Q9P278 (FNIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Folliculin-interacting protein 2

Alternative name(s):
FNIP1-like protein
O6-methylguanine-induced apoptosis 1 protein

Gene names

Name:	FNIP2
Synonyms:	FNIPL, KIAA1450, MAPO1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1114 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions By similarity. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Ref.4 Ref.5
Subunit structure	Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via C-terminus). Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase. Ref.4 Ref.5
Subcellular location	Cytoplasm. Note: Co-localizes with FLCN in the cytoplasm. Ref.4 Ref.5 Ref.6
Tissue specificity	Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than in normal kidney. Ref.4 Ref.5
Post-translational modification	Phosphorylated by AMPK. Ref.5
Miscellaneous	Elevated expression levels in histologic variants of renal tumors.
Sequence similarities	Belongs to the FNIP family.
Sequence caution	The sequence AAH07861.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH16638.1 differs from that shown. Reason: Potential poly-A sequence. The sequence BAA95974.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB14338.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	DNA damage
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intrinsic apoptotic signaling pathway in response to DNA damage Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 21209915. Source: UniProtKB positive regulation of peptidyl-serine phosphorylation Inferred from direct assay PubMed 19914239. Source: UniProtKB protein phosphorylation Inferred from direct assay Ref.5. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.4Ref.5Ref.6. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P278-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P278-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MAPTLLQKLFNKRGSSGSSAAASAQGRAPKEGPAF → MCGGTANTTN...RSTDHTELDN

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1114	1114	Folliculin-interacting protein 2		PRO_0000320553
Regions
	Region	544 – 911	368	Interaction with PRKAA1
	Compositional bias	95 – 116	22	Ser-rich
	Compositional bias	242 – 265	24	Ser-rich
Amino acid modifications
	Modified residue	723	1	Phosphoserine Ref.7
	Modified residue	726	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 35	35	MAPTL…EGPAF → MCGGTANTTNQPESWQDSAR CVSDAVPGAGRIYRALLCTK IKKHTGVDRSTDHTELDN in isoform 2.		VSP_031656
	Natural variant	298	1	T → S. Corresponds to variant rs2276938 [ dbSNP | Ensembl ].		VAR_045612

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 8951340C11EE0D5B	FASTA	1,114	122,115
	10 20 30 40 50 60 MAPTLLQKLF NKRGSSGSSA AASAQGRAPK EGPAFSWSCS EFDLNEIRLI VYQDCDRRGR 70 80 90 100 110 120 QVLFDSKAVQ KIEEVTAQKT EDVPIKISAK CCQGSSSVSS SSSSSISSHS SSGGSSHHAK 130 140 150 160 170 180 EQLPKYQYTR PASDVNMLGE MMFGSVAMSY KGSTLKIHYI RSPPQLMISK VFSARMGSFC 190 200 210 220 230 240 GSTNNLQDSF EYINQDPNLG KLNTNQNSLG PCRTGSNLAH STPVDMPSRG QNEDRDSGIA 250 260 270 280 290 300 RSASLSSLLI TPFPSPSSST SSSSSYQRRW LRSQTTSLEN GIIPRRSTDE TFSLAEETCS 310 320 330 340 350 360 SNPAMVRRKK IAISIIFSLC EKEEAQRNFQ DFFFSHFPLF ESHMNRLKSA IEKAMISCRK 370 380 390 400 410 420 IAESSLRVQF YVSRLMEALG EFRGTIWNLY SVPRIAEPVW LTMMSGTLEK NQLCQRFLKE 430 440 450 460 470 480 FTLLIEQINK NQFFAALLTA VLTYHLAWVP TVMPVDHPPI KAFSEKRTSQ SVNMLAKTHP 490 500 510 520 530 540 YNPLWAQLGD LYGAIGSPVR LTRTVVVGKQ KDLVQRILYV LTYFLRCSEL QENQLTWSGN 550 560 570 580 590 600 HGEGDQVLNG SKIITALEKG EVEESEYVVI TVRNEPALVP PILPPTAAER HNPWPTGFPE 610 620 630 640 650 660 CPEGTDSRDL GLKPDKEANR RPEQGSEACS AGCLGPASDA SWKPQNAFCG DEKNKEAPQD 670 680 690 700 710 720 GSSRLPSCEV LGAGMKMDQQ AVCELLKVEM PTRLPDRSVA WPCPDRHLRE KPSLEKVTFQ 730 740 750 760 770 780 IGSFASPESD FESRMKKMEE RVKACGPSLE ASEAADVAQD PQVSRSPFKP GFQENVCCPQ 790 800 810 820 830 840 NRLSEGDEGE SDKGFAEDRG SRNDMAADIA GQLSHAADLG TASHGAGGTG GRRLEATRGL 850 860 870 880 890 900 YVKAAEGPVL EPVAPRCVQR GPGLVAGANI PCGDDNKKAN FRTEGDIPRN ESSDSALGDS 910 920 930 940 950 960 DDEACASAML DLGHGGDRTG GSLEVELPLP RSQSISTQNV RNFGRSLLAG YCPTYMPDLV 970 980 990 1000 1010 1020 LHGTGSDEKL KQCLVADLVH TVHHPVLDEP IAEAVCIIAD TDKWSVQVAT SQRKVTDNMK 1030 1040 1050 1060 1070 1080 LGQDVLVSSQ VSSLLQSILQ LYKLHLPADF CIMHLEDRLQ EMYLKSKMLS EYLRGHTRVH 1090 1100 1110 VKELGVVLGI ESNDLPLLTA IASTHSPYVA QILL
	Isoform 2 [UniParc]. Checksum: EE3CE381023899EC	FASTA	1,137	124,860
	10 20 30 40 50 60 MCGGTANTTN QPESWQDSAR CVSDAVPGAG RIYRALLCTK IKKHTGVDRS TDHTELDNSW 70 80 90 100 110 120 SCSEFDLNEI RLIVYQDCDR RGRQVLFDSK AVQKIEEVTA QKTEDVPIKI SAKCCQGSSS 130 140 150 160 170 180 VSSSSSSSIS SHSSSGGSSH HAKEQLPKYQ YTRPASDVNM LGEMMFGSVA MSYKGSTLKI 190 200 210 220 230 240 HYIRSPPQLM ISKVFSARMG SFCGSTNNLQ DSFEYINQDP NLGKLNTNQN SLGPCRTGSN 250 260 270 280 290 300 LAHSTPVDMP SRGQNEDRDS GIARSASLSS LLITPFPSPS SSTSSSSSYQ RRWLRSQTTS 310 320 330 340 350 360 LENGIIPRRS TDETFSLAEE TCSSNPAMVR RKKIAISIIF SLCEKEEAQR NFQDFFFSHF 370 380 390 400 410 420 PLFESHMNRL KSAIEKAMIS CRKIAESSLR VQFYVSRLME ALGEFRGTIW NLYSVPRIAE 430 440 450 460 470 480 PVWLTMMSGT LEKNQLCQRF LKEFTLLIEQ INKNQFFAAL LTAVLTYHLA WVPTVMPVDH 490 500 510 520 530 540 PPIKAFSEKR TSQSVNMLAK THPYNPLWAQ LGDLYGAIGS PVRLTRTVVV GKQKDLVQRI 550 560 570 580 590 600 LYVLTYFLRC SELQENQLTW SGNHGEGDQV LNGSKIITAL EKGEVEESEY VVITVRNEPA 610 620 630 640 650 660 LVPPILPPTA AERHNPWPTG FPECPEGTDS RDLGLKPDKE ANRRPEQGSE ACSAGCLGPA 670 680 690 700 710 720 SDASWKPQNA FCGDEKNKEA PQDGSSRLPS CEVLGAGMKM DQQAVCELLK VEMPTRLPDR 730 740 750 760 770 780 SVAWPCPDRH LREKPSLEKV TFQIGSFASP ESDFESRMKK MEERVKACGP SLEASEAADV 790 800 810 820 830 840 AQDPQVSRSP FKPGFQENVC CPQNRLSEGD EGESDKGFAE DRGSRNDMAA DIAGQLSHAA 850 860 870 880 890 900 DLGTASHGAG GTGGRRLEAT RGLYVKAAEG PVLEPVAPRC VQRGPGLVAG ANIPCGDDNK 910 920 930 940 950 960 KANFRTEGDI PRNESSDSAL GDSDDEACAS AMLDLGHGGD RTGGSLEVEL PLPRSQSIST 970 980 990 1000 1010 1020 QNVRNFGRSL LAGYCPTYMP DLVLHGTGSD EKLKQCLVAD LVHTVHHPVL DEPIAEAVCI 1030 1040 1050 1060 1070 1080 IADTDKWSVQ VATSQRKVTD NMKLGQDVLV SSQVSSLLQS ILQLYKLHLP ADFCIMHLED 1090 1100 1110 1120 1130 RLQEMYLKSK MLSEYLRGHT RVHVKELGVV LGIESNDLPL LTAIASTHSP YVAQILL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-650 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 787-983 (ISOFORM 1). Tissue: Lymph and Uterus.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 663-1114 (ISOFORM 1).
[4]	"Identification and characterization of a novel folliculin-interacting protein FNIP2." Hasumi H., Baba M., Hong S.-B., Hasumi Y., Huang Y., Yao M., Valera V.A., Linehan W.M., Schmidt L.S. Gene 415:60-67(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, INTERACTION WITH FLCN; PRKAA1; PRKAB1 AND PRKAG1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]	"Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein." Takagi Y., Kobayashi T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., Hino O. Oncogene 27:5339-5347(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FLCN AND PRKAA1, TISSUE SPECIFICITY, PHOSPHORYLATION.
[6]	"A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA." Komori K., Takagi Y., Sanada M., Lim T.H., Nakatsu Y., Tsuzuki T., Sekiguchi M., Hidaka M. Oncogene 28:1142-1150(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-723 AND SER-726, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040883 mRNA. Translation: BAA95974.1. Different initiation. BC007861 mRNA. Translation: AAH07861.1. Different initiation. BC016638 mRNA. Translation: AAH16638.1. Sequence problems. AK022968 mRNA. Translation: BAB14338.1. Different initiation.
IPI	IPI00001790. IPI00885074.
RefSeq	NP_065891.1. NM_020840.1.
UniGene	Hs.652441. Hs.731810.
3D structure databases
ProteinModelPortal	Q9P278.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7298240.
STRING	9606.ENSP00000264433.
PTM databases
PhosphoSite	Q9P278.
Polymorphism databases
DMDM	189035874.
Proteomic databases
PaxDb	Q9P278.
PRIDE	Q9P278.
Protocols and materials databases
DNASU	57600.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264433; ENSP00000264433; ENSG00000052795. ENST00000379346; ENSP00000368651; ENSG00000052795.
GeneID	57600.
KEGG	hsa:57600.
UCSC	uc003iqe.4. human.
Organism-specific databases
CTD	57600.
GeneCards	GC04P159690.
HGNC	HGNC:29280. FNIP2.
HPA	HPA042779.
MIM	612768. gene.
neXtProt	NX_Q9P278.
PharmGKB	PA162388758.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG330489.
HOGENOM	HOG000112624.
HOVERGEN	HBG059425.
InParanoid	Q9P278.
OMA	ENQLTWS.
OrthoDB	EOG42821N.
Gene expression databases
ArrayExpress	Q9P278.
Bgee	Q9P278.
CleanEx	HS_FNIP2.
Genevestigator	Q9P278.
Family and domain databases
InterPro	IPR026156. FNIP_fam. [Graphical view]
PANTHER	PTHR21634. PTHR21634. 1 hit.
PRINTS	PR02073. FOLLICULNIP1.
ProtoNet	Search...
Other
ChiTaRS	FNIP2. human.
GenomeRNAi	57600.
NextBio	64218.
SOURCE	Search...

Entry information

Entry name

FNIP2_HUMAN

Accession

Primary (citable) accession number: Q9P278
Secondary accession number(s): Q05DC3, Q96I31, Q9H994

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.