Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9P217 (ZSWM5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger SWIM domain-containing protein 5
Gene names
Name:ZSWIM5
Synonyms:KIAA1511
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1185 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SWIM-type zinc finger.

Sequence caution

The sequence BAA96035.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from direct assay PubMed 22664934. Source: UniProt

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11851185Zinc finger SWIM domain-containing protein 5
PRO_0000223103

Regions

Zinc finger219 – 25638SWIM-type

Natural variations

Natural variant3681V → G.
Corresponds to variant rs12733746 [ dbSNP | Ensembl ].
VAR_053770

Sequences

Sequence LengthMass (Da)Tools
Q9P217 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: 5AFA403521115889

FASTA1,185130,634
        10         20         30         40         50         60 
MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS CLVLGARPHL 

        70         80         90        100        110        120 
QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW SFPRNEREIC MYSSFQYRGG 

       130        140        150        160        170        180 
PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF 

       190        200        210        220        230        240 
RRGIRLLDSG SVENVLQVGF HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK 

       250        260        270        280        290        300 
DIFYCAHVVA LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ 

       310        320        330        340        350        360 
KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS QGGYCGSGKQ 

       370        380        390        400        410        420 
LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR QQGTNMTDKC RQLWDELGAL 

       430        440        450        460        470        480 
WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV CPLEDGNYGH ELPNITNALP QSAIHSPDSL 

       490        500        510        520        530        540 
SRPRRTVFTR AIEGRELHWQ DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP 

       550        560        570        580        590        600 
TACARVDALR SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG 

       610        620        630        640        650        660 
WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS PNSSESYLSL 

       670        680        690        700        710        720 
ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ LDDELVQTLQ KQCILLLEGG 

       730        740        750        760        770        780 
PFSGLGEVIH RESVPMHTFA KYLFSALLPH DPDLSYKLAL RAMRLPVLEN SASAGDTSHP 

       790        800        810        820        830        840 
HHMVSVVPSR YPRWFTLGHL ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF 

       850        860        870        880        890        900 
KLAQDAFKIA TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV 

       910        920        930        940        950        960 
RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA RTLALQCAMK 

       970        980        990       1000       1010       1020 
DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL FTIARYMELR GYPLRAFKLA 

      1030       1040       1050       1060       1070       1080 
SLAMSHLNLA YNQDTHPAIN DVLWACALSH SLGKNELAAL IPLVVKSVHC ATVLSDILRR 

      1090       1100       1110       1120       1130       1140 
CTVTAPGLAG IPGRRSSGKL MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE 

      1150       1160       1170       1180 
FLSKARETFL LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040944 mRNA. Translation: BAA96035.1. Different initiation.
AL592294, AL359473 Genomic DNA. Translation: CAI21483.1.
AL359473, AL592294 Genomic DNA. Translation: CAI16443.1.
CCDSCCDS41319.1.
RefSeqNP_065934.1. NM_020883.1.
UniGeneHs.656613.

3D structure databases

ProteinModelPortalQ9P217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000352614.

PTM databases

PhosphoSiteQ9P217.

Polymorphism databases

DMDM41018482.

Proteomic databases

PaxDbQ9P217.
PRIDEQ9P217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359600; ENSP00000352614; ENSG00000162415.
GeneID57643.
KEGGhsa:57643.
UCSCuc001cnd.2. human.

Organism-specific databases

CTD57643.
GeneCardsGC01M045482.
HGNCHGNC:29299. ZSWIM5.
HPAHPA018211.
neXtProtNX_Q9P217.
PharmGKBPA134981647.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322060.
HOGENOMHOG000231419.
HOVERGENHBG058098.
InParanoidQ9P217.
OMACMYSSFQ.
OrthoDBEOG74J970.
PhylomeDBQ9P217.
TreeFamTF324881.

Gene expression databases

BgeeQ9P217.
CleanExHS_ZSWIM5.
GenevestigatorQ9P217.

Family and domain databases

InterProIPR007527. Znf_SWIM.
[Graphical view]
PROSITEPS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57643.
NextBio64362.
PROQ9P217.

Entry information

Entry nameZSWM5_HUMAN
AccessionPrimary (citable) accession number: Q9P217
Secondary accession number(s): Q5SXQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM