRVAR VCKNDVGGRF LLEDTWTTFM KARLNCSRPG EVPFYYNELQ 370 380 390 400 410 420 SAFHLPEQDL IYGVFTTNVN SIAASAVCAF NLSAISQAFN GPFRYQENPR AAWLPIANPI 430 440 450 460 470 480 PNFQCGTLPE TGPNENLTER SLQDAQRLFL MSEAVQPVTP EPCVTQDSVR FSHLVVDLVQ 490 500 510 520 530 540 AKDTLYHVLY IGTESGTILK ALSTASRSLH GCYLEELHVL PPGRREPLRS LRILHSARAL 550 560 570 580 590 600 FVGLRDGVLR VPLERCAAYR SQGACLGARD PYCGWDGKQQ RCSTLEDSSN MSLWTQNITA 610 620 630 640 650 660 CPVRNVTRDG GFGPWSPWQP CEHLDGDNSG SCLCRARSCD SPRPRCGGLD CLGPAIHIAN 670 680 690 700 710 720 CSRNGAWTPW SSWALCSTSC GIGFQVRQRS CSNPAPRHGG RICVGKSREE RFCNENTPCP 730 740 750 760 770 780 VPIFWASWGS WSKCSSNCGG GMQSRRRACE NGNSCLGCGE FKTCNPEGCP EVRRNTPWTP 790 800 810 820 830 840 WLPVNVTQGG ARQEQRFRFT CRAPLADPHG LQFGRRRTET RTCPADGSGS CDTDALVEVL 850 860 870 880 890 900 LRSGSTSPHT VSGGWAAWGP WSSCSRDCEL GFRVRKRTCT NPEPRNGGLP CVGDAAEYQD 910 920 930 940 950 960 CNPQACPVRG AWSCWTSWSP CSASCGGGHY QRTRSCTSPA PSPGEDICLG LHTEEALCAT 970 980 990 1000 1010 1020 QACPGWSPWS EWSKCTDDGA QSRSRHCEEL LPGSSACAGN SSQSRPCPYS EIPVILPASS 1030 1040 1050 1060 1070 1080 MEEATDCAGK RNRTYLMLRS SQPSSTPLQS LDSFHILLQT AKLCWGPHCF EMGSISSTWW 1090 PRASPASWAL GS
	Isoform 3 [UniParc]. Checksum: 20ECAB8D936AE0FA	FASTA	1,130	123,757
	10 20 30 40 50 60 MPCGFSPSPV AHHLVPGPPD TPAQQLRCGW TVGGWLLSLV RGLLPCLPPG ARTAEGPIMV 70 80 90 100 110 120 LAGPLAVSLL LPSLTLLVSH LSSSQDVSSE PSSEQQLCAL SKHPTVAFED LQPWVSNFTY 130 140 150 160 170 180 PGARDFSQLA LDPSGNQLIV GARNYLFRLS LANVSLLQAT EWASSEDTRR SCQSKGKTEE 190 200 210 220 230 240 ECQNYVRVLI VAGRKVFMCG TNAFSPMCTS RQVGNLSRTI EKINGVARCP YDPRHNSTAV 250 260 270 280 290 300 ISSQGELYAA TVIDFSGRDP AIYRSLGSGP PLRTAQYNSK WLNEPNFVAA YDIGLFAYFF 310 320 330 340 350 360 LRENAVEHDC GRTVYSRVAR VCKNDVGGRF LLEDTWTTFM KARLNCSRPG EVPFYYNELQ 370 380 390 400 410 420 SAFHLPEQDL IYGVFTTNVN SIAASAVCAF NLSAISQAFN GPFRYQENPR AAWLPIANPI 430 440 450 460 470 480 PNFQCGTLPE TGPNENLTER SLQDAQRLFL MSEAVQPVTP EPCVTQDSVR FSHLVVDLVQ 490 500 510 520 530 540 AKDTLYHVLY IGTESGTILK ALSTASRSLH GCYLEELHVL PPGRREPLRS LRILHSARAL 550 560 570 580 590 600 FVGLRDGVLR VPLERCAAYR SQGACLGARD PYCGWDGKQQ RCSTLEDSSN MSLWTQNITA 610 620 630 640 650 660 CPVRNVTRDG GFGPWSPWQP CEHLDGDNSG SCLCRARSCD SPRPRCGGLD CLGPAIHIAN 670 680 690 700 710 720 CSRNGAWTPW SSWALCSTSC GIGFQVRQRS CSNPAPRHGG RICVGKSREE RFCNENTPCP 730 740 750 760 770 780 VPIFWASWGS WSKCSSNCGG GMQSRRRACE NGNSCLGCGV EFKTCNPEGC PEVRRNTPWT 790 800 810 820 830 840 PWLPVNVTQG GARQEQRFRF TCRAPLADPH GLQFGRRRTE TRTCPADGSG SCDTDALVEV 850 860 870 880 890 900 LLRSGSTSPH TVSGGWAAWG PWSSCSRDCE LGFRVRKRTC TNPEPRNGGL PCVGDAAEYQ 910 920 930 940 950 960 DCNPQACPVR GAWSCWTSWS PCSASCGGGH YQRTRSCTSP APSPEGWSPW SEWSKCTDDG 970 980 990 1000 1010 1020 AQSRSRHCEE LLPGSSACAG NSSQSRPCPY SEIPVILPAS SMEEATDCAG FNLIHLVATG 1030 1040 1050 1060 1070 1080 ISCFLGSGLL TLAVYLSCQH CQRQSQESTL VHPATPNHLH YKGGGTPKNE KYTPMEFKTL 1090 1100 1110 1120 1130 NKNNLIPDDR ANFYPLQQTN VYTTTYYPSP LNKHSFRPEA SPGQRCFPNS
	Isoform 4 [UniParc]. Checksum: 9EA9AB44CC93588D	FASTA	1,205	131,904
	10 20 30 40 50 60 MLHLSAEEAI GCVRVRRSFI DELAFGRGHS TGTGKQKRRD RVSGSSWCLA CVSWMPCGFS 70 80 90 100 110 120 PSPVAHHLVP GPPDTPAQQL RCGWTVGGWL LSLVRGLLPC LPPGARTAEG PIMVLAGPLA 130 140 150 160 170 180 VSLLLPSLTL LVSHLSSSQD VSSEPSSEQQ LCALSKHPTV AFEDLQPWVS NFTYPGARDF 190 200 210 220 230 240 SQLALDPSGN QLIVGARNYL FRLSLANVSL LQATEWASSE DTRRSCQSKG KTEEECQNYV 250 260 270 280 290 300 RVLIVAGRKV FMCGTNAFSP MCTSRQVGNL SRTIEKINGV ARCPYDPRHN STAVISSQGE 310 320 330 340 350 360 LYAATVIDFS GRDPAIYRSL GSGPPLRTAQ YNSKWLNEPN FVAAYDIGLF AYFFLRENAV 370 380 390 400 410 420 EHDCGRTVYS RVARVCKNDV GGRFLLEDTW TTFMKARLNC SRPGEVPFYY NELQSAFHLP 430 440 450 460 470 480 EQDLIYGVFT TNVNSIAASA VCAFNLSAIS QAFNGPFRYQ ENPRAAWLPI ANPIPNFQCG 490 500 510 520 530 540 TLPETGPNEN LTERSLQDAQ RLFLMSEAVQ PVTPEPCVTQ DSVRFSHLVV DLVQAKDTLY 550 560 570 580 590 600 HVLYIGTESG TILKALSTAS RSLHGCYLEE LHVLPPGRRE PLRSLRILHS ARALFVGLRD 610 620 630 640 650 660 GVLRVPLERC AAYRSQGACL GARDPYCGWD GKQQRCSTLE DSSNMSLWTQ NITACPVRNV 670 680 690 700 710 720 TRDGGFGPWS PWQPCEHLDG DNSGSCLCRA RSCDSPRPRC GGLDCLGPAI HIANCSRNGA 730 740 750 760 770 780 WTPWSSWALC STSCGIGFQV RQRSCSNPAP RHGGRICVGK SREERFCNEN TPCPVPIFWA 790 800 810 820 830 840 SWGSWSKCSS NCGGGMQSRR RACENGNSCL GCGVEFKTCN PEGCPEVRRN TPWTPWLPVN 850 860 870 880 890 900 VTQGGARQEQ RFRFTCRAPL ADPHGLQFGR RRTETRTCPA DGSGSCDTDA LVEVLLRSGS 910 920 930 940 950 960 TSPHTVSGGW AAWGPWSSCS RDCELGFRVR KRTCTNPEPR NGGLPCVGDA AEYQDCNPQA 970 980 990 1000 1010 1020 CPVRGAWSCW TSWSPCSASC GGGHYQRTRS CTSPAPSPGE DICLGLHTEE ALCATQACPE 1030 1040 1050 1060 1070 1080 GWSPWSEWSK CTDDGAQSRS RHCEELLPGS SACAGNSSQS RPCPYSEIPV ILPASSMEEA 1090 1100 1110 1120 1130 1140 TDCAGFNLIH LVATGISCFL GSGLLTLAVY LSCQHCQRQS QESTLVHPAT PNHLHYKGGG 1150 1160 1170 1180 1190 1200 TPKNEKYTPM EFKTLNKNNL IPDDRANFYP LQQTNVYTTT YYPSPLNKHS FRPEASPGQR CFPNS

References

[1]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-220; ASP-840 AND GLY-1028. Tissue: Brain.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 935-1151 (ISOFORM 3), VARIANTS THR-220; THR-742; ASP-840 AND GLY-1028. Tissue: Brain and Hippocampus.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-840 AND GLY-1028. Tissue: Ovary.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-42 AND MET-223.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040878 mRNA. Translation: BAA95969.1. Different initiation. AY358124 mRNA. Translation: AAQ88491.1. AK001234 mRNA. Translation: BAA91570.1. Different initiation. AK291407 mRNA. Translation: BAF84096.1. AK295619 mRNA. Translation: BAH12129.1. AC078794 Genomic DNA. No translation available. AC083797 Genomic DNA. No translation available. AC109130 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79457.1. BC077726 mRNA. Translation: AAH77726.1.
IPI	IPI00395376. IPI00788999. IPI00945133. IPI01011436.
RefSeq	NP_001026872.2. NM_001031702.3. NP_001243275.1. NM_001256346.1. NP_001243276.1. NM_001256347.1.
UniGene	Hs.210870.
3D structure databases
ProteinModelPortal	Q9P283.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-8247359.
PTM databases
PhosphoSite	Q9P283.
Polymorphism databases
DMDM	212276522.
Proteomic databases
PaxDb	Q9P283.
PRIDE	Q9P283.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357599; ENSP00000350215; ENSG00000082684. ENST00000451055; ENSP00000389588; ENSG00000082684.
GeneID	54437.
KEGG	hsa:54437.
UCSC	uc003efz.1. human.
Organism-specific databases
CTD	54437.
GeneCards	GC03M122628.
H-InvDB	HIX0020193.
HGNC	HGNC:10737. SEMA5B.
HPA	HPA017084.
MIM	609298. gene.
neXtProt	NX_Q9P283.
PharmGKB	PA35659.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316291.
HOVERGEN	HBG062356.
InParanoid	Q9P283.
KO	K06841.
OMA	DSPRPRC.
OrthoDB	EOG4DJJVN.
Gene expression databases
ArrayExpress	Q9P283.
Bgee	Q9P283.
CleanEx	HS_SEMA5B.
Genevestigator	Q9P283.
GermOnline	ENSG00000082684. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002165. Plexin_repeat. IPR027231. Semaphorin. IPR001627. Semaphorin/CD100_Ag. IPR000884. Thrombospondin_1_rpt. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
PANTHER	PTHR11036. PTHR11036. 1 hit.
Pfam	PF01437. PSI. 1 hit. PF01403. Sema. 1 hit. PF00090. TSP_1. 5 hits. [Graphical view]
SMART	SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. SM00209. TSP1. 5 hits. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit. SSF101912. Sema. 1 hit. SSF82895. TSP1. 6 hits.
PROSITE	PS51004. SEMA. 1 hit. PS50092. TSP1. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54437.
NextBio	56654.
SOURCE	Search...

Entry information

Entry name

SEM5B_HUMAN

Accession

Primary (citable) accession number: Q9P283
Secondary accession number(s): A8K5U2 , B7Z393, F8W9U8, Q6DD89, Q6UY12, Q9NW17

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 4, 2008
Last modified:	May 29, 2013
This is version 102 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.