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Protein

Leucine-rich repeat and fibronectin type III domain-containing protein 1

Gene

LRFN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8849932. Synaptic adhesion-like molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and fibronectin type III domain-containing protein 1
Alternative name(s):
Synaptic adhesion-like molecule 2
Gene namesi
Name:LRFN1
Synonyms:KIAA1484, SALM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000128011.4.
HGNCiHGNC:29290. LRFN1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 536ExtracellularSequence analysisAdd BLAST505
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 771CytoplasmicSequence analysisAdd BLAST214

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128011.
PharmGKBiPA134871732.

Polymorphism and mutation databases

BioMutaiLRFN1.
DMDMi189028858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000033414532 – 771Leucine-rich repeat and fibronectin type III domain-containing protein 1Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi321 ↔ 370PROSITE-ProRule annotation
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei613PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9P244.
MaxQBiQ9P244.
PaxDbiQ9P244.
PeptideAtlasiQ9P244.
PRIDEiQ9P244.

PTM databases

iPTMnetiQ9P244.
PhosphoSitePlusiQ9P244.

Expressioni

Gene expression databases

BgeeiENSG00000128011.
CleanExiHS_LRFN1.
GenevisibleiQ9P244. HS.

Interactioni

Subunit structurei

Can form heteromeric complexes with LRFN2, LRFN3, LRFN4 and LRFN5 (By similarity). Forms homomeric complexes, but not across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4. Interacts with 2 AMPA receptor subunits GRIA1 and GRIA2 and NMDA receptor subunit GRIN1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi121668. 91 interactors.
IntActiQ9P244. 1 interactor.
MINTiMINT-8247594.
STRINGi9606.ENSP00000248668.

Structurei

3D structure databases

ProteinModelPortaliQ9P244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 65LRRNTAdd BLAST34
Repeati66 – 87LRR 1Add BLAST22
Repeati90 – 111LRR 2Add BLAST22
Repeati114 – 135LRR 3Add BLAST22
Repeati138 – 159LRR 4Add BLAST22
Repeati163 – 184LRR 5Add BLAST22
Repeati187 – 208LRR 6Add BLAST22
Repeati211 – 232LRR 7Add BLAST22
Domaini252 – 298LRRCTAdd BLAST47
Domaini299 – 386Ig-likeAdd BLAST88
Domaini424 – 520Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi768 – 771PDZ-binding4

Domaini

The PDZ-binding motif is required for neurite outgrowth promotion and for DLG1-, DLG3- and DLG4-binding.By similarity

Sequence similaritiesi

Belongs to the LRFN family.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000237343.
HOVERGENiHBG052352.
InParanoidiQ9P244.
KOiK16354.
OMAiCPGRCIC.
OrthoDBiEOG091G0360.
PhylomeDBiQ9P244.
TreeFamiTF350185.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
PfamiView protein in Pfam
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF13855. LRR_8. 2 hits.
SMARTiView protein in SMART
SM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGPFSSAL LSPPPAALPF LLLLWAGASR GQPCPGRCIC QNVAPTLTML
60 70 80 90 100
CAKTGLLFVP PAIDRRVVEL RLTDNFIAAV RRRDFANMTS LVHLTLSRNT
110 120 130 140 150
IGQVAAGAFA DLRALRALHL DSNRLAEVRG DQLRGLGNLR HLILGNNQIR
160 170 180 190 200
RVESAAFDAF LSTVEDLDLS YNNLEALPWE AVGQMVNLNT LTLDHNLIDH
210 220 230 240 250
IAEGTFVQLH KLVRLDMTSN RLHKLPPDGL FLRSQGTGPK PPTPLTVSFG
260 270 280 290 300
GNPLHCNCEL LWLRRLTRED DLETCATPEH LTDRYFWSIP EEEFLCEPPL
310 320 330 340 350
ITRQAGGRAL VVEGQAVSLR CRAVGDPEPV VHWVAPDGRL LGNSSRTRVR
360 370 380 390 400
GDGTLDVTIT TLRDSGTFTC IASNAAGEAT APVEVCVVPL PLMAPPPAAP
410 420 430 440 450
PPLTEPGSSD IATPGRPGAN DSAAERRLVA AELTSNSVLI RWPAQRPVPG
460 470 480 490 500
IRMYQVQYNS SVDDSLVYRM IPSTSQTFLV NDLAAGRAYD LCVLAVYDDG
510 520 530 540 550
ATALPATRVV GCVQFTTAGD PAPCRPLRAH FLGGTMIIAI GGVIVASVLV
560 570 580 590 600
FIVLLMIRYK VYGDGDSRRV KGSRSLPRVS HVCSQTNGAG TGAAQAPALP
610 620 630 640 650
AQDHYEALRE VESQAAPAVA VEAKAMEAET ASAEPEVVLG RSLGGSATSL
660 670 680 690 700
CLLPSEETSG EESRAAVGPR RSRSGALEPP TSAPPTLALV PGGAAARPRP
710 720 730 740 750
QQRYSFDGDY GALFQSHSYP RRARRTKRHR STPHLDGAGG GAAGEDGDLG
760 770
LGSARACLAF TSTEWMLEST V
Length:771
Mass (Da):82,318
Last modified:May 20, 2008 - v2
Checksum:i9B8D0CD3F1E7B9FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011445 Genomic DNA. No translation available.
AB040917 mRNA. Translation: BAA96008.1.
BC025310 mRNA. Translation: AAH25310.1.
CCDSiCCDS46071.1.
RefSeqiNP_065913.1. NM_020862.1.
XP_005259159.1. XM_005259102.4.
XP_016882522.1. XM_017027033.1.
UniGeneiHs.97860.

Genome annotation databases

EnsembliENST00000248668; ENSP00000248668; ENSG00000128011.
GeneIDi57622.
KEGGihsa:57622.
UCSCiuc002okw.3. human.

Similar proteinsi

Entry informationi

Entry nameiLRFN1_HUMAN
AccessioniPrimary (citable) accession number: Q9P244
Secondary accession number(s): Q8TBS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 22, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families