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Protein

Zinc finger protein 492

Gene

ZNF492

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri141 – 16323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 492
Alternative name(s):
Zinc finger protein 115
Gene namesi
Name:ZNF492
Synonyms:KIAA1473, ZNF115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23707. ZNF492.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940205.

Polymorphism and mutation databases

BioMutaiZNF492.
DMDMi148887468.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Zinc finger protein 492PRO_0000047615Add
BLAST

Proteomic databases

PaxDbiQ9P255.
PRIDEiQ9P255.

PTM databases

iPTMnetiQ9P255.
PhosphoSiteiQ9P255.

Expressioni

Gene expression databases

BgeeiQ9P255.
CleanExiHS_ZNF492.
GenevisibleiQ9P255. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000413660.

Structurei

3D structure databases

ProteinModelPortaliQ9P255.
SMRiQ9P255. Positions 111-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4343KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri141 – 16323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9P255.
KOiK09228.
OMAiAFSQCSY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9P255.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENYRNLVF VGIAASKPDL ITCLEQGKEP WNVKRHEMVA EPPVVCSYFA
60 70 80 90 100
RDLWPKQGKK NYFQKVILRR YKKCGCENLQ LRKYCKSMDE CKVHKECYNG
110 120 130 140 150
LNQCLTTTQN KIFQCDKYVK VFHKFSNSNR HTIRHTGKKS FKCKECEKSF
160 170 180 190 200
CMLSHLAQHK RIHSGEKPYK CKECGKAYNE TSNLSTHKRI HTGKKPYKCE
210 220 230 240 250
ECGKAFNRLS HLTTHKIIHT GKKPYKCEEC GKAFNQSANL TTHKRIHTGE
260 270 280 290 300
KPYKCEECGR AFSQSSTLTA HKIIHAGEKP YKCEECGKAF SQSSTLTTHK
310 320 330 340 350
IIHTGEKFYK CEECGKAFSQ LSHLTTHKRI HSGEKPYKCE ECGKAFKQSS
360 370 380 390 400
TLTTHKRIHA GEKFYKCEVC SKAFSRFSHL TTHKRIHTGE KPYKCEECGK
410 420 430 440 450
AFNLSSQLTT HKIIHTGEKP YKCEECGKAF NQSSTLSKHK VIHTGEKPYK
460 470 480 490 500
YEECGKAFNQ SSHLTTHKMI HTGEKPYKCE ECGKAFNNSS ILNRHKMIHT
510 520 530
GEKLYKPESC NNACDNIAKI SKYKRNCAGE K
Length:531
Mass (Da):61,158
Last modified:June 12, 2007 - v2
Checksum:iDF36DD14AD8570FD
GO

Sequence cautioni

The sequence BAA95997.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061T → K.
Corresponds to variant rs11672238 [ dbSNP | Ensembl ].
VAR_052845

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040906 mRNA. Translation: BAA95997.1. Different initiation.
BC110575 mRNA. No translation available.
CCDSiCCDS46032.1.
RefSeqiNP_065906.1. NM_020855.2.
UniGeneiHs.232108.

Genome annotation databases

EnsembliENST00000456783; ENSP00000413660; ENSG00000229676.
GeneIDi57615.
KEGGihsa:57615.
UCSCiuc002nqw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040906 mRNA. Translation: BAA95997.1. Different initiation.
BC110575 mRNA. No translation available.
CCDSiCCDS46032.1.
RefSeqiNP_065906.1. NM_020855.2.
UniGeneiHs.232108.

3D structure databases

ProteinModelPortaliQ9P255.
SMRiQ9P255. Positions 111-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000413660.

PTM databases

iPTMnetiQ9P255.
PhosphoSiteiQ9P255.

Polymorphism and mutation databases

BioMutaiZNF492.
DMDMi148887468.

Proteomic databases

PaxDbiQ9P255.
PRIDEiQ9P255.

Protocols and materials databases

DNASUi57615.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456783; ENSP00000413660; ENSG00000229676.
GeneIDi57615.
KEGGihsa:57615.
UCSCiuc002nqw.3. human.

Organism-specific databases

CTDi57615.
GeneCardsiZNF492.
HGNCiHGNC:23707. ZNF492.
neXtProtiNX_Q9P255.
PharmGKBiPA134940205.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9P255.
KOiK09228.
OMAiAFSQCSY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9P255.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii57615.
PROiQ9P255.

Gene expression databases

BgeeiQ9P255.
CleanExiHS_ZNF492.
GenevisibleiQ9P255. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZN492_HUMAN
AccessioniPrimary (citable) accession number: Q9P255
Secondary accession number(s): Q08EI7, Q08EI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 12, 2007
Last modified: June 8, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.