Q9P243 (ZFAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein ZFAT

Alternative name(s):
Zinc finger gene in AITD susceptibility region
Zinc finger protein 406

Gene names

Name:	ZFAT
Synonyms:	KIAA1485, ZFAT1, ZNF406

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1243 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm › cytosol By similarity.
Tissue specificity	Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes. Ref.1
Sequence similarities	Contains 19 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hematopoietic progenitor cell differentiation Inferred from electronic annotation. Source: Compara spongiotrophoblast layer development Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P243-1)

Also known as: ZFAT-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P243-2)

Also known as: ZFAT-2; ZFAT-3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Isoform 3 (identifier: Q9P243-3)

Also known as: TR-ZFAT;

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.
     826-858: DKRSYSCPVCEKSFSEDRLIKSHIKTNHPEVSM → VSSKPKRQPRLPWVLIAFSSLCLYVGVSAAGQP
     859-1243: Missing.

Isoform 4 (identifier: Q9P243-4)

The sequence of this isoform differs from the canonical sequence as follows:
     150-211: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1243

1243

Zinc finger protein ZFAT

PRO_0000047566

Regions

Zinc finger

12 – 35

24

C2H2-type 1

Zinc finger

116 – 141

26

C2H2-type 2; degenerate

Zinc finger

271 – 293

23

C2H2-type 3

Zinc finger

299 – 321

23

C2H2-type 4

Zinc finger

326 – 349

24

C2H2-type 5

Zinc finger

354 – 377

24

C2H2-type 6

Zinc finger

404 – 426

23

C2H2-type 7

Zinc finger

432 – 454

23

C2H2-type 8

Zinc finger

458 – 481

24

C2H2-type 9

Zinc finger

742 – 764

23

C2H2-type 10

Zinc finger

770 – 793

24

C2H2-type 11

Zinc finger

798 – 822

25

C2H2-type 12

Zinc finger

830 – 853

24

C2H2-type 13

Zinc finger

880 – 903

24

C2H2-type 14; degenerate

Zinc finger

909 – 931

23

C2H2-type 15

Zinc finger

937 – 959

23

C2H2-type 16

Zinc finger

966 – 988

23

C2H2-type 17

Zinc finger

994 – 1017

24

C2H2-type 18

Zinc finger

1041 – 1064

24

C2H2-type 19

Natural variations

Alternative sequence

1 – 12

12

Missing in isoform 2 and isoform 3.

VSP_016959

Alternative sequence

150 – 211

62

Missing in isoform 4.

VSP_045461

Alternative sequence

826 – 858

33

DKRSY…PEVSM → VSSKPKRQPRLPWVLIAFSS LCLYVGVSAAGQP in isoform 3.

VSP_034938

Alternative sequence

859 – 1243

385

Missing in isoform 3.

VSP_034939

Natural variant

64

1

G → R. Ref.1 Ref.3
Corresponds to variant rs17778003 [ dbSNP | Ensembl ].

VAR_024840

Natural variant

102

1

P → S. Ref.1
Corresponds to variant rs12541381 [ dbSNP | Ensembl ].

VAR_045815

Natural variant

672

1

R → K.
Corresponds to variant rs35003767 [ dbSNP | Ensembl ].

VAR_052819

Secondary structure

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1243

Helix Strand Turn

Details...

Turn

274 – 276

3

Beta strand

279 – 282

4

Helix

283 – 293

11

Beta strand

298 – 300

3

Beta strand

302 – 305

4

Beta strand

307 – 310

4

Helix

311 – 321

11

Turn

357 – 359

3

Helix

366 – 375

10

Beta strand

407 – 409

3

Beta strand

412 – 415

4

Helix

416 – 423

8

Turn

424 – 426

3

Beta strand

769 – 771

3

Beta strand

773 – 776

4

Beta strand

778 – 780

3

Helix

782 – 792

11

Beta strand

801 – 804

4

Beta strand

808 – 810

3

Helix

812 – 822

11

Turn

833 – 836

4

Helix

842 – 852

11

Beta strand

883 – 886

4

Helix

894 – 904

11

Beta strand

908 – 910

3

Beta strand

912 – 915

4

Beta strand

917 – 919

3

Helix

921 – 930

10

Turn

940 – 942

3

Helix

949 – 959

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ZFAT-1) [UniParc]. Last modified January 10, 2006. Version 2. Checksum: AF3E5339ED38D91C	FASTA	1,243	139,034
	10 20 30 40 50 60 METRAAENTA IFMCKCCNLF SPNQSELLSH VSEKHMEEGV NVDEIIIPLR PLSTPEPPNS 70 80 90 100 110 120 SKTGDEFLVM KRKRGRPKGS TKKSSTEEEL AENIVSPTED SPLAPEEGNS LPPSSLECSK 130 140 150 160 170 180 CCRKFSNTRQ LRKHICIIVL NLGEEEGEAG NESDLELEKK CKEDDREKAS KRPRSQKTEK 190 200 210 220 230 240 VQKISGKEAR QLSGAKKPII SVVLTAHEAI PGATKIVPVE AGPPETGATN SETTSADLVP 250 260 270 280 290 300 RRGYQEYAIQ QTPYEQPMKS SRLGPTQLKI FTCEYCNKVF KFKHSLQAHL RIHTNEKPYK 310 320 330 340 350 360 CPQCSYASAI KANLNVHLRK HTGEKFACDY CSFTCLSKGH LKVHIERVHK KIKQHCRFCK 370 380 390 400 410 420 KKYSDVKNLI KHIRDAHDPQ DKKVKEALDE LCLMTREGKR QLLYDCHICE RKFKNELDRD 430 440 450 460 470 480 RHMLVHGDKW PFACELCGHG ATKYQALELH VRKHPFVYVC AVCRKKFVSS IRLRTHIKEV 490 500 510 520 530 540 HGAAQEALVF TSSINQSFCL LEPGGDIQQE ALGDQLQLVE EEFALQGVNA LKEEACPGDT 550 560 570 580 590 600 QLEEGRKEPE APGEMPAPAV HLASPQAEST ALPPCELETT VVSSSDLHSQ EVVSDDFLLK 610 620 630 640 650 660 NDTSSAEAHA APEKPPDMQH RSSVQTQGEV ITLLLSKAQS AGSDQESHGA QSPLGEGQNM 670 680 690 700 710 720 AVLSAGDPDP SRCLRSNPAE ASDLLPPVAG GGDTITHQPD SCKAAPEHRS GITAFMKVLN 730 740 750 760 770 780 SLQKKQMNTS LCERIRKVYG DLECEYCGKL FWYQVHFDMH VRTHTREHLY YCSQCHYSSI 790 800 810 820 830 840 TKNCLKRHVI QKHSNILLKC PTDGCDYSTP DKYKLQAHLK VHTALDKRSY SCPVCEKSFS 850 860 870 880 890 900 EDRLIKSHIK TNHPEVSMST ISEVLGRRVQ LKGLIGKRAM KCPYCDFYFM KNGSDLQRHI 910 920 930 940 950 960 WAHEGVKPFK CSLCEYATRS KSNLKAHMNR HSTEKTHLCD MCGKKFKSKG TLKSHKLLHT 970 980 990 1000 1010 1020 ADGKQFKCTV CDYTAAQKPQ LLRHMEQHVS FKPFRCAHCH YSCNISGSLK RHYNRKHPNE 1030 1040 1050 1060 1070 1080 EYANVGTGEL AAEVLIQQGG LKCPVCSFVY GTKWEFNRHL KNKHGLKVVE IDGDPKWETA 1090 1100 1110 1120 1130 1140 TEAPEEPSTQ YLHITEAEED VQGTQAAVAA LQDLRYTSES GDRLDPTAVN ILQQIIELGA 1150 1160 1170 1180 1190 1200 ETHDATALAS VVAMAPGTVT VVKQVTEEEP SSNHTVMIQE TVQQASVELA EQHHLVVSSD 1210 1220 1230 1240 DVEGIETVTV YTQGGEASEF IVYVQEAMQP VEEQAVEQPA QEL
	Isoform 2 (ZFAT-2) (ZFAT-3) [UniParc]. Checksum: C4BA114EEC3AF2A6	FASTA	1,231	137,698
	10 20 30 40 50 60 MCKCCNLFSP NQSELLSHVS EKHMEEGVNV DEIIIPLRPL STPEPPNSSK TGDEFLVMKR 70 80 90 100 110 120 KRGRPKGSTK KSSTEEELAE NIVSPTEDSP LAPEEGNSLP PSSLECSKCC RKFSNTRQLR 130 140 150 160 170 180 KHICIIVLNL GEEEGEAGNE SDLELEKKCK EDDREKASKR PRSQKTEKVQ KISGKEARQL 190 200 210 220 230 240 SGAKKPIISV VLTAHEAIPG ATKIVPVEAG PPETGATNSE TTSADLVPRR GYQEYAIQQT 250 260 270 280 290 300 PYEQPMKSSR LGPTQLKIFT CEYCNKVFKF KHSLQAHLRI HTNEKPYKCP QCSYASAIKA 310 320 330 340 350 360 NLNVHLRKHT GEKFACDYCS FTCLSKGHLK VHIERVHKKI KQHCRFCKKK YSDVKNLIKH 370 380 390 400 410 420 IRDAHDPQDK KVKEALDELC LMTREGKRQL LYDCHICERK FKNELDRDRH MLVHGDKWPF 430 440 450 460 470 480 ACELCGHGAT KYQALELHVR KHPFVYVCAV CRKKFVSSIR LRTHIKEVHG AAQEALVFTS 490 500 510 520 530 540 SINQSFCLLE PGGDIQQEAL GDQLQLVEEE FALQGVNALK EEACPGDTQL EEGRKEPEAP 550 560 570 580 590 600 GEMPAPAVHL ASPQAESTAL PPCELETTVV SSSDLHSQEV VSDDFLLKND TSSAEAHAAP 610 620 630 640 650 660 EKPPDMQHRS SVQTQGEVIT LLLSKAQSAG SDQESHGAQS PLGEGQNMAV LSAGDPDPSR 670 680 690 700 710 720 CLRSNPAEAS DLLPPVAGGG DTITHQPDSC KAAPEHRSGI TAFMKVLNSL QKKQMNTSLC 730 740 750 760 770 780 ERIRKVYGDL ECEYCGKLFW YQVHFDMHVR THTREHLYYC SQCHYSSITK NCLKRHVIQK 790 800 810 820 830 840 HSNILLKCPT DGCDYSTPDK YKLQAHLKVH TALDKRSYSC PVCEKSFSED RLIKSHIKTN 850 860 870 880 890 900 HPEVSMSTIS EVLGRRVQLK GLIGKRAMKC PYCDFYFMKN GSDLQRHIWA HEGVKPFKCS 910 920 930 940 950 960 LCEYATRSKS NLKAHMNRHS TEKTHLCDMC GKKFKSKGTL KSHKLLHTAD GKQFKCTVCD 970 980 990 1000 1010 1020 YTAAQKPQLL RHMEQHVSFK PFRCAHCHYS CNISGSLKRH YNRKHPNEEY ANVGTGELAA 1030 1040 1050 1060 1070 1080 EVLIQQGGLK CPVCSFVYGT KWEFNRHLKN KHGLKVVEID GDPKWETATE APEEPSTQYL 1090 1100 1110 1120 1130 1140 HITEAEEDVQ GTQAAVAALQ DLRYTSESGD RLDPTAVNIL QQIIELGAET HDATALASVV 1150 1160 1170 1180 1190 1200 AMAPGTVTVV KQVTEEEPSS NHTVMIQETV QQASVELAEQ HHLVVSSDDV EGIETVTVYT 1210 1220 1230 QGGEASEFIV YVQEAMQPVE EQAVEQPAQE L
	Isoform 3 (TR-ZFAT) [UniParc]. Checksum: DD3B6FD75DEEF958	FASTA	846	94,437
	10 20 30 40 50 60 MCKCCNLFSP NQSELLSHVS EKHMEEGVNV DEIIIPLRPL STPEPPNSSK TGDEFLVMKR 70 80 90 100 110 120 KRGRPKGSTK KSSTEEELAE NIVSPTEDSP LAPEEGNSLP PSSLECSKCC RKFSNTRQLR 130 140 150 160 170 180 KHICIIVLNL GEEEGEAGNE SDLELEKKCK EDDREKASKR PRSQKTEKVQ KISGKEARQL 190 200 210 220 230 240 SGAKKPIISV VLTAHEAIPG ATKIVPVEAG PPETGATNSE TTSADLVPRR GYQEYAIQQT 250 260 270 280 290 300 PYEQPMKSSR LGPTQLKIFT CEYCNKVFKF KHSLQAHLRI HTNEKPYKCP QCSYASAIKA 310 320 330 340 350 360 NLNVHLRKHT GEKFACDYCS FTCLSKGHLK VHIERVHKKI KQHCRFCKKK YSDVKNLIKH 370 380 390 400 410 420 IRDAHDPQDK KVKEALDELC LMTREGKRQL LYDCHICERK FKNELDRDRH MLVHGDKWPF 430 440 450 460 470 480 ACELCGHGAT KYQALELHVR KHPFVYVCAV CRKKFVSSIR LRTHIKEVHG AAQEALVFTS 490 500 510 520 530 540 SINQSFCLLE PGGDIQQEAL GDQLQLVEEE FALQGVNALK EEACPGDTQL EEGRKEPEAP 550 560 570 580 590 600 GEMPAPAVHL ASPQAESTAL PPCELETTVV SSSDLHSQEV VSDDFLLKND TSSAEAHAAP 610 620 630 640 650 660 EKPPDMQHRS SVQTQGEVIT LLLSKAQSAG SDQESHGAQS PLGEGQNMAV LSAGDPDPSR 670 680 690 700 710 720 CLRSNPAEAS DLLPPVAGGG DTITHQPDSC KAAPEHRSGI TAFMKVLNSL QKKQMNTSLC 730 740 750 760 770 780 ERIRKVYGDL ECEYCGKLFW YQVHFDMHVR THTREHLYYC SQCHYSSITK NCLKRHVIQK 790 800 810 820 830 840 HSNILLKCPT DGCDYSTPDK YKLQAHLKVH TALVSSKPKR QPRLPWVLIA FSSLCLYVGV SAAGQP
	Isoform 4 [UniParc]. Checksum: 8CC03D90ACB3DD3B	FASTA	1,181	132,137
	10 20 30 40 50 60 METRAAENTA IFMCKCCNLF SPNQSELLSH VSEKHMEEGV NVDEIIIPLR PLSTPEPPNS 70 80 90 100 110 120 SKTGDEFLVM KRKRGRPKGS TKKSSTEEEL AENIVSPTED SPLAPEEGNS LPPSSLECSK 130 140 150 160 170 180 CCRKFSNTRQ LRKHICIIVL NLGEEEGEAG ATKIVPVEAG PPETGATNSE TTSADLVPRR 190 200 210 220 230 240 GYQEYAIQQT PYEQPMKSSR LGPTQLKIFT CEYCNKVFKF KHSLQAHLRI HTNEKPYKCP 250 260 270 280 290 300 QCSYASAIKA NLNVHLRKHT GEKFACDYCS FTCLSKGHLK VHIERVHKKI KQHCRFCKKK 310 320 330 340 350 360 YSDVKNLIKH IRDAHDPQDK KVKEALDELC LMTREGKRQL LYDCHICERK FKNELDRDRH 370 380 390 400 410 420 MLVHGDKWPF ACELCGHGAT KYQALELHVR KHPFVYVCAV CRKKFVSSIR LRTHIKEVHG 430 440 450 460 470 480 AAQEALVFTS SINQSFCLLE PGGDIQQEAL GDQLQLVEEE FALQGVNALK EEACPGDTQL 490 500 510 520 530 540 EEGRKEPEAP GEMPAPAVHL ASPQAESTAL PPCELETTVV SSSDLHSQEV VSDDFLLKND 550 560 570 580 590 600 TSSAEAHAAP EKPPDMQHRS SVQTQGEVIT LLLSKAQSAG SDQESHGAQS PLGEGQNMAV 610 620 630 640 650 660 LSAGDPDPSR CLRSNPAEAS DLLPPVAGGG DTITHQPDSC KAAPEHRSGI TAFMKVLNSL 670 680 690 700 710 720 QKKQMNTSLC ERIRKVYGDL ECEYCGKLFW YQVHFDMHVR THTREHLYYC SQCHYSSITK 730 740 750 760 770 780 NCLKRHVIQK HSNILLKCPT DGCDYSTPDK YKLQAHLKVH TALDKRSYSC PVCEKSFSED 790 800 810 820 830 840 RLIKSHIKTN HPEVSMSTIS EVLGRRVQLK GLIGKRAMKC PYCDFYFMKN GSDLQRHIWA 850 860 870 880 890 900 HEGVKPFKCS LCEYATRSKS NLKAHMNRHS TEKTHLCDMC GKKFKSKGTL KSHKLLHTAD 910 920 930 940 950 960 GKQFKCTVCD YTAAQKPQLL RHMEQHVSFK PFRCAHCHYS CNISGSLKRH YNRKHPNEEY 970 980 990 1000 1010 1020 ANVGTGELAA EVLIQQGGLK CPVCSFVYGT KWEFNRHLKN KHGLKVVEID GDPKWETATE 1030 1040 1050 1060 1070 1080 APEEPSTQYL HITEAEEDVQ GTQAAVAALQ DLRYTSESGD RLDPTAVNIL QQIIELGAET 1090 1100 1110 1120 1130 1140 HDATALASVV AMAPGTVTVV KQVTEEEPSS NHTVMIQETV QQASVELAEQ HHLVVSSDDV 1150 1160 1170 1180 EGIETVTVYT QGGEASEFIV YVQEAMQPVE EQAVEQPAQE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease." Shirasawa S., Harada H., Furugaki K., Akamizu T., Ishikawa N., Ito K., Ito K., Tamai H., Kuma K., Kubota S., Hiratani H., Tsuchiya T., Baba I., Ishikawa M., Tanaka M., Sakai K., Aoki M., Yamamoto K., Sasazuki T. Hum. Mol. Genet. 13:2221-2231(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, VARIANTS ARG-64 AND SER-102.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANTS ARG-64 AND SER_102. Tissue: Brain, Placenta and Skin.
[4]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-1243 (ISOFORM 1). Tissue: Brain.
[5]	RIKEN structural genomics initiative (RSGI) Submitted (MAR-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 269-325; 352-381; 398-430; 768-826; 828-857 AND 878-963.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB167738 mRNA. Translation: BAD12567.1.
AB167739 mRNA. Translation: BAD12568.1.
AB167740 mRNA. Translation: BAD12569.1.
AB167741 mRNA. Translation: BAD12570.1.
AC015599 Genomic DNA. No translation available.
AC087045 Genomic DNA. No translation available.
AC135075 Genomic DNA. No translation available.
BC025423 mRNA. Translation: AAH25423.1.
BC046180 mRNA. Translation: AAH46180.1.
BC101766 mRNA. Translation: AAI01767.1.
BC101768 mRNA. Translation: AAI01769.1.
BC143519 mRNA. Translation: AAI43520.1.
AB040918 mRNA. Translation: BAA96009.1.

IPI

IPI00418220.
IPI00657655.
IPI00956293.
IPI00982757.

RefSeq

NP_001025110.2. NM_001029939.3.
NP_001167628.1. NM_001174157.1.
NP_065914.2. NM_020863.3.

UniGene

Hs.446172.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ELM	NMR	-	A	768-797	[»]
2ELN	NMR	-	A	796-826	[»]
2ELO	NMR	-	A	828-857	[»]
2ELP	NMR	-	A	878-907	[»]
2ELQ	NMR	-	A	907-935	[»]
2ELR	NMR	-	A	935-963	[»]
2ELS	NMR	-	A	269-297	[»]
2ELT	NMR	-	A	297-325	[»]
2ELU	NMR	-	A	352-381	[»]
2ELV	NMR	-	A	402-430	[»]
2RSH	NMR	-	A	324-353	[»]
2RSI	NMR	-	A	297-381	[»]
2RSJ	NMR	-	A	269-353	[»]

ProteinModelPortal

Q9P243.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9P243. 2 interactions.

STRING

9606.ENSP00000367069.

PTM databases

PhosphoSite

Q9P243.

Polymorphism databases

DMDM

85681862.

Proteomic databases

PaxDb

Q9P243.

PRIDE

Q9P243.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000377838; ENSP00000367069; ENSG00000066827.
ENST00000520214; ENSP00000428483; ENSG00000066827.
ENST00000520727; ENSP00000427831; ENSG00000066827.
ENST00000523399; ENSP00000429091; ENSG00000066827.

GeneID

57623.

KEGG

hsa:57623.

UCSC

uc003yun.3. human.
uc003yur.3. human.

Organism-specific databases

CTD

57623.

GeneCards

GC08M135561.

HGNC

HGNC:19899. ZFAT.

HPA

HPA020989.

MIM

610931. gene.

neXtProt

NX_Q9P243.

PharmGKB

PA162409638.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5048.

HOVERGEN

HBG065928.

InParanoid

Q9P243.

OMA

GHLKVHV.

OrthoDB

EOG49ZXNF.

PhylomeDB

Q9P243.

Gene expression databases

ArrayExpress

Q9P243.

Bgee

Q9P243.

CleanEx

HS_ZFAT.

Genevestigator

Q9P243.

GermOnline

ENSG00000066827. Homo sapiens.

Family and domain databases

Gene3D

3.30.160.60. 8 hits.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 19 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

ProtoNet

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Other

ChiTaRS

ZFAT. human.

EvolutionaryTrace

Q9P243.

GenomeRNAi

57623.

NextBio

64310.

SOURCE

Search...

Entry information

Entry name

ZFAT_HUMAN

Accession

Primary (citable) accession number: Q9P243
Secondary accession number(s): B7ZL15 , E9PER3, Q3MIM5, Q6PJ01, Q75PJ6, Q75PJ7, Q75PJ9, Q86X64

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.