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Q9P215

- POGK_HUMAN

UniProt

Q9P215 - POGK_HUMAN

Protein

Pogo transposable element with KRAB domain

Gene

POGK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pogo transposable element with KRAB domain
    Gene namesi
    Name:POGK
    Synonyms:KIAA1513
    ORF Names:LST003, SLTP003
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18800. POGK.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38684.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 609609Pogo transposable element with KRAB domainPRO_0000126131Add
    BLAST

    Proteomic databases

    MaxQBiQ9P215.
    PaxDbiQ9P215.
    PRIDEiQ9P215.

    PTM databases

    PhosphoSiteiQ9P215.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P215.
    BgeeiQ9P215.
    CleanExiHS_POGK.
    GenevestigatoriQ9P215.

    Organism-specific databases

    HPAiHPA007838.
    HPA031630.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP90AB1P082382EBI-2555775,EBI-352572

    Protein-protein interaction databases

    BioGridi121682. 6 interactions.
    IntActiQ9P215. 3 interactions.
    MINTiMINT-8247625.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P215.
    SMRiQ9P215. Positions 41-95, 193-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 11872KRABPROSITE-ProRule annotationAdd
    BLAST
    Domaini250 – 32374HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini353 – 567215DDEAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili8 – 2821Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 207Poly-Glu

    Sequence similaritiesi

    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG284255.
    HOGENOMiHOG000285963.
    HOVERGENiHBG049433.
    InParanoidiQ9P215.
    OMAiWEIESEL.
    OrthoDBiEOG73JKWC.
    PhylomeDBiQ9P215.
    TreeFamiTF332951.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR018586. Brinker_DNA-bd.
    IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR001909. Krueppel-associated_box.
    [Graphical view]
    PfamiPF09607. BrkDBD. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    PF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    SM00349. KRAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    SSF46689. SSF46689. 1 hit.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    PS50805. KRAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P215-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD    50
    EVAIYFSDEE WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE 100
    GEEESQNSDE WQLQGGTSAE NEESDVKPPD WPNPMNATSQ FPQPQHFDSF 150
    GLRLPRDITE LPEWSEGYPF YMAMGFPGYD LSADDIAGKF QFSRGMRRSY 200
    DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ LQNAHAMRRA 250
    FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE 300
    KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR 350
    RAHDYEVAQM GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA 400
    MLGVLADGRK LPPYIILRGT YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL 450
    EVVWRRRTGA VPKQRGMLIL NGFRGHATDS VKNSMESMNT DMVIIPGGLT 500
    SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK KPPLGLFLEW 550
    VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC 600
    DTESMAESN 609
    Length:609
    Mass (Da):69,444
    Last modified:April 26, 2004 - v2
    Checksum:iAF25653D30FFC804
    GO

    Sequence cautioni

    The sequence AAM12422.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA96037.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040946 mRNA. Translation: BAA96037.1. Different initiation.
    AK056711 mRNA. Translation: BAG51796.1.
    AL008639 Genomic DNA. Translation: CAI23580.1.
    CH471067 Genomic DNA. Translation: EAW90775.1.
    BC131624 mRNA. Translation: AAI31625.1.
    AF111706 mRNA. Translation: AAM12422.1. Different initiation.
    CCDSiCCDS1254.1.
    RefSeqiNP_060012.3. NM_017542.3.
    XP_005245427.1. XM_005245370.1.
    UniGeneiHs.432752.

    Genome annotation databases

    EnsembliENST00000367875; ENSP00000356849; ENSG00000143157.
    ENST00000367876; ENSP00000356850; ENSG00000143157.
    GeneIDi57645.
    KEGGihsa:57645.
    UCSCiuc001gdt.1. human.

    Polymorphism databases

    DMDMi46577131.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040946 mRNA. Translation: BAA96037.1 . Different initiation.
    AK056711 mRNA. Translation: BAG51796.1 .
    AL008639 Genomic DNA. Translation: CAI23580.1 .
    CH471067 Genomic DNA. Translation: EAW90775.1 .
    BC131624 mRNA. Translation: AAI31625.1 .
    AF111706 mRNA. Translation: AAM12422.1 . Different initiation.
    CCDSi CCDS1254.1.
    RefSeqi NP_060012.3. NM_017542.3.
    XP_005245427.1. XM_005245370.1.
    UniGenei Hs.432752.

    3D structure databases

    ProteinModelPortali Q9P215.
    SMRi Q9P215. Positions 41-95, 193-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121682. 6 interactions.
    IntActi Q9P215. 3 interactions.
    MINTi MINT-8247625.

    PTM databases

    PhosphoSitei Q9P215.

    Polymorphism databases

    DMDMi 46577131.

    Proteomic databases

    MaxQBi Q9P215.
    PaxDbi Q9P215.
    PRIDEi Q9P215.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367875 ; ENSP00000356849 ; ENSG00000143157 .
    ENST00000367876 ; ENSP00000356850 ; ENSG00000143157 .
    GeneIDi 57645.
    KEGGi hsa:57645.
    UCSCi uc001gdt.1. human.

    Organism-specific databases

    CTDi 57645.
    GeneCardsi GC01P166809.
    HGNCi HGNC:18800. POGK.
    HPAi HPA007838.
    HPA031630.
    neXtProti NX_Q9P215.
    PharmGKBi PA38684.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284255.
    HOGENOMi HOG000285963.
    HOVERGENi HBG049433.
    InParanoidi Q9P215.
    OMAi WEIESEL.
    OrthoDBi EOG73JKWC.
    PhylomeDBi Q9P215.
    TreeFami TF332951.

    Miscellaneous databases

    GenomeRNAii 57645.
    NextBioi 64374.
    PROi Q9P215.

    Gene expression databases

    ArrayExpressi Q9P215.
    Bgeei Q9P215.
    CleanExi HS_POGK.
    Genevestigatori Q9P215.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR018586. Brinker_DNA-bd.
    IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR001909. Krueppel-associated_box.
    [Graphical view ]
    Pfami PF09607. BrkDBD. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    SM00349. KRAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    SSF46689. SSF46689. 1 hit.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    PS50805. KRAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Hui R.T., Liu B., Zhao B., Wang X.Y.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-609.
      Tissue: Aorta.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPOGK_HUMAN
    AccessioniPrimary (citable) accession number: Q9P215
    Secondary accession number(s): Q5TIJ1, Q8TE07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3