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Q9P241

- AT10D_HUMAN

UniProt

Q9P241 - AT10D_HUMAN

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Protein

Probable phospholipid-transporting ATPase VD

Gene

ATP10D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).Curated

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei438 – 43814-aspartylphosphate intermediateBy similarity
Metal bindingi1056 – 10561MagnesiumBy similarity
Metal bindingi1060 – 10601MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi996 – 10038ATPSequence Analysis
Nucleotide bindingi1364 – 13718ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. cation-transporting ATPase activity Source: InterPro
  3. magnesium ion binding Source: UniProtKB
  4. phospholipid-translocating ATPase activity Source: UniProtKB

GO - Biological processi

  1. cation transport Source: UniProtKB
  2. ion transmembrane transport Source: Reactome
  3. phospholipid translocation Source: UniProtKB
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_25149. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase VD (EC:3.6.3.1)
Alternative name(s):
ATPase class V type 10D
P4-ATPase flippase complex alpha subunit ATP10D
Gene namesi
Name:ATP10D
Synonyms:ATPVD, KIAA1487
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:13549. ATP10D.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication
Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
  3. nucleus Source: HPA
  4. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14261426Probable phospholipid-transporting ATPase VDPRO_0000046382Add
BLAST

Proteomic databases

PaxDbiQ9P241.
PRIDEiQ9P241.

PTM databases

PhosphoSiteiQ9P241.

Expressioni

Tissue specificityi

Expressed in placenta and, to a lesser extent, in kidney.1 Publication

Gene expression databases

BgeeiQ9P241.
CleanExiHS_ATP10D.
ExpressionAtlasiQ9P241. baseline and differential.
GenevestigatoriQ9P241.

Organism-specific databases

HPAiHPA050808.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

Protein-protein interaction databases

BioGridi121446. 1 interaction.
STRINGi9606.ENSP00000273859.

Structurei

3D structure databases

ProteinModelPortaliQ9P241.
SMRiQ9P241. Positions 1035-1091.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9797CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini119 – 1213Exoplasmic loopSequence Analysis
Topological domaini143 – 321179CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini343 – 36523Exoplasmic loopSequence AnalysisAdd
BLAST
Topological domaini387 – 1113727CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1135 – 114511Exoplasmic loopSequence AnalysisAdd
BLAST
Topological domaini1167 – 119529CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1217 – 12248Exoplasmic loopSequence Analysis
Topological domaini1246 – 12527CytoplasmicSequence Analysis
Topological domaini1274 – 129219Exoplasmic loopSequence AnalysisAdd
BLAST
Topological domaini1314 – 1426113CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence AnalysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Transmembranei1114 – 113421HelicalSequence AnalysisAdd
BLAST
Transmembranei1146 – 116621HelicalSequence AnalysisAdd
BLAST
Transmembranei1196 – 121621HelicalSequence AnalysisAdd
BLAST
Transmembranei1225 – 124521HelicalSequence AnalysisAdd
BLAST
Transmembranei1253 – 127321HelicalSequence AnalysisAdd
BLAST
Transmembranei1293 – 131321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00740000115303.
HOGENOMiHOG000202528.
HOVERGENiHBG107129.
InParanoidiQ9P241.
KOiK01530.
OMAiMDSTVQC.
OrthoDBiEOG76471S.
PhylomeDBiQ9P241.
TreeFamiTF354252.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P241-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH
60 70 80 90 100
RIVVPHIQPF KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN
110 120 130 140 150
LYFLFLVVLN WVPLVEAFQK EITMLPLVVV LTIIAIKDGL EDYRKYKIDK
160 170 180 190 200
QINNLITKVY SRKEKKYIDR CWKDVTVGDF IRLSCNEVIP ADMVLLFSTD
210 220 230 240 250
PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS SRIECESPNN
260 270 280 290 300
DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA
310 320 330 340 350
MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM
360 370 380 390 400
HFFNVPEPDG HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI
410 420 430 440 450
YFIQSDVDFY NEKMDSIVQC RALNIAEDLG QIQYLFSDKT GTLTENKMVF
460 470 480 490 500
RRCSVAGFDY CHEENARRLE SYQEAVSEDE DFIDTVSGSL SNMAKPRAPS
510 520 530 540 550
CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA FSSPIETDVV
560 570 580 590 600
PDTRLLDKFS QITPRLFMPL DETIQNPPME TLYIIDFFIA LAICNTVVVS
610 620 630 640 650
APNQPRQKIR HPSLGGLPIK SLEEIKSLFQ RWSVRRSSSP SLNSGKEPSS
660 670 680 690 700
GVPNAFVSRL PLFSRMKPAS PVEEEVSQVC ESPQCSSSSA CCTETEKQHG
710 720 730 740 750
DAGLLNGKAE SLPGQPLACN LCYEAESPDE AALVYAARAY QCTLRSRTPE
760 770 780 790 800
QVMVDFAALG PLTFQLLHIL PFDSVRKRMS VVVRHPLSNQ VVVYTKGADS
810 820 830 840 850
VIMELLSVAS PDGASLEKQQ MIVREKTQKH LDDYAKQGLR TLCIAKKVMS
860 870 880 890 900
DTEYAEWLRN HFLAETSIDN REELLLESAM RLENKLTLLG ATGIEDRLQE
910 920 930 940 950
GVPESIEALH KAGIKIWMLT GDKQETAVNI AYACKLLEPD DKLFILNTQS
960 970 980 990 1000
KDACGMLMST ILKELQKKTQ ALPEQVSLSE DLLQPPVPRD SGLRAGLIIT
1010 1020 1030 1040 1050
GKTLEFALQE SLQKQFLELT SWCQAVVCCR ATPLQKSEVV KLVRSHLQVM
1060 1070 1080 1090 1100
TLAIGDGAND VSMIQVADIG IGVSGQEGMQ AVMASDFAVS QFKHLSKLLL
1110 1120 1130 1140 1150
VHGHWCYTRL SNMILYFFYK NVAYVNLLFW YQFFCGFSGT SMTDYWVLIF
1160 1170 1180 1190 1200
FNLLFTSAPP VIYGVLEKDV SAETLMQLPE LYRSGQKSEA YLPHTFWITL
1210 1220 1230 1240 1250
LDAFYQSLVC FFVPYFTYQG SDTDIFAFGN PLNTAALFIV LLHLVIESKS
1260 1270 1280 1290 1300
LTWIHLLVII GSILSYFLFA IVFGAMCVTC NPPSNPYWIM QEHMLDPVFY
1310 1320 1330 1340 1350
LVCILTTSIA LLPRFVYRVL QGSLFPSPIL RAKHFDRLTP EERTKALKKW
1360 1370 1380 1390 1400
RGAGKMNQVT SKYANQSAGK SGRRPMPGPS AVFAMKSASS CAIEQGNLSL
1410 1420
CETALDQGYS ETKAFEMAGP SKGKES
Length:1,426
Mass (Da):160,274
Last modified:July 13, 2010 - v3
Checksum:i97EE929F81AC59AE
GO
Isoform 2 (identifier: Q9P241-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     553-747: Missing.

Note: No experimental confirmation available.

Show »
Length:1,231
Mass (Da):138,890
Checksum:i67D834DFFCEA7A54
GO

Sequence cautioni

The sequence BAB55221.1 differs from that shown. Reason: Frameshift at position 748.
The sequence BAC11299.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421D → G in CAD29577. (PubMed:12532265)Curated
Sequence conflicti1002 – 10021K → R in CAD29577. (PubMed:12532265)Curated
Sequence conflicti1090 – 10901S → Y in CAD29577. (PubMed:12532265)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431T → I.1 Publication
Corresponds to variant rs33995001 [ dbSNP | Ensembl ].
VAR_048385
Natural varianti171 – 1711C → R.
Corresponds to variant rs7683838 [ dbSNP | Ensembl ].
VAR_048386
Natural varianti320 – 3201T → I.
Corresponds to variant rs35596623 [ dbSNP | Ensembl ].
VAR_048387
Natural varianti337 – 3371A → T.
Corresponds to variant rs35012290 [ dbSNP | Ensembl ].
VAR_048388
Natural varianti511 – 5111N → S.
Corresponds to variant rs10003238 [ dbSNP | Ensembl ].
VAR_048389
Natural varianti522 – 5221F → L.
Corresponds to variant rs6843325 [ dbSNP | Ensembl ].
VAR_048390
Natural varianti716 – 7161P → T.
Corresponds to variant rs34208443 [ dbSNP | Ensembl ].
VAR_048391
Natural varianti720 – 7201N → S.
Corresponds to variant rs34169638 [ dbSNP | Ensembl ].
VAR_048392
Natural varianti959 – 9591S → N.
Corresponds to variant rs17462252 [ dbSNP | Ensembl ].
VAR_048393
Natural varianti1183 – 11831R → K.
Corresponds to variant rs16851681 [ dbSNP | Ensembl ].
VAR_048394
Natural varianti1240 – 12401V → I.1 Publication
Corresponds to variant rs1058793 [ dbSNP | Ensembl ].
VAR_020187
Natural varianti1389 – 13891S → T.1 Publication
Corresponds to variant rs4145944 [ dbSNP | Ensembl ].
VAR_024371
Natural varianti1392 – 13921A → G.
Corresponds to variant rs35375547 [ dbSNP | Ensembl ].
VAR_048395

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei553 – 747195Missing in isoform 2. 1 PublicationVSP_006954Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ441078 mRNA. Translation: CAD29577.1.
AC092597 Genomic DNA. No translation available.
AC107398 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW93036.1.
BC131535 mRNA. Translation: AAI31536.1.
AK027598 mRNA. Translation: BAB55221.1. Frameshift.
AK074930 mRNA. Translation: BAC11299.1. Different initiation.
AB040920 mRNA. Translation: BAA96011.1.
CCDSiCCDS3476.1. [Q9P241-1]
RefSeqiNP_065186.3. NM_020453.3. [Q9P241-1]
XP_005248175.1. XM_005248118.2. [Q9P241-1]
UniGeneiHs.437241.

Genome annotation databases

EnsembliENST00000273859; ENSP00000273859; ENSG00000145246. [Q9P241-1]
GeneIDi57205.
KEGGihsa:57205.
UCSCiuc003gxk.1. human. [Q9P241-1]
uc003gxl.1. human. [Q9P241-2]

Polymorphism databases

DMDMi300669610.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ441078 mRNA. Translation: CAD29577.1 .
AC092597 Genomic DNA. No translation available.
AC107398 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW93036.1 .
BC131535 mRNA. Translation: AAI31536.1 .
AK027598 mRNA. Translation: BAB55221.1 . Frameshift.
AK074930 mRNA. Translation: BAC11299.1 . Different initiation.
AB040920 mRNA. Translation: BAA96011.1 .
CCDSi CCDS3476.1. [Q9P241-1 ]
RefSeqi NP_065186.3. NM_020453.3. [Q9P241-1 ]
XP_005248175.1. XM_005248118.2. [Q9P241-1 ]
UniGenei Hs.437241.

3D structure databases

ProteinModelPortali Q9P241.
SMRi Q9P241. Positions 1035-1091.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121446. 1 interaction.
STRINGi 9606.ENSP00000273859.

PTM databases

PhosphoSitei Q9P241.

Polymorphism databases

DMDMi 300669610.

Proteomic databases

PaxDbi Q9P241.
PRIDEi Q9P241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273859 ; ENSP00000273859 ; ENSG00000145246 . [Q9P241-1 ]
GeneIDi 57205.
KEGGi hsa:57205.
UCSCi uc003gxk.1. human. [Q9P241-1 ]
uc003gxl.1. human. [Q9P241-2 ]

Organism-specific databases

CTDi 57205.
GeneCardsi GC04P047487.
HGNCi HGNC:13549. ATP10D.
HPAi HPA050808.
neXtProti NX_Q9P241.
PharmGKBi PA25100.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00740000115303.
HOGENOMi HOG000202528.
HOVERGENi HBG107129.
InParanoidi Q9P241.
KOi K01530.
OMAi MDSTVQC.
OrthoDBi EOG76471S.
PhylomeDBi Q9P241.
TreeFami TF354252.

Enzyme and pathway databases

Reactomei REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii 57205.
NextBioi 63294.
PROi Q9P241.

Gene expression databases

Bgeei Q9P241.
CleanExi HS_ATP10D.
ExpressionAtlasi Q9P241. baseline and differential.
Genevestigatori Q9P241.

Family and domain databases

Gene3Di 2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
PANTHERi PTHR24092. PTHR24092. 1 hit.
Pfami PF00122. E1-E2_ATPase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a putative type IV aminophospholipid transporter P-type ATPase."
    Flamant S., Pescher P., Lemercier B., Clement-Ziza M., Kepes F., Fellous M., Milon G., Marchal G., Besmond C.
    Mamm. Genome 14:21-30(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Monocyte.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-43 AND ILE-1240.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 354-1426 (ISOFORM 2).
  6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 777-1426, VARIANT THR-1389.
    Tissue: Brain.
  7. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
    Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
    J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAT10D_HUMAN
AccessioniPrimary (citable) accession number: Q9P241
Secondary accession number(s): A2RRC8
, D6REN2, Q8NC70, Q96SR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3