Q9P225 (DYH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein heavy chain 2, axonemal

Alternative name(s):
Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
Dynein heavy chain domain-containing protein 3

Gene names

Name:	DNAH2
Synonyms:	DNAHC2, DNHD3, KIAA1503

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4427 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme Potential.
Tissue specificity	Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. Ref.5
Domain	Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.
Sequence similarities	Belongs to the dynein heavy chain family. Contains 5 TPR repeats.
RNA editing	Modified position: not applicable. Exon 13 included in isoform 3 is extensively edited in brain. Ref.6
Sequence caution	The sequence AK128517 differs from that shown. Reason: Frameshift at position 3963. The sequence BAA96027.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism RNA editing
Domain	Coiled coil Repeat TPR repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC ciliary or flagellar motility Non-traceable author statement Ref.5. Source: UniProtKB microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	axonemal dynein complex Non-traceable author statement Ref.5. Source: UniProtKB cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro microtubule motor activity Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P225-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P225-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3062-3100: Missing.
     4211-4235: EKGIQGLIVMSTSLEEIFNCIFDAH → EIPSCVSHKSERVVLELSAVKHPRQ
     4236-4427: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9P225-3)

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: K → KMSNEIIRLC...FVQRCKDLIE
     636-790: SLLILFAEID...QREHRAAVQQ → YRSHLAPFPY...SPEPGRQRLQ
     791-4427: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4427	4427	Dynein heavy chain 2, axonemal		PRO_0000322542
Regions
	Repeat	1404 – 1439	36	TPR 1
	Repeat	2721 – 2754	34	TPR 2
	Repeat	3072 – 3105	34	TPR 3
	Repeat	4072 – 4104	33	TPR 4
	Repeat	4105 – 4140	36	TPR 5
	Nucleotide binding	1803 – 1810	8	ATP Potential
	Nucleotide binding	2084 – 2091	8	ATP Potential
	Nucleotide binding	2416 – 2423	8	ATP Potential
	Nucleotide binding	2762 – 2769	8	ATP Potential
	Region	1 – 1764	1764	Stem By similarity
	Region	1765 – 1986	222	AAA 1 By similarity
	Region	2046 – 2273	228	AAA 2 By similarity
	Region	2378 – 2625	248	AAA 3 By similarity
	Region	2722 – 2974	253	AAA 4 By similarity
	Region	2989 – 3272	284	Stalk By similarity
	Region	3358 – 3588	231	AAA 5 By similarity
	Region	3804 – 4023	220	AAA 6 By similarity
	Coiled coil	3012 – 3049	38	Potential
	Coiled coil	3216 – 3304	89	Potential
	Coiled coil	3523 – 3567	45	Potential
Natural variations
	Alternative sequence	390	1	K → KMSNEIIRLCCHAISLDRIF EGYVSSSKEDLQGCILCCHA WKDHYVQAVQMHIQFSSRGW VLDQTSIFAQVDAFVQRCKD LIE in isoform 3.		VSP_031913
	Alternative sequence	636 – 790	155	SLLIL…AAVQQ → YRSHLAPFPYTPLLQLSQEF HSHLLTPLFIILSLSHTICL LSSFYFFFSSFIFVSPHLPP CYQHFNFTTYLKTQQNKTMI GQARWLTPVIPALWEAEVGA SLEPRSLRTAWATWQNPVSA KNTKISWAWWHKPVVSATWE GEVGGSPEPGRQRLQ in isoform 3.		VSP_031914
	Alternative sequence	791 – 4427	3637	Missing in isoform 3.		VSP_031915
	Alternative sequence	3062 – 3100	39	Missing in isoform 2.		VSP_031916
	Alternative sequence	4211 – 4235	25	EKGIQ…IFDAH → EIPSCVSHKSERVVLELSAV KHPRQ in isoform 2.		VSP_031917
	Alternative sequence	4236 – 4427	192	Missing in isoform 2.		VSP_031918
	Natural variant	100	1	A → V. Corresponds to variant rs35664870 [ dbSNP | Ensembl ].		VAR_039407
	Natural variant	312	1	S → T. Corresponds to variant rs3744254 [ dbSNP | Ensembl ].		VAR_039408
	Natural variant	1326	1	E → G. Corresponds to variant rs11868946 [ dbSNP | Ensembl ].		VAR_039409
	Natural variant	2548	1	R → H. Corresponds to variant rs11656500 [ dbSNP | Ensembl ].		VAR_039410
	Natural variant	2904	1	R → H. Corresponds to variant rs2309808 [ dbSNP | Ensembl ].		VAR_060134
	Natural variant	3600	1	T → I. Corresponds to variant rs7213894 [ dbSNP | Ensembl ].		VAR_039411
Isoform 3:
	Natural variant	812	1	E → G in RNA edited version.
	Natural variant	814	1	E → G in RNA edited version.
	Natural variant	826	1	T → A in RNA edited version.
	Natural variant	833	1	N → D in RNA edited version.
	Natural variant	838	1	K → E in RNA edited version.
	Natural variant	839	1	N → D in RNA edited version.
	Natural variant	841	1	K → E in RNA edited version.
	Natural variant	843	1	S → G in RNA edited version.
	Natural variant	855	1	T → A in RNA edited version.
	Natural variant	865	1	E → G in RNA edited version.
	Natural variant	869	1	Q → R in RNA edited version.
	Natural variant	872	1	Q → R in RNA edited version.
Experimental info
	Sequence conflict	593	1	E → G in AAH34225. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: A270F73DBDE2C3C4	FASTA	4,427	507,698
	10 20 30 40 50 60 MSSKAEKKQR LSGRGSSQAS WSGRATRAAV ATQEQGNAPA VSEPELQAEL PKEEPEPRLE 70 80 90 100 110 120 GPQAQSEESV EPEADVKPLF LSRAALTGLA DAVWTQEHDA ILEHFAQDPT ESILTIFIDP 130 140 150 160 170 180 CFGLKLELGM PVQTQNQLVY FIRQAPVPIT WENFEATVQF GTVRGPYIPA LLRLLGGVFA 190 200 210 220 230 240 PQIFANTGWP ESIRNHFASH LHKFLACLTD TRYKLEGHTV LYIPAEAMNM KPEMVIKDKE 250 260 270 280 290 300 LVQRLETSMI HWTRQIKEML SAQETVETGE NLGPLEEIEF WRNRCMDLSG ISKQLVKKGV 310 320 330 340 350 360 KHVESILHLA KSSYLAPFMK LAQQIQDGSR QAQSNLTFLS ILKEPYQELA FMKPKDISSK 370 380 390 400 410 420 LPKLISLIRI IWVNSPHYNT RERLTSLFRK VCDCQYHFAR WEDGKQGPLP CFFGAQGPQI 430 440 450 460 470 480 TRNLLEIEDI FHKNLHTLRA VRGGILDVKN TCWHEDYNKF RAGIKDLEVM TQNLITSAFE 490 500 510 520 530 540 LVRDVPHGVL LLDTFHRLAS REAIKRTYDK KAVDLYMLFN SELALVNRER NKKWPDLEPY 550 560 570 580 590 600 VAQYSGKARW VHILRRRIDR VMTCLAGAHF LPRIGTGKES VHTYQQMVQA IDELVRKTFQ 610 620 630 640 650 660 EWTSSLDKDC IRRLDTPLLR ISQEKAGMLD VNFDKSLLIL FAEIDYWERL LFETPHYVVN 670 680 690 700 710 720 VAERAEDLRI LRENLLLVAR DYNRIIAMLS PDEQALFKER IRLLDKKIHP GLKKLHWALK 730 740 750 760 770 780 GASAFFITEC RIHASKVQMI VNEFKASTLT IGWRAQEMSE KLLVRISGKR VYRDLEFEED 790 800 810 820 830 840 QREHRAAVQQ KLMNLHQDVV TIMTNSYEVF KNDGPEIQQQ WMLYMIRLDR MMEDALRLNV 850 860 870 880 890 900 KWSLLELSKA INGDGKTSPN PLFQVLVILK NDLQGSVAQV EFSPTLQTLA GVVNDIGNHL 910 920 930 940 950 960 FSTISVFCHL PDILTKRKLH REPIQTVVEQ DEDIKKIQTQ ISSGMTNNAS LLQNYLKTWD 970 980 990 1000 1010 1020 MYREIWEINK DSFIHRYQRL NPPVSSFVAD IARYTEVANN VQKEETVTNI QFVLLDCSHL 1030 1040 1050 1060 1070 1080 KFSLVQHCNE WQNKFATLLR EMAAGRLLEL HTYLKENAEK ISRPPQTLEE LGVSLQLVDA 1090 1100 1110 1120 1130 1140 LKHDLANVET QIPPIHEQFA ILEKYEVPVE DSVLEMLDSL NGEWVVFQQT LLDSKQMLKK 1150 1160 1170 1180 1190 1200 HKEKFKTGLI HSADDFKKKA HTLLEDFEFK GHFTSNVGYM SALDQITQVR AMLMAMREEE 1210 1220 1230 1240 1250 1260 NSLRANLGIF KIEQPPSKDL QNLEKELDAL QQIWEIARDW EENWNEWKTG RFLILQTETM 1270 1280 1290 1300 1310 1320 ETTAHGLFRR LTKLAKEYKD RNWEIIETTR SKIEQFKRTM PLISDLRNPA LRERHWDQVR 1330 1340 1350 1360 1370 1380 DEIQREFDQE SESFTLEQIV ELGMDQHVEK IGEISASATK ELAIEVALQN IAKTWDVTQL 1390 1400 1410 1420 1430 1440 DIVPYKDKGH HRLRGTEEVF QALEDNQVAL STMKASRFVK AFEKDVDHWE RCLSLILEVI 1450 1460 1470 1480 1490 1500 EMILTVQRQW MYLENIFLGE DIRKQLPNES TLFDQVNSNW KAIMDRMNKD NNALRSTHHP 1510 1520 1530 1540 1550 1560 GLLDTLIEMN TILEDIQKSL DMYLETKRHI FPRFYFLSND DLLEILGQSR NPEAVQPHLK 1570 1580 1590 1600 1610 1620 KCFDNIKLLR IQKVGGPSSK WEAVGMFSGD GEYIDFLHSV FLEGPVESWL GDVEQTMRVT 1630 1640 1650 1660 1670 1680 LRDLLRNCHL ALRKFLNKRD KWVKEWAGQV VITASQIQWT ADVTKCLLTA KERADKKILK 1690 1700 1710 1720 1730 1740 VMKKNQVSIL NKYSEAIRGN LTKIMRLKIV ALVTIEIHAR DVLEKLYKSG LMDVNSFDWL 1750 1760 1770 1780 1790 1800 SQLRFYWEKD LDDCVIRQTN TQFQYNYEYL GNSGRLVITP LTDRCYMTLT TALHLHRGGS 1810 1820 1830 1840 1850 1860 PKGPAGTGKT ETVKDLGKAL GIYVIVVNCS EGLDYKSMGR MYSGLAQTGA WGCFDEFNRI 1870 1880 1890 1900 1910 1920 NIEVLSVVAH QILCILSALA AGLTHFHFDG FEINLVWSCG IFITMNPGYA GRTELPENLK 1930 1940 1950 1960 1970 1980 SMFRPIAMVV PDSTLIAEII LFGEGFGNCK ILAKKVYTLY SLAVQQLSRQ DHYDFGLRAL 1990 2000 2010 2020 2030 2040 TSLLRYAGKK RRLQPDLTDE EVLLLSMRDM NIAKLTSVDA PLFNAIVQDL FPNIELPVID 2050 2060 2070 2080 2090 2100 YGKLRETVEQ EIRDMGLQST PFTLTKVFQL YETKNSRHST MIVGCTGSGK TASWRILQAS 2110 2120 2130 2140 2150 2160 LSSLCRAGDP NFNIVREFPL NPKALSLGEL YGEYDLSTNE WTDGILSSVM RTACADEKPD 2170 2180 2190 2200 2210 2220 EKWILFDGPV DTLWIENMNS VMDDNKVLTL INGERIAMPE QVSLLFEVED LAMASPATVS 2230 2240 2250 2260 2270 2280 RCGMVYTDYA DLGWKPYVQS WLEKRPKAEV EPLQRMFEKL INKMLAFKKD NCKELVPLPE 2290 2300 2310 2320 2330 2340 YSGITSLCKL YSALATPENG VNPADGENYV TMVEMTFVFS MIWSVCASVD EEGRKRIDSY 2350 2360 2370 2380 2390 2400 LREIEGSFPN KDTVYEYFVD PKIRSWTSFE DKLPKSWRYP PNAPFYKIMV PTVDTVRYNY 2410 2420 2430 2440 2450 2460 LVSSLVANQN PILLVGPVGT GKTSIAQSVL QSLPSSQWSV LVVNMSAQTT SNNVQSIIES 2470 2480 2490 2500 2510 2520 RVEKRTKGVY VPFGGKSMIT FMDDLNMPAK DMFGSQPPLE LIRLWIDYGF WYDRTKQTIK 2530 2540 2550 2560 2570 2580 YIREMFLMAA MGPPGGGRTV ISPRLRSRFN IINMTFPTKS QIIRIFGTMI NQKLQDFEEE 2590 2600 2610 2620 2630 2640 VKPIGNVVTE ATLDMYNTVV QRFLPTPTKM HYLFNLRDIS KVFQGMLRAN KDFHDTKSSI 2650 2660 2670 2680 2690 2700 TRLWIHECFR VFSDRLVDAA DTEAFMGIIS DKLGSFFDLT FHHLCPSKRP PIFGDFLKEP 2710 2720 2730 2740 2750 2760 KVYEDLTDLT VLKTVMETAL NEYNLSPSVV PMQLVLFREA IEHITRIVRV IGQPRGNMLL 2770 2780 2790 2800 2810 2820 VGIGGSGRQS LARLASSICD YTTFQIEVTK HYRKQEFRDD IKRLYRQAGV ELKTTSFIFV 2830 2840 2850 2860 2870 2880 DTQIADESFL EDINNILSSG EVPNLYKPDE FEEIQSHIID QARVEQVPES SDSLFAYLIE 2890 2900 2910 2920 2930 2940 RVQNNLHIVL CLSPMGDPFR NWIRQYPALV NCTTINWFSE WPQEALLEVA EKCLIGVDLG 2950 2960 2970 2980 2990 3000 TQENIHRKVA QIFVTMHWSV AQYSQKMLLE LRRHNYVTPT KYLELLSGYK KLLGEKRQEL 3010 3020 3030 3040 3050 3060 LAQANKLRTG LFKIDETREK VQVMSLELED AKKKVAEFQK QCEEYLVIIV QQKREADEQQ 3070 3080 3090 3100 3110 3120 KAVTANSEKI AVEEIKCQAL ADNAQKDLEE ALPALEEAMR ALESLNKKDI GEIKSYGRPP 3130 3140 3150 3160 3170 3180 AQVEIVMQAV MILRGNEPTW AEAKRQLGEQ NFIKSLINFD KDNISDKVLK KIGAYCAQPD 3190 3200 3210 3220 3230 3240 FQPDIIGRVS LAAKSLCMWV RAMELYGRLY RVVEPKRIRM NAALAQLREK QAALAEAQEK 3250 3260 3270 3280 3290 3300 LREVAEKLEM LKKQYDEKLA QKEELRKKSE EMELKLERAG MLVSGLAGEK ARWEETVQGL 3310 3320 3330 3340 3350 3360 EEDLGYLVGD CLLAAAFLSY MGPFLTNYRD EIVNQIWIGK IWELQVPCSP SFAIDNFLCN 3370 3380 3390 3400 3410 3420 PTKVRDWNIQ GLPSDAFSTE NGIIVTRGNR WALMIDPQAQ ALKWIKNMEG GQGLKIIDLQ 3430 3440 3450 3460 3470 3480 MSDYLRILEH AIHFGYPVLL QNVQEYLDPT LNPMLNKSVA RIGGRLLMRI GDKEVEYNTN 3490 3500 3510 3520 3530 3540 FRFYITTKLS NPHYSPETSA KTTIVNFAVK EQGLEAQLLG IVVRKERPEL EEQKDSLVIN 3550 3560 3570 3580 3590 3600 IAAGKRKLKE LEDEILRLLN EATGSLLDDV QLVNTLHTSK ITATEVTEQL ETSETTEINT 3610 3620 3630 3640 3650 3660 DLAREAYRPC AQRASILFFV LNDMGCIDPM YQFSLDAYIS LFILSIDKSH RSNKLEDRID 3670 3680 3690 3700 3710 3720 YLNDYHTYAV YRYTCRTLFE RHKLLFSFHM CAKILETSGK LNMDEYNFFL RGGVVLDREG 3730 3740 3750 3760 3770 3780 QMDNPCSSWL ADAYWDNITE LDKLTNFHGL MNSFEQYPRD WHLWYTNAAP EKAMLPGEWE 3790 3800 3810 3820 3830 3840 NACNEMQRML IVRSLRQDRV AFCVTSFIIT NLGSRFIEPP VLNMKSVLED STPRSPLVFI 3850 3860 3870 3880 3890 3900 LSPGVDPTSA LLQLAEHMGM AQRFHALSLG QGQAPIAARL LREGVTQGHW VFLANCHLSL 3910 3920 3930 3940 3950 3960 SWMPNLDKLV EQLQVEDPHP SFRLWLSSIP HPDFPISILQ VSIKMTTEPP KGLKANMTRL 3970 3980 3990 4000 4010 4020 YQLMSEPQFS RCSKPAKYKK LLFSLCFFHS VLLERKKFLQ LGWNIIYGFN DSDFEVSENL 4030 4040 4050 4060 4070 4080 LSLYLDEYEE TPWDALKYLI AGINYGGHVT DDWDRRLLTT YINDYFCDQS LSTPFHRLSA 4090 4100 4110 4120 4130 4140 LETYFIPKDG SLASYKEYIS LLPGMDPPEA FGQHPNADVA SQITEAQTLF DTLLSLQPQI 4150 4160 4170 4180 4190 4200 TPTRAGGQTR EEKVLELAAD VKQKIPEMID YEGTQKLLAL DPSPLNVVLL QEIQRYNTLM 4210 4220 4230 4240 4250 4260 QTILFSLTDL EKGIQGLIVM STSLEEIFNC IFDAHVPPLW GKAYPSQKPL AAWTRDLAMR 4270 4280 4290 4300 4310 4320 VEQFELWASR ARPPVIFWLS GFTFPTGFLT AVLQSSARQN NVSVDSLSWE FIVSTVDDSN 4330 4340 4350 4360 4370 4380 LVYPPKDGVW VRGLYLEGAG WDRKNSCLVE AEPMQLVCLM PTIHFRPAES RKKSAKGMYS 4390 4400 4410 4420 CPCYYYPNRA GSSDRASFVI GIDLRSGAMT PDHWIKRGTA LLMSLDS
	Isoform 2 [UniParc]. Checksum: 9E166534301BA935	FASTA	4,196	481,999
	10 20 30 40 50 60 MSSKAEKKQR LSGRGSSQAS WSGRATRAAV ATQEQGNAPA VSEPELQAEL PKEEPEPRLE 70 80 90 100 110 120 GPQAQSEESV EPEADVKPLF LSRAALTGLA DAVWTQEHDA ILEHFAQDPT ESILTIFIDP 130 140 150 160 170 180 CFGLKLELGM PVQTQNQLVY FIRQAPVPIT WENFEATVQF GTVRGPYIPA LLRLLGGVFA 190 200 210 220 230 240 PQIFANTGWP ESIRNHFASH LHKFLACLTD TRYKLEGHTV LYIPAEAMNM KPEMVIKDKE 250 260 270 280 290 300 LVQRLETSMI HWTRQIKEML SAQETVETGE NLGPLEEIEF WRNRCMDLSG ISKQLVKKGV 310 320 330 340 350 360 KHVESILHLA KSSYLAPFMK LAQQIQDGSR QAQSNLTFLS ILKEPYQELA FMKPKDISSK 370 380 390 400 410 420 LPKLISLIRI IWVNSPHYNT RERLTSLFRK VCDCQYHFAR WEDGKQGPLP CFFGAQGPQI 430 440 450 460 470 480 TRNLLEIEDI FHKNLHTLRA VRGGILDVKN TCWHEDYNKF RAGIKDLEVM TQNLITSAFE 490 500 510 520 530 540 LVRDVPHGVL LLDTFHRLAS REAIKRTYDK KAVDLYMLFN SELALVNRER NKKWPDLEPY 550 560 570 580 590 600 VAQYSGKARW VHILRRRIDR VMTCLAGAHF LPRIGTGKES VHTYQQMVQA IDELVRKTFQ 610 620 630 640 650 660 EWTSSLDKDC IRRLDTPLLR ISQEKAGMLD VNFDKSLLIL FAEIDYWERL LFETPHYVVN 670 680 690 700 710 720 VAERAEDLRI LRENLLLVAR DYNRIIAMLS PDEQALFKER IRLLDKKIHP GLKKLHWALK 730 740 750 760 770 780 GASAFFITEC RIHASKVQMI VNEFKASTLT IGWRAQEMSE KLLVRISGKR VYRDLEFEED 790 800 810 820 830 840 QREHRAAVQQ KLMNLHQDVV TIMTNSYEVF KNDGPEIQQQ WMLYMIRLDR MMEDALRLNV 850 860 870 880 890 900 KWSLLELSKA INGDGKTSPN PLFQVLVILK NDLQGSVAQV EFSPTLQTLA GVVNDIGNHL 910 920 930 940 950 960 FSTISVFCHL PDILTKRKLH REPIQTVVEQ DEDIKKIQTQ ISSGMTNNAS LLQNYLKTWD 970 980 990 1000 1010 1020 MYREIWEINK DSFIHRYQRL NPPVSSFVAD IARYTEVANN VQKEETVTNI QFVLLDCSHL 1030 1040 1050 1060 1070 1080 KFSLVQHCNE WQNKFATLLR EMAAGRLLEL HTYLKENAEK ISRPPQTLEE LGVSLQLVDA 1090 1100 1110 1120 1130 1140 LKHDLANVET QIPPIHEQFA ILEKYEVPVE DSVLEMLDSL NGEWVVFQQT LLDSKQMLKK 1150 1160 1170 1180 1190 1200 HKEKFKTGLI HSADDFKKKA HTLLEDFEFK GHFTSNVGYM SALDQITQVR AMLMAMREEE 1210 1220 1230 1240 1250 1260 NSLRANLGIF KIEQPPSKDL QNLEKELDAL QQIWEIARDW EENWNEWKTG RFLILQTETM 1270 1280 1290 1300 1310 1320 ETTAHGLFRR LTKLAKEYKD RNWEIIETTR SKIEQFKRTM PLISDLRNPA LRERHWDQVR 1330 1340 1350 1360 1370 1380 DEIQREFDQE SESFTLEQIV ELGMDQHVEK IGEISASATK ELAIEVALQN IAKTWDVTQL 1390 1400 1410 1420 1430 1440 DIVPYKDKGH HRLRGTEEVF QALEDNQVAL STMKASRFVK AFEKDVDHWE RCLSLILEVI 1450 1460 1470 1480 1490 1500 EMILTVQRQW MYLENIFLGE DIRKQLPNES TLFDQVNSNW KAIMDRMNKD NNALRSTHHP 1510 1520 1530 1540 1550 1560 GLLDTLIEMN TILEDIQKSL DMYLETKRHI FPRFYFLSND DLLEILGQSR NPEAVQPHLK 1570 1580 1590 1600 1610 1620 KCFDNIKLLR IQKVGGPSSK WEAVGMFSGD GEYIDFLHSV FLEGPVESWL GDVEQTMRVT 1630 1640 1650 1660 1670 1680 LRDLLRNCHL ALRKFLNKRD KWVKEWAGQV VITASQIQWT ADVTKCLLTA KERADKKILK 1690 1700 1710 1720 1730 1740 VMKKNQVSIL NKYSEAIRGN LTKIMRLKIV ALVTIEIHAR DVLEKLYKSG LMDVNSFDWL 1750 1760 1770 1780 1790 1800 SQLRFYWEKD LDDCVIRQTN TQFQYNYEYL GNSGRLVITP LTDRCYMTLT TALHLHRGGS 1810 1820 1830 1840 1850 1860 PKGPAGTGKT ETVKDLGKAL GIYVIVVNCS EGLDYKSMGR MYSGLAQTGA WGCFDEFNRI 1870 1880 1890 1900 1910 1920 NIEVLSVVAH QILCILSALA AGLTHFHFDG FEINLVWSCG IFITMNPGYA GRTELPENLK 1930 1940 1950 1960 1970 1980 SMFRPIAMVV PDSTLIAEII LFGEGFGNCK ILAKKVYTLY SLAVQQLSRQ DHYDFGLRAL 1990 2000 2010 2020 2030 2040 TSLLRYAGKK RRLQPDLTDE EVLLLSMRDM NIAKLTSVDA PLFNAIVQDL FPNIELPVID 2050 2060 2070 2080 2090 2100 YGKLRETVEQ EIRDMGLQST PFTLTKVFQL YETKNSRHST MIVGCTGSGK TASWRILQAS 2110 2120 2130 2140 2150 2160 LSSLCRAGDP NFNIVREFPL NPKALSLGEL YGEYDLSTNE WTDGILSSVM RTACADEKPD 2170 2180 2190 2200 2210 2220 EKWILFDGPV DTLWIENMNS VMDDNKVLTL INGERIAMPE QVSLLFEVED LAMASPATVS 2230 2240 2250 2260 2270 2280 RCGMVYTDYA DLGWKPYVQS WLEKRPKAEV EPLQRMFEKL INKMLAFKKD NCKELVPLPE 2290 2300 2310 2320 2330 2340 YSGITSLCKL YSALATPENG VNPADGENYV TMVEMTFVFS MIWSVCASVD EEGRKRIDSY 2350 2360 2370 2380 2390 2400 LREIEGSFPN KDTVYEYFVD PKIRSWTSFE DKLPKSWRYP PNAPFYKIMV PTVDTVRYNY 2410 2420 2430 2440 2450 2460 LVSSLVANQN PILLVGPVGT GKTSIAQSVL QSLPSSQWSV LVVNMSAQTT SNNVQSIIES 2470 2480 2490 2500 2510 2520 RVEKRTKGVY VPFGGKSMIT FMDDLNMPAK DMFGSQPPLE LIRLWIDYGF WYDRTKQTIK 2530 2540 2550 2560 2570 2580 YIREMFLMAA MGPPGGGRTV ISPRLRSRFN IINMTFPTKS QIIRIFGTMI NQKLQDFEEE 2590 2600 2610 2620 2630 2640 VKPIGNVVTE ATLDMYNTVV QRFLPTPTKM HYLFNLRDIS KVFQGMLRAN KDFHDTKSSI 2650 2660 2670 2680 2690 2700 TRLWIHECFR VFSDRLVDAA DTEAFMGIIS DKLGSFFDLT FHHLCPSKRP PIFGDFLKEP 2710 2720 2730 2740 2750 2760 KVYEDLTDLT VLKTVMETAL NEYNLSPSVV PMQLVLFREA IEHITRIVRV IGQPRGNMLL 2770 2780 2790 2800 2810 2820 VGIGGSGRQS LARLASSICD YTTFQIEVTK HYRKQEFRDD IKRLYRQAGV ELKTTSFIFV 2830 2840 2850 2860 2870 2880 DTQIADESFL EDINNILSSG EVPNLYKPDE FEEIQSHIID QARVEQVPES SDSLFAYLIE 2890 2900 2910 2920 2930 2940 RVQNNLHIVL CLSPMGDPFR NWIRQYPALV NCTTINWFSE WPQEALLEVA EKCLIGVDLG 2950 2960 2970 2980 2990 3000 TQENIHRKVA QIFVTMHWSV AQYSQKMLLE LRRHNYVTPT KYLELLSGYK KLLGEKRQEL 3010 3020 3030 3040 3050 3060 LAQANKLRTG LFKIDETREK VQVMSLELED AKKKVAEFQK QCEEYLVIIV QQKREADEQQ 3070 3080 3090 3100 3110 3120 KALESLNKKD IGEIKSYGRP PAQVEIVMQA VMILRGNEPT WAEAKRQLGE QNFIKSLINF 3130 3140 3150 3160 3170 3180 DKDNISDKVL KKIGAYCAQP DFQPDIIGRV SLAAKSLCMW VRAMELYGRL YRVVEPKRIR 3190 3200 3210 3220 3230 3240 MNAALAQLRE KQAALAEAQE KLREVAEKLE MLKKQYDEKL AQKEELRKKS EEMELKLERA 3250 3260 3270 3280 3290 3300 GMLVSGLAGE KARWEETVQG LEEDLGYLVG DCLLAAAFLS YMGPFLTNYR DEIVNQIWIG 3310 3320 3330 3340 3350 3360 KIWELQVPCS PSFAIDNFLC NPTKVRDWNI QGLPSDAFST ENGIIVTRGN RWALMIDPQA 3370 3380 3390 3400 3410 3420 QALKWIKNME GGQGLKIIDL QMSDYLRILE HAIHFGYPVL LQNVQEYLDP TLNPMLNKSV 3430 3440 3450 3460 3470 3480 ARIGGRLLMR IGDKEVEYNT NFRFYITTKL SNPHYSPETS AKTTIVNFAV KEQGLEAQLL 3490 3500 3510 3520 3530 3540 GIVVRKERPE LEEQKDSLVI NIAAGKRKLK ELEDEILRLL NEATGSLLDD VQLVNTLHTS 3550 3560 3570 3580 3590 3600 KITATEVTEQ LETSETTEIN TDLAREAYRP CAQRASILFF VLNDMGCIDP MYQFSLDAYI 3610 3620 3630 3640 3650 3660 SLFILSIDKS HRSNKLEDRI DYLNDYHTYA VYRYTCRTLF ERHKLLFSFH MCAKILETSG 3670 3680 3690 3700 3710 3720 KLNMDEYNFF LRGGVVLDRE GQMDNPCSSW LADAYWDNIT ELDKLTNFHG LMNSFEQYPR 3730 3740 3750 3760 3770 3780 DWHLWYTNAA PEKAMLPGEW ENACNEMQRM LIVRSLRQDR VAFCVTSFII TNLGSRFIEP 3790 3800 3810 3820 3830 3840 PVLNMKSVLE DSTPRSPLVF ILSPGVDPTS ALLQLAEHMG MAQRFHALSL GQGQAPIAAR 3850 3860 3870 3880 3890 3900 LLREGVTQGH WVFLANCHLS LSWMPNLDKL VEQLQVEDPH PSFRLWLSSI PHPDFPISIL 3910 3920 3930 3940 3950 3960 QVSIKMTTEP PKGLKANMTR LYQLMSEPQF SRCSKPAKYK KLLFSLCFFH SVLLERKKFL 3970 3980 3990 4000 4010 4020 QLGWNIIYGF NDSDFEVSEN LLSLYLDEYE ETPWDALKYL IAGINYGGHV TDDWDRRLLT 4030 4040 4050 4060 4070 4080 TYINDYFCDQ SLSTPFHRLS ALETYFIPKD GSLASYKEYI SLLPGMDPPE AFGQHPNADV 4090 4100 4110 4120 4130 4140 ASQITEAQTL FDTLLSLQPQ ITPTRAGGQT REEKVLELAA DVKQKIPEMI DYEGTQKLLA 4150 4160 4170 4180 4190 LDPSPLNVVL LQEIQRYNTL MQTILFSLTD LEIPSCVSHK SERVVLELSA VKHPRQ
	Isoform 3 [UniParc]. Checksum: C8AF185FABA6E9C5	FASTA	872	99,915
	10 20 30 40 50 60 MSSKAEKKQR LSGRGSSQAS WSGRATRAAV ATQEQGNAPA VSEPELQAEL PKEEPEPRLE 70 80 90 100 110 120 GPQAQSEESV EPEADVKPLF LSRAALTGLA DAVWTQEHDA ILEHFAQDPT ESILTIFIDP 130 140 150 160 170 180 CFGLKLELGM PVQTQNQLVY FIRQAPVPIT WENFEATVQF GTVRGPYIPA LLRLLGGVFA 190 200 210 220 230 240 PQIFANTGWP ESIRNHFASH LHKFLACLTD TRYKLEGHTV LYIPAEAMNM KPEMVIKDKE 250 260 270 280 290 300 LVQRLETSMI HWTRQIKEML SAQETVETGE NLGPLEEIEF WRNRCMDLSG ISKQLVKKGV 310 320 330 340 350 360 KHVESILHLA KSSYLAPFMK LAQQIQDGSR QAQSNLTFLS ILKEPYQELA FMKPKDISSK 370 380 390 400 410 420 LPKLISLIRI IWVNSPHYNT RERLTSLFRK MSNEIIRLCC HAISLDRIFE GYVSSSKEDL 430 440 450 460 470 480 QGCILCCHAW KDHYVQAVQM HIQFSSRGWV LDQTSIFAQV DAFVQRCKDL IEVCDCQYHF 490 500 510 520 530 540 ARWEDGKQGP LPCFFGAQGP QITRNLLEIE DIFHKNLHTL RAVRGGILDV KNTCWHEDYN 550 560 570 580 590 600 KFRAGIKDLE VMTQNLITSA FELVRDVPHG VLLLDTFHRL ASREAIKRTY DKKAVDLYML 610 620 630 640 650 660 FNSELALVNR ERNKKWPDLE PYVAQYSGKA RWVHILRRRI DRVMTCLAGA HFLPRIGTGK 670 680 690 700 710 720 ESVHTYQQMV QAIDELVRKT FQEWTSSLDK DCIRRLDTPL LRISQEKAGM LDVNFDKYRS 730 740 750 760 770 780 HLAPFPYTPL LQLSQEFHSH LLTPLFIILS LSHTICLLSS FYFFFSSFIF VSPHLPPCYQ 790 800 810 820 830 840 HFNFTTYLKT QQNKTMIGQA RWLTPVIPAL WEAEVGASLE PRSLRTAWAT WQNPVSAKNT 850 860 870 KISWAWWHKP VVSATWEGEV GGSPEPGRQR LQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3013-4427 (ISOFORM 2). Tissue: Testis and Trachea.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[5]	"Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment." Chapelin C., Duriez B., Magnino F., Goossens M., Escudier E., Amselem S. FEBS Lett. 412:325-330(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1820-1902 (ISOFORM 1), TISSUE SPECIFICITY.
[6]	"Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome." Sakurai M., Yano T., Kawabata H., Ueda H., Suzuki T. Nat. Chem. Biol. 6:733-740(2010) [PubMed] [Europe PMC] [Abstract] Cited for: RNA EDITING VARIANTS (ISOFORM 3). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040936 mRNA. Translation: BAA96027.2. Different initiation. AK128517 mRNA. No translation available. AK292607 mRNA. Translation: BAF85296.1. AC025335 Genomic DNA. No translation available. AC087388 Genomic DNA. No translation available. BC034225 mRNA. Translation: AAH34225.1. U83570 Genomic DNA. Translation: AAB82760.1.
IPI	IPI00292777. IPI00651691. IPI00783464.
RefSeq	NP_065928.2. NM_020877.2.
UniGene	Hs.367649.
3D structure databases
ProteinModelPortal	Q9P225.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P225. 1 interaction.
STRING	9606.ENSP00000373825.
PTM databases
PhosphoSite	Q9P225.
Polymorphism databases
DMDM	172044680.
Proteomic databases
PaxDb	Q9P225.
PRIDE	Q9P225.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000082259; ENSP00000082259; ENSG00000183914. ENST00000389173; ENSP00000373825; ENSG00000183914. ENST00000570791; ENSP00000460245; ENSG00000183914. ENST00000572933; ENSP00000458355; ENSG00000183914.
GeneID	146754.
KEGG	hsa:146754.
UCSC	uc002git.3. human. uc002giu.1. human.
Organism-specific databases
CTD	146754.
GeneCards	GC17P007623.
H-InvDB	HIX0202391.
HGNC	HGNC:2948. DNAH2.
MIM	603333. gene.
neXtProt	NX_Q9P225.
PharmGKB	PA27401.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5245.
HOGENOM	HOG000237308.
HOVERGEN	HBG104828.
InParanoid	Q9P225.
KO	K10408.
OMA	KISRPPQ.
Gene expression databases
ArrayExpress	Q9P225.
Bgee	Q9P225.
CleanEx	HS_DNAH2.
Genevestigator	Q9P225.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR011704. ATPase_dyneun-rel_AAA. IPR026983. DHC_fam. IPR026976. DNAH2. IPR024743. Dynein_HC_stalk. IPR024317. Dynein_heavy_chain_D4_dom. IPR004273. Dynein_heavy_dom. IPR013594. Dynein_heavy_dom-1. IPR013602. Dynein_heavy_dom-2. [Graphical view]
PANTHER	PTHR10676. PTHR10676. 1 hit. PTHR10676:SF130. PTHR10676:SF130. 1 hit.
Pfam	PF07728. AAA_5. 1 hit. PF12780. AAA_8. 1 hit. PF08385. DHC_N1. 2 hits. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. PF12777. MT. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	146754.
NextBio	85439.
SOURCE	Search...

Entry information

Entry name

DYH2_HUMAN

Accession

Primary (citable) accession number: Q9P225
Secondary accession number(s): A8K992 , B5MDX5, O15434, Q6PIH3, Q6ZR42

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.