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Protein

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Gene

NYAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene namesi
Name:NYAP2
Synonyms:KIAA1486
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29291. NYAP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi57624.
OpenTargetsiENSG00000144460.
PharmGKBiPA165696738.

Polymorphism and mutation databases

BioMutaiNYAP2.
DMDMi296439320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258301 – 653Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2Add BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Omega-N-methylarginineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei268PhosphotyrosineBy similarity1
Modified residuei434PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9P242.
PaxDbiQ9P242.
PeptideAtlasiQ9P242.
PRIDEiQ9P242.

PTM databases

iPTMnetiQ9P242.
PhosphoSitePlusiQ9P242.

Expressioni

Gene expression databases

BgeeiENSG00000144460.
GenevisibleiQ9P242. HS.

Organism-specific databases

HPAiHPA045531.

Interactioni

Subunit structurei

Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AGFG1P525943EBI-10269689,EBI-996560
MORN4Q8NDC43EBI-10269689,EBI-10269566

Protein-protein interaction databases

BioGridi121670. 4 interactors.
IntActiQ9P242. 4 interactors.
STRINGi9606.ENSP00000272907.

Structurei

3D structure databases

ProteinModelPortaliQ9P242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 161Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi312 – 479Pro-richAdd BLAST168

Sequence similaritiesi

Belongs to the NYAP family.Curated

Phylogenomic databases

eggNOGiENOG410IH9T. Eukaryota.
ENOG410YEXE. LUCA.
GeneTreeiENSGT00450000040316.
HOGENOMiHOG000111596.
HOVERGENiHBG108036.
InParanoidiQ9P242.
OMAiISSKMMS.
OrthoDBiEOG091G047B.
PhylomeDBiQ9P242.

Family and domain databases

InterProiIPR026722. NYAP1/NYAP2.
IPR026723. NYAP2.
IPR029353. NYAP_C.
[Graphical view]
PANTHERiPTHR22633. PTHR22633. 1 hit.
PTHR22633:SF1. PTHR22633:SF1. 1 hit.
PfamiPF15452. NYAP_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR
60 70 80 90 100
NETNLAYLKE KNEKRRRQEE AIKRIGGEVG RGHEGSYVGK HFRMGFMTMP
110 120 130 140 150
APQDRLPHPC SSGFSVRSQS LHSVGGTDDD SSCGSRRQPP PKPKRDPSTK
160 170 180 190 200
LSTSSETVSS TAASKSGKTP ERTEASAKPR PHSDEYSKKI PPPKPKRNPN
210 220 230 240 250
TQLSTSFDET YIKKHGPRRT SLPRDSSLSQ MGSPAGDPEE EEPVYIEMVG
260 270 280 290 300
NILRDFRKED DDQSEAVYEE MKYPIFDDLG QDAKCDFDHH SCSSQCATPT
310 320 330 340 350
VPDLDFAKAS VPCPPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS
360 370 380 390 400
DESPLTPLEV TKLPVLENVS YMKQPAGASP STLPSHVPGH AKLEKEQAAA
410 420 430 440 450
LGPASATPAL SSSPPPPSTL YRTQSPHGYP KSHSTSPSPV SMGRSLTPLS
460 470 480 490 500
LKRPPPYDAV HSGSLSRSSP SVPHSTPRPV SQDGAKMVNA AVNTYGAAPG
510 520 530 540 550
GSRSRTPTSP LEELTSLFSS GRSLLRKSSS GRRSKEPAEK STEELKVRSH
560 570 580 590 600
STEPLPKLDN KERGHHGASS SREPVKAQEW DGTPGTPVVT SRLGRCSVSP
610 620 630 640 650
TLLAGNHSSE PKVSCKLGRS ASTSGVPPPS VTPLRQSSDL QQSQVPSSLA

NRD
Length:653
Mass (Da):70,548
Last modified:May 18, 2010 - v3
Checksum:i78451871EC7822C6
GO
Isoform 2 (identifier: Q9P242-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-145: GGEVGRGHEG...RRQPPPKPKR → NRGTESPKPQ...LVSGKPQFRA
     146-653: Missing.

Show »
Length:145
Mass (Da):16,536
Checksum:iA9A52FFBEADF74F2
GO
Isoform 3 (identifier: Q9P242-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-486: Missing.
     645-645: V → I
     646-653: Missing.

Show »
Length:159
Mass (Da):16,800
Checksum:iEC892A314083B052
GO

Sequence cautioni

The sequence BAA96010 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039933205T → A.Corresponds to variant rs7422680dbSNPEnsembl.1
Natural variantiVAR_039934586T → P.Corresponds to variant rs3748993dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0324311 – 486Missing in isoform 3. 1 PublicationAdd BLAST486
Alternative sequenceiVSP_03243276 – 145GGEVG…PKPKR → NRGTESPKPQHGAITKVGQQ GKRPPWGVFLQRACQSSGMG WNTRATCGHQSTRKMLCEPH LVSGKPQFRA in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_032433146 – 653Missing in isoform 2. 1 PublicationAdd BLAST508
Alternative sequenceiVSP_032434645V → I in isoform 3. 1 Publication1
Alternative sequenceiVSP_032435646 – 653Missing in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040919 mRNA. Translation: BAA96010.1. Different initiation.
AK055226 mRNA. Translation: BAB70880.1.
AC016717 Genomic DNA. No translation available.
AC019231 Genomic DNA. No translation available.
AC067961 Genomic DNA. No translation available.
AC106890 Genomic DNA. No translation available.
BC131727 mRNA. Translation: AAI31728.1.
CCDSiCCDS46529.1. [Q9P242-1]
RefSeqiNP_065915.1. NM_020864.1. [Q9P242-1]
XP_005246765.1. XM_005246708.3. [Q9P242-1]
UniGeneiHs.224409.

Genome annotation databases

EnsembliENST00000272907; ENSP00000272907; ENSG00000144460. [Q9P242-1]
ENST00000636099; ENSP00000490942; ENSG00000144460. [Q9P242-1]
GeneIDi57624.
KEGGihsa:57624.
UCSCiuc002voe.3. human. [Q9P242-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040919 mRNA. Translation: BAA96010.1. Different initiation.
AK055226 mRNA. Translation: BAB70880.1.
AC016717 Genomic DNA. No translation available.
AC019231 Genomic DNA. No translation available.
AC067961 Genomic DNA. No translation available.
AC106890 Genomic DNA. No translation available.
BC131727 mRNA. Translation: AAI31728.1.
CCDSiCCDS46529.1. [Q9P242-1]
RefSeqiNP_065915.1. NM_020864.1. [Q9P242-1]
XP_005246765.1. XM_005246708.3. [Q9P242-1]
UniGeneiHs.224409.

3D structure databases

ProteinModelPortaliQ9P242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121670. 4 interactors.
IntActiQ9P242. 4 interactors.
STRINGi9606.ENSP00000272907.

PTM databases

iPTMnetiQ9P242.
PhosphoSitePlusiQ9P242.

Polymorphism and mutation databases

BioMutaiNYAP2.
DMDMi296439320.

Proteomic databases

MaxQBiQ9P242.
PaxDbiQ9P242.
PeptideAtlasiQ9P242.
PRIDEiQ9P242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272907; ENSP00000272907; ENSG00000144460. [Q9P242-1]
ENST00000636099; ENSP00000490942; ENSG00000144460. [Q9P242-1]
GeneIDi57624.
KEGGihsa:57624.
UCSCiuc002voe.3. human. [Q9P242-1]

Organism-specific databases

CTDi57624.
DisGeNETi57624.
GeneCardsiNYAP2.
HGNCiHGNC:29291. NYAP2.
HPAiHPA045531.
MIMi615478. gene.
neXtProtiNX_Q9P242.
OpenTargetsiENSG00000144460.
PharmGKBiPA165696738.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH9T. Eukaryota.
ENOG410YEXE. LUCA.
GeneTreeiENSGT00450000040316.
HOGENOMiHOG000111596.
HOVERGENiHBG108036.
InParanoidiQ9P242.
OMAiISSKMMS.
OrthoDBiEOG091G047B.
PhylomeDBiQ9P242.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144460-MONOMER.

Miscellaneous databases

ChiTaRSiNYAP2. human.
GenomeRNAii57624.
PROiQ9P242.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144460.
GenevisibleiQ9P242. HS.

Family and domain databases

InterProiIPR026722. NYAP1/NYAP2.
IPR026723. NYAP2.
IPR029353. NYAP_C.
[Graphical view]
PANTHERiPTHR22633. PTHR22633. 1 hit.
PTHR22633:SF1. PTHR22633:SF1. 1 hit.
PfamiPF15452. NYAP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNYAP2_HUMAN
AccessioniPrimary (citable) accession number: Q9P242
Secondary accession number(s): A2RRN4, Q96NL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.