Q9P203 (BTBD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BTB/POZ domain-containing protein 7

Gene names

Name:	BTBD7
Synonyms:	KIAA1525

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1132 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 2 BTB (POZ) domains.
Sequence caution	The sequence BAA96049.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB13946.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB13946.1 differs from that shown. Reason: Probable cloning artifact. The sequence CAH10736.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P203-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q9P203-3)

The sequence of this isoform differs from the canonical sequence as follows:
     388-410: GCEDIIAESISLDTLIAILKWSS → EETTVIRPACAAELSNSCLLPQS
     411-1132: Missing.

Isoform 5 (identifier: Q9P203-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.
     352-387: SEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQ → MAGGAGAGADGGAGGGGGGGDGSGPSGSSSGGRSLR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1132	1132	BTB/POZ domain-containing protein 7		PRO_0000186215
Regions
	Domain	142 – 211	70	BTB 1
	Domain	247 – 341	95	BTB 2
	Compositional bias	756 – 825	70	Pro-rich
	Compositional bias	849 – 856	8	Poly-Ala
Amino acid modifications
	Modified residue	1119	1	Phosphoserine By similarity
	Lipidation	2	1	N-myristoyl glycine Ref.7
Natural variations
	Alternative sequence	1 – 351	351	Missing in isoform 5.		VSP_041481
	Alternative sequence	352 – 387	36	SEVQA…NMLAQ → MAGGAGAGADGGAGGGGGGG DGSGPSGSSSGGRSLR in isoform 5.		VSP_041482
	Alternative sequence	388 – 410	23	GCEDI…LKWSS → EETTVIRPACAAELSNSCLL PQS in isoform 3.		VSP_041483
	Alternative sequence	411 – 1132	722	Missing in isoform 3.		VSP_041487
Experimental info
	Sequence conflict	313	1	I → V in BAB13946. Ref.2
	Sequence conflict	408	1	W → R in BAB13946. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 7, 2005. Version 3. Checksum: 5C8AA7A8834AD588	FASTA	1,132	126,368
	10 20 30 40 50 60 MGANASNYPH SCSPRVGGNS QAQQTFIGTS SYSQQGYGCE SKLYSLDHGH EKPQDKKKRT 70 80 90 100 110 120 SGLATLKKKF IKRRKSNRSA DHAKQMRELL SGWDVRDVNA LVEEYEGTSA LKELSLQASL 130 140 150 160 170 180 ARPEARTLQK DMADLYEYKY CTDVDLIFQE TCFPVHRAIL AARCPFFKTL LSSSPEYGAE 190 200 210 220 230 240 IIMDINTAGI DMPMFSALLH YLYTGEFGME DSRFQNVDIL VQLSEEFGTP NSLDVDMRGL 250 260 270 280 290 300 FDYMCYYDVV LSFSSDSELV EAFGGNQNCL DEELKAHKAV ISARSPFFRN LLQRRIRTGE 310 320 330 340 350 360 EITDRTLRTP TRIILDESII PKKYATVILH CMYTDVVDLS VLHCSPSVGS LSEVQALVAG 370 380 390 400 410 420 KPNMTRAEEA MELYHIALFL EFNMLAQGCE DIIAESISLD TLIAILKWSS HPYGSKWVHR 430 440 450 460 470 480 QALHFLCEEF SQVMTSDVFY ELSKDHLLTA IQSDYLQASE QDILKYLIKW GEHQLMKRIA 490 500 510 520 530 540 DREPNLLSGT AHSVNKRGVK RRDLDMEELR EILSSLLPFV RIEHILPINS EVLSDAMKRG 550 560 570 580 590 600 LISTPPSDML PTTEGGKSNA WLRQKNAGIY VRPRLFSPYV EEAKSVLDEM MVEQTDLVRL 610 620 630 640 650 660 RMVRMSNVPD TLYMVNNAVP QCCHMISHQQ ISSNQSSPPS VVANEIPVPR LLIMKDMVRR 670 680 690 700 710 720 LQELRHTEQV QRAYALNCGE GATVSYEIQI RVLREFGLAD AAAELLQNPH KFFPDERFGD 730 740 750 760 770 780 ESPLLTMRQP GRCRVNSTPP AETMFTDLDS FVAFHPPLPP PPPPYHPPAT PIHNQLKAGW 790 800 810 820 830 840 KQRPPSQHPS RSFSYPCNHS LFHSRTAPKA GPPPVYLPSV KAAPPDCTST AGLGRQTVAA 850 860 870 880 890 900 AAATTTSTAT AAAAAASEKQ VRTQPVLNDL MPDIAVGVST LSLKDRRLPE LAVDTELSQS 910 920 930 940 950 960 VSEAGPGPPQ HLSCIPQRHT HTSRKKHTLE QKTDTRENPQ EYPDFYDFSN AACRPSTPAL 970 980 990 1000 1010 1020 SRRTPSPSQG GYFGPDLYSH NKASPSGLKS AYLPGQTSPK KQEEARREYP LSPDGHLHRQ 1030 1040 1050 1060 1070 1080 KNEPIHLDVV EQPPQRSDFP LAAPENASTG PAHVRGRTAV ETDLTFGLTP NRPSLSACSS 1090 1100 1110 1120 1130 EAPEERSGRR LADSESLGHG AQRNTDLERE DSISRGRRSP SKPDFLYKKS AL
	Isoform 3 [UniParc]. Checksum: AF393D8C00740623	FASTA	410	46,043
	10 20 30 40 50 60 MGANASNYPH SCSPRVGGNS QAQQTFIGTS SYSQQGYGCE SKLYSLDHGH EKPQDKKKRT 70 80 90 100 110 120 SGLATLKKKF IKRRKSNRSA DHAKQMRELL SGWDVRDVNA LVEEYEGTSA LKELSLQASL 130 140 150 160 170 180 ARPEARTLQK DMADLYEYKY CTDVDLIFQE TCFPVHRAIL AARCPFFKTL LSSSPEYGAE 190 200 210 220 230 240 IIMDINTAGI DMPMFSALLH YLYTGEFGME DSRFQNVDIL VQLSEEFGTP NSLDVDMRGL 250 260 270 280 290 300 FDYMCYYDVV LSFSSDSELV EAFGGNQNCL DEELKAHKAV ISARSPFFRN LLQRRIRTGE 310 320 330 340 350 360 EITDRTLRTP TRIILDESII PKKYATVILH CMYTDVVDLS VLHCSPSVGS LSEVQALVAG 370 380 390 400 410 KPNMTRAEEA MELYHIALFL EFNMLAQEET TVIRPACAAE LSNSCLLPQS
	Isoform 5 [UniParc]. Checksum: E876A2E8B17EEEA2	FASTA	781	85,546
	10 20 30 40 50 60 MAGGAGAGAD GGAGGGGGGG DGSGPSGSSS GGRSLRGCED IIAESISLDT LIAILKWSSH 70 80 90 100 110 120 PYGSKWVHRQ ALHFLCEEFS QVMTSDVFYE LSKDHLLTAI QSDYLQASEQ DILKYLIKWG 130 140 150 160 170 180 EHQLMKRIAD REPNLLSGTA HSVNKRGVKR RDLDMEELRE ILSSLLPFVR IEHILPINSE 190 200 210 220 230 240 VLSDAMKRGL ISTPPSDMLP TTEGGKSNAW LRQKNAGIYV RPRLFSPYVE EAKSVLDEMM 250 260 270 280 290 300 VEQTDLVRLR MVRMSNVPDT LYMVNNAVPQ CCHMISHQQI SSNQSSPPSV VANEIPVPRL 310 320 330 340 350 360 LIMKDMVRRL QELRHTEQVQ RAYALNCGEG ATVSYEIQIR VLREFGLADA AAELLQNPHK 370 380 390 400 410 420 FFPDERFGDE SPLLTMRQPG RCRVNSTPPA ETMFTDLDSF VAFHPPLPPP PPPYHPPATP 430 440 450 460 470 480 IHNQLKAGWK QRPPSQHPSR SFSYPCNHSL FHSRTAPKAG PPPVYLPSVK AAPPDCTSTA 490 500 510 520 530 540 GLGRQTVAAA AATTTSTATA AAAAASEKQV RTQPVLNDLM PDIAVGVSTL SLKDRRLPEL 550 560 570 580 590 600 AVDTELSQSV SEAGPGPPQH LSCIPQRHTH TSRKKHTLEQ KTDTRENPQE YPDFYDFSNA 610 620 630 640 650 660 ACRPSTPALS RRTPSPSQGG YFGPDLYSHN KASPSGLKSA YLPGQTSPKK QEEARREYPL 670 680 690 700 710 720 SPDGHLHRQK NEPIHLDVVE QPPQRSDFPL AAPENASTGP AHVRGRTAVE TDLTFGLTPN 730 740 750 760 770 780 RPSLSACSSE APEERSGRRL ADSESLGHGA QRNTDLERED SISRGRRSPS KPDFLYKKSA L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 135-536 (ISOFORM 1). Tissue: Brain.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 457-536 (ISOFORM 1). Tissue: Amygdala.
[6]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-938 (ISOFORM 5). Tissue: Neuroblastoma.
[7]	"Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system." Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T. Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract] Cited for: MYRISTOYLATION AT GLY-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040958 mRNA. Translation: BAA96049.2. Different initiation. AK001510 mRNA. Translation: BAA91730.1. AK021953 mRNA. Translation: BAB13946.1. Sequence problems. AK291422 mRNA. Translation: BAF84111.1. AL122023 Genomic DNA. No translation available. AL132838 Genomic DNA. No translation available. BC047071 mRNA. Translation: AAH47071.1. AL049394 mRNA. Translation: CAH10736.1. Sequence problems. BX248762 mRNA. Translation: CAD66569.1.
IPI	IPI00002061. IPI00018802. IPI00479933.
PIR	JC7757.
RefSeq	NP_001002860.2. NM_001002860.2. NP_060637.1. NM_018167.3.
UniGene	Hs.525549.
3D structure databases
ProteinModelPortal	Q9P203.
SMR	Q9P203. Positions 124-240.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000335615.
PTM databases
PhosphoSite	Q9P203.
Polymorphism databases
DMDM	67460591.
Proteomic databases
PaxDb	Q9P203.
PRIDE	Q9P203.
Protocols and materials databases
DNASU	55727.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298896; ENSP00000298896; ENSG00000011114. ENST00000334746; ENSP00000335615; ENSG00000011114. ENST00000554565; ENSP00000451010; ENSG00000011114.
GeneID	55727.
KEGG	hsa:55727.
UCSC	uc001ybo.3. human. uc001ybp.3. human. uc001ybq.4. human.
Organism-specific databases
CTD	55727.
GeneCards	GC14M093703.
HGNC	HGNC:18269. BTBD7.
HPA	HPA049926.
MIM	610386. gene.
neXtProt	NX_Q9P203.
PharmGKB	PA134938971.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293531.
HOVERGEN	HBG058828.
InParanoid	Q9P203.
KO	K10479.
OMA	NMLAQGC.
Gene expression databases
ArrayExpress	Q9P203.
Bgee	Q9P203.
CleanEx	HS_BTBD7.
Genevestigator	Q9P203.
GermOnline	ENSG00000011114. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 2 hits.
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. [Graphical view]
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 2 hits. [Graphical view]
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 2 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 2 hits.
PROSITE	PS50097. BTB. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BTBD7. human.
GenomeRNAi	55727.
NextBio	60639.
SOURCE	Search...

Entry information

Entry name

BTBD7_HUMAN

Accession

Primary (citable) accession number: Q9P203
Secondary accession number(s): A8K5V7 , Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	April 3, 2013
This is version 87 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.