Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized protein KIAA1522

Gene

KIAA1522

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162522-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1522
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29301. KIAA1522.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162522.
PharmGKBiPA142671612.

Polymorphism and mutation databases

BioMutaiKIAA1522.
DMDMi160395559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112461 – 1035Uncharacterized protein KIAA1522Add BLAST1035
Isoform 3 (identifier: Q9P206-3)
Initiator methionineiRemoved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei162PhosphothreonineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei320Asymmetric dimethylarginineBy similarity1
Modified residuei322PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei330PhosphoserineBy similarity1
Modified residuei338PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei404PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Modified residuei531PhosphothreonineBy similarity1
Modified residuei545PhosphoserineCombined sources1
Modified residuei593PhosphothreonineCombined sources1
Modified residuei612PhosphoserineBy similarity1
Modified residuei669PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei858PhosphoserineCombined sources1
Modified residuei862PhosphoserineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei959PhosphoserineCombined sources1
Modified residuei971PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Isoform 3 (identifier: Q9P206-3)
Lipidationi2N-myristoyl glycine1

Keywords - PTMi

Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9P206.
MaxQBiQ9P206.
PaxDbiQ9P206.
PeptideAtlasiQ9P206.
PRIDEiQ9P206.

PTM databases

iPTMnetiQ9P206.
PhosphoSitePlusiQ9P206.

Expressioni

Gene expression databases

BgeeiENSG00000162522.
CleanExiHS_KIAA1522.
GenevisibleiQ9P206. HS.

Organism-specific databases

HPAiHPA032050.
HPA032051.
HPA064839.

Interactioni

Protein-protein interaction databases

BioGridi121685. 20 interactors.
IntActiQ9P206. 16 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9P206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 160Poly-Arg7
Compositional biasi319 – 431Ser-richAdd BLAST113
Compositional biasi438 – 997Pro-richAdd BLAST560

Phylogenomic databases

eggNOGiENOG410IMX5. Eukaryota.
ENOG410YI5V. LUCA.
GeneTreeiENSGT00440000038119.
HOGENOMiHOG000074189.
HOVERGENiHBG108037.
InParanoidiQ9P206.
OMAiAVLQCHI.
OrthoDBiEOG091G00L6.
PhylomeDBiQ9P206.
TreeFamiTF333323.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P206-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVFVGRRLP ALLGLFKKKG SAKAENDKHL SVGPGQGPGS AVDEHQDNVF
60 70 80 90 100
FPSGRPPHLE ELHTQAQEGL RSLQHQEKQK LNKGGWDHGD TQSIQSSRTG
110 120 130 140 150
PDEDNISFCS QTTSYVAESS TAEDALSIRS EMIQRKGSTF RPHDSFPKSG
160 170 180 190 200
KSGRRRRERR STVLGLPQHV QKELGLRNER EAPGTPRAPG ARDAVRIPTV
210 220 230 240 250
DGRPRGTSGM GARVSLQALE AEAEAGAETE AMLQRHIDRV YRDDTFVGRS
260 270 280 290 300
TGTRAPPLTR PMSLAVPGLT GGAGPAEPLS PAMSISPQAT YLSKLIPHAV
310 320 330 340 350
LPPTVDVVAL GRCSLRTLSR CSLHSASPAS VRSLGRFSSV SSPQPRSRHP
360 370 380 390 400
SSSSDTWSHS QSSDTIVSDG STLSSKGGSE GQPESSTASN SVVPPPQGGS
410 420 430 440 450
GRGSPSGGST AEASDTLSIR SSGQLSGRSV SLRKLKRPPP PPRRTHSLHQ
460 470 480 490 500
RGLAVPDGPL GLPPKPERKQ QPQLPRPPTT GGSEGAGAAP CPPNPANSWV
510 520 530 540 550
PGLSPGGSRR PPRSPERTLS PSSGYSSQSG TPTLPPKGLA GPPASPGKAQ
560 570 580 590 600
PPKPERVTSL RSPGASVSSS LTSLCSSSSD PAPSDRSGPQ ILTPLGDRFV
610 620 630 640 650
IPPHPKVPAP FSPPPSKPRS PNPAAPALAA PAVVPGPVST TDASPQSPPT
660 670 680 690 700
PQTTLTPLQE SPVISKDQSP PPSPPPSYHP PPPPTKKPEV VVEAPSASET
710 720 730 740 750
AEEPLQDPNW PPPPPPAPEE QDLSMADFPP PEEAFFSVAS PEPAGPSGSP
760 770 780 790 800
ELVSSPAASS SSATALQIQP PGSPDPPPAP PAPAPASSAP GHVAKLPQKE
810 820 830 840 850
PVGCSKGGGP PREDVGAPLV TPSLLQMVRL RSVGAPGGAP TPALGPSAPQ
860 870 880 890 900
KPLRRALSGR ASPVPAPSSG LHAAVRLKAC SLAASEGLSS AQPNGPPEAE
910 920 930 940 950
PRPPQSPAST ASFIFSKGSR KLQLERPVSP ETQADLQRNL VAELRSISEQ
960 970 980 990 1000
RPPQAPKKSP KAPPPVARKP SVGVPPPASP SYPRAEPLTA PPTNGLPHTQ
1010 1020 1030
DRTKRELAEN GGVLQLVGPE EKMGLPGSDS QKELA
Length:1,035
Mass (Da):107,095
Last modified:November 13, 2007 - v2
Checksum:iCE674245F15108CE
GO
Isoform 2 (identifier: Q9P206-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MVVFVGRRLPALLGLFKKK → MAARAPPAAP...KAKRAKGKGR

Show »
Length:1,094
Mass (Da):113,062
Checksum:i214DF1694FAB0174
GO
Isoform 3 (identifier: Q9P206-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MVVFVGRRLPALLGLFKKK → MGNSHHKRKAPSGPRVRSFWRFGRSAKRPA

Show »
Length:1,046
Mass (Da):108,385
Checksum:iA7DE212FF521F3A9
GO
Isoform 4 (identifier: Q9P206-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-1028: Missing.

Show »
Length:143
Mass (Da):15,682
Checksum:i243512E893E0151D
GO

Sequence cautioni

The sequence BAA96046 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03719057P → S.Corresponds to variant rs11803515dbSNPEnsembl.1
Natural variantiVAR_037191114S → P.Corresponds to variant rs3737994dbSNPEnsembl.1
Natural variantiVAR_037192232M → V.Corresponds to variant rs12730560dbSNPEnsembl.1
Natural variantiVAR_037193310L → I.Corresponds to variant rs11582639dbSNPEnsembl.1
Natural variantiVAR_037194770P → L.Corresponds to variant rs581875dbSNPEnsembl.1
Natural variantiVAR_0371951021E → K.Corresponds to variant rs675928dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402171 – 19MVVFV…LFKKK → MAARAPPAAPAAEEPGNPGG PPRRKKSRSGASGLRRAFSW LRGKRRKKKAAGAEGAEPAA PRAKKAEDKAKRAKGKGR in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0416341 – 19MVVFV…LFKKK → MGNSHHKRKAPSGPRVRSFW RFGRSAKRPA in isoform 3. CuratedAdd BLAST19
Alternative sequenceiVSP_043215137 – 1028Missing in isoform 4. 1 PublicationAdd BLAST892

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040955 mRNA. Translation: BAA96046.1. Different initiation.
AK298965 mRNA. Translation: BAG61060.1.
AC114489 Genomic DNA. No translation available.
AI587184 mRNA. No translation available.
AL713671 mRNA. Translation: CAD28477.2.
CCDSiCCDS41298.1. [Q9P206-2]
CCDS55588.1. [Q9P206-1]
CCDS55589.1. [Q9P206-4]
RefSeqiNP_001185901.1. NM_001198972.1. [Q9P206-1]
NP_001185902.1. NM_001198973.1. [Q9P206-4]
NP_065939.2. NM_020888.2. [Q9P206-2]
XP_006710854.1. XM_006710791.3. [Q9P206-3]
UniGeneiHs.591502.

Genome annotation databases

EnsembliENST00000294521; ENSP00000294521; ENSG00000162522. [Q9P206-4]
ENST00000373480; ENSP00000362579; ENSG00000162522. [Q9P206-1]
ENST00000373481; ENSP00000362580; ENSG00000162522. [Q9P206-3]
ENST00000401073; ENSP00000383851; ENSG00000162522. [Q9P206-2]
GeneIDi57648.
KEGGihsa:57648.
UCSCiuc001bvu.2. human. [Q9P206-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040955 mRNA. Translation: BAA96046.1. Different initiation.
AK298965 mRNA. Translation: BAG61060.1.
AC114489 Genomic DNA. No translation available.
AI587184 mRNA. No translation available.
AL713671 mRNA. Translation: CAD28477.2.
CCDSiCCDS41298.1. [Q9P206-2]
CCDS55588.1. [Q9P206-1]
CCDS55589.1. [Q9P206-4]
RefSeqiNP_001185901.1. NM_001198972.1. [Q9P206-1]
NP_001185902.1. NM_001198973.1. [Q9P206-4]
NP_065939.2. NM_020888.2. [Q9P206-2]
XP_006710854.1. XM_006710791.3. [Q9P206-3]
UniGeneiHs.591502.

3D structure databases

ProteinModelPortaliQ9P206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121685. 20 interactors.
IntActiQ9P206. 16 interactors.

PTM databases

iPTMnetiQ9P206.
PhosphoSitePlusiQ9P206.

Polymorphism and mutation databases

BioMutaiKIAA1522.
DMDMi160395559.

Proteomic databases

EPDiQ9P206.
MaxQBiQ9P206.
PaxDbiQ9P206.
PeptideAtlasiQ9P206.
PRIDEiQ9P206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294521; ENSP00000294521; ENSG00000162522. [Q9P206-4]
ENST00000373480; ENSP00000362579; ENSG00000162522. [Q9P206-1]
ENST00000373481; ENSP00000362580; ENSG00000162522. [Q9P206-3]
ENST00000401073; ENSP00000383851; ENSG00000162522. [Q9P206-2]
GeneIDi57648.
KEGGihsa:57648.
UCSCiuc001bvu.2. human. [Q9P206-1]

Organism-specific databases

CTDi57648.
GeneCardsiKIAA1522.
HGNCiHGNC:29301. KIAA1522.
HPAiHPA032050.
HPA032051.
HPA064839.
neXtProtiNX_Q9P206.
OpenTargetsiENSG00000162522.
PharmGKBiPA142671612.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMX5. Eukaryota.
ENOG410YI5V. LUCA.
GeneTreeiENSGT00440000038119.
HOGENOMiHOG000074189.
HOVERGENiHBG108037.
InParanoidiQ9P206.
OMAiAVLQCHI.
OrthoDBiEOG091G00L6.
PhylomeDBiQ9P206.
TreeFamiTF333323.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162522-MONOMER.

Miscellaneous databases

ChiTaRSiKIAA1522. human.
GenomeRNAii57648.
PROiQ9P206.

Gene expression databases

BgeeiENSG00000162522.
CleanExiHS_KIAA1522.
GenevisibleiQ9P206. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiK1522_HUMAN
AccessioniPrimary (citable) accession number: Q9P206
Secondary accession number(s): B4DQU8
, B5MDY0, C9JH84, Q8TCQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.