Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Contactin-3

Gene

CNTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-3
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 1
Short name:
BIG-1
Plasmacytoma-associated neuronal glycoprotein
Gene namesi
Name:CNTN3
Synonyms:KIAA1496, PANG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2173. CNTN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26687.

Polymorphism and mutation databases

BioMutaiCNTN3.
DMDMi296439395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 1002983Contactin-3PRO_0000014705Add
BLAST
Propeptidei1003 – 102826Removed in mature formSequence analysisPRO_0000014706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence analysis
Glycosylationi489 – 4891N-linked (GlcNAc...)1 Publication
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi765 – 7651N-linked (GlcNAc...)Sequence analysis
Glycosylationi860 – 8601N-linked (GlcNAc...)1 Publication
Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence analysis
Glycosylationi913 – 9131N-linked (GlcNAc...)Sequence analysis
Glycosylationi931 – 9311N-linked (GlcNAc...)1 Publication
Glycosylationi956 – 9561N-linked (GlcNAc...)Sequence analysis
Lipidationi1002 – 10021GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ9P232.
PaxDbiQ9P232.
PRIDEiQ9P232.

PTM databases

iPTMnetiQ9P232.
PhosphoSiteiQ9P232.

Expressioni

Tissue specificityi

In brain, it is expressed in frontal lobe, occipital lobe, cerebellum and amygdala.1 Publication

Gene expression databases

BgeeiQ9P232.
CleanExiHS_CNTN3.
GenevisibleiQ9P232. HS.

Organism-specific databases

HPAiHPA003341.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

BioGridi111102. 1 interaction.
IntActiQ9P232. 4 interactions.
MINTiMINT-6783006.
STRINGi9606.ENSP00000263665.

Structurei

Secondary structure

1
1028
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi918 – 9225Combined sources
Beta strandi930 – 9323Combined sources
Beta strandi935 – 94612Combined sources
Beta strandi951 – 96313Combined sources
Beta strandi970 – 98011Combined sources
Beta strandi989 – 9913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WJ3NMR-A893-996[»]
ProteinModelPortaliQ9P232.
SMRiQ9P232. Positions 25-405, 886-996.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P232.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 11792Ig-like C2-type 1Add
BLAST
Domaini122 – 20887Ig-like C2-type 2Add
BLAST
Domaini227 – 31387Ig-like C2-type 3Add
BLAST
Domaini318 – 40285Ig-like C2-type 4Add
BLAST
Domaini408 – 49790Ig-like C2-type 5Add
BLAST
Domaini499 – 59395Ig-like C2-type 6Add
BLAST
Domaini600 – 69899Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini703 – 80098Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini805 – 90197Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini902 – 99897Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ9P232.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ9P232.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 4 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPWKQLIL LSFIGCLGGE LLLQGPVFIK EPSNSIFPVG SEDKKITLHC
60 70 80 90 100
EARGNPSPHY RWQLNGSDID MSMEHRYKLN GGNLVVINPN RNWDTGTYQC
110 120 130 140 150
FATNSLGTIV SREAKLQFAY LENFKTKMRS TVSVREGQGV VLLCGPPPHS
160 170 180 190 200
GELSYAWIFN EYPSFVEEDS RRFVSQETGH LYISKVEPSD VGNYTCVVTS
210 220 230 240 250
MVTNARVLGS PTPLVLRSDG VMGEYEPKIE VQFPETLPAA KGSTVKLECF
260 270 280 290 300
ALGNPIPQIN WRRSDGLPFS SKIKLRKFSG VLEIPNFQQE DAGSYECIAE
310 320 330 340 350
NSRGKNVARG RLTYYAKPHW VQLIKDVEIA VEDSLYWECR ASGKPKPSYR
360 370 380 390 400
WLKNGAALVL EERTQIENGA LTISNLSVTD SGMFQCIAEN KHGLVYSSAE
410 420 430 440 450
LKVVASAPDF SKNPMKKLVQ VQVGSLVSLD CKPRASPRAL SSWKKGDVSV
460 470 480 490 500
QEHERISLLN DGGLKIANVT KADAGTYTCM AENQFGKANG TTHLVVTEPT
510 520 530 540 550
RITLAPSNMD VSVGESVILP CQVQHDPLLD IIFTWYFNGA LADFKKDGSH
560 570 580 590 600
FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA DLIVRGSPGP
610 620 630 640 650
PENVKVDEIT DTTAQLSWKE GKDNHSPVIS YSIQARTPFS VGWQTVTTVP
660 670 680 690 700
EVIDGKTHTA TVVELNPWVE YEFRVVASNK IGGGEPSLPS EKVRTEEAVP
710 720 730 740 750
EVPPSEVNGG GGSRSELVIT WDPVPEELQN GEGFGYVVAF RPLGVTTWIQ
760 770 780 790 800
TVVTSPDTPR YVFRNESIVP YSPYEVKVGV YNNKGEGPFS PVTTVFSAEE
810 820 830 840 850
EPTVAPSQVS ANSLSSSEIE VSWNTIPWKL SNGHLLGYEV RYWNGGGKEE
860 870 880 890 900
SSSKMKVAGN ETSARLRGLK SNLAYYTAVR AYNSAGAGPF SATVNVTTKK
910 920 930 940 950
TPPSQPPGNV VWNATDTKVL LNWEQVKAME NESEVTGYKV FYRTSSQNNV
960 970 980 990 1000
QVLNTNKTSA ELVLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR
1010 1020
GSTSAISNVH PMSSYMPIVL FLIVYVLW
Length:1,028
Mass (Da):112,883
Last modified:May 18, 2010 - v3
Checksum:i575945CD75D21844
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti630 – 6301S → N.
Corresponds to variant rs626578 [ dbSNP | Ensembl ].
VAR_019906
Natural varianti708 – 7081N → S.1 Publication
Corresponds to variant rs626578 [ dbSNP | Ensembl ].
VAR_056042

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016950 Genomic DNA. No translation available.
AC024222 Genomic DNA. No translation available.
AC128653 Genomic DNA. No translation available.
AC128656 Genomic DNA. No translation available.
BC150608 mRNA. Translation: AAI50609.1.
AB040929 mRNA. Translation: BAA96020.1.
AL512746 mRNA. Translation: CAC21671.1.
CCDSiCCDS33790.1.
RefSeqiNP_065923.1. NM_020872.2.
XP_005264814.1. XM_005264757.2.
UniGeneiHs.12723.

Genome annotation databases

EnsembliENST00000263665; ENSP00000263665; ENSG00000113805.
GeneIDi5067.
KEGGihsa:5067.
UCSCiuc003dpm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016950 Genomic DNA. No translation available.
AC024222 Genomic DNA. No translation available.
AC128653 Genomic DNA. No translation available.
AC128656 Genomic DNA. No translation available.
BC150608 mRNA. Translation: AAI50609.1.
AB040929 mRNA. Translation: BAA96020.1.
AL512746 mRNA. Translation: CAC21671.1.
CCDSiCCDS33790.1.
RefSeqiNP_065923.1. NM_020872.2.
XP_005264814.1. XM_005264757.2.
UniGeneiHs.12723.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WJ3NMR-A893-996[»]
ProteinModelPortaliQ9P232.
SMRiQ9P232. Positions 25-405, 886-996.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111102. 1 interaction.
IntActiQ9P232. 4 interactions.
MINTiMINT-6783006.
STRINGi9606.ENSP00000263665.

PTM databases

iPTMnetiQ9P232.
PhosphoSiteiQ9P232.

Polymorphism and mutation databases

BioMutaiCNTN3.
DMDMi296439395.

Proteomic databases

EPDiQ9P232.
PaxDbiQ9P232.
PRIDEiQ9P232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263665; ENSP00000263665; ENSG00000113805.
GeneIDi5067.
KEGGihsa:5067.
UCSCiuc003dpm.2. human.

Organism-specific databases

CTDi5067.
GeneCardsiCNTN3.
H-InvDBHIX0003468.
HGNCiHGNC:2173. CNTN3.
HPAiHPA003341.
MIMi601325. gene.
neXtProtiNX_Q9P232.
PharmGKBiPA26687.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ9P232.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ9P232.
TreeFamiTF351103.

Miscellaneous databases

EvolutionaryTraceiQ9P232.
GeneWikiiCNTN3.
GenomeRNAii5067.
PROiQ9P232.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P232.
CleanExiHS_CNTN3.
GenevisibleiQ9P232. HS.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 4 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-708.
    Tissue: Testis.
  3. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1028.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 984-1028.
    Tissue: Brain.
  5. "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members."
    Kamei Y., Takeda Y., Teramoto K., Tsutsumi O., Taketani Y., Watanabe K.
    Genomics 69:113-119(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-489; ASN-860 AND ASN-931.
    Tissue: Plasma.
  7. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRG.
  8. "Solution structure of the fourth FN3 domain of KIAA1496 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 893-996.

Entry informationi

Entry nameiCNTN3_HUMAN
AccessioniPrimary (citable) accession number: Q9P232
Secondary accession number(s): B9EK50, Q9H039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.