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Protein

Contactin-3

Gene

CNTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-163125. Post-translational modification: synthesis of GPI-anchored proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-3
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 1
Short name:
BIG-1
Plasmacytoma-associated neuronal glycoprotein
Gene namesi
Name:CNTN3
Synonyms:KIAA1496, PANG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000113805.8.
HGNCiHGNC:2173. CNTN3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5067.
OpenTargetsiENSG00000113805.
PharmGKBiPA26687.

Polymorphism and mutation databases

BioMutaiCNTN3.
DMDMi296439395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001470520 – 1002Contactin-3Add BLAST983
PropeptideiPRO_00000147061003 – 1028Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi489N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi860N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi895N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi913N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi956N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi1002GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9P232.
PeptideAtlasiQ9P232.
PRIDEiQ9P232.

PTM databases

iPTMnetiQ9P232.
PhosphoSitePlusiQ9P232.

Expressioni

Tissue specificityi

In brain, it is expressed in frontal lobe, occipital lobe, cerebellum and amygdala.1 Publication

Gene expression databases

BgeeiENSG00000113805.
CleanExiHS_CNTN3.
GenevisibleiQ9P232. HS.

Organism-specific databases

HPAiHPA003341.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

IntActiQ9P232. 4 interactors.
MINTiMINT-6783006.
STRINGi9606.ENSP00000263665.

Structurei

Secondary structure

11028
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi918 – 922Combined sources5
Beta strandi930 – 932Combined sources3
Beta strandi935 – 946Combined sources12
Beta strandi951 – 963Combined sources13
Beta strandi970 – 980Combined sources11
Beta strandi989 – 991Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJ3NMR-A893-996[»]
ProteinModelPortaliQ9P232.
SMRiQ9P232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P232.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 117Ig-like C2-type 1Add BLAST92
Domaini122 – 208Ig-like C2-type 2Add BLAST87
Domaini227 – 313Ig-like C2-type 3Add BLAST87
Domaini318 – 402Ig-like C2-type 4Add BLAST85
Domaini408 – 497Ig-like C2-type 5Add BLAST90
Domaini499 – 593Ig-like C2-type 6Add BLAST95
Domaini600 – 698Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini703 – 800Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini805 – 901Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini902 – 998Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ9P232.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG091G00X7.
PhylomeDBiQ9P232.
TreeFamiTF351103.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
PfamiView protein in Pfam
PF00041. fn3. 4 hits.
PF07679. I-set. 2 hits.
SMARTiView protein in SMART
SM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPWKQLIL LSFIGCLGGE LLLQGPVFIK EPSNSIFPVG SEDKKITLHC
60 70 80 90 100
EARGNPSPHY RWQLNGSDID MSMEHRYKLN GGNLVVINPN RNWDTGTYQC
110 120 130 140 150
FATNSLGTIV SREAKLQFAY LENFKTKMRS TVSVREGQGV VLLCGPPPHS
160 170 180 190 200
GELSYAWIFN EYPSFVEEDS RRFVSQETGH LYISKVEPSD VGNYTCVVTS
210 220 230 240 250
MVTNARVLGS PTPLVLRSDG VMGEYEPKIE VQFPETLPAA KGSTVKLECF
260 270 280 290 300
ALGNPIPQIN WRRSDGLPFS SKIKLRKFSG VLEIPNFQQE DAGSYECIAE
310 320 330 340 350
NSRGKNVARG RLTYYAKPHW VQLIKDVEIA VEDSLYWECR ASGKPKPSYR
360 370 380 390 400
WLKNGAALVL EERTQIENGA LTISNLSVTD SGMFQCIAEN KHGLVYSSAE
410 420 430 440 450
LKVVASAPDF SKNPMKKLVQ VQVGSLVSLD CKPRASPRAL SSWKKGDVSV
460 470 480 490 500
QEHERISLLN DGGLKIANVT KADAGTYTCM AENQFGKANG TTHLVVTEPT
510 520 530 540 550
RITLAPSNMD VSVGESVILP CQVQHDPLLD IIFTWYFNGA LADFKKDGSH
560 570 580 590 600
FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA DLIVRGSPGP
610 620 630 640 650
PENVKVDEIT DTTAQLSWKE GKDNHSPVIS YSIQARTPFS VGWQTVTTVP
660 670 680 690 700
EVIDGKTHTA TVVELNPWVE YEFRVVASNK IGGGEPSLPS EKVRTEEAVP
710 720 730 740 750
EVPPSEVNGG GGSRSELVIT WDPVPEELQN GEGFGYVVAF RPLGVTTWIQ
760 770 780 790 800
TVVTSPDTPR YVFRNESIVP YSPYEVKVGV YNNKGEGPFS PVTTVFSAEE
810 820 830 840 850
EPTVAPSQVS ANSLSSSEIE VSWNTIPWKL SNGHLLGYEV RYWNGGGKEE
860 870 880 890 900
SSSKMKVAGN ETSARLRGLK SNLAYYTAVR AYNSAGAGPF SATVNVTTKK
910 920 930 940 950
TPPSQPPGNV VWNATDTKVL LNWEQVKAME NESEVTGYKV FYRTSSQNNV
960 970 980 990 1000
QVLNTNKTSA ELVLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR
1010 1020
GSTSAISNVH PMSSYMPIVL FLIVYVLW
Length:1,028
Mass (Da):112,883
Last modified:May 18, 2010 - v3
Checksum:i575945CD75D21844
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019906630S → N. Corresponds to variant dbSNP:rs626578Ensembl.1
Natural variantiVAR_056042708N → S1 PublicationCorresponds to variant dbSNP:rs626578Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016950 Genomic DNA. No translation available.
AC024222 Genomic DNA. No translation available.
AC128653 Genomic DNA. No translation available.
AC128656 Genomic DNA. No translation available.
BC150608 mRNA. Translation: AAI50609.1.
AB040929 mRNA. Translation: BAA96020.1.
AL512746 mRNA. Translation: CAC21671.1.
CCDSiCCDS33790.1.
RefSeqiNP_065923.1. NM_020872.2.
XP_005264814.1. XM_005264757.3.
XP_016861996.1. XM_017006507.1.
UniGeneiHs.12723.

Genome annotation databases

EnsembliENST00000263665; ENSP00000263665; ENSG00000113805.
GeneIDi5067.
KEGGihsa:5067.
UCSCiuc003dpm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNTN3_HUMAN
AccessioniPrimary (citable) accession number: Q9P232
Secondary accession number(s): B9EK50, Q9H039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families