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Protein

Teneurin-3

Gene

TENM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Differentiation

Enzyme and pathway databases

BioCyciZFISH:G66-32150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Teneurin-3
Short name:
Ten-3
Alternative name(s):
Protein Odd Oz/ten-m homolog 3
Tenascin-M3
Short name:
Ten-m3
Teneurin transmembrane protein 3
Gene namesi
Name:TENM3
Synonyms:KIAA1455, ODZ3, TNM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29944. TENM3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 310CytoplasmicSequence analysisAdd BLAST310
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 2699ExtracellularSequence analysisAdd BLAST2368

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Involvement in diseasei

Microphthalmia, isolated, with coloboma, 9 (MCOPCB9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure).
See also OMIM:615145

Keywords - Diseasei

Microphthalmia

Organism-specific databases

DisGeNETi55714.
MalaCardsiTENM3.
MIMi615145. phenotype.
OpenTargetsiENSG00000218336.
Orphaneti98938. Colobomatous microphthalmia.
PharmGKBiPA134961178.

Polymorphism and mutation databases

BioMutaiTENM3.
DMDMi118573058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595051 – 2699Teneurin-3Add BLAST2699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi380N-linked (GlcNAc...)Sequence analysis1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi518 ↔ 528PROSITE-ProRule annotation
Disulfide bondi522 ↔ 533PROSITE-ProRule annotation
Disulfide bondi535 ↔ 544PROSITE-ProRule annotation
Disulfide bondi553 ↔ 564PROSITE-ProRule annotation
Disulfide bondi566 ↔ 575PROSITE-ProRule annotation
Disulfide bondi582 ↔ 593PROSITE-ProRule annotation
Disulfide bondi587 ↔ 598PROSITE-ProRule annotation
Disulfide bondi600 ↔ 609PROSITE-ProRule annotation
Disulfide bondi614 ↔ 625PROSITE-ProRule annotation
Disulfide bondi619 ↔ 630PROSITE-ProRule annotation
Disulfide bondi632 ↔ 641PROSITE-ProRule annotation
Disulfide bondi652 ↔ 665PROSITE-ProRule annotation
Disulfide bondi667 ↔ 676PROSITE-ProRule annotation
Glycosylationi670N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi681 ↔ 691PROSITE-ProRule annotation
Disulfide bondi685 ↔ 696PROSITE-ProRule annotation
Disulfide bondi698 ↔ 707PROSITE-ProRule annotation
Disulfide bondi712 ↔ 722PROSITE-ProRule annotation
Disulfide bondi716 ↔ 727PROSITE-ProRule annotation
Disulfide bondi729 ↔ 738PROSITE-ProRule annotation
Disulfide bondi743 ↔ 753PROSITE-ProRule annotation
Disulfide bondi747 ↔ 762PROSITE-ProRule annotation
Disulfide bondi764 ↔ 773PROSITE-ProRule annotation
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1
Glycosylationi883N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1202N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1527N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1544N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1640N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1677N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1735N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1820N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1921N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2124N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2264N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2576N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9P273.
MaxQBiQ9P273.
PaxDbiQ9P273.
PeptideAtlasiQ9P273.
PRIDEiQ9P273.

PTM databases

iPTMnetiQ9P273.
PhosphoSitePlusiQ9P273.

Expressioni

Tissue specificityi

Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.2 Publications

Gene expression databases

BgeeiENSG00000218336.
CleanExiHS_ODZ3.
ExpressionAtlasiQ9P273. baseline and differential.
GenevisibleiQ9P273. HS.

Organism-specific databases

HPAiHPA047043.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120836. 9 interactors.
IntActiQ9P273. 4 interactors.
MINTiMINT-1191493.
STRINGi9606.ENSP00000385276.

Structurei

3D structure databases

ProteinModelPortaliQ9P273.
SMRiQ9P273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 309Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST309
Domaini514 – 545EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini546 – 576EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini578 – 610EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini611 – 642EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Domaini644 – 677EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini678 – 709EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Domaini710 – 739EGF-like 7PROSITE-ProRule annotationAdd BLAST30
Domaini740 – 774EGF-like 8PROSITE-ProRule annotationAdd BLAST35
Repeati1200 – 1244NHL 1Add BLAST45
Repeati1270 – 1314NHL 2Add BLAST45
Repeati1331 – 1371NHL 3Add BLAST41
Repeati1402 – 1429NHL 4Add BLAST28
Repeati1458 – 1501NHL 5Add BLAST44
Repeati1511 – 1530YD 1Add BLAST20
Repeati1547 – 1567YD 2Add BLAST21
Repeati1610 – 1629YD 3Add BLAST20
Repeati1630 – 1652YD 4Add BLAST23
Repeati1823 – 1842YD 5Add BLAST20
Repeati1864 – 1882YD 6Add BLAST19
Repeati1883 – 1903YD 7Add BLAST21
Repeati1910 – 1927YD 8Add BLAST18
Repeati1928 – 1949YD 9Add BLAST22
Repeati1950 – 1967YD 10Add BLAST18
Repeati1970 – 1990YD 11Add BLAST21
Repeati1993 – 2013YD 12Add BLAST21
Repeati2021 – 2040YD 13Add BLAST20
Repeati2046 – 2063YD 14Add BLAST18
Repeati2064 – 2090YD 15Add BLAST27
Repeati2092 – 2105YD 16Add BLAST14
Repeati2106 – 2129YD 17Add BLAST24
Repeati2132 – 2152YD 18Add BLAST21
Repeati2153 – 2173YD 19Add BLAST21
Repeati2175 – 2195YD 20Add BLAST21
Repeati2207 – 2227YD 21Add BLAST21
Repeati2229 – 2249YD 22Add BLAST21
Repeati2275 – 2316YD 23Add BLAST42

Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated
Contains 8 EGF-like domains.PROSITE-ProRule annotation
Contains 5 NHL repeats.Curated
Contains 1 teneurin N-terminal domain.PROSITE-ProRule annotation
Contains 23 YD repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4659. Eukaryota.
ENOG410XQQD. LUCA.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ9P273.
OMAiCLDLILW.
OrthoDBiEOG091G02H3.
PhylomeDBiQ9P273.
TreeFamiTF316833.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR022385. Rhs_assc_core.
IPR027689. Ten-3.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR017986. WD40_repeat_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF10. PTHR11219:SF10. 1 hit.
PfamiPF06484. Ten_N. 2 hits.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF50978. SSF50978. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 2 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 4 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVKERRPYC SLTKSRREKE RRYTNSSADN EECRVPTQKS YSSSETLKAF
60 70 80 90 100
DHDSSRLLYG NRVKDLVHRE ADEFTRQGQN FTLRQLGVCE PATRRGLAFC
110 120 130 140 150
AEMGLPHRGY SISAGSDADT ENEAVMSPEH AMRLWGRGVK SGRSSCLSSR
160 170 180 190 200
SNSALTLTDT EHENKSDSEN EQPASNQGQS TLQPLPPSHK QHSAQHHPSI
210 220 230 240 250
TSLNRNSLTN RRNQSPAPPA ALPAELQTTP ESVQLQDSWV LGSNVPLESR
260 270 280 290 300
HFLFKTGTGT TPLFSTATPG YTMASGSVYS PPTRPLPRNT LSRSAFKFKK
310 320 330 340 350
SSKYCSWKCT ALCAVGVSVL LAILLSYFIA MHLFGLNWQL QQTENDTFEN
360 370 380 390 400
GKVNSDTMPT NTVSLPSGDN GKLGGFTQEN NTIDSGELDI GRRAIQEIPP
410 420 430 440 450
GIFWRSQLFI DQPQFLKFNI SLQKDALIGV YGRKGLPPSH TQYDFVELLD
460 470 480 490 500
GSRLIAREQR SLLETERAGR QARSVSLHEA GFIQYLDSGI WHLAFYNDGK
510 520 530 540 550
NAEQVSFNTI VIESVVECPR NCHGNGECVS GTCHCFPGFL GPDCSRAACP
560 570 580 590 600
VLCSGNGQYS KGRCLCFSGW KGTECDVPTT QCIDPQCGGR GICIMGSCAC
610 620 630 640 650
NSGYKGESCE EADCIDPGCS NHGVCIHGEC HCSPGWGGSN CEILKTMCPD
660 670 680 690 700
QCSGHGTYLQ ESGSCTCDPN WTGPDCSNEI CSVDCGSHGV CMGGTCRCEE
710 720 730 740 750
GWTGPACNQR ACHPRCAEHG TCKDGKCECS QGWNGEHCTI EGCPGLCNSN
760 770 780 790 800
GRCTLDQNGW HCVCQPGWRG AGCDVAMETL CTDSKDNEGD GLIDCMDPDC
810 820 830 840 850
CLQSSCQNQP YCRGLPDPQD IISQSLQSPS QQAAKSFYDR ISFLIGSDST
860 870 880 890 900
HVIPGESPFN KSLASVIRGQ VLTADGTPLI GVNVSFFHYP EYGYTITRQD
910 920 930 940 950
GMFDLVANGG ASLTLVFERS PFLTQYHTVW IPWNVFYVMD TLVMKKEEND
960 970 980 990 1000
IPSCDLSGFV RPNPIIVSSP LSTFFRSSPE DSPIIPETQV LHEETTIPGT
1010 1020 1030 1040 1050
DLKLSYLSSR AAGYKSVLKI TMTQSIIPFN LMKVHLMVAV VGRLFQKWFP
1060 1070 1080 1090 1100
ASPNLAYTFI WDKTDAYNQK VYGLSEAVVS VGYEYESCLD LTLWEKRTAI
1110 1120 1130 1140 1150
LQGYELDASN MGGWTLDKHH VLDVQNGILY KGNGENQFIS QQPPVVSSIM
1160 1170 1180 1190 1200
GNGRRRSISC PSCNGQADGN KLLAPVALAC GIDGSLYVGD FNYVRRIFPS
1210 1220 1230 1240 1250
GNVTSVLELS SNPAHRYYLA TDPVTGDLYV SDTNTRRIYR PKSLTGAKDL
1260 1270 1280 1290 1300
TKNAEVVAGT GEQCLPFDEA RCGDGGKAVE ATLMSPKGMA VDKNGLIYFV
1310 1320 1330 1340 1350
DGTMIRKVDQ NGIISTLLGS NDLTSARPLT CDTSMHISQV RLEWPTDLAI
1360 1370 1380 1390 1400
NPMDNSIYVL DNNVVLQITE NRQVRIAAGR PMHCQVPGVE YPVGKHAVQT
1410 1420 1430 1440 1450
TLESATAIAV SYSGVLYITE TDEKKINRIR QVTTDGEISL VAGIPSECDC
1460 1470 1480 1490 1500
KNDANCDCYQ SGDGYAKDAK LSAPSSLAAS PDGTLYIADL GNIRIRAVSK
1510 1520 1530 1540 1550
NKPLLNSMNF YEVASPTDQE LYIFDINGTH QYTVSLVTGD YLYNFSYSND
1560 1570 1580 1590 1600
NDITAVTDSN GNTLRIRRDP NRMPVRVVSP DNQVIWLTIG TNGCLKSMTA
1610 1620 1630 1640 1650
QGLELVLFTY HGNSGLLATK SDETGWTTFF DYDSEGRLTN VTFPTGVVTN
1660 1670 1680 1690 1700
LHGDMDKAIT VDIESSSREE DVSITSNLSS IDSFYTMVQD QLRNSYQIGY
1710 1720 1730 1740 1750
DGSLRIIYAS GLDSHYQTEP HVLAGTANPT VAKRNMTLPG ENGQNLVEWR
1760 1770 1780 1790 1800
FRKEQAQGKV NVFGRKLRVN GRNLLSVDFD RTTKTEKIYD DHRKFLLRIA
1810 1820 1830 1840 1850
YDTSGHPTLW LPSSKLMAVN VTYSSTGQIA SIQRGTTSEK VDYDGQGRIV
1860 1870 1880 1890 1900
SRVFADGKTW SYTYLEKSMV LLLHSQRQYI FEYDMWDRLS AITMPSVARH
1910 1920 1930 1940 1950
TMQTIRSIGY YRNIYNPPES NASIITDYNE EGLLLQTAFL GTSRRVLFKY
1960 1970 1980 1990 2000
RRQTRLSEIL YDSTRVSFTY DETAGVLKTV NLQSDGFICT IRYRQIGPLI
2010 2020 2030 2040 2050
DRQIFRFSED GMVNARFDYS YDNSFRVTSM QGVINETPLP IDLYQFDDIS
2060 2070 2080 2090 2100
GKVEQFGKFG VIYYDINQII STAVMTYTKH FDAHGRIKEI QYEIFRSLMY
2110 2120 2130 2140 2150
WITIQYDNMG RVTKREIKIG PFANTTKYAY EYDVDGQLQT VYLNEKIMWR
2160 2170 2180 2190 2200
YNYDLNGNLH LLNPSNSARL TPLRYDLRDR ITRLGDVQYR LDEDGFLRQR
2210 2220 2230 2240 2250
GTEIFEYSSK GLLTRVYSKG SGWTVIYRYD GLGRRVSSKT SLGQHLQFFY
2260 2270 2280 2290 2300
ADLTYPTRIT HVYNHSSSEI TSLYYDLQGH LFAMEISSGD EFYIASDNTG
2310 2320 2330 2340 2350
TPLAVFSSNG LMLKQIQYTA YGEIYFDSNI DFQLVIGFHG GLYDPLTKLI
2360 2370 2380 2390 2400
HFGERDYDIL AGRWTTPDIE IWKRIGKDPA PFNLYMFRNN NPASKIHDVK
2410 2420 2430 2440 2450
DYITDVNSWL VTFGFHLHNA IPGFPVPKFD LTEPSYELVK SQQWDDIPPI
2460 2470 2480 2490 2500
FGVQQQVARQ AKAFLSLGKM AEVQVSRRRA GGAQSWLWFA TVKSLIGKGV
2510 2520 2530 2540 2550
MLAVSQGRVQ TNVLNIANED CIKVAAVLNN AFYLENLHFT IEGKDTHYFI
2560 2570 2580 2590 2600
KTTTPESDLG TLRLTSGRKA LENGINVTVS QSTTVVNGRT RRFADVEMQF
2610 2620 2630 2640 2650
GALALHVRYG MTLDEEKARI LEQARQRALA RAWAREQQRV RDGEEGARLW
2660 2670 2680 2690
TEGEKRQLLS AGKVQGYDGY YVLSVEQYPE LADSANNIQF LRQSEIGRR
Length:2,699
Mass (Da):300,950
Last modified:October 31, 2006 - v3
Checksum:iB26701AD7D85560F
GO

Sequence cautioni

The sequence BAA91633 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91879 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55138 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti435G → K in AAF28318 (PubMed:10625539).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053796385S → C.Corresponds to variant rs3749509dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131943 Genomic DNA. No translation available.
AC093601 Genomic DNA. No translation available.
AC109353 Genomic DNA. No translation available.
AC105288 Genomic DNA. No translation available.
AC079226 Genomic DNA. No translation available.
AF195420 mRNA. Translation: AAF28318.1.
AB040888 mRNA. Translation: BAA95979.2.
AK001336 mRNA. Translation: BAA91633.1. Different initiation.
AK001748 mRNA. Translation: BAA91879.1. Different initiation.
AK027473 mRNA. Translation: BAB55138.1. Different initiation.
AY736855 Genomic DNA. Translation: AAU84915.1.
CCDSiCCDS47165.1.
RefSeqiNP_001073946.1. NM_001080477.3.
XP_016863882.1. XM_017008393.1.
UniGeneiHs.130438.

Genome annotation databases

EnsembliENST00000511685; ENSP00000424226; ENSG00000218336.
GeneIDi55714.
KEGGihsa:55714.
UCSCiuc003ivd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131943 Genomic DNA. No translation available.
AC093601 Genomic DNA. No translation available.
AC109353 Genomic DNA. No translation available.
AC105288 Genomic DNA. No translation available.
AC079226 Genomic DNA. No translation available.
AF195420 mRNA. Translation: AAF28318.1.
AB040888 mRNA. Translation: BAA95979.2.
AK001336 mRNA. Translation: BAA91633.1. Different initiation.
AK001748 mRNA. Translation: BAA91879.1. Different initiation.
AK027473 mRNA. Translation: BAB55138.1. Different initiation.
AY736855 Genomic DNA. Translation: AAU84915.1.
CCDSiCCDS47165.1.
RefSeqiNP_001073946.1. NM_001080477.3.
XP_016863882.1. XM_017008393.1.
UniGeneiHs.130438.

3D structure databases

ProteinModelPortaliQ9P273.
SMRiQ9P273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120836. 9 interactors.
IntActiQ9P273. 4 interactors.
MINTiMINT-1191493.
STRINGi9606.ENSP00000385276.

PTM databases

iPTMnetiQ9P273.
PhosphoSitePlusiQ9P273.

Polymorphism and mutation databases

BioMutaiTENM3.
DMDMi118573058.

Proteomic databases

EPDiQ9P273.
MaxQBiQ9P273.
PaxDbiQ9P273.
PeptideAtlasiQ9P273.
PRIDEiQ9P273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000511685; ENSP00000424226; ENSG00000218336.
GeneIDi55714.
KEGGihsa:55714.
UCSCiuc003ivd.2. human.

Organism-specific databases

CTDi55714.
DisGeNETi55714.
GeneCardsiTENM3.
H-InvDBHIX0004656.
HGNCiHGNC:29944. TENM3.
HPAiHPA047043.
MalaCardsiTENM3.
MIMi610083. gene.
615145. phenotype.
neXtProtiNX_Q9P273.
OpenTargetsiENSG00000218336.
Orphaneti98938. Colobomatous microphthalmia.
PharmGKBiPA134961178.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4659. Eukaryota.
ENOG410XQQD. LUCA.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ9P273.
OMAiCLDLILW.
OrthoDBiEOG091G02H3.
PhylomeDBiQ9P273.
TreeFamiTF316833.

Enzyme and pathway databases

BioCyciZFISH:G66-32150-MONOMER.

Miscellaneous databases

GenomeRNAii55714.
PROiQ9P273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000218336.
CleanExiHS_ODZ3.
ExpressionAtlasiQ9P273. baseline and differential.
GenevisibleiQ9P273. HS.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR022385. Rhs_assc_core.
IPR027689. Ten-3.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR017986. WD40_repeat_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF10. PTHR11219:SF10. 1 hit.
PfamiPF06484. Ten_N. 2 hits.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF50978. SSF50978. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 2 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 4 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEN3_HUMAN
AccessioniPrimary (citable) accession number: Q9P273
Secondary accession number(s): Q5XUL9
, Q96SY2, Q9NV77, Q9NVW1, Q9NZJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.