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Protein

Zinc finger SWIM domain-containing protein 5

Gene

ZSWIM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri219 – 25638SWIM-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 5
Gene namesi
Name:ZSWIM5
Synonyms:KIAA1511
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29299. ZSWIM5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981647.

Polymorphism and mutation databases

BioMutaiZSWIM5.
DMDMi41018482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11851185Zinc finger SWIM domain-containing protein 5PRO_0000223103Add
BLAST

Proteomic databases

MaxQBiQ9P217.
PaxDbiQ9P217.
PRIDEiQ9P217.

PTM databases

PhosphoSiteiQ9P217.

Expressioni

Gene expression databases

BgeeiQ9P217.
CleanExiHS_ZSWIM5.
GenevisibleiQ9P217. HS.

Organism-specific databases

HPAiHPA018211.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352614.

Structurei

3D structure databases

ProteinModelPortaliQ9P217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri219 – 25638SWIM-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG322060.
GeneTreeiENSGT00390000012572.
HOGENOMiHOG000231419.
HOVERGENiHBG058098.
InParanoidiQ9P217.
OMAiCMYSSFQ.
OrthoDBiEOG74J970.
PhylomeDBiQ9P217.
TreeFamiTF324881.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS
60 70 80 90 100
CLVLGARPHL QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW
110 120 130 140 150
SFPRNEREIC MYSSFQYRGG PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG
160 170 180 190 200
SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF RRGIRLLDSG SVENVLQVGF
210 220 230 240 250
HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK DIFYCAHVVA
260 270 280 290 300
LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ
310 320 330 340 350
KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS
360 370 380 390 400
QGGYCGSGKQ LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR
410 420 430 440 450
QQGTNMTDKC RQLWDELGAL WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV
460 470 480 490 500
CPLEDGNYGH ELPNITNALP QSAIHSPDSL SRPRRTVFTR AIEGRELHWQ
510 520 530 540 550
DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP TACARVDALR
560 570 580 590 600
SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG
610 620 630 640 650
WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS
660 670 680 690 700
PNSSESYLSL ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ
710 720 730 740 750
LDDELVQTLQ KQCILLLEGG PFSGLGEVIH RESVPMHTFA KYLFSALLPH
760 770 780 790 800
DPDLSYKLAL RAMRLPVLEN SASAGDTSHP HHMVSVVPSR YPRWFTLGHL
810 820 830 840 850
ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF KLAQDAFKIA
860 870 880 890 900
TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV
910 920 930 940 950
RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA
960 970 980 990 1000
RTLALQCAMK DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL
1010 1020 1030 1040 1050
FTIARYMELR GYPLRAFKLA SLAMSHLNLA YNQDTHPAIN DVLWACALSH
1060 1070 1080 1090 1100
SLGKNELAAL IPLVVKSVHC ATVLSDILRR CTVTAPGLAG IPGRRSSGKL
1110 1120 1130 1140 1150
MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE FLSKARETFL
1160 1170 1180
LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG
Length:1,185
Mass (Da):130,634
Last modified:January 16, 2004 - v2
Checksum:i5AFA403521115889
GO

Sequence cautioni

The sequence BAA96035.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti368 – 3681V → G.
Corresponds to variant rs12733746 [ dbSNP | Ensembl ].
VAR_053770

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040944 mRNA. Translation: BAA96035.1. Different initiation.
AL592294, AL359473 Genomic DNA. Translation: CAI21483.1.
AL359473, AL592294 Genomic DNA. Translation: CAI16443.1.
CCDSiCCDS41319.1.
RefSeqiNP_065934.1. NM_020883.1.
UniGeneiHs.656613.

Genome annotation databases

EnsembliENST00000359600; ENSP00000352614; ENSG00000162415.
GeneIDi57643.
KEGGihsa:57643.
UCSCiuc001cnd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040944 mRNA. Translation: BAA96035.1. Different initiation.
AL592294, AL359473 Genomic DNA. Translation: CAI21483.1.
AL359473, AL592294 Genomic DNA. Translation: CAI16443.1.
CCDSiCCDS41319.1.
RefSeqiNP_065934.1. NM_020883.1.
UniGeneiHs.656613.

3D structure databases

ProteinModelPortaliQ9P217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352614.

PTM databases

PhosphoSiteiQ9P217.

Polymorphism and mutation databases

BioMutaiZSWIM5.
DMDMi41018482.

Proteomic databases

MaxQBiQ9P217.
PaxDbiQ9P217.
PRIDEiQ9P217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359600; ENSP00000352614; ENSG00000162415.
GeneIDi57643.
KEGGihsa:57643.
UCSCiuc001cnd.2. human.

Organism-specific databases

CTDi57643.
GeneCardsiGC01M045482.
HGNCiHGNC:29299. ZSWIM5.
HPAiHPA018211.
neXtProtiNX_Q9P217.
PharmGKBiPA134981647.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG322060.
GeneTreeiENSGT00390000012572.
HOGENOMiHOG000231419.
HOVERGENiHBG058098.
InParanoidiQ9P217.
OMAiCMYSSFQ.
OrthoDBiEOG74J970.
PhylomeDBiQ9P217.
TreeFamiTF324881.

Miscellaneous databases

ChiTaRSiZSWIM5. human.
GenomeRNAii57643.
NextBioi64362.
PROiQ9P217.

Gene expression databases

BgeeiQ9P217.
CleanExiHS_ZSWIM5.
GenevisibleiQ9P217. HS.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZSWM5_HUMAN
AccessioniPrimary (citable) accession number: Q9P217
Secondary accession number(s): Q5SXQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: June 24, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.