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Protein

Probable phospholipid-transporting ATPase VD

Gene

ATP10D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).Curated

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4384-aspartylphosphate intermediateBy similarity1
Metal bindingi1056MagnesiumBy similarity1
Metal bindingi1060MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi996 – 1003ATPSequence analysis8
Nucleotide bindingi1364 – 1371ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • phospholipid-translocating ATPase activity Source: UniProtKB

GO - Biological processi

  • cation transport Source: UniProtKB
  • ion transmembrane transport Source: Reactome
  • phospholipid translocation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS07239-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase VD (EC:3.6.3.1)
Alternative name(s):
ATPase class V type 10D
P4-ATPase flippase complex alpha subunit ATP10D
Gene namesi
Name:ATP10D
Synonyms:ATPVD, KIAA1487
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:13549. ATP10D.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 121Exoplasmic loopSequence analysis3
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 321CytoplasmicSequence analysisAdd BLAST179
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 365Exoplasmic loopSequence analysisAdd BLAST23
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 1113CytoplasmicSequence analysisAdd BLAST727
Transmembranei1114 – 1134HelicalSequence analysisAdd BLAST21
Topological domaini1135 – 1145Exoplasmic loopSequence analysisAdd BLAST11
Transmembranei1146 – 1166HelicalSequence analysisAdd BLAST21
Topological domaini1167 – 1195CytoplasmicSequence analysisAdd BLAST29
Transmembranei1196 – 1216HelicalSequence analysisAdd BLAST21
Topological domaini1217 – 1224Exoplasmic loopSequence analysis8
Transmembranei1225 – 1245HelicalSequence analysisAdd BLAST21
Topological domaini1246 – 1252CytoplasmicSequence analysis7
Transmembranei1253 – 1273HelicalSequence analysisAdd BLAST21
Topological domaini1274 – 1292Exoplasmic loopSequence analysisAdd BLAST19
Transmembranei1293 – 1313HelicalSequence analysisAdd BLAST21
Topological domaini1314 – 1426CytoplasmicSequence analysisAdd BLAST113

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57205.
OpenTargetsiENSG00000145246.
PharmGKBiPA25100.

Polymorphism and mutation databases

BioMutaiATP10D.
DMDMi300669610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463821 – 1426Probable phospholipid-transporting ATPase VDAdd BLAST1426

Proteomic databases

EPDiQ9P241.
PaxDbiQ9P241.
PeptideAtlasiQ9P241.
PRIDEiQ9P241.

PTM databases

iPTMnetiQ9P241.
PhosphoSitePlusiQ9P241.

Expressioni

Tissue specificityi

Expressed in placenta and, to a lesser extent, in kidney.1 Publication

Gene expression databases

BgeeiENSG00000145246.
CleanExiHS_ATP10D.
ExpressionAtlasiQ9P241. baseline and differential.
GenevisibleiQ9P241. HS.

Organism-specific databases

HPAiHPA050808.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

Protein-protein interaction databases

BioGridi121446. 1 interactor.
STRINGi9606.ENSP00000273859.

Structurei

3D structure databases

ProteinModelPortaliQ9P241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
ENOG410XSS0. LUCA.
GeneTreeiENSGT00860000133775.
HOGENOMiHOG000202528.
HOVERGENiHBG107129.
InParanoidiQ9P241.
KOiK01530.
OMAiEVSQVCE.
OrthoDBiEOG091G0139.
PhylomeDBiQ9P241.
TreeFamiTF354252.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR030360. ATP10D.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 3 hits.
PTHR24092:SF84. PTHR24092:SF84. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH
60 70 80 90 100
RIVVPHIQPF KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN
110 120 130 140 150
LYFLFLVVLN WVPLVEAFQK EITMLPLVVV LTIIAIKDGL EDYRKYKIDK
160 170 180 190 200
QINNLITKVY SRKEKKYIDR CWKDVTVGDF IRLSCNEVIP ADMVLLFSTD
210 220 230 240 250
PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS SRIECESPNN
260 270 280 290 300
DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA
310 320 330 340 350
MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM
360 370 380 390 400
HFFNVPEPDG HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI
410 420 430 440 450
YFIQSDVDFY NEKMDSIVQC RALNIAEDLG QIQYLFSDKT GTLTENKMVF
460 470 480 490 500
RRCSVAGFDY CHEENARRLE SYQEAVSEDE DFIDTVSGSL SNMAKPRAPS
510 520 530 540 550
CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA FSSPIETDVV
560 570 580 590 600
PDTRLLDKFS QITPRLFMPL DETIQNPPME TLYIIDFFIA LAICNTVVVS
610 620 630 640 650
APNQPRQKIR HPSLGGLPIK SLEEIKSLFQ RWSVRRSSSP SLNSGKEPSS
660 670 680 690 700
GVPNAFVSRL PLFSRMKPAS PVEEEVSQVC ESPQCSSSSA CCTETEKQHG
710 720 730 740 750
DAGLLNGKAE SLPGQPLACN LCYEAESPDE AALVYAARAY QCTLRSRTPE
760 770 780 790 800
QVMVDFAALG PLTFQLLHIL PFDSVRKRMS VVVRHPLSNQ VVVYTKGADS
810 820 830 840 850
VIMELLSVAS PDGASLEKQQ MIVREKTQKH LDDYAKQGLR TLCIAKKVMS
860 870 880 890 900
DTEYAEWLRN HFLAETSIDN REELLLESAM RLENKLTLLG ATGIEDRLQE
910 920 930 940 950
GVPESIEALH KAGIKIWMLT GDKQETAVNI AYACKLLEPD DKLFILNTQS
960 970 980 990 1000
KDACGMLMST ILKELQKKTQ ALPEQVSLSE DLLQPPVPRD SGLRAGLIIT
1010 1020 1030 1040 1050
GKTLEFALQE SLQKQFLELT SWCQAVVCCR ATPLQKSEVV KLVRSHLQVM
1060 1070 1080 1090 1100
TLAIGDGAND VSMIQVADIG IGVSGQEGMQ AVMASDFAVS QFKHLSKLLL
1110 1120 1130 1140 1150
VHGHWCYTRL SNMILYFFYK NVAYVNLLFW YQFFCGFSGT SMTDYWVLIF
1160 1170 1180 1190 1200
FNLLFTSAPP VIYGVLEKDV SAETLMQLPE LYRSGQKSEA YLPHTFWITL
1210 1220 1230 1240 1250
LDAFYQSLVC FFVPYFTYQG SDTDIFAFGN PLNTAALFIV LLHLVIESKS
1260 1270 1280 1290 1300
LTWIHLLVII GSILSYFLFA IVFGAMCVTC NPPSNPYWIM QEHMLDPVFY
1310 1320 1330 1340 1350
LVCILTTSIA LLPRFVYRVL QGSLFPSPIL RAKHFDRLTP EERTKALKKW
1360 1370 1380 1390 1400
RGAGKMNQVT SKYANQSAGK SGRRPMPGPS AVFAMKSASS CAIEQGNLSL
1410 1420
CETALDQGYS ETKAFEMAGP SKGKES
Length:1,426
Mass (Da):160,274
Last modified:July 13, 2010 - v3
Checksum:i97EE929F81AC59AE
GO
Isoform 2 (identifier: Q9P241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     553-747: Missing.

Note: No experimental confirmation available.
Show »
Length:1,231
Mass (Da):138,890
Checksum:i67D834DFFCEA7A54
GO

Sequence cautioni

The sequence BAB55221 differs from that shown. Reason: Frameshift at position 748.Curated
The sequence BAC11299 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142D → G in CAD29577 (PubMed:12532265).Curated1
Sequence conflicti1002K → R in CAD29577 (PubMed:12532265).Curated1
Sequence conflicti1090S → Y in CAD29577 (PubMed:12532265).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04838543T → I.1 PublicationCorresponds to variant rs33995001dbSNPEnsembl.1
Natural variantiVAR_048386171C → R.Corresponds to variant rs7683838dbSNPEnsembl.1
Natural variantiVAR_048387320T → I.Corresponds to variant rs35596623dbSNPEnsembl.1
Natural variantiVAR_048388337A → T.Corresponds to variant rs35012290dbSNPEnsembl.1
Natural variantiVAR_048389511N → S.Corresponds to variant rs10003238dbSNPEnsembl.1
Natural variantiVAR_048390522F → L.Corresponds to variant rs6843325dbSNPEnsembl.1
Natural variantiVAR_048391716P → T.Corresponds to variant rs34208443dbSNPEnsembl.1
Natural variantiVAR_048392720N → S.Corresponds to variant rs34169638dbSNPEnsembl.1
Natural variantiVAR_048393959S → N.Corresponds to variant rs17462252dbSNPEnsembl.1
Natural variantiVAR_0483941183R → K.Corresponds to variant rs16851681dbSNPEnsembl.1
Natural variantiVAR_0201871240V → I.1 PublicationCorresponds to variant rs1058793dbSNPEnsembl.1
Natural variantiVAR_0243711389S → T.1 PublicationCorresponds to variant rs4145944dbSNPEnsembl.1
Natural variantiVAR_0483951392A → G.Corresponds to variant rs35375547dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006954553 – 747Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ441078 mRNA. Translation: CAD29577.1.
AC092597 Genomic DNA. No translation available.
AC107398 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW93036.1.
BC131535 mRNA. Translation: AAI31536.1.
AK027598 mRNA. Translation: BAB55221.1. Frameshift.
AK074930 mRNA. Translation: BAC11299.1. Different initiation.
AB040920 mRNA. Translation: BAA96011.1.
CCDSiCCDS3476.1. [Q9P241-1]
RefSeqiNP_065186.3. NM_020453.3. [Q9P241-1]
UniGeneiHs.437241.

Genome annotation databases

EnsembliENST00000273859; ENSP00000273859; ENSG00000145246. [Q9P241-1]
GeneIDi57205.
KEGGihsa:57205.
UCSCiuc003gxk.2. human. [Q9P241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ441078 mRNA. Translation: CAD29577.1.
AC092597 Genomic DNA. No translation available.
AC107398 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW93036.1.
BC131535 mRNA. Translation: AAI31536.1.
AK027598 mRNA. Translation: BAB55221.1. Frameshift.
AK074930 mRNA. Translation: BAC11299.1. Different initiation.
AB040920 mRNA. Translation: BAA96011.1.
CCDSiCCDS3476.1. [Q9P241-1]
RefSeqiNP_065186.3. NM_020453.3. [Q9P241-1]
UniGeneiHs.437241.

3D structure databases

ProteinModelPortaliQ9P241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121446. 1 interactor.
STRINGi9606.ENSP00000273859.

PTM databases

iPTMnetiQ9P241.
PhosphoSitePlusiQ9P241.

Polymorphism and mutation databases

BioMutaiATP10D.
DMDMi300669610.

Proteomic databases

EPDiQ9P241.
PaxDbiQ9P241.
PeptideAtlasiQ9P241.
PRIDEiQ9P241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273859; ENSP00000273859; ENSG00000145246. [Q9P241-1]
GeneIDi57205.
KEGGihsa:57205.
UCSCiuc003gxk.2. human. [Q9P241-1]

Organism-specific databases

CTDi57205.
DisGeNETi57205.
GeneCardsiATP10D.
HGNCiHGNC:13549. ATP10D.
HPAiHPA050808.
neXtProtiNX_Q9P241.
OpenTargetsiENSG00000145246.
PharmGKBiPA25100.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
ENOG410XSS0. LUCA.
GeneTreeiENSGT00860000133775.
HOGENOMiHOG000202528.
HOVERGENiHBG107129.
InParanoidiQ9P241.
KOiK01530.
OMAiEVSQVCE.
OrthoDBiEOG091G0139.
PhylomeDBiQ9P241.
TreeFamiTF354252.

Enzyme and pathway databases

BioCyciZFISH:HS07239-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii57205.
PROiQ9P241.

Gene expression databases

BgeeiENSG00000145246.
CleanExiHS_ATP10D.
ExpressionAtlasiQ9P241. baseline and differential.
GenevisibleiQ9P241. HS.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR030360. ATP10D.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 3 hits.
PTHR24092:SF84. PTHR24092:SF84. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT10D_HUMAN
AccessioniPrimary (citable) accession number: Q9P241
Secondary accession number(s): A2RRC8
, D6REN2, Q8NC70, Q96SR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.