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Q9P215

- POGK_HUMAN

UniProt

Q9P215 - POGK_HUMAN

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Protein

Pogo transposable element with KRAB domain

Gene

POGK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with KRAB domain
Gene namesi
Name:POGK
Synonyms:KIAA1513
ORF Names:LST003, SLTP003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18800. POGK.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Pogo transposable element with KRAB domainPRO_0000126131Add
BLAST

Proteomic databases

MaxQBiQ9P215.
PaxDbiQ9P215.
PRIDEiQ9P215.

PTM databases

PhosphoSiteiQ9P215.

Expressioni

Gene expression databases

BgeeiQ9P215.
CleanExiHS_POGK.
ExpressionAtlasiQ9P215. baseline and differential.
GenevestigatoriQ9P215.

Organism-specific databases

HPAiHPA007838.
HPA031630.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-2555775,EBI-352572

Protein-protein interaction databases

BioGridi121682. 9 interactions.
IntActiQ9P215. 3 interactions.
MINTiMINT-8247625.

Structurei

3D structure databases

ProteinModelPortaliQ9P215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 11872KRABPROSITE-ProRule annotationAdd
BLAST
Domaini250 – 32374HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini353 – 567215DDEAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 2821Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 207Poly-Glu

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG284255.
GeneTreeiENSGT00440000039028.
HOGENOMiHOG000285963.
HOVERGENiHBG049433.
InParanoidiQ9P215.
OMAiWEIESEL.
OrthoDBiEOG73JKWC.
PhylomeDBiQ9P215.
TreeFamiTF332951.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR018586. Brinker_DNA-bd.
IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR001909. Krueppel-associated_box.
[Graphical view]
PfamiPF09607. BrkDBD. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50805. KRAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P215-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD
60 70 80 90 100
EVAIYFSDEE WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE
110 120 130 140 150
GEEESQNSDE WQLQGGTSAE NEESDVKPPD WPNPMNATSQ FPQPQHFDSF
160 170 180 190 200
GLRLPRDITE LPEWSEGYPF YMAMGFPGYD LSADDIAGKF QFSRGMRRSY
210 220 230 240 250
DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ LQNAHAMRRA
260 270 280 290 300
FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE
310 320 330 340 350
KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR
360 370 380 390 400
RAHDYEVAQM GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA
410 420 430 440 450
MLGVLADGRK LPPYIILRGT YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL
460 470 480 490 500
EVVWRRRTGA VPKQRGMLIL NGFRGHATDS VKNSMESMNT DMVIIPGGLT
510 520 530 540 550
SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK KPPLGLFLEW
560 570 580 590 600
VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC

DTESMAESN
Length:609
Mass (Da):69,444
Last modified:April 26, 2004 - v2
Checksum:iAF25653D30FFC804
GO

Sequence cautioni

The sequence AAM12422.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA96037.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040946 mRNA. Translation: BAA96037.1. Different initiation.
AK056711 mRNA. Translation: BAG51796.1.
AL008639 Genomic DNA. Translation: CAI23580.1.
CH471067 Genomic DNA. Translation: EAW90775.1.
BC131624 mRNA. Translation: AAI31625.1.
AF111706 mRNA. Translation: AAM12422.1. Different initiation.
CCDSiCCDS1254.1.
RefSeqiNP_060012.3. NM_017542.3.
XP_005245427.1. XM_005245370.1.
UniGeneiHs.432752.

Genome annotation databases

EnsembliENST00000367875; ENSP00000356849; ENSG00000143157.
ENST00000367876; ENSP00000356850; ENSG00000143157.
GeneIDi57645.
KEGGihsa:57645.
UCSCiuc001gdt.1. human.

Polymorphism databases

DMDMi46577131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040946 mRNA. Translation: BAA96037.1 . Different initiation.
AK056711 mRNA. Translation: BAG51796.1 .
AL008639 Genomic DNA. Translation: CAI23580.1 .
CH471067 Genomic DNA. Translation: EAW90775.1 .
BC131624 mRNA. Translation: AAI31625.1 .
AF111706 mRNA. Translation: AAM12422.1 . Different initiation.
CCDSi CCDS1254.1.
RefSeqi NP_060012.3. NM_017542.3.
XP_005245427.1. XM_005245370.1.
UniGenei Hs.432752.

3D structure databases

ProteinModelPortali Q9P215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121682. 9 interactions.
IntActi Q9P215. 3 interactions.
MINTi MINT-8247625.

PTM databases

PhosphoSitei Q9P215.

Polymorphism databases

DMDMi 46577131.

Proteomic databases

MaxQBi Q9P215.
PaxDbi Q9P215.
PRIDEi Q9P215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367875 ; ENSP00000356849 ; ENSG00000143157 .
ENST00000367876 ; ENSP00000356850 ; ENSG00000143157 .
GeneIDi 57645.
KEGGi hsa:57645.
UCSCi uc001gdt.1. human.

Organism-specific databases

CTDi 57645.
GeneCardsi GC01P166809.
HGNCi HGNC:18800. POGK.
HPAi HPA007838.
HPA031630.
neXtProti NX_Q9P215.
PharmGKBi PA38684.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284255.
GeneTreei ENSGT00440000039028.
HOGENOMi HOG000285963.
HOVERGENi HBG049433.
InParanoidi Q9P215.
OMAi WEIESEL.
OrthoDBi EOG73JKWC.
PhylomeDBi Q9P215.
TreeFami TF332951.

Miscellaneous databases

GenomeRNAii 57645.
NextBioi 64374.
PROi Q9P215.

Gene expression databases

Bgeei Q9P215.
CleanExi HS_POGK.
ExpressionAtlasi Q9P215. baseline and differential.
Genevestigatori Q9P215.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR018586. Brinker_DNA-bd.
IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR001909. Krueppel-associated_box.
[Graphical view ]
Pfami PF09607. BrkDBD. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
SM00349. KRAB. 1 hit.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
SSF46689. SSF46689. 1 hit.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS50805. KRAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Hui R.T., Liu B., Zhao B., Wang X.Y.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-609.
    Tissue: Aorta.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOGK_HUMAN
AccessioniPrimary (citable) accession number: Q9P215
Secondary accession number(s): Q5TIJ1, Q8TE07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3