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Protein

Signal-regulatory protein gamma

Gene

SIRPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.1 Publication

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell-cell signaling Source: ProtInc
  • intracellular signal transduction Source: ProtInc
  • leukocyte migration Source: Reactome
  • negative regulation of cell proliferation Source: ProtInc
  • positive regulation of cell-cell adhesion Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of T cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089012-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-391160. Signal regulatory protein (SIRP) family interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein gamma
Short name:
SIRP-gamma
Alternative name(s):
CD172 antigen-like family member B
Signal-regulatory protein beta-2
Short name:
SIRP-b2
Short name:
SIRP-beta-2
CD_antigen: CD172g
Gene namesi
Name:SIRPG
Synonyms:SIRPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15757. SIRPG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 360ExtracellularSequence analysisAdd BLAST332
Transmembranei361 – 383HelicalSequence analysisAdd BLAST23
Topological domaini384 – 387CytoplasmicSequence analysis4

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55423.
OpenTargetsiENSG00000089012.
PharmGKBiPA38034.

Polymorphism and mutation databases

BioMutaiSIRPG.
DMDMi124053651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001495729 – 387Signal-regulatory protein gammaAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 119PROSITE-ProRule annotation1 Publication
Disulfide bondi168 ↔ 226PROSITE-ProRule annotation
Glycosylationi243N-linked (GlcNAc...)1 Publication1
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi271 ↔ 329PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9P1W8.
MaxQBiQ9P1W8.
PaxDbiQ9P1W8.
PeptideAtlasiQ9P1W8.
PRIDEiQ9P1W8.

PTM databases

iPTMnetiQ9P1W8.
PhosphoSitePlusiQ9P1W8.

Expressioni

Tissue specificityi

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.2 Publications

Gene expression databases

BgeeiENSG00000089012.
CleanExiHS_SIRPG.
GenevisibleiQ9P1W8. HS.

Interactioni

Subunit structurei

Interacts with CD47.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CD47Q087222EBI-1268284,EBI-1268321

Protein-protein interaction databases

BioGridi120664. 3 interactors.
IntActiQ9P1W8. 1 interactor.
STRINGi9606.ENSP00000305529.

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 43Combined sources5
Beta strandi49 – 51Combined sources3
Beta strandi54 – 56Combined sources3
Beta strandi64 – 71Combined sources8
Beta strandi75 – 82Combined sources8
Beta strandi88 – 92Combined sources5
Beta strandi104 – 106Combined sources3
Helixi111 – 113Combined sources3
Beta strandi115 – 123Combined sources9
Beta strandi126 – 128Combined sources3
Beta strandi130 – 134Combined sources5
Beta strandi138 – 142Combined sources5
Beta strandi150 – 152Combined sources3
Beta strandi163 – 176Combined sources14
Beta strandi179 – 184Combined sources6
Beta strandi192 – 197Combined sources6
Beta strandi205 – 214Combined sources10
Beta strandi223 – 229Combined sources7
Turni231 – 235Combined sources5
Beta strandi238 – 243Combined sources6
Helixi244 – 246Combined sources3
Beta strandi253 – 260Combined sources8
Beta strandi262 – 279Combined sources18
Beta strandi281 – 287Combined sources7
Beta strandi297 – 302Combined sources6
Beta strandi308 – 317Combined sources10
Beta strandi326 – 333Combined sources8
Beta strandi339 – 344Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJWX-ray1.70A29-147[»]
4I2XX-ray2.48E/F29-347[»]
ProteinModelPortaliQ9P1W8.
SMRiQ9P1W8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P1W8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 137Ig-like V-typeAdd BLAST109
Domaini146 – 245Ig-like C1-type 1Add BLAST100
Domaini252 – 340Ig-like C1-type 2Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiQ9P1W8.
KOiK06551.
OMAiELISITW.
OrthoDBiEOG091G05RP.
PhylomeDBiQ9P1W8.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT
60 70 80 90 100
LHCTVTSLLP VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM
110 120 130 140 150
DFSIRISSIT PADVGTYYCV KFRKGSPENV EFKSGPGTEM ALGAKPSAPV
160 170 180 190 200
VLGPAARTTP EHTVSFTCES HGFSPRDITL KWFKNGNELS DFQTNVDPTG
210 220 230 240 250
QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG TANLSEAIRV
260 270 280 290 300
PPTLEVTQQP MRVGNQVNVT CQVRKFYPQS LQLTWSENGN VCQRETASTL
310 320 330 340 350
TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH
360 370 380
QKDQSSDATP GPASSLTALL LIAVLLGPIY VPWKQKT
Length:387
Mass (Da):42,498
Last modified:January 23, 2007 - v3
Checksum:i0F5099BE1DE35AC8
GO
Isoform 2 (identifier: Q9P1W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):38,962
Checksum:i41D5122588FE7C42
GO
Isoform 3 (identifier: Q9P1W8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-360: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):18,466
Checksum:i0439DB85CAAB167A
GO
Isoform 4 (identifier: Q9P1W8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-360: Missing.

Show »
Length:276
Mass (Da):29,967
Checksum:iAF76A8692051D6C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049936263V → A.1 PublicationCorresponds to variant rs6043409dbSNPEnsembl.1
Natural variantiVAR_049937286S → L.1 PublicationCorresponds to variant rs6034239dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0070271 – 33Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_007028144 – 360Missing in isoform 3. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_026960250 – 360Missing in isoform 4. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042624 mRNA. Translation: BAA95692.1.
AY748247 mRNA. Translation: AAV88530.1.
AY748248 mRNA. Translation: AAV88531.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28283.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28284.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28285.1.
CH471133 Genomic DNA. Translation: EAX10616.1.
BC020629 mRNA. Translation: AAH20629.2.
BC064532 mRNA. Translation: AAH64532.1.
CCDSiCCDS13020.2. [Q9P1W8-1]
CCDS13021.2. [Q9P1W8-3]
CCDS33434.1. [Q9P1W8-4]
RefSeqiNP_001034597.1. NM_001039508.1. [Q9P1W8-4]
NP_061026.2. NM_018556.3. [Q9P1W8-1]
NP_543006.2. NM_080816.2. [Q9P1W8-3]
XP_011527588.1. XM_011529286.2. [Q9P1W8-2]
UniGeneiHs.590883.

Genome annotation databases

EnsembliENST00000216927; ENSP00000216927; ENSG00000089012. [Q9P1W8-4]
ENST00000303415; ENSP00000305529; ENSG00000089012. [Q9P1W8-1]
ENST00000344103; ENSP00000342759; ENSG00000089012. [Q9P1W8-3]
ENST00000381580; ENSP00000370992; ENSG00000089012. [Q9P1W8-2]
ENST00000381583; ENSP00000370995; ENSG00000089012. [Q9P1W8-4]
GeneIDi55423.
KEGGihsa:55423.
UCSCiuc002wfm.1. human. [Q9P1W8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042624 mRNA. Translation: BAA95692.1.
AY748247 mRNA. Translation: AAV88530.1.
AY748248 mRNA. Translation: AAV88531.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28283.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28284.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28285.1.
CH471133 Genomic DNA. Translation: EAX10616.1.
BC020629 mRNA. Translation: AAH20629.2.
BC064532 mRNA. Translation: AAH64532.1.
CCDSiCCDS13020.2. [Q9P1W8-1]
CCDS13021.2. [Q9P1W8-3]
CCDS33434.1. [Q9P1W8-4]
RefSeqiNP_001034597.1. NM_001039508.1. [Q9P1W8-4]
NP_061026.2. NM_018556.3. [Q9P1W8-1]
NP_543006.2. NM_080816.2. [Q9P1W8-3]
XP_011527588.1. XM_011529286.2. [Q9P1W8-2]
UniGeneiHs.590883.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJWX-ray1.70A29-147[»]
4I2XX-ray2.48E/F29-347[»]
ProteinModelPortaliQ9P1W8.
SMRiQ9P1W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120664. 3 interactors.
IntActiQ9P1W8. 1 interactor.
STRINGi9606.ENSP00000305529.

PTM databases

iPTMnetiQ9P1W8.
PhosphoSitePlusiQ9P1W8.

Polymorphism and mutation databases

BioMutaiSIRPG.
DMDMi124053651.

Proteomic databases

EPDiQ9P1W8.
MaxQBiQ9P1W8.
PaxDbiQ9P1W8.
PeptideAtlasiQ9P1W8.
PRIDEiQ9P1W8.

Protocols and materials databases

DNASUi55423.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216927; ENSP00000216927; ENSG00000089012. [Q9P1W8-4]
ENST00000303415; ENSP00000305529; ENSG00000089012. [Q9P1W8-1]
ENST00000344103; ENSP00000342759; ENSG00000089012. [Q9P1W8-3]
ENST00000381580; ENSP00000370992; ENSG00000089012. [Q9P1W8-2]
ENST00000381583; ENSP00000370995; ENSG00000089012. [Q9P1W8-4]
GeneIDi55423.
KEGGihsa:55423.
UCSCiuc002wfm.1. human. [Q9P1W8-1]

Organism-specific databases

CTDi55423.
DisGeNETi55423.
GeneCardsiSIRPG.
HGNCiHGNC:15757. SIRPG.
MIMi605466. gene.
neXtProtiNX_Q9P1W8.
OpenTargetsiENSG00000089012.
PharmGKBiPA38034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiQ9P1W8.
KOiK06551.
OMAiELISITW.
OrthoDBiEOG091G05RP.
PhylomeDBiQ9P1W8.
TreeFamiTF341862.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089012-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-391160. Signal regulatory protein (SIRP) family interactions.

Miscellaneous databases

EvolutionaryTraceiQ9P1W8.
GeneWikiiSIRPG.
GenomeRNAii55423.
PROiQ9P1W8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089012.
CleanExiHS_SIRPG.
GenevisibleiQ9P1W8. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIRPG_HUMAN
AccessioniPrimary (citable) accession number: Q9P1W8
Secondary accession number(s): B1AKP6
, Q5D051, Q5JV25, Q5MKL4, Q8WWA5, Q9NQK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.