Reviewed,
UniProtKB/Swiss-Prot Q9P241 (AT10D_HUMAN)
Last modified
February 9, 2010.
Version 86.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable phospholipid-transporting ATPase VD EC=3.6.3.1 Alternative name(s): ATPase class V type 10D | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1426 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out). |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Tissue specificity | Expressed in placenta and, to a lesser extent, in kidney. Ref.1 |
| Sequence similarities | Belongs to the cation transport ATPase (P-type) family. Type IV subfamily. |
| Sequence caution | The sequence BAB55221.1 differs from that shown. Reason: Frameshift at position 748. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9P241-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9P241-2) The sequence of this isoform differs from the canonical sequence as follows: 553-747: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1426 | 1426 | Probable phospholipid-transporting ATPase VD | PRO_0000046382 | |||||
Regions | |||||||||
| Topological domain | 1 – 97 | 97 | Cytoplasmic Potential | ||||||
| Transmembrane | 98 – 118 | 21 | Potential | ||||||
| Topological domain | 119 – 121 | 3 | Extracellular Potential | ||||||
| Transmembrane | 122 – 142 | 21 | Potential | ||||||
| Topological domain | 143 – 321 | 179 | Cytoplasmic Potential | ||||||
| Transmembrane | 322 – 342 | 21 | Potential | ||||||
| Topological domain | 343 – 365 | 23 | Extracellular Potential | ||||||
| Transmembrane | 366 – 386 | 21 | Potential | ||||||
| Topological domain | 387 – 1113 | 727 | Cytoplasmic Potential | ||||||
| Transmembrane | 1114 – 1134 | 21 | Potential | ||||||
| Topological domain | 1135 – 1145 | 11 | Extracellular Potential | ||||||
| Transmembrane | 1146 – 1166 | 21 | Potential | ||||||
| Topological domain | 1167 – 1195 | 29 | Cytoplasmic Potential | ||||||
| Transmembrane | 1196 – 1216 | 21 | Potential | ||||||
| Topological domain | 1217 – 1224 | 8 | Extracellular Potential | ||||||
| Transmembrane | 1225 – 1245 | 21 | Potential | ||||||
| Topological domain | 1246 – 1252 | 7 | Cytoplasmic Potential | ||||||
| Transmembrane | 1253 – 1273 | 21 | Potential | ||||||
| Topological domain | 1274 – 1292 | 19 | Extracellular Potential | ||||||
| Transmembrane | 1293 – 1313 | 21 | Potential | ||||||
| Topological domain | 1314 – 1426 | 113 | Cytoplasmic Potential | ||||||
| Nucleotide binding | 996 – 1003 | 8 | ATP Potential | ||||||
| Nucleotide binding | 1364 – 1371 | 8 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 438 | 1 | 4-aspartylphosphate intermediate By similarity | ||||||
| Metal binding | 1056 | 1 | Magnesium By similarity | ||||||
| Metal binding | 1060 | 1 | Magnesium By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 553 – 747 | 195 | Missing in isoform 2. | VSP_006954 | |||||
| Natural variant | 43 | 1 | T → I: dbSNP rs33995001. | VAR_048385 | |||||
| Natural variant | 171 | 1 | C → R: dbSNP rs7683838. | VAR_048386 | |||||
| Natural variant | 320 | 1 | T → I: dbSNP rs35596623. | VAR_048387 | |||||
| Natural variant | 337 | 1 | A → T: dbSNP rs35012290. | VAR_048388 | |||||
| Natural variant | 511 | 1 | N → S: dbSNP rs10003238. | VAR_048389 | |||||
| Natural variant | 522 | 1 | F → L: dbSNP rs6843325. | VAR_048390 | |||||
| Natural variant | 716 | 1 | P → T: dbSNP rs34208443. | VAR_048391 | |||||
| Natural variant | 720 | 1 | N → S: dbSNP rs34169638. | VAR_048392 | |||||
| Natural variant | 959 | 1 | S → N: dbSNP rs17462252. | VAR_048393 | |||||
| Natural variant | 1183 | 1 | R → K: dbSNP rs16851681. | VAR_048394 | |||||
| Natural variant | 1240 | 1 | V → I: dbSNP rs1058793. | VAR_020187 | |||||
| Natural variant | 1389 | 1 | S → T: dbSNP rs4145944. Ref.3 | VAR_024371 | |||||
| Natural variant | 1392 | 1 | A → G: dbSNP rs35375547. | VAR_048395 | |||||
Experimental info | |||||||||
| Sequence conflict | 1002 | 1 | R → K Ref.2 | ||||||
| Sequence conflict | 1002 | 1 | R → K Ref.3 | ||||||
| Sequence conflict | 1090 | 1 | Y → S Ref.2 | ||||||
| Sequence conflict | 1090 | 1 | Y → S Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of a putative type IV aminophospholipid transporter P-type ATPase." Flamant S., Pescher P., Lemercier B., Clement-Ziza M., Kepes F., Fellous M., Milon G., Marchal G., Besmond C. Mamm. Genome 14:21-30(2003) [PubMed: 12532265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Monocyte. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 354-1426 (ISOFORM 2). |
| [3] | "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 777-1426, VARIANT THR-1389. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ441078 mRNA. Translation: CAD29577.1. AK027598 mRNA. Translation: BAB55221.1. Frameshift. AK074930 mRNA. Translation: BAC11299.1. Different initiation. AB040920 mRNA. Translation: BAA96011.1. |
| IPI | IPI00001723. IPI00216521. |
| RefSeq | NP_065186.3. |
| UniGene | Hs.437241 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9P241. |
Genome annotation databases | |
| Ensembl | ENST00000273859; ENSP00000273859; ENSG00000145246; Homo sapiens. [Genome view] |
| GeneID | 57205. |
| KEGG | hsa:57205. |
| UCSC | uc003gxk.1. human. |
Organism-specific databases | |
| CTD | 57205. |
| GeneCards | GC04P047182. |
| HGNC | HGNC:13549. ATP10D. |
| PharmGKB | PA25100. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG745019. |
| HOVERGEN | Q9P241. |
| InParanoid | Q9P241. |
| PhylomeDB | Q9P241. |
Enzyme and pathway databases | |
| BRENDA | 3.6.3.1. 247. |
Gene expression databases | |
| ArrayExpress | Q9P241. |
| Bgee | Q9P241. |
| CleanEx | HS_ATP10D. |
| Genevestigator | Q9P241. |
| GermOnline | ENSG00000145246. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR005834. Dehalogen-like_hydro. [Graphical view] |
| PANTHER | PTHR11939. ATPase_P. 1 hit. |
| Pfam | PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view] |
| PRINTS | PR00119. CATATPASE. |
| TIGRFAMs | TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 3 hits. |
| PROSITE | PS00154. ATPASE_E1_E2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 63294. |
Entry information
| Entry name | AT10D_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9P241 Secondary accession number(s): Q8NC70, Q96SR3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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