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Q9P215

- POGK_HUMAN

UniProt

Q9P215 - POGK_HUMAN

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Protein

Pogo transposable element with KRAB domain

Gene
POGK, KIAA1513, LST003, SLTP003
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: IntAct

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with KRAB domain
Gene namesi
Name:POGK
Synonyms:KIAA1513
ORF Names:LST003, SLTP003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18800. POGK.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Pogo transposable element with KRAB domainPRO_0000126131Add
BLAST

Proteomic databases

MaxQBiQ9P215.
PaxDbiQ9P215.
PRIDEiQ9P215.

PTM databases

PhosphoSiteiQ9P215.

Expressioni

Gene expression databases

ArrayExpressiQ9P215.
BgeeiQ9P215.
CleanExiHS_POGK.
GenevestigatoriQ9P215.

Organism-specific databases

HPAiHPA007838.
HPA031630.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-2555775,EBI-352572

Protein-protein interaction databases

BioGridi121682. 6 interactions.
IntActiQ9P215. 3 interactions.
MINTiMINT-8247625.

Structurei

3D structure databases

ProteinModelPortaliQ9P215.
SMRiQ9P215. Positions 41-95, 193-318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 11872KRABAdd
BLAST
Domaini250 – 32374HTH CENPB-typeAdd
BLAST
Domaini353 – 567215DDEAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 2821 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 207Poly-Glu

Sequence similaritiesi

Contains 1 DDE domain.
Contains 1 KRAB domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG284255.
HOGENOMiHOG000285963.
HOVERGENiHBG049433.
InParanoidiQ9P215.
OMAiWEIESEL.
OrthoDBiEOG73JKWC.
PhylomeDBiQ9P215.
TreeFamiTF332951.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR018586. Brinker_DNA-bd.
IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR001909. Krueppel-associated_box.
[Graphical view]
PfamiPF09607. BrkDBD. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50805. KRAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P215-1 [UniParc]FASTAAdd to Basket

« Hide

MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD    50
EVAIYFSDEE WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE 100
GEEESQNSDE WQLQGGTSAE NEESDVKPPD WPNPMNATSQ FPQPQHFDSF 150
GLRLPRDITE LPEWSEGYPF YMAMGFPGYD LSADDIAGKF QFSRGMRRSY 200
DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ LQNAHAMRRA 250
FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE 300
KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR 350
RAHDYEVAQM GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA 400
MLGVLADGRK LPPYIILRGT YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL 450
EVVWRRRTGA VPKQRGMLIL NGFRGHATDS VKNSMESMNT DMVIIPGGLT 500
SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK KPPLGLFLEW 550
VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC 600
DTESMAESN 609
Length:609
Mass (Da):69,444
Last modified:April 26, 2004 - v2
Checksum:iAF25653D30FFC804
GO

Sequence cautioni

The sequence AAM12422.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA96037.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040946 mRNA. Translation: BAA96037.1. Different initiation.
AK056711 mRNA. Translation: BAG51796.1.
AL008639 Genomic DNA. Translation: CAI23580.1.
CH471067 Genomic DNA. Translation: EAW90775.1.
BC131624 mRNA. Translation: AAI31625.1.
AF111706 mRNA. Translation: AAM12422.1. Different initiation.
CCDSiCCDS1254.1.
RefSeqiNP_060012.3. NM_017542.3.
XP_005245427.1. XM_005245370.1.
UniGeneiHs.432752.

Genome annotation databases

EnsembliENST00000367875; ENSP00000356849; ENSG00000143157.
ENST00000367876; ENSP00000356850; ENSG00000143157.
GeneIDi57645.
KEGGihsa:57645.
UCSCiuc001gdt.1. human.

Polymorphism databases

DMDMi46577131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040946 mRNA. Translation: BAA96037.1 . Different initiation.
AK056711 mRNA. Translation: BAG51796.1 .
AL008639 Genomic DNA. Translation: CAI23580.1 .
CH471067 Genomic DNA. Translation: EAW90775.1 .
BC131624 mRNA. Translation: AAI31625.1 .
AF111706 mRNA. Translation: AAM12422.1 . Different initiation.
CCDSi CCDS1254.1.
RefSeqi NP_060012.3. NM_017542.3.
XP_005245427.1. XM_005245370.1.
UniGenei Hs.432752.

3D structure databases

ProteinModelPortali Q9P215.
SMRi Q9P215. Positions 41-95, 193-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121682. 6 interactions.
IntActi Q9P215. 3 interactions.
MINTi MINT-8247625.

PTM databases

PhosphoSitei Q9P215.

Polymorphism databases

DMDMi 46577131.

Proteomic databases

MaxQBi Q9P215.
PaxDbi Q9P215.
PRIDEi Q9P215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367875 ; ENSP00000356849 ; ENSG00000143157 .
ENST00000367876 ; ENSP00000356850 ; ENSG00000143157 .
GeneIDi 57645.
KEGGi hsa:57645.
UCSCi uc001gdt.1. human.

Organism-specific databases

CTDi 57645.
GeneCardsi GC01P166809.
HGNCi HGNC:18800. POGK.
HPAi HPA007838.
HPA031630.
neXtProti NX_Q9P215.
PharmGKBi PA38684.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284255.
HOGENOMi HOG000285963.
HOVERGENi HBG049433.
InParanoidi Q9P215.
OMAi WEIESEL.
OrthoDBi EOG73JKWC.
PhylomeDBi Q9P215.
TreeFami TF332951.

Miscellaneous databases

GenomeRNAii 57645.
NextBioi 64374.
PROi Q9P215.

Gene expression databases

ArrayExpressi Q9P215.
Bgeei Q9P215.
CleanExi HS_POGK.
Genevestigatori Q9P215.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR018586. Brinker_DNA-bd.
IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR001909. Krueppel-associated_box.
[Graphical view ]
Pfami PF09607. BrkDBD. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
SM00349. KRAB. 1 hit.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
SSF46689. SSF46689. 1 hit.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS50805. KRAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Hui R.T., Liu B., Zhao B., Wang X.Y.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-609.
    Tissue: Aorta.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOGK_HUMAN
AccessioniPrimary (citable) accession number: Q9P215
Secondary accession number(s): Q5TIJ1, Q8TE07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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