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Protein

Probable tRNA methyltransferase 9B

Gene

TRMT9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA methyltransferase 9BCurated
Alternative name(s):
Probable tRNA methyltransferase 9-like protein1 Publication (EC:2.1.1.-)
Gene namesi
Name:TRMT9BImported
Synonyms:C8orf79, KIAA1456, TRM9L1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000250305.8
HGNCiHGNC:26725 TRMT9B
MIMi615666 gene
neXtProtiNX_Q8N9K7
NX_Q9P272

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi57604
OpenTargetsiENSG00000250305
PharmGKBiPA143485343

Polymorphism and mutation databases

BioMutaiHEATR5B
DMDMi269849677

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287921 – 454Probable tRNA methyltransferase 9BAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P272
PeptideAtlasiQ9P272
PRIDEiQ9P272

PTM databases

iPTMnetiQ9P272
PhosphoSitePlusiQ9P272

Expressioni

Tissue specificityi

Down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas.1 Publication

Gene expression databases

BgeeiENSG00000250305
CleanExiHS_C8orf79
ExpressionAtlasiQ9P272 baseline and differential
GenevisibleiQ9P272 HS

Organism-specific databases

HPAiHPA024673

Interactioni

Protein-protein interaction databases

BioGridi121652, 4 interactors
STRINGi9606.ENSP00000432695

Structurei

3D structure databases

ProteinModelPortaliQ9P272
SMRiQ9P272
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410JHV7 Eukaryota
KOG1331 Eukaryota
COG0500 LUCA
ENOG41115D2 LUCA
GeneTreeiENSGT00530000063536
HOGENOMiHOG000113166
HOVERGENiHBG055799
InParanoidiQ9P272
OMAiMRYYHVF
OrthoDBiEOG091G05XA
PhylomeDBiQ9P272

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR029063 SAM-dependent_MTases
IPR032873 Trm9
PANTHERiPTHR13069:SF21 PTHR13069:SF21, 1 hit
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P272-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHEAAQLEK QHVHNVYEST APYFSDLQSK AWPRVRQFLQ EQKPGSLIAD
60 70 80 90 100
IGCGTGKYLK VNSQVHTVGC DYCGPLVEIA RNRGCEAMVC DNLNLPFRDE
110 120 130 140 150
GFDAIISIGV IHHFSTKQRR IRAIKEMARV LVPGGQLMIY VWAMEQKNRH
160 170 180 190 200
FEKQDVLVPW NRALCSQLFS ESSQSGRKRQ CGYPERGHPY HPPCSECSCS
210 220 230 240 250
VCFKEQCGSK RSHSVGYEPA MARTCFANIS KEGEEEYGFY STLGKSFRSW
260 270 280 290 300
FFSRSLDEST LRKQIERVRP LKNTEVWASS TVTVQPSRHS SLDFDHQEPF
310 320 330 340 350
STKGQSLDEE VFVESSSGKH LEWLRAPGTL KHLNGDHQGE MRRNGGGNFL
360 370 380 390 400
DSTNTGVNCV DAGNIEDDNP SASKILRRIS AVDSTDFNPD DTMSVEDPQT
410 420 430 440 450
DVLDSTAFMR YYHVFREGEL CSLLKENVSE LRILSSGNDH GNWCIIAEKK

RGCD
Length:454
Mass (Da):51,299
Last modified:November 24, 2009 - v3
Checksum:i72074CFF852A0331
GO
Isoform 2 (identifier: Q9P272-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-60: CGTGKYLK → NQAASSLT
     61-454: Missing.

Show »
Length:60
Mass (Da):6,768
Checksum:i4E1F72443EB7A233
GO

Sequence cautioni

The sequence BAC04326 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07783293L → F Found in a child with sporadic epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs757023992Ensembl.1
Natural variantiVAR_061378150H → R2 PublicationsCorresponds to variant dbSNP:rs528255Ensembl.1
Natural variantiVAR_061379207C → G2 PublicationsCorresponds to variant dbSNP:rs3739310Ensembl.1
Natural variantiVAR_056243219P → T. Corresponds to variant dbSNP:rs505480Ensembl.1
Natural variantiVAR_056244265I → T. Corresponds to variant dbSNP:rs3739308Ensembl.1
Natural variantiVAR_061380304G → E2 PublicationsCorresponds to variant dbSNP:rs502882Ensembl.1
Natural variantiVAR_056245337H → L. Corresponds to variant dbSNP:rs34995506Ensembl.1
Natural variantiVAR_061381451R → G2 PublicationsCorresponds to variant dbSNP:rs608052Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05937853 – 60CGTGKYLK → NQAASSLT in isoform 2. 8
Alternative sequenceiVSP_05937961 – 454Missing in isoform 2. Add BLAST394

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135352 Genomic DNA No translation available.
AB040889 mRNA Translation: BAA95980.1
BC035082 mRNA No translation available.
AK094299 mRNA Translation: BAC04326.1 Sequence problems.
BC016633 mRNA Translation: AAH16633.2
CCDSiCCDS47808.1 [Q9P272-1]
RefSeqiNP_065895.2, NM_020844.2 [Q9P272-1]
XP_005273643.1, XM_005273586.4 [Q9P272-1]
XP_016869194.1, XM_017013705.1 [Q9P272-1]
XP_016869195.1, XM_017013706.1 [Q9P272-1]
XP_016869196.1, XM_017013707.1 [Q9P272-1]
UniGeneiHs.202521

Genome annotation databases

EnsembliENST00000400069; ENSP00000468715; ENSG00000250305 [Q9P272-3]
ENST00000524591; ENSP00000432695; ENSG00000250305 [Q9P272-1]
ENST00000528753; ENSP00000466330; ENSG00000250305 [Q9P272-3]
GeneIDi57604
KEGGihsa:57604
UCSCiuc010lsq.4 human [Q9P272-1]
uc064kkg.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRM9B_HUMAN
AccessioniPrimary (citable) accession number: Q9P272
Secondary accession number(s): K7EM26, Q8N9K7, Q96AW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 24, 2009
Last modified: May 23, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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