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Protein

Probable phospholipid-transporting ATPase VD

Gene

ATP10D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).Curated

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4384-aspartylphosphate intermediateBy similarity1
Metal bindingi1056MagnesiumBy similarity1
Metal bindingi1060MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi996 – 1003ATPSequence analysis8
Nucleotide bindingi1364 – 1371ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

  • cation transport Source: UniProtKB
  • ion transmembrane transport Source: Reactome
  • phospholipid translocation Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase VD (EC:3.6.3.1)
Alternative name(s):
ATPase class V type 10D
P4-ATPase flippase complex alpha subunit ATP10D
Gene namesi
Name:ATP10D
Synonyms:ATPVD, KIAA1487
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145246.13
HGNCiHGNC:13549 ATP10D
neXtProtiNX_Q9P241

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 121Exoplasmic loopSequence analysis3
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 321CytoplasmicSequence analysisAdd BLAST179
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 365Exoplasmic loopSequence analysisAdd BLAST23
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 1113CytoplasmicSequence analysisAdd BLAST727
Transmembranei1114 – 1134HelicalSequence analysisAdd BLAST21
Topological domaini1135 – 1145Exoplasmic loopSequence analysisAdd BLAST11
Transmembranei1146 – 1166HelicalSequence analysisAdd BLAST21
Topological domaini1167 – 1195CytoplasmicSequence analysisAdd BLAST29
Transmembranei1196 – 1216HelicalSequence analysisAdd BLAST21
Topological domaini1217 – 1224Exoplasmic loopSequence analysis8
Transmembranei1225 – 1245HelicalSequence analysisAdd BLAST21
Topological domaini1246 – 1252CytoplasmicSequence analysis7
Transmembranei1253 – 1273HelicalSequence analysisAdd BLAST21
Topological domaini1274 – 1292Exoplasmic loopSequence analysisAdd BLAST19
Transmembranei1293 – 1313HelicalSequence analysisAdd BLAST21
Topological domaini1314 – 1426CytoplasmicSequence analysisAdd BLAST113

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57205
OpenTargetsiENSG00000145246
PharmGKBiPA25100

Polymorphism and mutation databases

BioMutaiATP10D
DMDMi300669610

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463821 – 1426Probable phospholipid-transporting ATPase VDAdd BLAST1426

Proteomic databases

EPDiQ9P241
PaxDbiQ9P241
PeptideAtlasiQ9P241
PRIDEiQ9P241
ProteomicsDBi83721
83722 [Q9P241-2]

PTM databases

iPTMnetiQ9P241
PhosphoSitePlusiQ9P241

Expressioni

Tissue specificityi

Expressed in placenta and, to a lesser extent, in kidney.1 Publication

Gene expression databases

BgeeiENSG00000145246
CleanExiHS_ATP10D
ExpressionAtlasiQ9P241 baseline and differential
GenevisibleiQ9P241 HS

Organism-specific databases

HPAiHPA050808

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

Protein-protein interaction databases

BioGridi121446, 1 interactor
STRINGi9606.ENSP00000273859

Structurei

3D structure databases

ProteinModelPortaliQ9P241
SMRiQ9P241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
ENOG410XSS0 LUCA
GeneTreeiENSGT00910000144008
HOGENOMiHOG000202528
HOVERGENiHBG107129
InParanoidiQ9P241
KOiK01530
OMAiCHEENAK
OrthoDBiEOG091G0139
PhylomeDBiQ9P241
TreeFamiTF354252

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030360 ATP10D
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF84 PTHR24092:SF84, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH
60 70 80 90 100
RIVVPHIQPF KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN
110 120 130 140 150
LYFLFLVVLN WVPLVEAFQK EITMLPLVVV LTIIAIKDGL EDYRKYKIDK
160 170 180 190 200
QINNLITKVY SRKEKKYIDR CWKDVTVGDF IRLSCNEVIP ADMVLLFSTD
210 220 230 240 250
PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS SRIECESPNN
260 270 280 290 300
DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA
310 320 330 340 350
MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM
360 370 380 390 400
HFFNVPEPDG HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI
410 420 430 440 450
YFIQSDVDFY NEKMDSIVQC RALNIAEDLG QIQYLFSDKT GTLTENKMVF
460 470 480 490 500
RRCSVAGFDY CHEENARRLE SYQEAVSEDE DFIDTVSGSL SNMAKPRAPS
510 520 530 540 550
CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA FSSPIETDVV
560 570 580 590 600
PDTRLLDKFS QITPRLFMPL DETIQNPPME TLYIIDFFIA LAICNTVVVS
610 620 630 640 650
APNQPRQKIR HPSLGGLPIK SLEEIKSLFQ RWSVRRSSSP SLNSGKEPSS
660 670 680 690 700
GVPNAFVSRL PLFSRMKPAS PVEEEVSQVC ESPQCSSSSA CCTETEKQHG
710 720 730 740 750
DAGLLNGKAE SLPGQPLACN LCYEAESPDE AALVYAARAY QCTLRSRTPE
760 770 780 790 800
QVMVDFAALG PLTFQLLHIL PFDSVRKRMS VVVRHPLSNQ VVVYTKGADS
810 820 830 840 850
VIMELLSVAS PDGASLEKQQ MIVREKTQKH LDDYAKQGLR TLCIAKKVMS
860 870 880 890 900
DTEYAEWLRN HFLAETSIDN REELLLESAM RLENKLTLLG ATGIEDRLQE
910 920 930 940 950
GVPESIEALH KAGIKIWMLT GDKQETAVNI AYACKLLEPD DKLFILNTQS
960 970 980 990 1000
KDACGMLMST ILKELQKKTQ ALPEQVSLSE DLLQPPVPRD SGLRAGLIIT
1010 1020 1030 1040 1050
GKTLEFALQE SLQKQFLELT SWCQAVVCCR ATPLQKSEVV KLVRSHLQVM
1060 1070 1080 1090 1100
TLAIGDGAND VSMIQVADIG IGVSGQEGMQ AVMASDFAVS QFKHLSKLLL
1110 1120 1130 1140 1150
VHGHWCYTRL SNMILYFFYK NVAYVNLLFW YQFFCGFSGT SMTDYWVLIF
1160 1170 1180 1190 1200
FNLLFTSAPP VIYGVLEKDV SAETLMQLPE LYRSGQKSEA YLPHTFWITL
1210 1220 1230 1240 1250
LDAFYQSLVC FFVPYFTYQG SDTDIFAFGN PLNTAALFIV LLHLVIESKS
1260 1270 1280 1290 1300
LTWIHLLVII GSILSYFLFA IVFGAMCVTC NPPSNPYWIM QEHMLDPVFY
1310 1320 1330 1340 1350
LVCILTTSIA LLPRFVYRVL QGSLFPSPIL RAKHFDRLTP EERTKALKKW
1360 1370 1380 1390 1400
RGAGKMNQVT SKYANQSAGK SGRRPMPGPS AVFAMKSASS CAIEQGNLSL
1410 1420
CETALDQGYS ETKAFEMAGP SKGKES
Length:1,426
Mass (Da):160,274
Last modified:July 13, 2010 - v3
Checksum:i97EE929F81AC59AE
GO
Isoform 2 (identifier: Q9P241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     553-747: Missing.

Note: No experimental confirmation available.
Show »
Length:1,231
Mass (Da):138,890
Checksum:i67D834DFFCEA7A54
GO

Sequence cautioni

The sequence BAB55221 differs from that shown. Reason: Frameshift at position 748.Curated
The sequence BAC11299 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142D → G in CAD29577 (PubMed:12532265).Curated1
Sequence conflicti1002K → R in CAD29577 (PubMed:12532265).Curated1
Sequence conflicti1090S → Y in CAD29577 (PubMed:12532265).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04838543T → I1 PublicationCorresponds to variant dbSNP:rs33995001Ensembl.1
Natural variantiVAR_048386171C → R. Corresponds to variant dbSNP:rs7683838Ensembl.1
Natural variantiVAR_048387320T → I. Corresponds to variant dbSNP:rs35596623Ensembl.1
Natural variantiVAR_048388337A → T. Corresponds to variant dbSNP:rs35012290Ensembl.1
Natural variantiVAR_048389511N → S. Corresponds to variant dbSNP:rs10003238Ensembl.1
Natural variantiVAR_048390522F → L. Corresponds to variant dbSNP:rs6843325Ensembl.1
Natural variantiVAR_048391716P → T. Corresponds to variant dbSNP:rs34208443Ensembl.1
Natural variantiVAR_048392720N → S. Corresponds to variant dbSNP:rs34169638Ensembl.1
Natural variantiVAR_048393959S → N. Corresponds to variant dbSNP:rs17462252Ensembl.1
Natural variantiVAR_0483941183R → K. Corresponds to variant dbSNP:rs16851681Ensembl.1
Natural variantiVAR_0201871240V → I1 PublicationCorresponds to variant dbSNP:rs1058793Ensembl.1
Natural variantiVAR_0243711389S → T1 PublicationCorresponds to variant dbSNP:rs4145944Ensembl.1
Natural variantiVAR_0483951392A → G. Corresponds to variant dbSNP:rs35375547Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006954553 – 747Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ441078 mRNA Translation: CAD29577.1
AC092597 Genomic DNA No translation available.
AC107398 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93036.1
BC131535 mRNA Translation: AAI31536.1
AK027598 mRNA Translation: BAB55221.1 Frameshift.
AK074930 mRNA Translation: BAC11299.1 Different initiation.
AB040920 mRNA Translation: BAA96011.1
CCDSiCCDS3476.1 [Q9P241-1]
RefSeqiNP_065186.3, NM_020453.3 [Q9P241-1]
UniGeneiHs.437241

Genome annotation databases

EnsembliENST00000273859; ENSP00000273859; ENSG00000145246 [Q9P241-1]
GeneIDi57205
KEGGihsa:57205
UCSCiuc003gxk.2 human [Q9P241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAT10D_HUMAN
AccessioniPrimary (citable) accession number: Q9P241
Secondary accession number(s): A2RRC8
, D6REN2, Q8NC70, Q96SR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 13, 2010
Last modified: June 20, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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