ID   ZSWM5_HUMAN             Reviewed;        1185 AA.
AC   Q9P217; Q5SXQ9;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   24-JAN-2024, entry version 142.
DE   RecName: Full=Zinc finger SWIM domain-containing protein 5;
GN   Name=ZSWIM5; Synonyms=KIAA1511;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:143-150(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA96035.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB040944; BAA96035.1; ALT_INIT; mRNA.
DR   EMBL; AL592294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS41319.1; -.
DR   RefSeq; NP_065934.1; NM_020883.1.
DR   AlphaFoldDB; Q9P217; -.
DR   BioGRID; 121680; 5.
DR   STRING; 9606.ENSP00000352614; -.
DR   iPTMnet; Q9P217; -.
DR   PhosphoSitePlus; Q9P217; -.
DR   BioMuta; ZSWIM5; -.
DR   DMDM; 41018482; -.
DR   jPOST; Q9P217; -.
DR   MassIVE; Q9P217; -.
DR   MaxQB; Q9P217; -.
DR   PaxDb; 9606-ENSP00000352614; -.
DR   PeptideAtlas; Q9P217; -.
DR   ProteomicsDB; 83708; -.
DR   Antibodypedia; 2902; 89 antibodies from 16 providers.
DR   DNASU; 57643; -.
DR   Ensembl; ENST00000359600.6; ENSP00000352614.5; ENSG00000162415.7.
DR   GeneID; 57643; -.
DR   KEGG; hsa:57643; -.
DR   MANE-Select; ENST00000359600.6; ENSP00000352614.5; NM_020883.2; NP_065934.1.
DR   UCSC; uc001cnd.3; human.
DR   AGR; HGNC:29299; -.
DR   CTD; 57643; -.
DR   DisGeNET; 57643; -.
DR   GeneCards; ZSWIM5; -.
DR   HGNC; HGNC:29299; ZSWIM5.
DR   HPA; ENSG00000162415; Low tissue specificity.
DR   MIM; 620132; gene.
DR   neXtProt; NX_Q9P217; -.
DR   OpenTargets; ENSG00000162415; -.
DR   PharmGKB; PA134981647; -.
DR   VEuPathDB; HostDB:ENSG00000162415; -.
DR   eggNOG; KOG3615; Eukaryota.
DR   GeneTree; ENSGT00940000158362; -.
DR   HOGENOM; CLU_005301_1_0_1; -.
DR   InParanoid; Q9P217; -.
DR   OMA; ADDEHTW; -.
DR   OrthoDB; 3266353at2759; -.
DR   PhylomeDB; Q9P217; -.
DR   TreeFam; TF324881; -.
DR   PathwayCommons; Q9P217; -.
DR   BioGRID-ORCS; 57643; 11 hits in 1149 CRISPR screens.
DR   ChiTaRS; ZSWIM5; human.
DR   GenomeRNAi; 57643; -.
DR   Pharos; Q9P217; Tdark.
DR   PRO; PR:Q9P217; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q9P217; Protein.
DR   Bgee; ENSG00000162415; Expressed in ileal mucosa and 112 other cell types or tissues.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR007527; Znf_SWIM.
DR   InterPro; IPR048370; ZSWIM4-8_C.
DR   PANTHER; PTHR22619; ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6; 1.
DR   PANTHER; PTHR22619:SF2; ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 5; 1.
DR   Pfam; PF21055; ZSWIM4-8_C; 1.
DR   PROSITE; PS50966; ZF_SWIM; 1.
DR   Genevisible; Q9P217; HS.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..1185
FT                   /note="Zinc finger SWIM domain-containing protein 5"
FT                   /id="PRO_0000223103"
FT   ZN_FING         219..256
FT                   /note="SWIM-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         368
FT                   /note="V -> G (in dbSNP:rs12733746)"
FT                   /id="VAR_053770"
SQ   SEQUENCE   1185 AA;  130634 MW;  5AFA403521115889 CRC64;
     MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS CLVLGARPHL
     QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW SFPRNEREIC MYSSFQYRGG
     PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF
     RRGIRLLDSG SVENVLQVGF HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK
     DIFYCAHVVA LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ
     KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS QGGYCGSGKQ
     LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR QQGTNMTDKC RQLWDELGAL
     WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV CPLEDGNYGH ELPNITNALP QSAIHSPDSL
     SRPRRTVFTR AIEGRELHWQ DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP
     TACARVDALR SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG
     WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS PNSSESYLSL
     ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ LDDELVQTLQ KQCILLLEGG
     PFSGLGEVIH RESVPMHTFA KYLFSALLPH DPDLSYKLAL RAMRLPVLEN SASAGDTSHP
     HHMVSVVPSR YPRWFTLGHL ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF
     KLAQDAFKIA TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV
     RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA RTLALQCAMK
     DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL FTIARYMELR GYPLRAFKLA
     SLAMSHLNLA YNQDTHPAIN DVLWACALSH SLGKNELAAL IPLVVKSVHC ATVLSDILRR
     CTVTAPGLAG IPGRRSSGKL MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE
     FLSKARETFL LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG
//