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Q9P217

- ZSWM5_HUMAN

UniProt

Q9P217 - ZSWM5_HUMAN

Protein

Zinc finger SWIM domain-containing protein 5

Gene

ZSWIM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri219 – 25638SWIM-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger SWIM domain-containing protein 5
    Gene namesi
    Name:ZSWIM5
    Synonyms:KIAA1511
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29299. ZSWIM5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134981647.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11851185Zinc finger SWIM domain-containing protein 5PRO_0000223103Add
    BLAST

    Proteomic databases

    PaxDbiQ9P217.
    PRIDEiQ9P217.

    PTM databases

    PhosphoSiteiQ9P217.

    Expressioni

    Gene expression databases

    BgeeiQ9P217.
    CleanExiHS_ZSWIM5.
    GenevestigatoriQ9P217.

    Organism-specific databases

    HPAiHPA018211.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352614.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri219 – 25638SWIM-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG322060.
    HOGENOMiHOG000231419.
    HOVERGENiHBG058098.
    InParanoidiQ9P217.
    OMAiCMYSSFQ.
    OrthoDBiEOG74J970.
    PhylomeDBiQ9P217.
    TreeFamiTF324881.

    Family and domain databases

    InterProiIPR007527. Znf_SWIM.
    [Graphical view]
    PROSITEiPS50966. ZF_SWIM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P217-1 [UniParc]FASTAAdd to Basket

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    MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS     50
    CLVLGARPHL QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW 100
    SFPRNEREIC MYSSFQYRGG PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG 150
    SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF RRGIRLLDSG SVENVLQVGF 200
    HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK DIFYCAHVVA 250
    LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ 300
    KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS 350
    QGGYCGSGKQ LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR 400
    QQGTNMTDKC RQLWDELGAL WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV 450
    CPLEDGNYGH ELPNITNALP QSAIHSPDSL SRPRRTVFTR AIEGRELHWQ 500
    DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP TACARVDALR 550
    SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG 600
    WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS 650
    PNSSESYLSL ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ 700
    LDDELVQTLQ KQCILLLEGG PFSGLGEVIH RESVPMHTFA KYLFSALLPH 750
    DPDLSYKLAL RAMRLPVLEN SASAGDTSHP HHMVSVVPSR YPRWFTLGHL 800
    ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF KLAQDAFKIA 850
    TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV 900
    RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA 950
    RTLALQCAMK DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL 1000
    FTIARYMELR GYPLRAFKLA SLAMSHLNLA YNQDTHPAIN DVLWACALSH 1050
    SLGKNELAAL IPLVVKSVHC ATVLSDILRR CTVTAPGLAG IPGRRSSGKL 1100
    MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE FLSKARETFL 1150
    LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG 1185
    Length:1,185
    Mass (Da):130,634
    Last modified:January 16, 2004 - v2
    Checksum:i5AFA403521115889
    GO

    Sequence cautioni

    The sequence BAA96035.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti368 – 3681V → G.
    Corresponds to variant rs12733746 [ dbSNP | Ensembl ].
    VAR_053770

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040944 mRNA. Translation: BAA96035.1. Different initiation.
    AL592294, AL359473 Genomic DNA. Translation: CAI21483.1.
    AL359473, AL592294 Genomic DNA. Translation: CAI16443.1.
    CCDSiCCDS41319.1.
    RefSeqiNP_065934.1. NM_020883.1.
    UniGeneiHs.656613.

    Genome annotation databases

    EnsembliENST00000359600; ENSP00000352614; ENSG00000162415.
    GeneIDi57643.
    KEGGihsa:57643.
    UCSCiuc001cnd.2. human.

    Polymorphism databases

    DMDMi41018482.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040944 mRNA. Translation: BAA96035.1 . Different initiation.
    AL592294 , AL359473 Genomic DNA. Translation: CAI21483.1 .
    AL359473 , AL592294 Genomic DNA. Translation: CAI16443.1 .
    CCDSi CCDS41319.1.
    RefSeqi NP_065934.1. NM_020883.1.
    UniGenei Hs.656613.

    3D structure databases

    ProteinModelPortali Q9P217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000352614.

    PTM databases

    PhosphoSitei Q9P217.

    Polymorphism databases

    DMDMi 41018482.

    Proteomic databases

    PaxDbi Q9P217.
    PRIDEi Q9P217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359600 ; ENSP00000352614 ; ENSG00000162415 .
    GeneIDi 57643.
    KEGGi hsa:57643.
    UCSCi uc001cnd.2. human.

    Organism-specific databases

    CTDi 57643.
    GeneCardsi GC01M045482.
    HGNCi HGNC:29299. ZSWIM5.
    HPAi HPA018211.
    neXtProti NX_Q9P217.
    PharmGKBi PA134981647.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322060.
    HOGENOMi HOG000231419.
    HOVERGENi HBG058098.
    InParanoidi Q9P217.
    OMAi CMYSSFQ.
    OrthoDBi EOG74J970.
    PhylomeDBi Q9P217.
    TreeFami TF324881.

    Miscellaneous databases

    GenomeRNAii 57643.
    NextBioi 64362.
    PROi Q9P217.

    Gene expression databases

    Bgeei Q9P217.
    CleanExi HS_ZSWIM5.
    Genevestigatori Q9P217.

    Family and domain databases

    InterProi IPR007527. Znf_SWIM.
    [Graphical view ]
    PROSITEi PS50966. ZF_SWIM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiZSWM5_HUMAN
    AccessioniPrimary (citable) accession number: Q9P217
    Secondary accession number(s): Q5SXQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3