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Q9P1W8

- SIRPG_HUMAN

UniProt

Q9P1W8 - SIRPG_HUMAN

Protein

Signal-regulatory protein gamma

Gene

SIRPG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell adhesion Source: UniProtKB-KW
    3. cell-cell signaling Source: ProtInc
    4. intracellular signal transduction Source: ProtInc
    5. leukocyte migration Source: Reactome
    6. negative regulation of cell proliferation Source: ProtInc
    7. positive regulation of cell-cell adhesion Source: UniProtKB
    8. positive regulation of cell proliferation Source: UniProtKB
    9. positive regulation of T cell activation Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
    REACT_23916. Signal regulatory protein (SIRP) family interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal-regulatory protein gamma
    Short name:
    SIRP-gamma
    Alternative name(s):
    CD172 antigen-like family member B
    Signal-regulatory protein beta-2
    Short name:
    SIRP-b2
    Short name:
    SIRP-beta-2
    CD_antigen: CD172g
    Gene namesi
    Name:SIRPG
    Synonyms:SIRPB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15757. SIRPG.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38034.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 387359Signal-regulatory protein gammaPRO_0000014957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 1191 PublicationPROSITE-ProRule annotation
    Disulfide bondi168 ↔ 226PROSITE-ProRule annotation
    Glycosylationi243 – 2431N-linked (GlcNAc...)1 Publication
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi271 ↔ 329PROSITE-ProRule annotation
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9P1W8.
    PaxDbiQ9P1W8.
    PRIDEiQ9P1W8.

    PTM databases

    PhosphoSiteiQ9P1W8.

    Expressioni

    Tissue specificityi

    Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.2 Publications

    Gene expression databases

    BgeeiQ9P1W8.
    CleanExiHS_SIRPG.
    GenevestigatoriQ9P1W8.

    Interactioni

    Subunit structurei

    Interacts with CD47.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CD47Q087222EBI-1268284,EBI-1268321

    Protein-protein interaction databases

    BioGridi120664. 1 interaction.
    IntActiQ9P1W8. 1 interaction.
    STRINGi9606.ENSP00000305529.

    Structurei

    Secondary structure

    1
    387
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 435
    Beta strandi49 – 513
    Beta strandi54 – 563
    Beta strandi64 – 718
    Beta strandi75 – 828
    Beta strandi88 – 925
    Beta strandi104 – 1063
    Helixi111 – 1133
    Beta strandi115 – 1239
    Beta strandi126 – 1283
    Beta strandi130 – 1345
    Beta strandi138 – 1425
    Beta strandi150 – 1523
    Beta strandi163 – 17614
    Beta strandi179 – 1846
    Beta strandi192 – 1976
    Beta strandi205 – 21410
    Beta strandi223 – 2297
    Turni231 – 2355
    Beta strandi238 – 2436
    Helixi244 – 2463
    Beta strandi253 – 2608
    Beta strandi262 – 27918
    Beta strandi281 – 2877
    Beta strandi297 – 3026
    Beta strandi308 – 31710
    Beta strandi326 – 3338
    Beta strandi339 – 3446

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JJWX-ray1.70A29-147[»]
    4I2XX-ray2.48E/F29-347[»]
    ProteinModelPortaliQ9P1W8.
    SMRiQ9P1W8. Positions 30-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9P1W8.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 360332ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini384 – 3874CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei361 – 38323HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 137109Ig-like V-typeAdd
    BLAST
    Domaini146 – 245100Ig-like C1-type 1Add
    BLAST
    Domaini252 – 34089Ig-like C1-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291387.
    HOVERGENiHBG056632.
    InParanoidiQ9P1W8.
    KOiK06551.
    OMAiELISITW.
    OrthoDBiEOG7CG6ZQ.
    PhylomeDBiQ9P1W8.
    TreeFamiTF341862.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07654. C1-set. 2 hits.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00407. IGc1. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P1W8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT    50
    LHCTVTSLLP VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM 100
    DFSIRISSIT PADVGTYYCV KFRKGSPENV EFKSGPGTEM ALGAKPSAPV 150
    VLGPAARTTP EHTVSFTCES HGFSPRDITL KWFKNGNELS DFQTNVDPTG 200
    QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG TANLSEAIRV 250
    PPTLEVTQQP MRVGNQVNVT CQVRKFYPQS LQLTWSENGN VCQRETASTL 300
    TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH 350
    QKDQSSDATP GPASSLTALL LIAVLLGPIY VPWKQKT 387
    Length:387
    Mass (Da):42,498
    Last modified:January 23, 2007 - v3
    Checksum:i0F5099BE1DE35AC8
    GO
    Isoform 2 (identifier: Q9P1W8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:354
    Mass (Da):38,962
    Checksum:i41D5122588FE7C42
    GO
    Isoform 3 (identifier: Q9P1W8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         144-360: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:170
    Mass (Da):18,466
    Checksum:i0439DB85CAAB167A
    GO
    Isoform 4 (identifier: Q9P1W8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         250-360: Missing.

    Show »
    Length:276
    Mass (Da):29,967
    Checksum:iAF76A8692051D6C1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti263 – 2631V → A.1 Publication
    Corresponds to variant rs6043409 [ dbSNP | Ensembl ].
    VAR_049936
    Natural varianti286 – 2861S → L.1 Publication
    Corresponds to variant rs6034239 [ dbSNP | Ensembl ].
    VAR_049937

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3333Missing in isoform 2. 1 PublicationVSP_007027Add
    BLAST
    Alternative sequencei144 – 360217Missing in isoform 3. 1 PublicationVSP_007028Add
    BLAST
    Alternative sequencei250 – 360111Missing in isoform 4. 1 PublicationVSP_026960Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042624 mRNA. Translation: BAA95692.1.
    AY748247 mRNA. Translation: AAV88530.1.
    AY748248 mRNA. Translation: AAV88531.1.
    AL109809, AL138804 Genomic DNA. Translation: CAM28283.1.
    AL109809, AL138804 Genomic DNA. Translation: CAM28284.1.
    AL109809, AL138804 Genomic DNA. Translation: CAM28285.1.
    CH471133 Genomic DNA. Translation: EAX10616.1.
    BC020629 mRNA. Translation: AAH20629.2.
    BC064532 mRNA. Translation: AAH64532.1.
    CCDSiCCDS13020.2. [Q9P1W8-1]
    CCDS13021.2. [Q9P1W8-3]
    CCDS33434.1. [Q9P1W8-4]
    RefSeqiNP_001034597.1. NM_001039508.1. [Q9P1W8-4]
    NP_061026.2. NM_018556.3. [Q9P1W8-1]
    NP_543006.2. NM_080816.2. [Q9P1W8-3]
    UniGeneiHs.590883.

    Genome annotation databases

    EnsembliENST00000216927; ENSP00000216927; ENSG00000089012. [Q9P1W8-4]
    ENST00000303415; ENSP00000305529; ENSG00000089012. [Q9P1W8-1]
    ENST00000344103; ENSP00000342759; ENSG00000089012. [Q9P1W8-3]
    ENST00000381580; ENSP00000370992; ENSG00000089012. [Q9P1W8-2]
    ENST00000381583; ENSP00000370995; ENSG00000089012. [Q9P1W8-4]
    GeneIDi55423.
    KEGGihsa:55423.
    UCSCiuc002wfm.1. human. [Q9P1W8-1]
    uc002wfn.1. human. [Q9P1W8-4]
    uc002wfo.1. human. [Q9P1W8-3]

    Polymorphism databases

    DMDMi124053651.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042624 mRNA. Translation: BAA95692.1 .
    AY748247 mRNA. Translation: AAV88530.1 .
    AY748248 mRNA. Translation: AAV88531.1 .
    AL109809 , AL138804 Genomic DNA. Translation: CAM28283.1 .
    AL109809 , AL138804 Genomic DNA. Translation: CAM28284.1 .
    AL109809 , AL138804 Genomic DNA. Translation: CAM28285.1 .
    CH471133 Genomic DNA. Translation: EAX10616.1 .
    BC020629 mRNA. Translation: AAH20629.2 .
    BC064532 mRNA. Translation: AAH64532.1 .
    CCDSi CCDS13020.2. [Q9P1W8-1 ]
    CCDS13021.2. [Q9P1W8-3 ]
    CCDS33434.1. [Q9P1W8-4 ]
    RefSeqi NP_001034597.1. NM_001039508.1. [Q9P1W8-4 ]
    NP_061026.2. NM_018556.3. [Q9P1W8-1 ]
    NP_543006.2. NM_080816.2. [Q9P1W8-3 ]
    UniGenei Hs.590883.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JJW X-ray 1.70 A 29-147 [» ]
    4I2X X-ray 2.48 E/F 29-347 [» ]
    ProteinModelPortali Q9P1W8.
    SMRi Q9P1W8. Positions 30-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120664. 1 interaction.
    IntActi Q9P1W8. 1 interaction.
    STRINGi 9606.ENSP00000305529.

    PTM databases

    PhosphoSitei Q9P1W8.

    Polymorphism databases

    DMDMi 124053651.

    Proteomic databases

    MaxQBi Q9P1W8.
    PaxDbi Q9P1W8.
    PRIDEi Q9P1W8.

    Protocols and materials databases

    DNASUi 55423.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216927 ; ENSP00000216927 ; ENSG00000089012 . [Q9P1W8-4 ]
    ENST00000303415 ; ENSP00000305529 ; ENSG00000089012 . [Q9P1W8-1 ]
    ENST00000344103 ; ENSP00000342759 ; ENSG00000089012 . [Q9P1W8-3 ]
    ENST00000381580 ; ENSP00000370992 ; ENSG00000089012 . [Q9P1W8-2 ]
    ENST00000381583 ; ENSP00000370995 ; ENSG00000089012 . [Q9P1W8-4 ]
    GeneIDi 55423.
    KEGGi hsa:55423.
    UCSCi uc002wfm.1. human. [Q9P1W8-1 ]
    uc002wfn.1. human. [Q9P1W8-4 ]
    uc002wfo.1. human. [Q9P1W8-3 ]

    Organism-specific databases

    CTDi 55423.
    GeneCardsi GC20M001558.
    HGNCi HGNC:15757. SIRPG.
    MIMi 605466. gene.
    neXtProti NX_Q9P1W8.
    PharmGKBi PA38034.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291387.
    HOVERGENi HBG056632.
    InParanoidi Q9P1W8.
    KOi K06551.
    OMAi ELISITW.
    OrthoDBi EOG7CG6ZQ.
    PhylomeDBi Q9P1W8.
    TreeFami TF341862.

    Enzyme and pathway databases

    Reactomei REACT_12051. Cell surface interactions at the vascular wall.
    REACT_23916. Signal regulatory protein (SIRP) family interactions.

    Miscellaneous databases

    EvolutionaryTracei Q9P1W8.
    GeneWikii SIRPG.
    GenomeRNAii 55423.
    NextBioi 59818.
    PROi Q9P1W8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P1W8.
    CleanExi HS_SIRPG.
    Genevestigatori Q9P1W8.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 2 hits.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00407. IGc1. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family."
      Ichigotani Y., Matsuda S., Machida K., Oshima K., Iwamoto T., Yamaki K., Hayakawa T., Hamaguchi M.
      J. Hum. Genet. 45:378-382(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANTS ALA-263 AND LEU-286.
      Tissue: Placenta.
    2. "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."
      Piccio L., Vermi W., Boles K.S., Fuchs A., Strader C.A., Facchetti F., Cella M., Colonna M.
      Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, INTERACTION WITH CD47, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: T-cell.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Lung and Ovary.
    6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-243.
      Tissue: Leukemic T-cell.
    7. "Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
      Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N.
      Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 29-147, DISULFIDE BOND.

    Entry informationi

    Entry nameiSIRPG_HUMAN
    AccessioniPrimary (citable) accession number: Q9P1W8
    Secondary accession number(s): B1AKP6
    , Q5D051, Q5JV25, Q5MKL4, Q8WWA5, Q9NQK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3