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Protein

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Gene

NYAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene namesi
Name:NYAP2
Synonyms:KIAA1486
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29291. NYAP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165696738.

Polymorphism and mutation databases

BioMutaiNYAP2.
DMDMi296439320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2PRO_0000325830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201PhosphoserineBy similarity
Modified residuei206 – 2061PhosphoserineBy similarity
Modified residuei268 – 2681PhosphotyrosineBy similarity
Modified residuei434 – 4341PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P242.
PaxDbiQ9P242.
PeptideAtlasiQ9P242.
PRIDEiQ9P242.

PTM databases

iPTMnetiQ9P242.
PhosphoSiteiQ9P242.

Expressioni

Gene expression databases

BgeeiQ9P242.
GenevisibleiQ9P242. HS.

Organism-specific databases

HPAiHPA045531.

Interactioni

Subunit structurei

Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AGFG1P525943EBI-10269689,EBI-996560
MORN4Q8NDC43EBI-10269689,EBI-10269566

Protein-protein interaction databases

BioGridi121670. 4 interactions.
IntActiQ9P242. 4 interactions.
STRINGi9606.ENSP00000272907.

Structurei

3D structure databases

ProteinModelPortaliQ9P242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 16112Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi312 – 479168Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the NYAP family.Curated

Phylogenomic databases

eggNOGiENOG410IH9T. Eukaryota.
ENOG410YEXE. LUCA.
GeneTreeiENSGT00450000040316.
HOGENOMiHOG000111596.
HOVERGENiHBG108036.
InParanoidiQ9P242.
OMAiISSKMMS.
OrthoDBiEOG7Z69C3.
PhylomeDBiQ9P242.

Family and domain databases

InterProiIPR026722. NYAP1/NYAP2.
IPR026723. NYAP2.
IPR029353. NYAP_C.
[Graphical view]
PANTHERiPTHR22633. PTHR22633. 1 hit.
PTHR22633:SF1. PTHR22633:SF1. 1 hit.
PfamiPF15452. NYAP_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR
60 70 80 90 100
NETNLAYLKE KNEKRRRQEE AIKRIGGEVG RGHEGSYVGK HFRMGFMTMP
110 120 130 140 150
APQDRLPHPC SSGFSVRSQS LHSVGGTDDD SSCGSRRQPP PKPKRDPSTK
160 170 180 190 200
LSTSSETVSS TAASKSGKTP ERTEASAKPR PHSDEYSKKI PPPKPKRNPN
210 220 230 240 250
TQLSTSFDET YIKKHGPRRT SLPRDSSLSQ MGSPAGDPEE EEPVYIEMVG
260 270 280 290 300
NILRDFRKED DDQSEAVYEE MKYPIFDDLG QDAKCDFDHH SCSSQCATPT
310 320 330 340 350
VPDLDFAKAS VPCPPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS
360 370 380 390 400
DESPLTPLEV TKLPVLENVS YMKQPAGASP STLPSHVPGH AKLEKEQAAA
410 420 430 440 450
LGPASATPAL SSSPPPPSTL YRTQSPHGYP KSHSTSPSPV SMGRSLTPLS
460 470 480 490 500
LKRPPPYDAV HSGSLSRSSP SVPHSTPRPV SQDGAKMVNA AVNTYGAAPG
510 520 530 540 550
GSRSRTPTSP LEELTSLFSS GRSLLRKSSS GRRSKEPAEK STEELKVRSH
560 570 580 590 600
STEPLPKLDN KERGHHGASS SREPVKAQEW DGTPGTPVVT SRLGRCSVSP
610 620 630 640 650
TLLAGNHSSE PKVSCKLGRS ASTSGVPPPS VTPLRQSSDL QQSQVPSSLA

NRD
Length:653
Mass (Da):70,548
Last modified:May 18, 2010 - v3
Checksum:i78451871EC7822C6
GO
Isoform 2 (identifier: Q9P242-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-145: GGEVGRGHEG...RRQPPPKPKR → NRGTESPKPQ...LVSGKPQFRA
     146-653: Missing.

Show »
Length:145
Mass (Da):16,536
Checksum:iA9A52FFBEADF74F2
GO
Isoform 3 (identifier: Q9P242-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-486: Missing.
     645-645: V → I
     646-653: Missing.

Show »
Length:159
Mass (Da):16,800
Checksum:iEC892A314083B052
GO

Sequence cautioni

The sequence BAA96010.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti205 – 2051T → A.
Corresponds to variant rs7422680 [ dbSNP | Ensembl ].
VAR_039933
Natural varianti586 – 5861T → P.
Corresponds to variant rs3748993 [ dbSNP | Ensembl ].
VAR_039934

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 486486Missing in isoform 3. 1 PublicationVSP_032431Add
BLAST
Alternative sequencei76 – 14570GGEVG…PKPKR → NRGTESPKPQHGAITKVGQQ GKRPPWGVFLQRACQSSGMG WNTRATCGHQSTRKMLCEPH LVSGKPQFRA in isoform 2. 1 PublicationVSP_032432Add
BLAST
Alternative sequencei146 – 653508Missing in isoform 2. 1 PublicationVSP_032433Add
BLAST
Alternative sequencei645 – 6451V → I in isoform 3. 1 PublicationVSP_032434
Alternative sequencei646 – 6538Missing in isoform 3. 1 PublicationVSP_032435

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040919 mRNA. Translation: BAA96010.1. Different initiation.
AK055226 mRNA. Translation: BAB70880.1.
AC016717 Genomic DNA. No translation available.
AC019231 Genomic DNA. No translation available.
AC067961 Genomic DNA. No translation available.
AC106890 Genomic DNA. No translation available.
BC131727 mRNA. Translation: AAI31728.1.
CCDSiCCDS46529.1. [Q9P242-1]
RefSeqiNP_065915.1. NM_020864.1. [Q9P242-1]
XP_005246765.1. XM_005246708.2. [Q9P242-1]
UniGeneiHs.224409.

Genome annotation databases

EnsembliENST00000272907; ENSP00000272907; ENSG00000144460. [Q9P242-1]
GeneIDi57624.
KEGGihsa:57624.
UCSCiuc002voe.3. human. [Q9P242-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040919 mRNA. Translation: BAA96010.1. Different initiation.
AK055226 mRNA. Translation: BAB70880.1.
AC016717 Genomic DNA. No translation available.
AC019231 Genomic DNA. No translation available.
AC067961 Genomic DNA. No translation available.
AC106890 Genomic DNA. No translation available.
BC131727 mRNA. Translation: AAI31728.1.
CCDSiCCDS46529.1. [Q9P242-1]
RefSeqiNP_065915.1. NM_020864.1. [Q9P242-1]
XP_005246765.1. XM_005246708.2. [Q9P242-1]
UniGeneiHs.224409.

3D structure databases

ProteinModelPortaliQ9P242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121670. 4 interactions.
IntActiQ9P242. 4 interactions.
STRINGi9606.ENSP00000272907.

PTM databases

iPTMnetiQ9P242.
PhosphoSiteiQ9P242.

Polymorphism and mutation databases

BioMutaiNYAP2.
DMDMi296439320.

Proteomic databases

MaxQBiQ9P242.
PaxDbiQ9P242.
PeptideAtlasiQ9P242.
PRIDEiQ9P242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272907; ENSP00000272907; ENSG00000144460. [Q9P242-1]
GeneIDi57624.
KEGGihsa:57624.
UCSCiuc002voe.3. human. [Q9P242-1]

Organism-specific databases

CTDi57624.
GeneCardsiNYAP2.
HGNCiHGNC:29291. NYAP2.
HPAiHPA045531.
MIMi615478. gene.
neXtProtiNX_Q9P242.
PharmGKBiPA165696738.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH9T. Eukaryota.
ENOG410YEXE. LUCA.
GeneTreeiENSGT00450000040316.
HOGENOMiHOG000111596.
HOVERGENiHBG108036.
InParanoidiQ9P242.
OMAiISSKMMS.
OrthoDBiEOG7Z69C3.
PhylomeDBiQ9P242.

Miscellaneous databases

ChiTaRSiNYAP2. human.
GenomeRNAii57624.
PROiQ9P242.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P242.
GenevisibleiQ9P242. HS.

Family and domain databases

InterProiIPR026722. NYAP1/NYAP2.
IPR026723. NYAP2.
IPR029353. NYAP_C.
[Graphical view]
PANTHERiPTHR22633. PTHR22633. 1 hit.
PTHR22633:SF1. PTHR22633:SF1. 1 hit.
PfamiPF15452. NYAP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNYAP2_HUMAN
AccessioniPrimary (citable) accession number: Q9P242
Secondary accession number(s): A2RRN4, Q96NL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.