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Q9P217

- ZSWM5_HUMAN

UniProt

Q9P217 - ZSWM5_HUMAN

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Protein

Zinc finger SWIM domain-containing protein 5

Gene

ZSWIM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri219 – 25638SWIM-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 5
Gene namesi
Name:ZSWIM5
Synonyms:KIAA1511
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29299. ZSWIM5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11851185Zinc finger SWIM domain-containing protein 5PRO_0000223103Add
BLAST

Proteomic databases

MaxQBiQ9P217.
PaxDbiQ9P217.
PRIDEiQ9P217.

PTM databases

PhosphoSiteiQ9P217.

Expressioni

Gene expression databases

BgeeiQ9P217.
CleanExiHS_ZSWIM5.
GenevestigatoriQ9P217.

Organism-specific databases

HPAiHPA018211.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352614.

Structurei

3D structure databases

ProteinModelPortaliQ9P217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri219 – 25638SWIM-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG322060.
GeneTreeiENSGT00390000012572.
HOGENOMiHOG000231419.
HOVERGENiHBG058098.
InParanoidiQ9P217.
OMAiCMYSSFQ.
OrthoDBiEOG74J970.
PhylomeDBiQ9P217.
TreeFamiTF324881.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P217-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS
60 70 80 90 100
CLVLGARPHL QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW
110 120 130 140 150
SFPRNEREIC MYSSFQYRGG PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG
160 170 180 190 200
SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF RRGIRLLDSG SVENVLQVGF
210 220 230 240 250
HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK DIFYCAHVVA
260 270 280 290 300
LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ
310 320 330 340 350
KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS
360 370 380 390 400
QGGYCGSGKQ LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR
410 420 430 440 450
QQGTNMTDKC RQLWDELGAL WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV
460 470 480 490 500
CPLEDGNYGH ELPNITNALP QSAIHSPDSL SRPRRTVFTR AIEGRELHWQ
510 520 530 540 550
DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP TACARVDALR
560 570 580 590 600
SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG
610 620 630 640 650
WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS
660 670 680 690 700
PNSSESYLSL ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ
710 720 730 740 750
LDDELVQTLQ KQCILLLEGG PFSGLGEVIH RESVPMHTFA KYLFSALLPH
760 770 780 790 800
DPDLSYKLAL RAMRLPVLEN SASAGDTSHP HHMVSVVPSR YPRWFTLGHL
810 820 830 840 850
ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF KLAQDAFKIA
860 870 880 890 900
TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV
910 920 930 940 950
RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA
960 970 980 990 1000
RTLALQCAMK DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL
1010 1020 1030 1040 1050
FTIARYMELR GYPLRAFKLA SLAMSHLNLA YNQDTHPAIN DVLWACALSH
1060 1070 1080 1090 1100
SLGKNELAAL IPLVVKSVHC ATVLSDILRR CTVTAPGLAG IPGRRSSGKL
1110 1120 1130 1140 1150
MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE FLSKARETFL
1160 1170 1180
LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG
Length:1,185
Mass (Da):130,634
Last modified:January 16, 2004 - v2
Checksum:i5AFA403521115889
GO

Sequence cautioni

The sequence BAA96035.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti368 – 3681V → G.
Corresponds to variant rs12733746 [ dbSNP | Ensembl ].
VAR_053770

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040944 mRNA. Translation: BAA96035.1. Different initiation.
AL592294, AL359473 Genomic DNA. Translation: CAI21483.1.
AL359473, AL592294 Genomic DNA. Translation: CAI16443.1.
CCDSiCCDS41319.1.
RefSeqiNP_065934.1. NM_020883.1.
UniGeneiHs.656613.

Genome annotation databases

EnsembliENST00000359600; ENSP00000352614; ENSG00000162415.
GeneIDi57643.
KEGGihsa:57643.
UCSCiuc001cnd.2. human.

Polymorphism databases

DMDMi41018482.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040944 mRNA. Translation: BAA96035.1 . Different initiation.
AL592294 , AL359473 Genomic DNA. Translation: CAI21483.1 .
AL359473 , AL592294 Genomic DNA. Translation: CAI16443.1 .
CCDSi CCDS41319.1.
RefSeqi NP_065934.1. NM_020883.1.
UniGenei Hs.656613.

3D structure databases

ProteinModelPortali Q9P217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000352614.

PTM databases

PhosphoSitei Q9P217.

Polymorphism databases

DMDMi 41018482.

Proteomic databases

MaxQBi Q9P217.
PaxDbi Q9P217.
PRIDEi Q9P217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359600 ; ENSP00000352614 ; ENSG00000162415 .
GeneIDi 57643.
KEGGi hsa:57643.
UCSCi uc001cnd.2. human.

Organism-specific databases

CTDi 57643.
GeneCardsi GC01M045482.
HGNCi HGNC:29299. ZSWIM5.
HPAi HPA018211.
neXtProti NX_Q9P217.
PharmGKBi PA134981647.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322060.
GeneTreei ENSGT00390000012572.
HOGENOMi HOG000231419.
HOVERGENi HBG058098.
InParanoidi Q9P217.
OMAi CMYSSFQ.
OrthoDBi EOG74J970.
PhylomeDBi Q9P217.
TreeFami TF324881.

Miscellaneous databases

GenomeRNAii 57643.
NextBioi 64362.
PROi Q9P217.

Gene expression databases

Bgeei Q9P217.
CleanExi HS_ZSWIM5.
Genevestigatori Q9P217.

Family and domain databases

InterProi IPR007527. Znf_SWIM.
[Graphical view ]
PROSITEi PS50966. ZF_SWIM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZSWM5_HUMAN
AccessioniPrimary (citable) accession number: Q9P217
Secondary accession number(s): Q5SXQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3