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Protein

Pogo transposable element with KRAB domain

Gene

POGK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with KRAB domain
Gene namesi
Name:POGK
Synonyms:KIAA1513
ORF Names:LST003, SLTP003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18800. POGK.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Pogo transposable element with KRAB domainPRO_0000126131Add
BLAST

Proteomic databases

MaxQBiQ9P215.
PaxDbiQ9P215.
PRIDEiQ9P215.

PTM databases

PhosphoSiteiQ9P215.

Expressioni

Gene expression databases

BgeeiQ9P215.
CleanExiHS_POGK.
ExpressionAtlasiQ9P215. baseline and differential.
GenevestigatoriQ9P215.

Organism-specific databases

HPAiHPA007838.
HPA031630.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-2555775,EBI-352572

Protein-protein interaction databases

BioGridi121682. 9 interactions.
IntActiQ9P215. 3 interactions.
MINTiMINT-8247625.

Structurei

3D structure databases

ProteinModelPortaliQ9P215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 11872KRABPROSITE-ProRule annotationAdd
BLAST
Domaini250 – 32374HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini353 – 567215DDEAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 2821Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 207Poly-Glu

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG284255.
GeneTreeiENSGT00440000039028.
HOGENOMiHOG000285963.
HOVERGENiHBG049433.
InParanoidiQ9P215.
OMAiWEIESEL.
OrthoDBiEOG73JKWC.
PhylomeDBiQ9P215.
TreeFamiTF332951.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR018586. Brinker_DNA-bd.
IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR001909. Krueppel-associated_box.
[Graphical view]
PfamiPF09607. BrkDBD. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50805. KRAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD
60 70 80 90 100
EVAIYFSDEE WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE
110 120 130 140 150
GEEESQNSDE WQLQGGTSAE NEESDVKPPD WPNPMNATSQ FPQPQHFDSF
160 170 180 190 200
GLRLPRDITE LPEWSEGYPF YMAMGFPGYD LSADDIAGKF QFSRGMRRSY
210 220 230 240 250
DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ LQNAHAMRRA
260 270 280 290 300
FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE
310 320 330 340 350
KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR
360 370 380 390 400
RAHDYEVAQM GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA
410 420 430 440 450
MLGVLADGRK LPPYIILRGT YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL
460 470 480 490 500
EVVWRRRTGA VPKQRGMLIL NGFRGHATDS VKNSMESMNT DMVIIPGGLT
510 520 530 540 550
SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK KPPLGLFLEW
560 570 580 590 600
VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC

DTESMAESN
Length:609
Mass (Da):69,444
Last modified:April 26, 2004 - v2
Checksum:iAF25653D30FFC804
GO

Sequence cautioni

The sequence AAM12422.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA96037.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040946 mRNA. Translation: BAA96037.1. Different initiation.
AK056711 mRNA. Translation: BAG51796.1.
AL008639 Genomic DNA. Translation: CAI23580.1.
CH471067 Genomic DNA. Translation: EAW90775.1.
BC131624 mRNA. Translation: AAI31625.1.
AF111706 mRNA. Translation: AAM12422.1. Different initiation.
CCDSiCCDS1254.1.
RefSeqiNP_060012.3. NM_017542.3.
XP_005245427.1. XM_005245370.1.
UniGeneiHs.432752.

Genome annotation databases

EnsembliENST00000367875; ENSP00000356849; ENSG00000143157.
ENST00000367876; ENSP00000356850; ENSG00000143157.
GeneIDi57645.
KEGGihsa:57645.
UCSCiuc001gdt.1. human.

Polymorphism databases

DMDMi46577131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040946 mRNA. Translation: BAA96037.1. Different initiation.
AK056711 mRNA. Translation: BAG51796.1.
AL008639 Genomic DNA. Translation: CAI23580.1.
CH471067 Genomic DNA. Translation: EAW90775.1.
BC131624 mRNA. Translation: AAI31625.1.
AF111706 mRNA. Translation: AAM12422.1. Different initiation.
CCDSiCCDS1254.1.
RefSeqiNP_060012.3. NM_017542.3.
XP_005245427.1. XM_005245370.1.
UniGeneiHs.432752.

3D structure databases

ProteinModelPortaliQ9P215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121682. 9 interactions.
IntActiQ9P215. 3 interactions.
MINTiMINT-8247625.

PTM databases

PhosphoSiteiQ9P215.

Polymorphism databases

DMDMi46577131.

Proteomic databases

MaxQBiQ9P215.
PaxDbiQ9P215.
PRIDEiQ9P215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367875; ENSP00000356849; ENSG00000143157.
ENST00000367876; ENSP00000356850; ENSG00000143157.
GeneIDi57645.
KEGGihsa:57645.
UCSCiuc001gdt.1. human.

Organism-specific databases

CTDi57645.
GeneCardsiGC01P166809.
HGNCiHGNC:18800. POGK.
HPAiHPA007838.
HPA031630.
neXtProtiNX_Q9P215.
PharmGKBiPA38684.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284255.
GeneTreeiENSGT00440000039028.
HOGENOMiHOG000285963.
HOVERGENiHBG049433.
InParanoidiQ9P215.
OMAiWEIESEL.
OrthoDBiEOG73JKWC.
PhylomeDBiQ9P215.
TreeFamiTF332951.

Miscellaneous databases

GenomeRNAii57645.
NextBioi64374.
PROiQ9P215.

Gene expression databases

BgeeiQ9P215.
CleanExiHS_POGK.
ExpressionAtlasiQ9P215. baseline and differential.
GenevestigatoriQ9P215.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR018586. Brinker_DNA-bd.
IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR001909. Krueppel-associated_box.
[Graphical view]
PfamiPF09607. BrkDBD. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Hui R.T., Liu B., Zhao B., Wang X.Y.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-609.
    Tissue: Aorta.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOGK_HUMAN
AccessioniPrimary (citable) accession number: Q9P215
Secondary accession number(s): Q5TIJ1, Q8TE07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: January 7, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.