ID POGK_HUMAN Reviewed; 609 AA. AC Q9P215; Q5TIJ1; Q8TE07; DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 26-APR-2004, sequence version 2. DT 27-MAR-2024, entry version 164. DE RecName: Full=Pogo transposable element with KRAB domain; GN Name=POGK; Synonyms=KIAA1513; ORFNames=LST003, SLTP003; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=10819331; DOI=10.1093/dnares/7.2.143; RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XVII. The RT complete sequences of 100 new cDNA clones from brain which code for large RT proteins in vitro."; RL DNA Res. 7:143-150(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-609. RC TISSUE=Aorta; RA Hui R.T., Liu B., Zhao B., Wang X.Y.; RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [8] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-13, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25218447; DOI=10.1038/nsmb.2890; RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., RA Vertegaal A.C.; RT "Uncovering global SUMOylation signaling networks in a site-specific RT manner."; RL Nat. Struct. Mol. Biol. 21:927-936(2014). RN [9] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-13 AND LYS-384, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- INTERACTION: CC Q9P215; P08238: HSP90AB1; NbExp=2; IntAct=EBI-2555775, EBI-352572; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAM12422.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=BAA96037.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB040946; BAA96037.1; ALT_INIT; mRNA. DR EMBL; AK056711; BAG51796.1; -; mRNA. DR EMBL; AL008639; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471067; EAW90775.1; -; Genomic_DNA. DR EMBL; BC131624; AAI31625.1; -; mRNA. DR EMBL; AF111706; AAM12422.1; ALT_INIT; mRNA. DR CCDS; CCDS1254.1; -. DR RefSeq; NP_060012.3; NM_017542.4. DR RefSeq; XP_005245427.1; XM_005245370.3. DR RefSeq; XP_011508116.1; XM_011509814.2. DR RefSeq; XP_016857403.1; XM_017001914.1. DR AlphaFoldDB; Q9P215; -. DR SMR; Q9P215; -. DR BioGRID; 121682; 29. DR IntAct; Q9P215; 8. DR MINT; Q9P215; -. DR STRING; 9606.ENSP00000356849; -. DR iPTMnet; Q9P215; -. DR PhosphoSitePlus; Q9P215; -. DR BioMuta; POGK; -. DR DMDM; 46577131; -. DR EPD; Q9P215; -. DR jPOST; Q9P215; -. DR MassIVE; Q9P215; -. DR MaxQB; Q9P215; -. DR PaxDb; 9606-ENSP00000356849; -. DR PeptideAtlas; Q9P215; -. DR ProteomicsDB; 83707; -. DR Pumba; Q9P215; -. DR Antibodypedia; 1662; 391 antibodies from 26 providers. DR DNASU; 57645; -. DR Ensembl; ENST00000367875.1; ENSP00000356849.1; ENSG00000143157.12. DR Ensembl; ENST00000367876.9; ENSP00000356850.4; ENSG00000143157.12. DR GeneID; 57645; -. DR KEGG; hsa:57645; -. DR MANE-Select; ENST00000367876.9; ENSP00000356850.4; NM_017542.5; NP_060012.3. DR UCSC; uc001gdt.2; human. DR AGR; HGNC:18800; -. DR CTD; 57645; -. DR GeneCards; POGK; -. DR HGNC; HGNC:18800; POGK. DR HPA; ENSG00000143157; Low tissue specificity. DR MIM; 620039; gene. DR neXtProt; NX_Q9P215; -. DR OpenTargets; ENSG00000143157; -. DR PharmGKB; PA38684; -. DR VEuPathDB; HostDB:ENSG00000143157; -. DR eggNOG; KOG3105; Eukaryota. DR GeneTree; ENSGT00440000039028; -. DR HOGENOM; CLU_031292_0_0_1; -. DR InParanoid; Q9P215; -. DR OMA; EELMQDW; -. DR OrthoDB; 2884029at2759; -. DR PhylomeDB; Q9P215; -. DR TreeFam; TF332951; -. DR PathwayCommons; Q9P215; -. DR SignaLink; Q9P215; -. DR BioGRID-ORCS; 57645; 9 hits in 1159 CRISPR screens. DR ChiTaRS; POGK; human. DR GenomeRNAi; 57645; -. DR Pharos; Q9P215; Tdark. DR PRO; PR:Q9P215; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9P215; Protein. DR Bgee; ENSG00000143157; Expressed in Brodmann (1909) area 46 and 202 other cell types or tissues. DR ExpressionAtlas; Q9P215; baseline and differential. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IBA:GO_Central. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd07765; KRAB_A-box; 1. DR Gene3D; 6.10.140.140; -; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 2. DR InterPro; IPR003655; aKRAB. DR InterPro; IPR018586; Brinker_DNA-bd. DR InterPro; IPR004875; DDE_SF_endonuclease_dom. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR PANTHER; PTHR19303:SF21; POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN; 1. DR PANTHER; PTHR19303; TRANSPOSON; 1. DR Pfam; PF09607; BrkDBD; 1. DR Pfam; PF03184; DDE_1; 1. DR Pfam; PF03221; HTH_Tnp_Tc5; 1. DR Pfam; PF01352; KRAB; 1. DR SMART; SM00674; CENPB; 1. DR SMART; SM00349; KRAB; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS51253; HTH_CENPB; 1. DR PROSITE; PS50805; KRAB; 1. DR Genevisible; Q9P215; HS. PE 1: Evidence at protein level; KW Coiled coil; Developmental protein; DNA-binding; Isopeptide bond; Nucleus; KW Reference proteome; Ubl conjugation. FT CHAIN 1..609 FT /note="Pogo transposable element with KRAB domain" FT /id="PRO_0000126131" FT DOMAIN 47..118 FT /note="KRAB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119" FT DOMAIN 250..323 FT /note="HTH CENPB-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583" FT DOMAIN 353..567 FT /note="DDE-1" FT /evidence="ECO:0000255" FT REGION 1..28 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 100..127 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 588..609 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 8..28 FT /evidence="ECO:0000255" FT COMPBIAS 592..609 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CROSSLNK 13 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:25218447, FT ECO:0007744|PubMed:28112733" FT CROSSLNK 384 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" SQ SEQUENCE 609 AA; 69444 MW; AF25653D30FFC804 CRC64; MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD EVAIYFSDEE WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE GEEESQNSDE WQLQGGTSAE NEESDVKPPD WPNPMNATSQ FPQPQHFDSF GLRLPRDITE LPEWSEGYPF YMAMGFPGYD LSADDIAGKF QFSRGMRRSY DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ LQNAHAMRRA FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR RAHDYEVAQM GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA MLGVLADGRK LPPYIILRGT YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL EVVWRRRTGA VPKQRGMLIL NGFRGHATDS VKNSMESMNT DMVIIPGGLT SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK KPPLGLFLEW VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC DTESMAESN //