Reviewed, UniProtKB/Swiss-Prot Q9P241 (AT10D_HUMAN)

Names and origin

Protein names

Recommended name:
    Probable phospholipid-transporting ATPase VD
    EC=3.6.3.1
Alternative name(s):
    ATPase class V type 10D

Gene names

Name:	ATP10D
Synonyms:	ATPVD, KIAA1487

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1426 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in placenta and, to a lesser extent, in kidney. Ref.1
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.
Sequence caution	The sequence BAB55221.1 differs from that shown. Reason: Frameshift at position 748.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro cation transport Ref.1 Non-traceable author statement. Source: UniProtKB phospholipid transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	ATP binding Ref.1 Non-traceable author statement. Source: UniProtKB ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Ref.1 Non-traceable author statement. Source: UniProtKB phospholipid-translocating ATPase activity Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P241-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P241-2)

The sequence of this isoform differs from the canonical sequence as follows:
     553-747: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1426	1426	Probable phospholipid-transporting ATPase VD		PRO_0000046382
Regions
	Topological domain	1 – 97	97	Cytoplasmic Potential
	Transmembrane	98 – 118	21	Potential
	Topological domain	119 – 121	3	Extracellular Potential
	Transmembrane	122 – 142	21	Potential
	Topological domain	143 – 321	179	Cytoplasmic Potential
	Transmembrane	322 – 342	21	Potential
	Topological domain	343 – 365	23	Extracellular Potential
	Transmembrane	366 – 386	21	Potential
	Topological domain	387 – 1113	727	Cytoplasmic Potential
	Transmembrane	1114 – 1134	21	Potential
	Topological domain	1135 – 1145	11	Extracellular Potential
	Transmembrane	1146 – 1166	21	Potential
	Topological domain	1167 – 1195	29	Cytoplasmic Potential
	Transmembrane	1196 – 1216	21	Potential
	Topological domain	1217 – 1224	8	Extracellular Potential
	Transmembrane	1225 – 1245	21	Potential
	Topological domain	1246 – 1252	7	Cytoplasmic Potential
	Transmembrane	1253 – 1273	21	Potential
	Topological domain	1274 – 1292	19	Extracellular Potential
	Transmembrane	1293 – 1313	21	Potential
	Topological domain	1314 – 1426	113	Cytoplasmic Potential
	Nucleotide binding	996 – 1003	8	ATP Potential
	Nucleotide binding	1364 – 1371	8	ATP Potential
Sites
	Active site	438	1	4-aspartylphosphate intermediate By similarity
	Metal binding	1056	1	Magnesium By similarity
	Metal binding	1060	1	Magnesium By similarity
Natural variations
	Alternative sequence	553 – 747	195	Missing in isoform 2.		VSP_006954
	Natural variant	43	1	T → I: dbSNP rs33995001.		VAR_048385
	Natural variant	171	1	C → R: dbSNP rs7683838.		VAR_048386
	Natural variant	320	1	T → I: dbSNP rs35596623.		VAR_048387
	Natural variant	337	1	A → T: dbSNP rs35012290.		VAR_048388
	Natural variant	511	1	N → S: dbSNP rs10003238.		VAR_048389
	Natural variant	522	1	F → L: dbSNP rs6843325.		VAR_048390
	Natural variant	716	1	P → T: dbSNP rs34208443.		VAR_048391
	Natural variant	720	1	N → S: dbSNP rs34169638.		VAR_048392
	Natural variant	959	1	S → N: dbSNP rs17462252.		VAR_048393
	Natural variant	1183	1	R → K: dbSNP rs16851681.		VAR_048394
	Natural variant	1240	1	V → I: dbSNP rs1058793.		VAR_020187
	Natural variant	1389	1	S → T: dbSNP rs4145944. Ref.3		VAR_024371
	Natural variant	1392	1	A → G: dbSNP rs35375547.		VAR_048395
Experimental info
	Sequence conflict	1002	1	R → K Ref.2
	Sequence conflict	1002	1	R → K Ref.3
	Sequence conflict	1090	1	Y → S Ref.2
	Sequence conflict	1090	1	Y → S Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 25, 2003. Version 2. Checksum: 5A260F1537ADD705	FASTA	1,426	160,320
	10 20 30 40 50 60 MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH RIVVPHIQPF 70 80 90 100 110 120 KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN LYFLFLVVLN WVPLVEAFQK 130 140 150 160 170 180 EITMLPLVVV LTIIAIKDGL EGYRKYKIDK QINNLITKVY SRKEKKYIDR CWKDVTVGDF 190 200 210 220 230 240 IRLSCNEVIP ADMVLLFSTD PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS 250 260 270 280 290 300 SRIECESPNN DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA 310 320 330 340 350 360 MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM HFFNVPEPDG 370 380 390 400 410 420 HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI YFIQSDVDFY NEKMDSIVQC 430 440 450 460 470 480 RALNIAEDLG QIQYLFSDKT GTLTENKMVF RRCSVAGFDY CHEENARRLE SYQEAVSEDE 490 500 510 520 530 540 DFIDTVSGSL SNMAKPRAPS CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA 550 560 570 580 590 600 FSSPIETDVV PDTRLLDKFS QITPRLFMPL DETIQNPPME TLYIIDFFIA LAICNTVVVS 610 620 630 640 650 660 APNQPRQKIR HPSLGGLPIK SLEEIKSLFQ RWSVRRSSSP SLNSGKEPSS GVPNAFVSRL 670 680 690 700 710 720 PLFSRMKPAS PVEEEVSQVC ESPQCSSSSA CCTETEKQHG DAGLLNGKAE SLPGQPLACN 730 740 750 760 770 780 LCYEAESPDE AALVYAARAY QCTLRSRTPE QVMVDFAALG PLTFQLLHIL PFDSVRKRMS 790 800 810 820 830 840 VVVRHPLSNQ VVVYTKGADS VIMELLSVAS PDGASLEKQQ MIVREKTQKH LDDYAKQGLR 850 860 870 880 890 900 TLCIAKKVMS DTEYAEWLRN HFLAETSIDN REELLLESAM RLENKLTLLG ATGIEDRLQE 910 920 930 940 950 960 GVPESIEALH KAGIKIWMLT GDKQETAVNI AYACKLLEPD DKLFILNTQS KDACGMLMST 970 980 990 1000 1010 1020 ILKELQKKTQ ALPEQVSLSE DLLQPPVPRD SGLRAGLIIT GRTLEFALQE SLQKQFLELT 1030 1040 1050 1060 1070 1080 SWCQAVVCCR ATPLQKSEVV KLVRSHLQVM TLAIGDGAND VSMIQVADIG IGVSGQEGMQ 1090 1100 1110 1120 1130 1140 AVMASDFAVY QFKHLSKLLL VHGHWCYTRL SNMILYFFYK NVAYVNLLFW YQFFCGFSGT 1150 1160 1170 1180 1190 1200 SMTDYWVLIF FNLLFTSAPP VIYGVLEKDV SAETLMQLPE LYRSGQKSEA YLPHTFWITL 1210 1220 1230 1240 1250 1260 LDAFYQSLVC FFVPYFTYQG SDTDIFAFGN PLNTAALFIV LLHLVIESKS LTWIHLLVII 1270 1280 1290 1300 1310 1320 GSILSYFLFA IVFGAMCVTC NPPSNPYWIM QEHMLDPVFY LVCILTTSIA LLPRFVYRVL 1330 1340 1350 1360 1370 1380 QGSLFPSPIL RAKHFDRLTP EERTKALKKW RGAGKMNQVT SKYANQSAGK SGRRPMPGPS 1390 1400 1410 1420 AVFAMKSASS CAIEQGNLSL CETALDQGYS ETKAFEMAGP SKGKES
	Isoform 2. Checksum: A50E1F1CA3D04042	FASTA	1,231	138,937
	10 20 30 40 50 60 MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH RIVVPHIQPF 70 80 90 100 110 120 KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN LYFLFLVVLN WVPLVEAFQK 130 140 150 160 170 180 EITMLPLVVV LTIIAIKDGL EGYRKYKIDK QINNLITKVY SRKEKKYIDR CWKDVTVGDF 190 200 210 220 230 240 IRLSCNEVIP ADMVLLFSTD PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS 250 260 270 280 290 300 SRIECESPNN DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA 310 320 330 340 350 360 MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM HFFNVPEPDG 370 380 390 400 410 420 HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI YFIQSDVDFY NEKMDSIVQC 430 440 450 460 470 480 RALNIAEDLG QIQYLFSDKT GTLTENKMVF RRCSVAGFDY CHEENARRLE SYQEAVSEDE 490 500 510 520 530 540 DFIDTVSGSL SNMAKPRAPS CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA 550 560 570 580 590 600 FSSPIETDVV PDTPEQVMVD FAALGPLTFQ LLHILPFDSV RKRMSVVVRH PLSNQVVVYT 610 620 630 640 650 660 KGADSVIMEL LSVASPDGAS LEKQQMIVRE KTQKHLDDYA KQGLRTLCIA KKVMSDTEYA 670 680 690 700 710 720 EWLRNHFLAE TSIDNREELL LESAMRLENK LTLLGATGIE DRLQEGVPES IEALHKAGIK 730 740 750 760 770 780 IWMLTGDKQE TAVNIAYACK LLEPDDKLFI LNTQSKDACG MLMSTILKEL QKKTQALPEQ 790 800 810 820 830 840 VSLSEDLLQP PVPRDSGLRA GLIITGRTLE FALQESLQKQ FLELTSWCQA VVCCRATPLQ 850 860 870 880 890 900 KSEVVKLVRS HLQVMTLAIG DGANDVSMIQ VADIGIGVSG QEGMQAVMAS DFAVYQFKHL 910 920 930 940 950 960 SKLLLVHGHW CYTRLSNMIL YFFYKNVAYV NLLFWYQFFC GFSGTSMTDY WVLIFFNLLF 970 980 990 1000 1010 1020 TSAPPVIYGV LEKDVSAETL MQLPELYRSG QKSEAYLPHT FWITLLDAFY QSLVCFFVPY 1030 1040 1050 1060 1070 1080 FTYQGSDTDI FAFGNPLNTA ALFIVLLHLV IESKSLTWIH LLVIIGSILS YFLFAIVFGA 1090 1100 1110 1120 1130 1140 MCVTCNPPSN PYWIMQEHML DPVFYLVCIL TTSIALLPRF VYRVLQGSLF PSPILRAKHF 1150 1160 1170 1180 1190 1200 DRLTPEERTK ALKKWRGAGK MNQVTSKYAN QSAGKSGRRP MPGPSAVFAM KSASSCAIEQ 1210 1220 1230 GNLSLCETAL DQGYSETKAF EMAGPSKGKE S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a putative type IV aminophospholipid transporter P-type ATPase." Flamant S., Pescher P., Lemercier B., Clement-Ziza M., Kepes F., Fellous M., Milon G., Marchal G., Besmond C. Mamm. Genome 14:21-30(2003) [PubMed: 12532265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Monocyte.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 354-1426 (ISOFORM 2).
[3]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 777-1426, VARIANT THR-1389. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ441078 mRNA. Translation: CAD29577.1. AK027598 mRNA. Translation: BAB55221.1. Frameshift. AK074930 mRNA. Translation: BAC11299.1. Different initiation. AB040920 mRNA. Translation: BAA96011.1.
IPI	IPI00001723. IPI00216521.
RefSeq	NP_065186.3.
UniGene	Hs.437241
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9P241.
Genome annotation databases
Ensembl	ENST00000273859; ENSP00000273859; ENSG00000145246; Homo sapiens. [Genome view]
GeneID	57205.
KEGG	hsa:57205.
UCSC	uc003gxk.1. human.
Organism-specific databases
CTD	57205.
GeneCards	GC04P047182.
HGNC	HGNC:13549. ATP10D.
PharmGKB	PA25100.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG745019.
HOVERGEN	Q9P241.
InParanoid	Q9P241.
PhylomeDB	Q9P241.
Enzyme and pathway databases
BRENDA	3.6.3.1. 247.
Gene expression databases
ArrayExpress	Q9P241.
Bgee	Q9P241.
CleanEx	HS_ATP10D.
Genevestigator	Q9P241.
GermOnline	ENSG00000145246. Homo sapiens.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	63294.

Entry information

Entry name

AT10D_HUMAN

Accession

Primary (citable) accession number: Q9P241
Secondary accession number(s): Q8NC70, Q96SR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	March 25, 2003
Last modified:	February 9, 2010
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.