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Q9P225

- DYH2_HUMAN

UniProt

Q9P225 - DYH2_HUMAN

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Protein
Dynein heavy chain 2, axonemal
Gene
DNAH2, DNAHC2, DNHD3, KIAA1503
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1803 – 18108ATP Reviewed prediction
Nucleotide bindingi2084 – 20918ATP Reviewed prediction
Nucleotide bindingi2416 – 24238ATP Reviewed prediction
Nucleotide bindingi2762 – 27698ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
  3. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. cilium or flagellum-dependent cell motility Source: UniProtKB
  2. metabolic process Source: GOC
  3. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 2, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
Dynein heavy chain domain-containing protein 3
Gene namesi
Name:DNAH2
Synonyms:DNAHC2, DNHD3, KIAA1503
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:2948. DNAH2.

Subcellular locationi

Cytoplasmcytoskeletoncilium axoneme Reviewed prediction

GO - Cellular componenti

  1. axonemal dynein complex Source: UniProtKB
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 44274427Dynein heavy chain 2, axonemal
PRO_0000322542Add
BLAST

Proteomic databases

PaxDbiQ9P225.
PRIDEiQ9P225.

PTM databases

PhosphoSiteiQ9P225.

Expressioni

Tissue specificityi

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.1 Publication

Gene expression databases

ArrayExpressiQ9P225.
BgeeiQ9P225.
CleanExiHS_DNAH2.
GenevestigatoriQ9P225.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

BioGridi127007. 3 interactions.
IntActiQ9P225. 1 interaction.
STRINGi9606.ENSP00000373825.

Structurei

3D structure databases

ProteinModelPortaliQ9P225.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1404 – 143936TPR 1
Add
BLAST
Repeati2721 – 275434TPR 2
Add
BLAST
Repeati3072 – 310534TPR 3
Add
BLAST
Repeati4072 – 410433TPR 4
Add
BLAST
Repeati4105 – 414036TPR 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 17641764Stem By similarity
Add
BLAST
Regioni1765 – 1986222AAA 1 By similarity
Add
BLAST
Regioni2046 – 2273228AAA 2 By similarity
Add
BLAST
Regioni2378 – 2625248AAA 3 By similarity
Add
BLAST
Regioni2722 – 2974253AAA 4 By similarity
Add
BLAST
Regioni2989 – 3272284Stalk By similarity
Add
BLAST
Regioni3358 – 3588231AAA 5 By similarity
Add
BLAST
Regioni3804 – 4023220AAA 6 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3012 – 304938 Reviewed prediction
Add
BLAST
Coiled coili3216 – 330489 Reviewed prediction
Add
BLAST
Coiled coili3523 – 356745 Reviewed prediction
Add
BLAST

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.

Sequence similaritiesi

Contains 5 TPR repeats.

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5245.
HOGENOMiHOG000237308.
HOVERGENiHBG104828.
InParanoidiQ9P225.
KOiK10408.
OMAiKISRPPQ.
OrthoDBiEOG7F5115.
PhylomeDBiQ9P225.
TreeFamiTF316836.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P225-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSKAEKKQR LSGRGSSQAS WSGRATRAAV ATQEQGNAPA VSEPELQAEL     50
PKEEPEPRLE GPQAQSEESV EPEADVKPLF LSRAALTGLA DAVWTQEHDA 100
ILEHFAQDPT ESILTIFIDP CFGLKLELGM PVQTQNQLVY FIRQAPVPIT 150
WENFEATVQF GTVRGPYIPA LLRLLGGVFA PQIFANTGWP ESIRNHFASH 200
LHKFLACLTD TRYKLEGHTV LYIPAEAMNM KPEMVIKDKE LVQRLETSMI 250
HWTRQIKEML SAQETVETGE NLGPLEEIEF WRNRCMDLSG ISKQLVKKGV 300
KHVESILHLA KSSYLAPFMK LAQQIQDGSR QAQSNLTFLS ILKEPYQELA 350
FMKPKDISSK LPKLISLIRI IWVNSPHYNT RERLTSLFRK VCDCQYHFAR 400
WEDGKQGPLP CFFGAQGPQI TRNLLEIEDI FHKNLHTLRA VRGGILDVKN 450
TCWHEDYNKF RAGIKDLEVM TQNLITSAFE LVRDVPHGVL LLDTFHRLAS 500
REAIKRTYDK KAVDLYMLFN SELALVNRER NKKWPDLEPY VAQYSGKARW 550
VHILRRRIDR VMTCLAGAHF LPRIGTGKES VHTYQQMVQA IDELVRKTFQ 600
EWTSSLDKDC IRRLDTPLLR ISQEKAGMLD VNFDKSLLIL FAEIDYWERL 650
LFETPHYVVN VAERAEDLRI LRENLLLVAR DYNRIIAMLS PDEQALFKER 700
IRLLDKKIHP GLKKLHWALK GASAFFITEC RIHASKVQMI VNEFKASTLT 750
IGWRAQEMSE KLLVRISGKR VYRDLEFEED QREHRAAVQQ KLMNLHQDVV 800
TIMTNSYEVF KNDGPEIQQQ WMLYMIRLDR MMEDALRLNV KWSLLELSKA 850
INGDGKTSPN PLFQVLVILK NDLQGSVAQV EFSPTLQTLA GVVNDIGNHL 900
FSTISVFCHL PDILTKRKLH REPIQTVVEQ DEDIKKIQTQ ISSGMTNNAS 950
LLQNYLKTWD MYREIWEINK DSFIHRYQRL NPPVSSFVAD IARYTEVANN 1000
VQKEETVTNI QFVLLDCSHL KFSLVQHCNE WQNKFATLLR EMAAGRLLEL 1050
HTYLKENAEK ISRPPQTLEE LGVSLQLVDA LKHDLANVET QIPPIHEQFA 1100
ILEKYEVPVE DSVLEMLDSL NGEWVVFQQT LLDSKQMLKK HKEKFKTGLI 1150
HSADDFKKKA HTLLEDFEFK GHFTSNVGYM SALDQITQVR AMLMAMREEE 1200
NSLRANLGIF KIEQPPSKDL QNLEKELDAL QQIWEIARDW EENWNEWKTG 1250
RFLILQTETM ETTAHGLFRR LTKLAKEYKD RNWEIIETTR SKIEQFKRTM 1300
PLISDLRNPA LRERHWDQVR DEIQREFDQE SESFTLEQIV ELGMDQHVEK 1350
IGEISASATK ELAIEVALQN IAKTWDVTQL DIVPYKDKGH HRLRGTEEVF 1400
QALEDNQVAL STMKASRFVK AFEKDVDHWE RCLSLILEVI EMILTVQRQW 1450
MYLENIFLGE DIRKQLPNES TLFDQVNSNW KAIMDRMNKD NNALRSTHHP 1500
GLLDTLIEMN TILEDIQKSL DMYLETKRHI FPRFYFLSND DLLEILGQSR 1550
NPEAVQPHLK KCFDNIKLLR IQKVGGPSSK WEAVGMFSGD GEYIDFLHSV 1600
FLEGPVESWL GDVEQTMRVT LRDLLRNCHL ALRKFLNKRD KWVKEWAGQV 1650
VITASQIQWT ADVTKCLLTA KERADKKILK VMKKNQVSIL NKYSEAIRGN 1700
LTKIMRLKIV ALVTIEIHAR DVLEKLYKSG LMDVNSFDWL SQLRFYWEKD 1750
LDDCVIRQTN TQFQYNYEYL GNSGRLVITP LTDRCYMTLT TALHLHRGGS 1800
PKGPAGTGKT ETVKDLGKAL GIYVIVVNCS EGLDYKSMGR MYSGLAQTGA 1850
WGCFDEFNRI NIEVLSVVAH QILCILSALA AGLTHFHFDG FEINLVWSCG 1900
IFITMNPGYA GRTELPENLK SMFRPIAMVV PDSTLIAEII LFGEGFGNCK 1950
ILAKKVYTLY SLAVQQLSRQ DHYDFGLRAL TSLLRYAGKK RRLQPDLTDE 2000
EVLLLSMRDM NIAKLTSVDA PLFNAIVQDL FPNIELPVID YGKLRETVEQ 2050
EIRDMGLQST PFTLTKVFQL YETKNSRHST MIVGCTGSGK TASWRILQAS 2100
LSSLCRAGDP NFNIVREFPL NPKALSLGEL YGEYDLSTNE WTDGILSSVM 2150
RTACADEKPD EKWILFDGPV DTLWIENMNS VMDDNKVLTL INGERIAMPE 2200
QVSLLFEVED LAMASPATVS RCGMVYTDYA DLGWKPYVQS WLEKRPKAEV 2250
EPLQRMFEKL INKMLAFKKD NCKELVPLPE YSGITSLCKL YSALATPENG 2300
VNPADGENYV TMVEMTFVFS MIWSVCASVD EEGRKRIDSY LREIEGSFPN 2350
KDTVYEYFVD PKIRSWTSFE DKLPKSWRYP PNAPFYKIMV PTVDTVRYNY 2400
LVSSLVANQN PILLVGPVGT GKTSIAQSVL QSLPSSQWSV LVVNMSAQTT 2450
SNNVQSIIES RVEKRTKGVY VPFGGKSMIT FMDDLNMPAK DMFGSQPPLE 2500
LIRLWIDYGF WYDRTKQTIK YIREMFLMAA MGPPGGGRTV ISPRLRSRFN 2550
IINMTFPTKS QIIRIFGTMI NQKLQDFEEE VKPIGNVVTE ATLDMYNTVV 2600
QRFLPTPTKM HYLFNLRDIS KVFQGMLRAN KDFHDTKSSI TRLWIHECFR 2650
VFSDRLVDAA DTEAFMGIIS DKLGSFFDLT FHHLCPSKRP PIFGDFLKEP 2700
KVYEDLTDLT VLKTVMETAL NEYNLSPSVV PMQLVLFREA IEHITRIVRV 2750
IGQPRGNMLL VGIGGSGRQS LARLASSICD YTTFQIEVTK HYRKQEFRDD 2800
IKRLYRQAGV ELKTTSFIFV DTQIADESFL EDINNILSSG EVPNLYKPDE 2850
FEEIQSHIID QARVEQVPES SDSLFAYLIE RVQNNLHIVL CLSPMGDPFR 2900
NWIRQYPALV NCTTINWFSE WPQEALLEVA EKCLIGVDLG TQENIHRKVA 2950
QIFVTMHWSV AQYSQKMLLE LRRHNYVTPT KYLELLSGYK KLLGEKRQEL 3000
LAQANKLRTG LFKIDETREK VQVMSLELED AKKKVAEFQK QCEEYLVIIV 3050
QQKREADEQQ KAVTANSEKI AVEEIKCQAL ADNAQKDLEE ALPALEEAMR 3100
ALESLNKKDI GEIKSYGRPP AQVEIVMQAV MILRGNEPTW AEAKRQLGEQ 3150
NFIKSLINFD KDNISDKVLK KIGAYCAQPD FQPDIIGRVS LAAKSLCMWV 3200
RAMELYGRLY RVVEPKRIRM NAALAQLREK QAALAEAQEK LREVAEKLEM 3250
LKKQYDEKLA QKEELRKKSE EMELKLERAG MLVSGLAGEK ARWEETVQGL 3300
EEDLGYLVGD CLLAAAFLSY MGPFLTNYRD EIVNQIWIGK IWELQVPCSP 3350
SFAIDNFLCN PTKVRDWNIQ GLPSDAFSTE NGIIVTRGNR WALMIDPQAQ 3400
ALKWIKNMEG GQGLKIIDLQ MSDYLRILEH AIHFGYPVLL QNVQEYLDPT 3450
LNPMLNKSVA RIGGRLLMRI GDKEVEYNTN FRFYITTKLS NPHYSPETSA 3500
KTTIVNFAVK EQGLEAQLLG IVVRKERPEL EEQKDSLVIN IAAGKRKLKE 3550
LEDEILRLLN EATGSLLDDV QLVNTLHTSK ITATEVTEQL ETSETTEINT 3600
DLAREAYRPC AQRASILFFV LNDMGCIDPM YQFSLDAYIS LFILSIDKSH 3650
RSNKLEDRID YLNDYHTYAV YRYTCRTLFE RHKLLFSFHM CAKILETSGK 3700
LNMDEYNFFL RGGVVLDREG QMDNPCSSWL ADAYWDNITE LDKLTNFHGL 3750
MNSFEQYPRD WHLWYTNAAP EKAMLPGEWE NACNEMQRML IVRSLRQDRV 3800
AFCVTSFIIT NLGSRFIEPP VLNMKSVLED STPRSPLVFI LSPGVDPTSA 3850
LLQLAEHMGM AQRFHALSLG QGQAPIAARL LREGVTQGHW VFLANCHLSL 3900
SWMPNLDKLV EQLQVEDPHP SFRLWLSSIP HPDFPISILQ VSIKMTTEPP 3950
KGLKANMTRL YQLMSEPQFS RCSKPAKYKK LLFSLCFFHS VLLERKKFLQ 4000
LGWNIIYGFN DSDFEVSENL LSLYLDEYEE TPWDALKYLI AGINYGGHVT 4050
DDWDRRLLTT YINDYFCDQS LSTPFHRLSA LETYFIPKDG SLASYKEYIS 4100
LLPGMDPPEA FGQHPNADVA SQITEAQTLF DTLLSLQPQI TPTRAGGQTR 4150
EEKVLELAAD VKQKIPEMID YEGTQKLLAL DPSPLNVVLL QEIQRYNTLM 4200
QTILFSLTDL EKGIQGLIVM STSLEEIFNC IFDAHVPPLW GKAYPSQKPL 4250
AAWTRDLAMR VEQFELWASR ARPPVIFWLS GFTFPTGFLT AVLQSSARQN 4300
NVSVDSLSWE FIVSTVDDSN LVYPPKDGVW VRGLYLEGAG WDRKNSCLVE 4350
AEPMQLVCLM PTIHFRPAES RKKSAKGMYS CPCYYYPNRA GSSDRASFVI 4400
GIDLRSGAMT PDHWIKRGTA LLMSLDS 4427
Length:4,427
Mass (Da):507,698
Last modified:February 26, 2008 - v3
Checksum:iA270F73DBDE2C3C4
GO
Isoform 2 (identifier: Q9P225-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3062-3100: Missing.
     4211-4235: EKGIQGLIVMSTSLEEIFNCIFDAH → EIPSCVSHKSERVVLELSAVKHPRQ
     4236-4427: Missing.

Note: No experimental confirmation available.

Show »
Length:4,196
Mass (Da):481,999
Checksum:i9E166534301BA935
GO
Isoform 3 (identifier: Q9P225-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: K → KMSNEIIRLC...FVQRCKDLIE
     636-790: SLLILFAEID...QREHRAAVQQ → YRSHLAPFPY...SPEPGRQRLQ
     791-4427: Missing.

Show »
Length:872
Mass (Da):99,915
Checksum:iC8AF185FABA6E9C5
GO

Sequence cautioni

The sequence AK128517 differs from that shown. Reason: Frameshift at position 3963.
The sequence BAA96027.2 differs from that shown. Reason: Erroneous initiation.

RNA editingi

Exon 13 included in isoform 3 is extensively edited in brain.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001A → V.
Corresponds to variant rs35664870 [ dbSNP | Ensembl ].
VAR_039407
Natural varianti312 – 3121S → T.
Corresponds to variant rs3744254 [ dbSNP | Ensembl ].
VAR_039408
Natural varianti1326 – 13261E → G.
Corresponds to variant rs11868946 [ dbSNP | Ensembl ].
VAR_039409
Natural varianti2548 – 25481R → H.
Corresponds to variant rs11656500 [ dbSNP | Ensembl ].
VAR_039410
Natural varianti2904 – 29041R → H.
Corresponds to variant rs2309808 [ dbSNP | Ensembl ].
VAR_060134
Natural varianti3600 – 36001T → I.
Corresponds to variant rs7213894 [ dbSNP | Ensembl ].
VAR_039411
Isoform 3 (identifier: Q9P225-3)
Natural varianti812 – 8121E → G in RNA edited version.
Natural varianti814 – 8141E → G in RNA edited version.
Natural varianti826 – 8261T → A in RNA edited version.
Natural varianti833 – 8331N → D in RNA edited version.
Natural varianti838 – 8381K → E in RNA edited version.
Natural varianti839 – 8391N → D in RNA edited version.
Natural varianti841 – 8411K → E in RNA edited version.
Natural varianti843 – 8431S → G in RNA edited version.
Natural varianti855 – 8551T → A in RNA edited version.
Natural varianti865 – 8651E → G in RNA edited version.
Natural varianti869 – 8691Q → R in RNA edited version.
Natural varianti872 – 8721Q → R in RNA edited version.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei390 – 3901K → KMSNEIIRLCCHAISLDRIF EGYVSSSKEDLQGCILCCHA WKDHYVQAVQMHIQFSSRGW VLDQTSIFAQVDAFVQRCKD LIE in isoform 3.
VSP_031913
Alternative sequencei636 – 790155SLLIL…AAVQQ → YRSHLAPFPYTPLLQLSQEF HSHLLTPLFIILSLSHTICL LSSFYFFFSSFIFVSPHLPP CYQHFNFTTYLKTQQNKTMI GQARWLTPVIPALWEAEVGA SLEPRSLRTAWATWQNPVSA KNTKISWAWWHKPVVSATWE GEVGGSPEPGRQRLQ in isoform 3.
VSP_031914Add
BLAST
Alternative sequencei791 – 44273637Missing in isoform 3.
VSP_031915Add
BLAST
Alternative sequencei3062 – 310039Missing in isoform 2.
VSP_031916Add
BLAST
Alternative sequencei4211 – 423525EKGIQ…IFDAH → EIPSCVSHKSERVVLELSAV KHPRQ in isoform 2.
VSP_031917Add
BLAST
Alternative sequencei4236 – 4427192Missing in isoform 2.
VSP_031918Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti593 – 5931E → G in AAH34225. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040936 mRNA. Translation: BAA96027.2. Different initiation.
AK128517 mRNA. No translation available.
AK292607 mRNA. Translation: BAF85296.1.
AC025335 Genomic DNA. No translation available.
AC087388 Genomic DNA. No translation available.
BC034225 mRNA. Translation: AAH34225.1.
U83570 Genomic DNA. Translation: AAB82760.1.
CCDSiCCDS32551.1. [Q9P225-1]
RefSeqiNP_065928.2. NM_020877.2. [Q9P225-1]
XP_005256527.1. XM_005256470.1. [Q9P225-1]
UniGeneiHs.367649.

Genome annotation databases

EnsembliENST00000082259; ENSP00000082259; ENSG00000183914. [Q9P225-3]
ENST00000389173; ENSP00000373825; ENSG00000183914. [Q9P225-1]
ENST00000570791; ENSP00000460245; ENSG00000183914. [Q9P225-3]
ENST00000572933; ENSP00000458355; ENSG00000183914. [Q9P225-1]
GeneIDi146754.
KEGGihsa:146754.
UCSCiuc002git.3. human. [Q9P225-3]
uc002giu.1. human. [Q9P225-1]

Polymorphism databases

DMDMi172044680.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040936 mRNA. Translation: BAA96027.2 . Different initiation.
AK128517 mRNA. No translation available.
AK292607 mRNA. Translation: BAF85296.1 .
AC025335 Genomic DNA. No translation available.
AC087388 Genomic DNA. No translation available.
BC034225 mRNA. Translation: AAH34225.1 .
U83570 Genomic DNA. Translation: AAB82760.1 .
CCDSi CCDS32551.1. [Q9P225-1 ]
RefSeqi NP_065928.2. NM_020877.2. [Q9P225-1 ]
XP_005256527.1. XM_005256470.1. [Q9P225-1 ]
UniGenei Hs.367649.

3D structure databases

ProteinModelPortali Q9P225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127007. 3 interactions.
IntActi Q9P225. 1 interaction.
STRINGi 9606.ENSP00000373825.

PTM databases

PhosphoSitei Q9P225.

Polymorphism databases

DMDMi 172044680.

Proteomic databases

PaxDbi Q9P225.
PRIDEi Q9P225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000082259 ; ENSP00000082259 ; ENSG00000183914 . [Q9P225-3 ]
ENST00000389173 ; ENSP00000373825 ; ENSG00000183914 . [Q9P225-1 ]
ENST00000570791 ; ENSP00000460245 ; ENSG00000183914 . [Q9P225-3 ]
ENST00000572933 ; ENSP00000458355 ; ENSG00000183914 . [Q9P225-1 ]
GeneIDi 146754.
KEGGi hsa:146754.
UCSCi uc002git.3. human. [Q9P225-3 ]
uc002giu.1. human. [Q9P225-1 ]

Organism-specific databases

CTDi 146754.
GeneCardsi GC17P007623.
H-InvDB HIX0202391.
HGNCi HGNC:2948. DNAH2.
MIMi 603333. gene.
neXtProti NX_Q9P225.
PharmGKBi PA27401.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5245.
HOGENOMi HOG000237308.
HOVERGENi HBG104828.
InParanoidi Q9P225.
KOi K10408.
OMAi KISRPPQ.
OrthoDBi EOG7F5115.
PhylomeDBi Q9P225.
TreeFami TF316836.

Miscellaneous databases

GenomeRNAii 146754.
NextBioi 85439.
PROi Q9P225.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9P225.
Bgeei Q9P225.
CleanExi HS_DNAH2.
Genevestigatori Q9P225.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10676. PTHR10676. 1 hit.
Pfami PF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3013-4427 (ISOFORM 2).
    Tissue: Testis and Trachea.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  5. "Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment."
    Chapelin C., Duriez B., Magnino F., Goossens M., Escudier E., Amselem S.
    FEBS Lett. 412:325-330(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1820-1902 (ISOFORM 1), TISSUE SPECIFICITY.
  6. "Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome."
    Sakurai M., Yano T., Kawabata H., Ueda H., Suzuki T.
    Nat. Chem. Biol. 6:733-740(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING VARIANTS (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiDYH2_HUMAN
AccessioniPrimary (citable) accession number: Q9P225
Secondary accession number(s): A8K992
, B5MDX5, O15434, Q6PIH3, Q6ZR42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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