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Protein

Rho GTPase-activating protein 23

Gene

ARHGAP23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 23
Alternative name(s):
Rho-type GTPase-activating protein 23
Gene namesi
Name:ARHGAP23
Synonyms:KIAA1501
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29293. ARHGAP23.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiARHGAP23.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14911491Rho GTPase-activating protein 23PRO_0000280471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei372 – 3721PhosphoserineCombined sources
Modified residuei423 – 4231PhosphoserineCombined sources
Modified residuei517 – 5171PhosphoserineBy similarity
Modified residuei583 – 5831PhosphoserineBy similarity
Modified residuei611 – 6111PhosphoserineBy similarity
Modified residuei623 – 6231PhosphoserineBy similarity
Modified residuei656 – 6561PhosphothreonineBy similarity
Modified residuei659 – 6591PhosphoserineBy similarity
Modified residuei662 – 6621PhosphoserineBy similarity
Modified residuei677 – 6771PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P227.
MaxQBiQ9P227.
PaxDbiQ9P227.
PRIDEiQ9P227.

PTM databases

iPTMnetiQ9P227.
PhosphoSiteiQ9P227.

Expressioni

Tissue specificityi

Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.1 Publication

Gene expression databases

BgeeiQ9P227.
CleanExiHS_ARHGAP23.
ExpressionAtlasiQ9P227. baseline and differential.
GenevisibleiQ9P227. HS.

Organism-specific databases

HPAiHPA019818.
HPA047291.

Interactioni

Protein-protein interaction databases

BioGridi121677. 5 interactions.
STRINGi9606.ENSP00000393539.

Structurei

3D structure databases

ProteinModelPortaliQ9P227.
SMRiQ9P227. Positions 41-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 15585PDZPROSITE-ProRule annotationAdd
BLAST
Domaini688 – 808121PHPROSITE-ProRule annotationAdd
BLAST
Domaini905 – 1097193Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 27997Pro-richAdd
BLAST
Compositional biasi1320 – 140586Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4407. Eukaryota.
ENOG410YY7B. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000049125.
HOVERGENiHBG093896.
InParanoidiQ9P227.
OMAiSTWATMV.
PhylomeDBiQ9P227.
TreeFamiTF329345.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P227-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGVAFCLVG IPPRPEPRPP QLPLGPRDGC SPRRPFPWQG PRTLLLYKSP
60 70 80 90 100
QDGFGFTLRH FIVYPPESAV HCSLKEEENG GRGGGPSPRY RLEPMDTIFV
110 120 130 140 150
KNVKEDGPAH RAGLRTGDRL VKVNGESVIG KTYSQVIALI QNSDDTLELS
160 170 180 190 200
IMPKDEDILQ LAYSQDAYLK GNEPYSGEAR SIPEPPPICY PRKTYAPPAR
210 220 230 240 250
ASTRATMVPE PTSALPSDPR SPAAWSDPGL RVPPAARAHL DNSSLGMSQP
260 270 280 290 300
RPSPGAFPHL SSEPRTPRAF PEPGSRVPPS RLECQQALSH WLSNQVPRRA
310 320 330 340 350
GERRCPAMAP RARSASQDRL EEVAAPRPWP CSTSQDALSQ LGQEGWHRAR
360 370 380 390 400
SDDYLSRATR SAEALGPGAL VSPRFERCGW ASQRSSARTP ACPTRDLPGP
410 420 430 440 450
QAPPPSGLQG LDDLGYIGYR SYSPSFQRRT GLLHALSFRD SPFGGLPTFN
460 470 480 490 500
LAQSPASFPP EASEPPRVVR PEPSTRALEP PAEDRGDEVV LRQKPPTGRK
510 520 530 540 550
VQLTPARQMN LGFGDESPEP EASGRGERLG RKVAPLATTE DSLASIPFID
560 570 580 590 600
EPTSPSIDLQ AKHVPASAVV SSAMNSAPVL GTSPSSPTFT FTLGRHYSQD
610 620 630 640 650
CSSIKAGRRS SYLLAITTER SKSCDDGLNT FRDEGRVLRR LPNRIPSLRM
660 670 680 690 700
LRSFFTDGSL DSWGTSEDAD APSKRHSTSD LSDATFSDIR REGWLYYKQI
710 720 730 740 750
LTKKGKKAGS GLRQWKRVYA ALRARSLSLS KERREPGPAA AGAAAAGAGE
760 770 780 790 800
DEAAPVCIGS CLVDISYSET KRRHVFRLTT ADFCEYLFQA EDRDDMLGWI
810 820 830 840 850
RAIRENSRAE GEDPGCANQA LISKKLNDYR KVSHSSGPKA DSSPKGSRGL
860 870 880 890 900
GGLKSEFLKQ SAARGLRTQD LPAGSKDDSA AAPKTPWGIN IIKKNKKAAP
910 920 930 940 950
RAFGVRLEEC QPATENQRVP LIVAACCRIV EARGLESTGI YRVPGNNAVV
960 970 980 990 1000
SSLQEQLNRG PGDINLQDER WQDLNVISSL LKSFFRKLPE PLFTDDKYND
1010 1020 1030 1040 1050
FIEANRIEDA RERMRTLRKL IRDLPGHYYE TLKFLVGHLK TIADHSEKNK
1060 1070 1080 1090 1100
MEPRNLALVF GPTLVRTSED NMTDMVTHMP DRYKIVETLI QHSDWFFSDE
1110 1120 1130 1140 1150
EDKGERTPVG DKEPQAVPNI EYLLPNIGRT VPPGDPGSDS TTCSSAKSKG
1160 1170 1180 1190 1200
SWAPKKEPYA REMLAISFIS AVNRKRKKRR EARGLGSSTD DDSEQEAHKP
1210 1220 1230 1240 1250
GAGATAPGTQ ERPQGPLPGA VAPEAPGRLS PPAAPEERPA ADTRSIVSGY
1260 1270 1280 1290 1300
STLSTMDRSV CSGASGRRAG AGDEADDERS ELSHVETDTE GAAGAGPGGR
1310 1320 1330 1340 1350
LTRRPSFSSH HLMPCDTLAR RRLARGRPDG EGAGRGGPRA PEPPGSASSS
1360 1370 1380 1390 1400
SQESLRPPAA ALASRPSRME ALRLRLRGTA DDMLAVRLRR PLSPETRRRR
1410 1420 1430 1440 1450
SSWRRHTVVV QSPLTDLNFN EWKELGGGGP PEPAGARAHS DNKDSGLSSL
1460 1470 1480 1490
ESTKARAPSS AASQPPAPGD TGSLQSQPPR RSAASRLHQC L
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:1,491
Mass (Da):162,192
Last modified:March 20, 2007 - v2
Checksum:i1700D3F1AEF5C0B1
GO
Isoform 2 (identifier: Q9P227-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1139-1144: DSTTCS → ADLLEI
     1145-1491: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,144
Mass (Da):125,710
Checksum:i18AACA715BFDF853
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1139 – 11446DSTTCS → ADLLEI in isoform 2. 1 PublicationVSP_023708
Alternative sequencei1145 – 1491347Missing in isoform 2. 1 PublicationVSP_023709Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115090 Genomic DNA. No translation available.
AB040934 mRNA. Translation: BAA96025.1.
CCDSiCCDS56027.1. [Q9P227-1]
PIRiA59434.
RefSeqiNP_001186346.1. NM_001199417.1. [Q9P227-1]
XP_006722057.1. XM_006721994.2. [Q9P227-2]
XP_006725396.1. XM_006725333.2. [Q9P227-2]
UniGeneiHs.374446.

Genome annotation databases

EnsembliENST00000610551; ENSP00000479208; ENSG00000273780. [Q9P227-1]
ENST00000620417; ENSP00000482992; ENSG00000275832. [Q9P227-2]
ENST00000622683; ENSP00000481862; ENSG00000275832. [Q9P227-1]
ENST00000631799; ENSP00000488428; ENSG00000273780. [Q9P227-2]
GeneIDi57636.
KEGGihsa:57636.
UCSCiuc021twd.2. human. [Q9P227-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115090 Genomic DNA. No translation available.
AB040934 mRNA. Translation: BAA96025.1.
CCDSiCCDS56027.1. [Q9P227-1]
PIRiA59434.
RefSeqiNP_001186346.1. NM_001199417.1. [Q9P227-1]
XP_006722057.1. XM_006721994.2. [Q9P227-2]
XP_006725396.1. XM_006725333.2. [Q9P227-2]
UniGeneiHs.374446.

3D structure databases

ProteinModelPortaliQ9P227.
SMRiQ9P227. Positions 41-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121677. 5 interactions.
STRINGi9606.ENSP00000393539.

PTM databases

iPTMnetiQ9P227.
PhosphoSiteiQ9P227.

Polymorphism and mutation databases

BioMutaiARHGAP23.

Proteomic databases

EPDiQ9P227.
MaxQBiQ9P227.
PaxDbiQ9P227.
PRIDEiQ9P227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610551; ENSP00000479208; ENSG00000273780. [Q9P227-1]
ENST00000620417; ENSP00000482992; ENSG00000275832. [Q9P227-2]
ENST00000622683; ENSP00000481862; ENSG00000275832. [Q9P227-1]
ENST00000631799; ENSP00000488428; ENSG00000273780. [Q9P227-2]
GeneIDi57636.
KEGGihsa:57636.
UCSCiuc021twd.2. human. [Q9P227-1]

Organism-specific databases

CTDi57636.
GeneCardsiARHGAP23.
H-InvDBHIX0022865.
HGNCiHGNC:29293. ARHGAP23.
HPAiHPA019818.
HPA047291.
MIMi610590. gene.
neXtProtiNX_Q9P227.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4407. Eukaryota.
ENOG410YY7B. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000049125.
HOVERGENiHBG093896.
InParanoidiQ9P227.
OMAiSTWATMV.
PhylomeDBiQ9P227.
TreeFamiTF329345.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARHGAP23. human.
GenomeRNAii57636.
NextBioi64349.
PROiQ9P227.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P227.
CleanExiHS_ARHGAP23.
ExpressionAtlasiQ9P227. baseline and differential.
GenevisibleiQ9P227. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 410-1491 (ISOFORM 2).
    Tissue: Brain.
  3. "Identification and characterization of human ARHGAP23 gene in silico."
    Katoh M., Katoh M.
    Int. J. Oncol. 25:535-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRHG23_HUMAN
AccessioniPrimary (citable) accession number: Q9P227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 11, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.