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Q9P241

- AT10D_HUMAN

UniProt

Q9P241 - AT10D_HUMAN

Protein

Probable phospholipid-transporting ATPase VD

Gene

ATP10D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules Probable.Curated

    Catalytic activityi

    ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei438 – 43814-aspartylphosphate intermediateBy similarity
    Metal bindingi1056 – 10561MagnesiumBy similarity
    Metal bindingi1060 – 10601MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi996 – 10038ATPSequence Analysis
    Nucleotide bindingi1364 – 13718ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. cation-transporting ATPase activity Source: InterPro
    3. magnesium ion binding Source: UniProtKB
    4. phospholipid-translocating ATPase activity Source: UniProtKB
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. cation transport Source: UniProtKB
    2. ion transmembrane transport Source: Reactome
    3. phospholipid translocation Source: UniProtKB
    4. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phospholipid-transporting ATPase VD (EC:3.6.3.1)
    Alternative name(s):
    ATPase class V type 10D
    P4-ATPase flippase complex alpha subunit ATP10D
    Gene namesi
    Name:ATP10D
    Synonyms:ATPVD, KIAA1487
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:13549. ATP10D.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication
    Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB
    4. nucleus Source: HPA
    5. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25100.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14261426Probable phospholipid-transporting ATPase VDPRO_0000046382Add
    BLAST

    Proteomic databases

    PaxDbiQ9P241.
    PRIDEiQ9P241.

    PTM databases

    PhosphoSiteiQ9P241.

    Expressioni

    Tissue specificityi

    Expressed in placenta and, to a lesser extent, in kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ9P241.
    BgeeiQ9P241.
    CleanExiHS_ATP10D.
    GenevestigatoriQ9P241.

    Organism-specific databases

    HPAiHPA050808.

    Interactioni

    Subunit structurei

    Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

    Protein-protein interaction databases

    BioGridi121446. 1 interaction.
    STRINGi9606.ENSP00000273859.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P241.
    SMRiQ9P241. Positions 1035-1091.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9797CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini119 – 1213Exoplasmic loopSequence Analysis
    Topological domaini143 – 321179CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini343 – 36523Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini387 – 1113727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1135 – 114511Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini1167 – 119529CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1217 – 12248Exoplasmic loopSequence Analysis
    Topological domaini1246 – 12527CytoplasmicSequence Analysis
    Topological domaini1274 – 129219Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini1314 – 1426113CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1114 – 113421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1146 – 116621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1196 – 121621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1225 – 124521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1253 – 127321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1293 – 131321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000202528.
    HOVERGENiHBG107129.
    InParanoidiQ9P241.
    KOiK01530.
    OMAiMDSTVQC.
    OrthoDBiEOG76471S.
    PhylomeDBiQ9P241.
    TreeFamiTF354252.

    Family and domain databases

    Gene3Di2.70.150.10. 2 hits.
    3.40.1110.10. 3 hits.
    3.40.50.1000. 2 hits.
    InterProiIPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PANTHERiPTHR24092. PTHR24092. 1 hit.
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P241-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH     50
    RIVVPHIQPF KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN 100
    LYFLFLVVLN WVPLVEAFQK EITMLPLVVV LTIIAIKDGL EDYRKYKIDK 150
    QINNLITKVY SRKEKKYIDR CWKDVTVGDF IRLSCNEVIP ADMVLLFSTD 200
    PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS SRIECESPNN 250
    DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA 300
    MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM 350
    HFFNVPEPDG HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI 400
    YFIQSDVDFY NEKMDSIVQC RALNIAEDLG QIQYLFSDKT GTLTENKMVF 450
    RRCSVAGFDY CHEENARRLE SYQEAVSEDE DFIDTVSGSL SNMAKPRAPS 500
    CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA FSSPIETDVV 550
    PDTRLLDKFS QITPRLFMPL DETIQNPPME TLYIIDFFIA LAICNTVVVS 600
    APNQPRQKIR HPSLGGLPIK SLEEIKSLFQ RWSVRRSSSP SLNSGKEPSS 650
    GVPNAFVSRL PLFSRMKPAS PVEEEVSQVC ESPQCSSSSA CCTETEKQHG 700
    DAGLLNGKAE SLPGQPLACN LCYEAESPDE AALVYAARAY QCTLRSRTPE 750
    QVMVDFAALG PLTFQLLHIL PFDSVRKRMS VVVRHPLSNQ VVVYTKGADS 800
    VIMELLSVAS PDGASLEKQQ MIVREKTQKH LDDYAKQGLR TLCIAKKVMS 850
    DTEYAEWLRN HFLAETSIDN REELLLESAM RLENKLTLLG ATGIEDRLQE 900
    GVPESIEALH KAGIKIWMLT GDKQETAVNI AYACKLLEPD DKLFILNTQS 950
    KDACGMLMST ILKELQKKTQ ALPEQVSLSE DLLQPPVPRD SGLRAGLIIT 1000
    GKTLEFALQE SLQKQFLELT SWCQAVVCCR ATPLQKSEVV KLVRSHLQVM 1050
    TLAIGDGAND VSMIQVADIG IGVSGQEGMQ AVMASDFAVS QFKHLSKLLL 1100
    VHGHWCYTRL SNMILYFFYK NVAYVNLLFW YQFFCGFSGT SMTDYWVLIF 1150
    FNLLFTSAPP VIYGVLEKDV SAETLMQLPE LYRSGQKSEA YLPHTFWITL 1200
    LDAFYQSLVC FFVPYFTYQG SDTDIFAFGN PLNTAALFIV LLHLVIESKS 1250
    LTWIHLLVII GSILSYFLFA IVFGAMCVTC NPPSNPYWIM QEHMLDPVFY 1300
    LVCILTTSIA LLPRFVYRVL QGSLFPSPIL RAKHFDRLTP EERTKALKKW 1350
    RGAGKMNQVT SKYANQSAGK SGRRPMPGPS AVFAMKSASS CAIEQGNLSL 1400
    CETALDQGYS ETKAFEMAGP SKGKES 1426
    Length:1,426
    Mass (Da):160,274
    Last modified:July 13, 2010 - v3
    Checksum:i97EE929F81AC59AE
    GO
    Isoform 2 (identifier: Q9P241-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         553-747: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,231
    Mass (Da):138,890
    Checksum:i67D834DFFCEA7A54
    GO

    Sequence cautioni

    The sequence BAB55221.1 differs from that shown. Reason: Frameshift at position 748.
    The sequence BAC11299.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421D → G in CAD29577. (PubMed:12532265)Curated
    Sequence conflicti1002 – 10021K → R in CAD29577. (PubMed:12532265)Curated
    Sequence conflicti1090 – 10901S → Y in CAD29577. (PubMed:12532265)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431T → I.1 Publication
    Corresponds to variant rs33995001 [ dbSNP | Ensembl ].
    VAR_048385
    Natural varianti171 – 1711C → R.
    Corresponds to variant rs7683838 [ dbSNP | Ensembl ].
    VAR_048386
    Natural varianti320 – 3201T → I.
    Corresponds to variant rs35596623 [ dbSNP | Ensembl ].
    VAR_048387
    Natural varianti337 – 3371A → T.
    Corresponds to variant rs35012290 [ dbSNP | Ensembl ].
    VAR_048388
    Natural varianti511 – 5111N → S.
    Corresponds to variant rs10003238 [ dbSNP | Ensembl ].
    VAR_048389
    Natural varianti522 – 5221F → L.
    Corresponds to variant rs6843325 [ dbSNP | Ensembl ].
    VAR_048390
    Natural varianti716 – 7161P → T.
    Corresponds to variant rs34208443 [ dbSNP | Ensembl ].
    VAR_048391
    Natural varianti720 – 7201N → S.
    Corresponds to variant rs34169638 [ dbSNP | Ensembl ].
    VAR_048392
    Natural varianti959 – 9591S → N.
    Corresponds to variant rs17462252 [ dbSNP | Ensembl ].
    VAR_048393
    Natural varianti1183 – 11831R → K.
    Corresponds to variant rs16851681 [ dbSNP | Ensembl ].
    VAR_048394
    Natural varianti1240 – 12401V → I.1 Publication
    Corresponds to variant rs1058793 [ dbSNP | Ensembl ].
    VAR_020187
    Natural varianti1389 – 13891S → T.1 Publication
    Corresponds to variant rs4145944 [ dbSNP | Ensembl ].
    VAR_024371
    Natural varianti1392 – 13921A → G.
    Corresponds to variant rs35375547 [ dbSNP | Ensembl ].
    VAR_048395

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei553 – 747195Missing in isoform 2. 1 PublicationVSP_006954Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ441078 mRNA. Translation: CAD29577.1.
    AC092597 Genomic DNA. No translation available.
    AC107398 Genomic DNA. No translation available.
    CH471069 Genomic DNA. Translation: EAW93036.1.
    BC131535 mRNA. Translation: AAI31536.1.
    AK027598 mRNA. Translation: BAB55221.1. Frameshift.
    AK074930 mRNA. Translation: BAC11299.1. Different initiation.
    AB040920 mRNA. Translation: BAA96011.1.
    CCDSiCCDS3476.1. [Q9P241-1]
    RefSeqiNP_065186.3. NM_020453.3. [Q9P241-1]
    XP_005248175.1. XM_005248118.2. [Q9P241-1]
    UniGeneiHs.437241.

    Genome annotation databases

    EnsembliENST00000273859; ENSP00000273859; ENSG00000145246. [Q9P241-1]
    GeneIDi57205.
    KEGGihsa:57205.
    UCSCiuc003gxk.1. human. [Q9P241-1]
    uc003gxl.1. human. [Q9P241-2]

    Polymorphism databases

    DMDMi300669610.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ441078 mRNA. Translation: CAD29577.1 .
    AC092597 Genomic DNA. No translation available.
    AC107398 Genomic DNA. No translation available.
    CH471069 Genomic DNA. Translation: EAW93036.1 .
    BC131535 mRNA. Translation: AAI31536.1 .
    AK027598 mRNA. Translation: BAB55221.1 . Frameshift.
    AK074930 mRNA. Translation: BAC11299.1 . Different initiation.
    AB040920 mRNA. Translation: BAA96011.1 .
    CCDSi CCDS3476.1. [Q9P241-1 ]
    RefSeqi NP_065186.3. NM_020453.3. [Q9P241-1 ]
    XP_005248175.1. XM_005248118.2. [Q9P241-1 ]
    UniGenei Hs.437241.

    3D structure databases

    ProteinModelPortali Q9P241.
    SMRi Q9P241. Positions 1035-1091.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121446. 1 interaction.
    STRINGi 9606.ENSP00000273859.

    PTM databases

    PhosphoSitei Q9P241.

    Polymorphism databases

    DMDMi 300669610.

    Proteomic databases

    PaxDbi Q9P241.
    PRIDEi Q9P241.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273859 ; ENSP00000273859 ; ENSG00000145246 . [Q9P241-1 ]
    GeneIDi 57205.
    KEGGi hsa:57205.
    UCSCi uc003gxk.1. human. [Q9P241-1 ]
    uc003gxl.1. human. [Q9P241-2 ]

    Organism-specific databases

    CTDi 57205.
    GeneCardsi GC04P047487.
    HGNCi HGNC:13549. ATP10D.
    HPAi HPA050808.
    neXtProti NX_Q9P241.
    PharmGKBi PA25100.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000202528.
    HOVERGENi HBG107129.
    InParanoidi Q9P241.
    KOi K01530.
    OMAi MDSTVQC.
    OrthoDBi EOG76471S.
    PhylomeDBi Q9P241.
    TreeFami TF354252.

    Enzyme and pathway databases

    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    GenomeRNAii 57205.
    NextBioi 63294.
    PROi Q9P241.

    Gene expression databases

    ArrayExpressi Q9P241.
    Bgeei Q9P241.
    CleanExi HS_ATP10D.
    Genevestigatori Q9P241.

    Family and domain databases

    Gene3Di 2.70.150.10. 2 hits.
    3.40.1110.10. 3 hits.
    3.40.50.1000. 2 hits.
    InterProi IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    PANTHERi PTHR24092. PTHR24092. 1 hit.
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01652. ATPase-Plipid. 2 hits.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a putative type IV aminophospholipid transporter P-type ATPase."
      Flamant S., Pescher P., Lemercier B., Clement-Ziza M., Kepes F., Fellous M., Milon G., Marchal G., Besmond C.
      Mamm. Genome 14:21-30(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Monocyte.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-43 AND ILE-1240.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 354-1426 (ISOFORM 2).
    6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 777-1426, VARIANT THR-1389.
      Tissue: Brain.
    7. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
      Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
      J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAT10D_HUMAN
    AccessioniPrimary (citable) accession number: Q9P241
    Secondary accession number(s): A2RRC8
    , D6REN2, Q8NC70, Q96SR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3