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Protein

Signal-regulatory protein gamma

Gene

SIRPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.1 Publication

GO - Biological processi

  • blood coagulation Source: Reactome
  • cell adhesion Source: UniProtKB-KW
  • cell-cell signaling Source: ProtInc
  • intracellular signal transduction Source: ProtInc
  • leukocyte migration Source: Reactome
  • negative regulation of cell proliferation Source: ProtInc
  • positive regulation of cell-cell adhesion Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of T cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_23916. Signal regulatory protein (SIRP) family interactions.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein gamma
Short name:
SIRP-gamma
Alternative name(s):
CD172 antigen-like family member B
Signal-regulatory protein beta-2
Short name:
SIRP-b2
Short name:
SIRP-beta-2
CD_antigen: CD172g
Gene namesi
Name:SIRPG
Synonyms:SIRPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15757. SIRPG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 360332ExtracellularSequence AnalysisAdd
BLAST
Transmembranei361 – 38323HelicalSequence AnalysisAdd
BLAST
Topological domaini384 – 3874CytoplasmicSequence Analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38034.

Polymorphism and mutation databases

BioMutaiSIRPG.
DMDMi124053651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 387359Signal-regulatory protein gammaPRO_0000014957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 119PROSITE-ProRule annotation1 Publication
Disulfide bondi168 ↔ 226PROSITE-ProRule annotation
Glycosylationi243 – 2431N-linked (GlcNAc...)1 Publication
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi271 ↔ 329PROSITE-ProRule annotation
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9P1W8.
PaxDbiQ9P1W8.
PRIDEiQ9P1W8.

PTM databases

PhosphoSiteiQ9P1W8.

Expressioni

Tissue specificityi

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.2 Publications

Gene expression databases

BgeeiQ9P1W8.
CleanExiHS_SIRPG.
GenevisibleiQ9P1W8. HS.

Interactioni

Subunit structurei

Interacts with CD47.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CD47Q087222EBI-1268284,EBI-1268321

Protein-protein interaction databases

BioGridi120664. 3 interactions.
IntActiQ9P1W8. 1 interaction.
STRINGi9606.ENSP00000305529.

Structurei

Secondary structure

1
387
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 435Combined sources
Beta strandi49 – 513Combined sources
Beta strandi54 – 563Combined sources
Beta strandi64 – 718Combined sources
Beta strandi75 – 828Combined sources
Beta strandi88 – 925Combined sources
Beta strandi104 – 1063Combined sources
Helixi111 – 1133Combined sources
Beta strandi115 – 1239Combined sources
Beta strandi126 – 1283Combined sources
Beta strandi130 – 1345Combined sources
Beta strandi138 – 1425Combined sources
Beta strandi150 – 1523Combined sources
Beta strandi163 – 17614Combined sources
Beta strandi179 – 1846Combined sources
Beta strandi192 – 1976Combined sources
Beta strandi205 – 21410Combined sources
Beta strandi223 – 2297Combined sources
Turni231 – 2355Combined sources
Beta strandi238 – 2436Combined sources
Helixi244 – 2463Combined sources
Beta strandi253 – 2608Combined sources
Beta strandi262 – 27918Combined sources
Beta strandi281 – 2877Combined sources
Beta strandi297 – 3026Combined sources
Beta strandi308 – 31710Combined sources
Beta strandi326 – 3338Combined sources
Beta strandi339 – 3446Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JJWX-ray1.70A29-147[»]
4I2XX-ray2.48E/F29-347[»]
ProteinModelPortaliQ9P1W8.
SMRiQ9P1W8. Positions 30-345.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P1W8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 137109Ig-like V-typeAdd
BLAST
Domaini146 – 245100Ig-like C1-type 1Add
BLAST
Domaini252 – 34089Ig-like C1-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291387.
GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiQ9P1W8.
KOiK06551.
OMAiELISITW.
OrthoDBiEOG7CG6ZQ.
PhylomeDBiQ9P1W8.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00407. IGc1. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT
60 70 80 90 100
LHCTVTSLLP VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM
110 120 130 140 150
DFSIRISSIT PADVGTYYCV KFRKGSPENV EFKSGPGTEM ALGAKPSAPV
160 170 180 190 200
VLGPAARTTP EHTVSFTCES HGFSPRDITL KWFKNGNELS DFQTNVDPTG
210 220 230 240 250
QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG TANLSEAIRV
260 270 280 290 300
PPTLEVTQQP MRVGNQVNVT CQVRKFYPQS LQLTWSENGN VCQRETASTL
310 320 330 340 350
TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH
360 370 380
QKDQSSDATP GPASSLTALL LIAVLLGPIY VPWKQKT
Length:387
Mass (Da):42,498
Last modified:January 23, 2007 - v3
Checksum:i0F5099BE1DE35AC8
GO
Isoform 2 (identifier: Q9P1W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):38,962
Checksum:i41D5122588FE7C42
GO
Isoform 3 (identifier: Q9P1W8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-360: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):18,466
Checksum:i0439DB85CAAB167A
GO
Isoform 4 (identifier: Q9P1W8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-360: Missing.

Show »
Length:276
Mass (Da):29,967
Checksum:iAF76A8692051D6C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631V → A.1 Publication
Corresponds to variant rs6043409 [ dbSNP | Ensembl ].
VAR_049936
Natural varianti286 – 2861S → L.1 Publication
Corresponds to variant rs6034239 [ dbSNP | Ensembl ].
VAR_049937

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3333Missing in isoform 2. 1 PublicationVSP_007027Add
BLAST
Alternative sequencei144 – 360217Missing in isoform 3. 1 PublicationVSP_007028Add
BLAST
Alternative sequencei250 – 360111Missing in isoform 4. 1 PublicationVSP_026960Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042624 mRNA. Translation: BAA95692.1.
AY748247 mRNA. Translation: AAV88530.1.
AY748248 mRNA. Translation: AAV88531.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28283.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28284.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28285.1.
CH471133 Genomic DNA. Translation: EAX10616.1.
BC020629 mRNA. Translation: AAH20629.2.
BC064532 mRNA. Translation: AAH64532.1.
CCDSiCCDS13020.2. [Q9P1W8-1]
CCDS13021.2. [Q9P1W8-3]
CCDS33434.1. [Q9P1W8-4]
RefSeqiNP_001034597.1. NM_001039508.1. [Q9P1W8-4]
NP_061026.2. NM_018556.3. [Q9P1W8-1]
NP_543006.2. NM_080816.2. [Q9P1W8-3]
UniGeneiHs.590883.

Genome annotation databases

EnsembliENST00000216927; ENSP00000216927; ENSG00000089012. [Q9P1W8-4]
ENST00000303415; ENSP00000305529; ENSG00000089012. [Q9P1W8-1]
ENST00000344103; ENSP00000342759; ENSG00000089012. [Q9P1W8-3]
ENST00000381580; ENSP00000370992; ENSG00000089012. [Q9P1W8-2]
ENST00000381583; ENSP00000370995; ENSG00000089012. [Q9P1W8-4]
GeneIDi55423.
KEGGihsa:55423.
UCSCiuc002wfm.1. human. [Q9P1W8-1]
uc002wfn.1. human. [Q9P1W8-4]
uc002wfo.1. human. [Q9P1W8-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042624 mRNA. Translation: BAA95692.1.
AY748247 mRNA. Translation: AAV88530.1.
AY748248 mRNA. Translation: AAV88531.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28283.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28284.1.
AL109809, AL138804 Genomic DNA. Translation: CAM28285.1.
CH471133 Genomic DNA. Translation: EAX10616.1.
BC020629 mRNA. Translation: AAH20629.2.
BC064532 mRNA. Translation: AAH64532.1.
CCDSiCCDS13020.2. [Q9P1W8-1]
CCDS13021.2. [Q9P1W8-3]
CCDS33434.1. [Q9P1W8-4]
RefSeqiNP_001034597.1. NM_001039508.1. [Q9P1W8-4]
NP_061026.2. NM_018556.3. [Q9P1W8-1]
NP_543006.2. NM_080816.2. [Q9P1W8-3]
UniGeneiHs.590883.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JJWX-ray1.70A29-147[»]
4I2XX-ray2.48E/F29-347[»]
ProteinModelPortaliQ9P1W8.
SMRiQ9P1W8. Positions 30-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120664. 3 interactions.
IntActiQ9P1W8. 1 interaction.
STRINGi9606.ENSP00000305529.

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSiteiQ9P1W8.

Polymorphism and mutation databases

BioMutaiSIRPG.
DMDMi124053651.

Proteomic databases

MaxQBiQ9P1W8.
PaxDbiQ9P1W8.
PRIDEiQ9P1W8.

Protocols and materials databases

DNASUi55423.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216927; ENSP00000216927; ENSG00000089012. [Q9P1W8-4]
ENST00000303415; ENSP00000305529; ENSG00000089012. [Q9P1W8-1]
ENST00000344103; ENSP00000342759; ENSG00000089012. [Q9P1W8-3]
ENST00000381580; ENSP00000370992; ENSG00000089012. [Q9P1W8-2]
ENST00000381583; ENSP00000370995; ENSG00000089012. [Q9P1W8-4]
GeneIDi55423.
KEGGihsa:55423.
UCSCiuc002wfm.1. human. [Q9P1W8-1]
uc002wfn.1. human. [Q9P1W8-4]
uc002wfo.1. human. [Q9P1W8-3]

Organism-specific databases

CTDi55423.
GeneCardsiGC20M001558.
HGNCiHGNC:15757. SIRPG.
MIMi605466. gene.
neXtProtiNX_Q9P1W8.
PharmGKBiPA38034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG291387.
GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiQ9P1W8.
KOiK06551.
OMAiELISITW.
OrthoDBiEOG7CG6ZQ.
PhylomeDBiQ9P1W8.
TreeFamiTF341862.

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_23916. Signal regulatory protein (SIRP) family interactions.

Miscellaneous databases

EvolutionaryTraceiQ9P1W8.
GeneWikiiSIRPG.
GenomeRNAii55423.
NextBioi59818.
PROiQ9P1W8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P1W8.
CleanExiHS_SIRPG.
GenevisibleiQ9P1W8. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00407. IGc1. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family."
    Ichigotani Y., Matsuda S., Machida K., Oshima K., Iwamoto T., Yamaki K., Hayakawa T., Hamaguchi M.
    J. Hum. Genet. 45:378-382(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANTS ALA-263 AND LEU-286.
    Tissue: Placenta.
  2. "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."
    Piccio L., Vermi W., Boles K.S., Fuchs A., Strader C.A., Facchetti F., Cella M., Colonna M.
    Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, INTERACTION WITH CD47, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: T-cell.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lung and Ovary.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-243.
    Tissue: Leukemic T-cell.
  7. "Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
    Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N.
    Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 29-147, DISULFIDE BOND.

Entry informationi

Entry nameiSIRPG_HUMAN
AccessioniPrimary (citable) accession number: Q9P1W8
Secondary accession number(s): B1AKP6
, Q5D051, Q5JV25, Q5MKL4, Q8WWA5, Q9NQK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.