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Q9P225

- DYH2_HUMAN

UniProt

Q9P225 - DYH2_HUMAN

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Protein

Dynein heavy chain 2, axonemal

Gene

DNAH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1803 – 18108ATPSequence Analysis
Nucleotide bindingi2084 – 20918ATPSequence Analysis
Nucleotide bindingi2416 – 24238ATPSequence Analysis
Nucleotide bindingi2762 – 27698ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. cilium or flagellum-dependent cell motility Source: UniProtKB
  2. metabolic process Source: GOC
  3. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 2, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
Dynein heavy chain domain-containing protein 3
Gene namesi
Name:DNAH2
Synonyms:DNAHC2, DNHD3, KIAA1503
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:2948. DNAH2.

Subcellular locationi

GO - Cellular componenti

  1. axonemal dynein complex Source: UniProtKB
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 44274427Dynein heavy chain 2, axonemalPRO_0000322542Add
BLAST

Proteomic databases

PaxDbiQ9P225.
PRIDEiQ9P225.

PTM databases

PhosphoSiteiQ9P225.

Expressioni

Tissue specificityi

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.1 Publication

Gene expression databases

BgeeiQ9P225.
CleanExiHS_DNAH2.
ExpressionAtlasiQ9P225. baseline and differential.
GenevestigatoriQ9P225.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

BioGridi127007. 3 interactions.
IntActiQ9P225. 1 interaction.
STRINGi9606.ENSP00000373825.

Structurei

3D structure databases

ProteinModelPortaliQ9P225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1404 – 143936TPR 1Add
BLAST
Repeati2721 – 275434TPR 2Add
BLAST
Repeati3072 – 310534TPR 3Add
BLAST
Repeati4072 – 410433TPR 4Add
BLAST
Repeati4105 – 414036TPR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 17641764StemBy similarityAdd
BLAST
Regioni1765 – 1986222AAA 1By similarityAdd
BLAST
Regioni2046 – 2273228AAA 2By similarityAdd
BLAST
Regioni2378 – 2625248AAA 3By similarityAdd
BLAST
Regioni2722 – 2974253AAA 4By similarityAdd
BLAST
Regioni2989 – 3272284StalkBy similarityAdd
BLAST
Regioni3358 – 3588231AAA 5By similarityAdd
BLAST
Regioni3804 – 4023220AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3012 – 304938Sequence AnalysisAdd
BLAST
Coiled coili3216 – 330489Sequence AnalysisAdd
BLAST
Coiled coili3523 – 356745Sequence AnalysisAdd
BLAST

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated
Contains 5 TPR repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5245.
GeneTreeiENSGT00760000118964.
HOGENOMiHOG000237308.
HOVERGENiHBG104828.
InParanoidiQ9P225.
KOiK10408.
OMAiKISRPPQ.
OrthoDBiEOG7F5115.
PhylomeDBiQ9P225.
TreeFamiTF316836.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P225-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKAEKKQR LSGRGSSQAS WSGRATRAAV ATQEQGNAPA VSEPELQAEL
60 70 80 90 100
PKEEPEPRLE GPQAQSEESV EPEADVKPLF LSRAALTGLA DAVWTQEHDA
110 120 130 140 150
ILEHFAQDPT ESILTIFIDP CFGLKLELGM PVQTQNQLVY FIRQAPVPIT
160 170 180 190 200
WENFEATVQF GTVRGPYIPA LLRLLGGVFA PQIFANTGWP ESIRNHFASH
210 220 230 240 250
LHKFLACLTD TRYKLEGHTV LYIPAEAMNM KPEMVIKDKE LVQRLETSMI
260 270 280 290 300
HWTRQIKEML SAQETVETGE NLGPLEEIEF WRNRCMDLSG ISKQLVKKGV
310 320 330 340 350
KHVESILHLA KSSYLAPFMK LAQQIQDGSR QAQSNLTFLS ILKEPYQELA
360 370 380 390 400
FMKPKDISSK LPKLISLIRI IWVNSPHYNT RERLTSLFRK VCDCQYHFAR
410 420 430 440 450
WEDGKQGPLP CFFGAQGPQI TRNLLEIEDI FHKNLHTLRA VRGGILDVKN
460 470 480 490 500
TCWHEDYNKF RAGIKDLEVM TQNLITSAFE LVRDVPHGVL LLDTFHRLAS
510 520 530 540 550
REAIKRTYDK KAVDLYMLFN SELALVNRER NKKWPDLEPY VAQYSGKARW
560 570 580 590 600
VHILRRRIDR VMTCLAGAHF LPRIGTGKES VHTYQQMVQA IDELVRKTFQ
610 620 630 640 650
EWTSSLDKDC IRRLDTPLLR ISQEKAGMLD VNFDKSLLIL FAEIDYWERL
660 670 680 690 700
LFETPHYVVN VAERAEDLRI LRENLLLVAR DYNRIIAMLS PDEQALFKER
710 720 730 740 750
IRLLDKKIHP GLKKLHWALK GASAFFITEC RIHASKVQMI VNEFKASTLT
760 770 780 790 800
IGWRAQEMSE KLLVRISGKR VYRDLEFEED QREHRAAVQQ KLMNLHQDVV
810 820 830 840 850
TIMTNSYEVF KNDGPEIQQQ WMLYMIRLDR MMEDALRLNV KWSLLELSKA
860 870 880 890 900
INGDGKTSPN PLFQVLVILK NDLQGSVAQV EFSPTLQTLA GVVNDIGNHL
910 920 930 940 950
FSTISVFCHL PDILTKRKLH REPIQTVVEQ DEDIKKIQTQ ISSGMTNNAS
960 970 980 990 1000
LLQNYLKTWD MYREIWEINK DSFIHRYQRL NPPVSSFVAD IARYTEVANN
1010 1020 1030 1040 1050
VQKEETVTNI QFVLLDCSHL KFSLVQHCNE WQNKFATLLR EMAAGRLLEL
1060 1070 1080 1090 1100
HTYLKENAEK ISRPPQTLEE LGVSLQLVDA LKHDLANVET QIPPIHEQFA
1110 1120 1130 1140 1150
ILEKYEVPVE DSVLEMLDSL NGEWVVFQQT LLDSKQMLKK HKEKFKTGLI
1160 1170 1180 1190 1200
HSADDFKKKA HTLLEDFEFK GHFTSNVGYM SALDQITQVR AMLMAMREEE
1210 1220 1230 1240 1250
NSLRANLGIF KIEQPPSKDL QNLEKELDAL QQIWEIARDW EENWNEWKTG
1260 1270 1280 1290 1300
RFLILQTETM ETTAHGLFRR LTKLAKEYKD RNWEIIETTR SKIEQFKRTM
1310 1320 1330 1340 1350
PLISDLRNPA LRERHWDQVR DEIQREFDQE SESFTLEQIV ELGMDQHVEK
1360 1370 1380 1390 1400
IGEISASATK ELAIEVALQN IAKTWDVTQL DIVPYKDKGH HRLRGTEEVF
1410 1420 1430 1440 1450
QALEDNQVAL STMKASRFVK AFEKDVDHWE RCLSLILEVI EMILTVQRQW
1460 1470 1480 1490 1500
MYLENIFLGE DIRKQLPNES TLFDQVNSNW KAIMDRMNKD NNALRSTHHP
1510 1520 1530 1540 1550
GLLDTLIEMN TILEDIQKSL DMYLETKRHI FPRFYFLSND DLLEILGQSR
1560 1570 1580 1590 1600
NPEAVQPHLK KCFDNIKLLR IQKVGGPSSK WEAVGMFSGD GEYIDFLHSV
1610 1620 1630 1640 1650
FLEGPVESWL GDVEQTMRVT LRDLLRNCHL ALRKFLNKRD KWVKEWAGQV
1660 1670 1680 1690 1700
VITASQIQWT ADVTKCLLTA KERADKKILK VMKKNQVSIL NKYSEAIRGN
1710 1720 1730 1740 1750
LTKIMRLKIV ALVTIEIHAR DVLEKLYKSG LMDVNSFDWL SQLRFYWEKD
1760 1770 1780 1790 1800
LDDCVIRQTN TQFQYNYEYL GNSGRLVITP LTDRCYMTLT TALHLHRGGS
1810 1820 1830 1840 1850
PKGPAGTGKT ETVKDLGKAL GIYVIVVNCS EGLDYKSMGR MYSGLAQTGA
1860 1870 1880 1890 1900
WGCFDEFNRI NIEVLSVVAH QILCILSALA AGLTHFHFDG FEINLVWSCG
1910 1920 1930 1940 1950
IFITMNPGYA GRTELPENLK SMFRPIAMVV PDSTLIAEII LFGEGFGNCK
1960 1970 1980 1990 2000
ILAKKVYTLY SLAVQQLSRQ DHYDFGLRAL TSLLRYAGKK RRLQPDLTDE
2010 2020 2030 2040 2050
EVLLLSMRDM NIAKLTSVDA PLFNAIVQDL FPNIELPVID YGKLRETVEQ
2060 2070 2080 2090 2100
EIRDMGLQST PFTLTKVFQL YETKNSRHST MIVGCTGSGK TASWRILQAS
2110 2120 2130 2140 2150
LSSLCRAGDP NFNIVREFPL NPKALSLGEL YGEYDLSTNE WTDGILSSVM
2160 2170 2180 2190 2200
RTACADEKPD EKWILFDGPV DTLWIENMNS VMDDNKVLTL INGERIAMPE
2210 2220 2230 2240 2250
QVSLLFEVED LAMASPATVS RCGMVYTDYA DLGWKPYVQS WLEKRPKAEV
2260 2270 2280 2290 2300
EPLQRMFEKL INKMLAFKKD NCKELVPLPE YSGITSLCKL YSALATPENG
2310 2320 2330 2340 2350
VNPADGENYV TMVEMTFVFS MIWSVCASVD EEGRKRIDSY LREIEGSFPN
2360 2370 2380 2390 2400
KDTVYEYFVD PKIRSWTSFE DKLPKSWRYP PNAPFYKIMV PTVDTVRYNY
2410 2420 2430 2440 2450
LVSSLVANQN PILLVGPVGT GKTSIAQSVL QSLPSSQWSV LVVNMSAQTT
2460 2470 2480 2490 2500
SNNVQSIIES RVEKRTKGVY VPFGGKSMIT FMDDLNMPAK DMFGSQPPLE
2510 2520 2530 2540 2550
LIRLWIDYGF WYDRTKQTIK YIREMFLMAA MGPPGGGRTV ISPRLRSRFN
2560 2570 2580 2590 2600
IINMTFPTKS QIIRIFGTMI NQKLQDFEEE VKPIGNVVTE ATLDMYNTVV
2610 2620 2630 2640 2650
QRFLPTPTKM HYLFNLRDIS KVFQGMLRAN KDFHDTKSSI TRLWIHECFR
2660 2670 2680 2690 2700
VFSDRLVDAA DTEAFMGIIS DKLGSFFDLT FHHLCPSKRP PIFGDFLKEP
2710 2720 2730 2740 2750
KVYEDLTDLT VLKTVMETAL NEYNLSPSVV PMQLVLFREA IEHITRIVRV
2760 2770 2780 2790 2800
IGQPRGNMLL VGIGGSGRQS LARLASSICD YTTFQIEVTK HYRKQEFRDD
2810 2820 2830 2840 2850
IKRLYRQAGV ELKTTSFIFV DTQIADESFL EDINNILSSG EVPNLYKPDE
2860 2870 2880 2890 2900
FEEIQSHIID QARVEQVPES SDSLFAYLIE RVQNNLHIVL CLSPMGDPFR
2910 2920 2930 2940 2950
NWIRQYPALV NCTTINWFSE WPQEALLEVA EKCLIGVDLG TQENIHRKVA
2960 2970 2980 2990 3000
QIFVTMHWSV AQYSQKMLLE LRRHNYVTPT KYLELLSGYK KLLGEKRQEL
3010 3020 3030 3040 3050
LAQANKLRTG LFKIDETREK VQVMSLELED AKKKVAEFQK QCEEYLVIIV
3060 3070 3080 3090 3100
QQKREADEQQ KAVTANSEKI AVEEIKCQAL ADNAQKDLEE ALPALEEAMR
3110 3120 3130 3140 3150
ALESLNKKDI GEIKSYGRPP AQVEIVMQAV MILRGNEPTW AEAKRQLGEQ
3160 3170 3180 3190 3200
NFIKSLINFD KDNISDKVLK KIGAYCAQPD FQPDIIGRVS LAAKSLCMWV
3210 3220 3230 3240 3250
RAMELYGRLY RVVEPKRIRM NAALAQLREK QAALAEAQEK LREVAEKLEM
3260 3270 3280 3290 3300
LKKQYDEKLA QKEELRKKSE EMELKLERAG MLVSGLAGEK ARWEETVQGL
3310 3320 3330 3340 3350
EEDLGYLVGD CLLAAAFLSY MGPFLTNYRD EIVNQIWIGK IWELQVPCSP
3360 3370 3380 3390 3400
SFAIDNFLCN PTKVRDWNIQ GLPSDAFSTE NGIIVTRGNR WALMIDPQAQ
3410 3420 3430 3440 3450
ALKWIKNMEG GQGLKIIDLQ MSDYLRILEH AIHFGYPVLL QNVQEYLDPT
3460 3470 3480 3490 3500
LNPMLNKSVA RIGGRLLMRI GDKEVEYNTN FRFYITTKLS NPHYSPETSA
3510 3520 3530 3540 3550
KTTIVNFAVK EQGLEAQLLG IVVRKERPEL EEQKDSLVIN IAAGKRKLKE
3560 3570 3580 3590 3600
LEDEILRLLN EATGSLLDDV QLVNTLHTSK ITATEVTEQL ETSETTEINT
3610 3620 3630 3640 3650
DLAREAYRPC AQRASILFFV LNDMGCIDPM YQFSLDAYIS LFILSIDKSH
3660 3670 3680 3690 3700
RSNKLEDRID YLNDYHTYAV YRYTCRTLFE RHKLLFSFHM CAKILETSGK
3710 3720 3730 3740 3750
LNMDEYNFFL RGGVVLDREG QMDNPCSSWL ADAYWDNITE LDKLTNFHGL
3760 3770 3780 3790 3800
MNSFEQYPRD WHLWYTNAAP EKAMLPGEWE NACNEMQRML IVRSLRQDRV
3810 3820 3830 3840 3850
AFCVTSFIIT NLGSRFIEPP VLNMKSVLED STPRSPLVFI LSPGVDPTSA
3860 3870 3880 3890 3900
LLQLAEHMGM AQRFHALSLG QGQAPIAARL LREGVTQGHW VFLANCHLSL
3910 3920 3930 3940 3950
SWMPNLDKLV EQLQVEDPHP SFRLWLSSIP HPDFPISILQ VSIKMTTEPP
3960 3970 3980 3990 4000
KGLKANMTRL YQLMSEPQFS RCSKPAKYKK LLFSLCFFHS VLLERKKFLQ
4010 4020 4030 4040 4050
LGWNIIYGFN DSDFEVSENL LSLYLDEYEE TPWDALKYLI AGINYGGHVT
4060 4070 4080 4090 4100
DDWDRRLLTT YINDYFCDQS LSTPFHRLSA LETYFIPKDG SLASYKEYIS
4110 4120 4130 4140 4150
LLPGMDPPEA FGQHPNADVA SQITEAQTLF DTLLSLQPQI TPTRAGGQTR
4160 4170 4180 4190 4200
EEKVLELAAD VKQKIPEMID YEGTQKLLAL DPSPLNVVLL QEIQRYNTLM
4210 4220 4230 4240 4250
QTILFSLTDL EKGIQGLIVM STSLEEIFNC IFDAHVPPLW GKAYPSQKPL
4260 4270 4280 4290 4300
AAWTRDLAMR VEQFELWASR ARPPVIFWLS GFTFPTGFLT AVLQSSARQN
4310 4320 4330 4340 4350
NVSVDSLSWE FIVSTVDDSN LVYPPKDGVW VRGLYLEGAG WDRKNSCLVE
4360 4370 4380 4390 4400
AEPMQLVCLM PTIHFRPAES RKKSAKGMYS CPCYYYPNRA GSSDRASFVI
4410 4420
GIDLRSGAMT PDHWIKRGTA LLMSLDS
Length:4,427
Mass (Da):507,698
Last modified:February 26, 2008 - v3
Checksum:iA270F73DBDE2C3C4
GO
Isoform 2 (identifier: Q9P225-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3062-3100: Missing.
     4211-4235: EKGIQGLIVMSTSLEEIFNCIFDAH → EIPSCVSHKSERVVLELSAVKHPRQ
     4236-4427: Missing.

Note: No experimental confirmation available.

Show »
Length:4,196
Mass (Da):481,999
Checksum:i9E166534301BA935
GO
Isoform 3 (identifier: Q9P225-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: K → KMSNEIIRLC...FVQRCKDLIE
     636-790: SLLILFAEID...QREHRAAVQQ → YRSHLAPFPY...SPEPGRQRLQ
     791-4427: Missing.

Show »
Length:872
Mass (Da):99,915
Checksum:iC8AF185FABA6E9C5
GO

Sequence cautioni

The sequence AK128517 differs from that shown. Reason: Frameshift at position 3963.
The sequence BAA96027.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti593 – 5931E → G in AAH34225. (PubMed:15489334)Curated

RNA editingi

Exon 13 included in isoform 3 is extensively edited in brain.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001A → V.
Corresponds to variant rs35664870 [ dbSNP | Ensembl ].
VAR_039407
Natural varianti312 – 3121S → T.
Corresponds to variant rs3744254 [ dbSNP | Ensembl ].
VAR_039408
Natural varianti1326 – 13261E → G.
Corresponds to variant rs11868946 [ dbSNP | Ensembl ].
VAR_039409
Natural varianti2548 – 25481R → H.
Corresponds to variant rs11656500 [ dbSNP | Ensembl ].
VAR_039410
Natural varianti2904 – 29041R → H.
Corresponds to variant rs2309808 [ dbSNP | Ensembl ].
VAR_060134
Natural varianti3600 – 36001T → I.
Corresponds to variant rs7213894 [ dbSNP | Ensembl ].
VAR_039411
Isoform 3 (identifier: Q9P225-3)
Natural varianti812 – 8121E → G in RNA edited version.
Natural varianti814 – 8141E → G in RNA edited version.
Natural varianti826 – 8261T → A in RNA edited version.
Natural varianti833 – 8331N → D in RNA edited version.
Natural varianti838 – 8381K → E in RNA edited version.
Natural varianti839 – 8391N → D in RNA edited version.
Natural varianti841 – 8411K → E in RNA edited version.
Natural varianti843 – 8431S → G in RNA edited version.
Natural varianti855 – 8551T → A in RNA edited version.
Natural varianti865 – 8651E → G in RNA edited version.
Natural varianti869 – 8691Q → R in RNA edited version.
Natural varianti872 – 8721Q → R in RNA edited version.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei390 – 3901K → KMSNEIIRLCCHAISLDRIF EGYVSSSKEDLQGCILCCHA WKDHYVQAVQMHIQFSSRGW VLDQTSIFAQVDAFVQRCKD LIE in isoform 3. 2 PublicationsVSP_031913
Alternative sequencei636 – 790155SLLIL…AAVQQ → YRSHLAPFPYTPLLQLSQEF HSHLLTPLFIILSLSHTICL LSSFYFFFSSFIFVSPHLPP CYQHFNFTTYLKTQQNKTMI GQARWLTPVIPALWEAEVGA SLEPRSLRTAWATWQNPVSA KNTKISWAWWHKPVVSATWE GEVGGSPEPGRQRLQ in isoform 3. 2 PublicationsVSP_031914Add
BLAST
Alternative sequencei791 – 44273637Missing in isoform 3. 2 PublicationsVSP_031915Add
BLAST
Alternative sequencei3062 – 310039Missing in isoform 2. 1 PublicationVSP_031916Add
BLAST
Alternative sequencei4211 – 423525EKGIQ…IFDAH → EIPSCVSHKSERVVLELSAV KHPRQ in isoform 2. 1 PublicationVSP_031917Add
BLAST
Alternative sequencei4236 – 4427192Missing in isoform 2. 1 PublicationVSP_031918Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040936 mRNA. Translation: BAA96027.2. Different initiation.
AK128517 mRNA. No translation available.
AK292607 mRNA. Translation: BAF85296.1.
AC025335 Genomic DNA. No translation available.
AC087388 Genomic DNA. No translation available.
BC034225 mRNA. Translation: AAH34225.1.
U83570 Genomic DNA. Translation: AAB82760.1.
CCDSiCCDS32551.1. [Q9P225-1]
RefSeqiNP_065928.2. NM_020877.2. [Q9P225-1]
XP_005256527.1. XM_005256470.1. [Q9P225-1]
UniGeneiHs.367649.

Genome annotation databases

EnsembliENST00000389173; ENSP00000373825; ENSG00000183914. [Q9P225-1]
ENST00000570791; ENSP00000460245; ENSG00000183914. [Q9P225-3]
ENST00000572933; ENSP00000458355; ENSG00000183914. [Q9P225-1]
GeneIDi146754.
KEGGihsa:146754.
UCSCiuc002git.3. human. [Q9P225-3]
uc002giu.1. human. [Q9P225-1]

Polymorphism databases

DMDMi172044680.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040936 mRNA. Translation: BAA96027.2 . Different initiation.
AK128517 mRNA. No translation available.
AK292607 mRNA. Translation: BAF85296.1 .
AC025335 Genomic DNA. No translation available.
AC087388 Genomic DNA. No translation available.
BC034225 mRNA. Translation: AAH34225.1 .
U83570 Genomic DNA. Translation: AAB82760.1 .
CCDSi CCDS32551.1. [Q9P225-1 ]
RefSeqi NP_065928.2. NM_020877.2. [Q9P225-1 ]
XP_005256527.1. XM_005256470.1. [Q9P225-1 ]
UniGenei Hs.367649.

3D structure databases

ProteinModelPortali Q9P225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127007. 3 interactions.
IntActi Q9P225. 1 interaction.
STRINGi 9606.ENSP00000373825.

PTM databases

PhosphoSitei Q9P225.

Polymorphism databases

DMDMi 172044680.

Proteomic databases

PaxDbi Q9P225.
PRIDEi Q9P225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389173 ; ENSP00000373825 ; ENSG00000183914 . [Q9P225-1 ]
ENST00000570791 ; ENSP00000460245 ; ENSG00000183914 . [Q9P225-3 ]
ENST00000572933 ; ENSP00000458355 ; ENSG00000183914 . [Q9P225-1 ]
GeneIDi 146754.
KEGGi hsa:146754.
UCSCi uc002git.3. human. [Q9P225-3 ]
uc002giu.1. human. [Q9P225-1 ]

Organism-specific databases

CTDi 146754.
GeneCardsi GC17P007623.
H-InvDB HIX0202391.
HGNCi HGNC:2948. DNAH2.
MIMi 603333. gene.
neXtProti NX_Q9P225.
PharmGKBi PA27401.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5245.
GeneTreei ENSGT00760000118964.
HOGENOMi HOG000237308.
HOVERGENi HBG104828.
InParanoidi Q9P225.
KOi K10408.
OMAi KISRPPQ.
OrthoDBi EOG7F5115.
PhylomeDBi Q9P225.
TreeFami TF316836.

Miscellaneous databases

GenomeRNAii 146754.
NextBioi 85439.
PROi Q9P225.
SOURCEi Search...

Gene expression databases

Bgeei Q9P225.
CleanExi HS_DNAH2.
ExpressionAtlasi Q9P225. baseline and differential.
Genevestigatori Q9P225.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10676. PTHR10676. 1 hit.
Pfami PF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3013-4427 (ISOFORM 2).
    Tissue: Testis and Trachea.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  5. "Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment."
    Chapelin C., Duriez B., Magnino F., Goossens M., Escudier E., Amselem S.
    FEBS Lett. 412:325-330(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1820-1902 (ISOFORM 1), TISSUE SPECIFICITY.
  6. "Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome."
    Sakurai M., Yano T., Kawabata H., Ueda H., Suzuki T.
    Nat. Chem. Biol. 6:733-740(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING VARIANTS (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiDYH2_HUMAN
AccessioniPrimary (citable) accession number: Q9P225
Secondary accession number(s): A8K992
, B5MDX5, O15434, Q6PIH3, Q6ZR42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3