Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pogo transposable element with KRAB domain

Gene

POGK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with KRAB domain
Gene namesi
Name:POGK
Synonyms:KIAA1513
ORF Names:LST003, SLTP003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143157.11
HGNCiHGNC:18800 POGK
neXtProtiNX_Q9P215

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57645
OpenTargetsiENSG00000143157
PharmGKBiPA38684

Polymorphism and mutation databases

BioMutaiPOGK
DMDMi46577131

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001261311 – 609Pogo transposable element with KRAB domainAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9P215
MaxQBiQ9P215
PaxDbiQ9P215
PeptideAtlasiQ9P215
PRIDEiQ9P215

PTM databases

iPTMnetiQ9P215
PhosphoSitePlusiQ9P215

Expressioni

Gene expression databases

BgeeiENSG00000143157
CleanExiHS_POGK
ExpressionAtlasiQ9P215 baseline and differential
GenevisibleiQ9P215 HS

Organism-specific databases

HPAiHPA007838
HPA031630

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-2555775,EBI-352572

Protein-protein interaction databases

BioGridi12168211 interactors.
IntActiQ9P215 3 interactors.
MINTiQ9P215
STRINGi9606.ENSP00000356849

Structurei

3D structure databases

ProteinModelPortaliQ9P215
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 118KRABPROSITE-ProRule annotationAdd BLAST72
Domaini250 – 323HTH CENPB-typePROSITE-ProRule annotationAdd BLAST74
Domaini353 – 567DDE-1Sequence analysisAdd BLAST215

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili8 – 28Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 20Poly-Glu7

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00440000039028
HOGENOMiHOG000285963
HOVERGENiHBG049433
InParanoidiQ9P215
OMAiDLMQDWL
OrthoDBiEOG091G0P6J
PhylomeDBiQ9P215
TreeFamiTF332951

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR018586 Brinker_DNA-bd
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR001909 KRAB
IPR036051 KRAB_dom_sf
PfamiView protein in Pfam
PF09607 BrkDBD, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SM00349 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
SSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50805 KRAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD
60 70 80 90 100
EVAIYFSDEE WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE
110 120 130 140 150
GEEESQNSDE WQLQGGTSAE NEESDVKPPD WPNPMNATSQ FPQPQHFDSF
160 170 180 190 200
GLRLPRDITE LPEWSEGYPF YMAMGFPGYD LSADDIAGKF QFSRGMRRSY
210 220 230 240 250
DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ LQNAHAMRRA
260 270 280 290 300
FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE
310 320 330 340 350
KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR
360 370 380 390 400
RAHDYEVAQM GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA
410 420 430 440 450
MLGVLADGRK LPPYIILRGT YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL
460 470 480 490 500
EVVWRRRTGA VPKQRGMLIL NGFRGHATDS VKNSMESMNT DMVIIPGGLT
510 520 530 540 550
SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK KPPLGLFLEW
560 570 580 590 600
VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC

DTESMAESN
Length:609
Mass (Da):69,444
Last modified:April 26, 2004 - v2
Checksum:iAF25653D30FFC804
GO

Sequence cautioni

The sequence AAM12422 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA96037 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040946 mRNA Translation: BAA96037.1 Different initiation.
AK056711 mRNA Translation: BAG51796.1
AL008639 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90775.1
BC131624 mRNA Translation: AAI31625.1
AF111706 mRNA Translation: AAM12422.1 Different initiation.
CCDSiCCDS1254.1
RefSeqiNP_060012.3, NM_017542.4
XP_005245427.1, XM_005245370.3
XP_011508116.1, XM_011509814.2
XP_016857403.1, XM_017001914.1
UniGeneiHs.432752

Genome annotation databases

EnsembliENST00000367875; ENSP00000356849; ENSG00000143157
ENST00000367876; ENSP00000356850; ENSG00000143157
GeneIDi57645
KEGGihsa:57645
UCSCiuc001gdt.2 human

Similar proteinsi

Entry informationi

Entry nameiPOGK_HUMAN
AccessioniPrimary (citable) accession number: Q9P215
Secondary accession number(s): Q5TIJ1, Q8TE07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome