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Q9P217

- ZSWM5_HUMAN

UniProt

Q9P217 - ZSWM5_HUMAN

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Protein
Zinc finger SWIM domain-containing protein 5
Gene
ZSWIM5, KIAA1511
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri219 – 25638SWIM-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 5
Gene namesi
Name:ZSWIM5
Synonyms:KIAA1511
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29299. ZSWIM5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11851185Zinc finger SWIM domain-containing protein 5
PRO_0000223103Add
BLAST

Proteomic databases

PaxDbiQ9P217.
PRIDEiQ9P217.

PTM databases

PhosphoSiteiQ9P217.

Expressioni

Gene expression databases

BgeeiQ9P217.
CleanExiHS_ZSWIM5.
GenevestigatoriQ9P217.

Organism-specific databases

HPAiHPA018211.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352614.

Structurei

3D structure databases

ProteinModelPortaliQ9P217.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG322060.
HOGENOMiHOG000231419.
HOVERGENiHBG058098.
InParanoidiQ9P217.
OMAiCMYSSFQ.
OrthoDBiEOG74J970.
PhylomeDBiQ9P217.
TreeFamiTF324881.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P217-1 [UniParc]FASTAAdd to Basket

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MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS     50
CLVLGARPHL QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW 100
SFPRNEREIC MYSSFQYRGG PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG 150
SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF RRGIRLLDSG SVENVLQVGF 200
HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK DIFYCAHVVA 250
LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ 300
KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS 350
QGGYCGSGKQ LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR 400
QQGTNMTDKC RQLWDELGAL WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV 450
CPLEDGNYGH ELPNITNALP QSAIHSPDSL SRPRRTVFTR AIEGRELHWQ 500
DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP TACARVDALR 550
SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG 600
WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS 650
PNSSESYLSL ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ 700
LDDELVQTLQ KQCILLLEGG PFSGLGEVIH RESVPMHTFA KYLFSALLPH 750
DPDLSYKLAL RAMRLPVLEN SASAGDTSHP HHMVSVVPSR YPRWFTLGHL 800
ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF KLAQDAFKIA 850
TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV 900
RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA 950
RTLALQCAMK DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL 1000
FTIARYMELR GYPLRAFKLA SLAMSHLNLA YNQDTHPAIN DVLWACALSH 1050
SLGKNELAAL IPLVVKSVHC ATVLSDILRR CTVTAPGLAG IPGRRSSGKL 1100
MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE FLSKARETFL 1150
LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG 1185
Length:1,185
Mass (Da):130,634
Last modified:January 16, 2004 - v2
Checksum:i5AFA403521115889
GO

Sequence cautioni

The sequence BAA96035.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti368 – 3681V → G.
Corresponds to variant rs12733746 [ dbSNP | Ensembl ].
VAR_053770

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040944 mRNA. Translation: BAA96035.1. Different initiation.
AL592294, AL359473 Genomic DNA. Translation: CAI21483.1.
AL359473, AL592294 Genomic DNA. Translation: CAI16443.1.
CCDSiCCDS41319.1.
RefSeqiNP_065934.1. NM_020883.1.
UniGeneiHs.656613.

Genome annotation databases

EnsembliENST00000359600; ENSP00000352614; ENSG00000162415.
GeneIDi57643.
KEGGihsa:57643.
UCSCiuc001cnd.2. human.

Polymorphism databases

DMDMi41018482.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040944 mRNA. Translation: BAA96035.1 . Different initiation.
AL592294 , AL359473 Genomic DNA. Translation: CAI21483.1 .
AL359473 , AL592294 Genomic DNA. Translation: CAI16443.1 .
CCDSi CCDS41319.1.
RefSeqi NP_065934.1. NM_020883.1.
UniGenei Hs.656613.

3D structure databases

ProteinModelPortali Q9P217.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000352614.

PTM databases

PhosphoSitei Q9P217.

Polymorphism databases

DMDMi 41018482.

Proteomic databases

PaxDbi Q9P217.
PRIDEi Q9P217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359600 ; ENSP00000352614 ; ENSG00000162415 .
GeneIDi 57643.
KEGGi hsa:57643.
UCSCi uc001cnd.2. human.

Organism-specific databases

CTDi 57643.
GeneCardsi GC01M045482.
HGNCi HGNC:29299. ZSWIM5.
HPAi HPA018211.
neXtProti NX_Q9P217.
PharmGKBi PA134981647.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322060.
HOGENOMi HOG000231419.
HOVERGENi HBG058098.
InParanoidi Q9P217.
OMAi CMYSSFQ.
OrthoDBi EOG74J970.
PhylomeDBi Q9P217.
TreeFami TF324881.

Miscellaneous databases

GenomeRNAii 57643.
NextBioi 64362.
PROi Q9P217.

Gene expression databases

Bgeei Q9P217.
CleanExi HS_ZSWIM5.
Genevestigatori Q9P217.

Family and domain databases

InterProi IPR007527. Znf_SWIM.
[Graphical view ]
PROSITEi PS50966. ZF_SWIM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZSWM5_HUMAN
AccessioniPrimary (citable) accession number: Q9P217
Secondary accession number(s): Q5SXQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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