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Protein

Sterile alpha motif domain-containing protein 15

Gene

SAMD15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 15
Short name:
SAM domain-containing protein 15
Gene namesi
Name:SAMD15
Synonyms:C14orf174, FAM15A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:18631. SAMD15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903169.

Polymorphism and mutation databases

BioMutaiSAMD15.
DMDMi74753112.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Sterile alpha motif domain-containing protein 15PRO_0000279427Add
BLAST

Proteomic databases

PaxDbiQ9P1V8.
PRIDEiQ9P1V8.

PTM databases

iPTMnetiQ9P1V8.
PhosphoSiteiQ9P1V8.

Expressioni

Gene expression databases

BgeeiQ9P1V8.
CleanExiHS_C14orf174.
ExpressionAtlasiQ9P1V8. baseline and differential.
GenevisibleiQ9P1V8. HS.

Organism-specific databases

HPAiHPA030673.
HPA030677.

Structurei

3D structure databases

ProteinModelPortaliQ9P1V8.
SMRiQ9P1V8. Positions 547-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini545 – 60864SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFK7. Eukaryota.
ENOG4111WA8. LUCA.
GeneTreeiENSGT00630000089942.
HOVERGENiHBG081285.
InParanoidiQ9P1V8.
OMAiVPEDYDS.
OrthoDBiEOG7TJ3MK.
PhylomeDBiQ9P1V8.
TreeFamiTF351017.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1V8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEVPEDYDS GPDEDGELEP ERPELPGLHK LYENAEPDTM AKADSKLPAE
60 70 80 90 100
IYQEPQPETE EEDFKEGEPD SAKNVQLKPG GTSQEGIAKE SKRDVPSETE
110 120 130 140 150
PGIHQEVKSE TSREMGEFFK DLEAPMDETH KESDLEPPEE AKPNVTEDVF
160 170 180 190 200
LESAMETDPD PVPPTETMSE VSGATVRERN LELLEEETEP GVPEESLRVQ
210 220 230 240 250
HEETGLEPPE QTKQDFPSEK LGESLEETDL QPPKMTKPET PEETQRESTE
260 270 280 290 300
KKRTEPPEQA RLEFLEKEPR KSSEEAGLEP PEETQPEVPE EMQRKATEEK
310 320 330 340 350
GTELPERTKP DFPDHKPRKS TDENVPEPLE EIKLEFPEEE SRKTNEETIL
360 370 380 390 400
EQSEMMKPES PEEIRKSNEK KNPQPPEETG PVLPQEINPQ VEEKTQTKPT
410 420 430 440 450
EKILELPDET KPRETHVEFS KEDRPEPIKS KYSVGNDELE HREPKRGKLS
460 470 480 490 500
LSDKFRKEYY ALGSLRESEE SIGTHYEFLQ PLQKLLNVSE ECSYSDPSES
510 520 530 540 550
QTELSEFVHE KEVVDLSQEL KERVSEDDET QPEKGTELQF EHLNWDPEEV
560 570 580 590 600
AEWISQLGFP QYKECFITNF ISGRKLIHVN CSNLPQMGIT NFEDMKAISR
610 620 630 640 650
HTQELLEIEE PLFKRSISLP YRDIIGLYLE QKGHTGIKSD SLTLSEFVKA
660 670
AGLQDYAPEI TAPEENEELP CTEP
Length:674
Mass (Da):77,151
Last modified:October 1, 2000 - v1
Checksum:i21F439D7A43AA59E
GO
Isoform 2 (identifier: Q9P1V8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-570: ECFITNF → VYKNKMF
     571-674: Missing.

Show »
Length:570
Mass (Da):65,526
Checksum:i8547FAB52E2B3800
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181L → P.
Corresponds to variant rs11844594 [ dbSNP | Ensembl ].
VAR_030890
Natural varianti168 – 1681M → I.
Corresponds to variant rs45527334 [ dbSNP | Ensembl ].
VAR_061613
Natural varianti370 – 3701K → E.
Corresponds to variant rs4903576 [ dbSNP | Ensembl ].
VAR_030891
Natural varianti454 – 4541K → E.
Corresponds to variant rs2193595 [ dbSNP | Ensembl ].
VAR_030892

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei564 – 5707ECFITNF → VYKNKMF in isoform 2. 1 PublicationVSP_023431
Alternative sequencei571 – 674104Missing in isoform 2. 1 PublicationVSP_023432Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007954 Genomic DNA. Translation: AAF62561.1.
BC104834 mRNA. Translation: AAI04835.1.
BC104836 mRNA. Translation: AAI04837.1.
CCDSiCCDS32126.1. [Q9P1V8-1]
RefSeqiNP_001010860.1. NM_001010860.1. [Q9P1V8-1]
UniGeneiHs.421961.

Genome annotation databases

EnsembliENST00000216471; ENSP00000216471; ENSG00000100583. [Q9P1V8-1]
GeneIDi161394.
KEGGihsa:161394.
UCSCiuc001xtq.2. human. [Q9P1V8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007954 Genomic DNA. Translation: AAF62561.1.
BC104834 mRNA. Translation: AAI04835.1.
BC104836 mRNA. Translation: AAI04837.1.
CCDSiCCDS32126.1. [Q9P1V8-1]
RefSeqiNP_001010860.1. NM_001010860.1. [Q9P1V8-1]
UniGeneiHs.421961.

3D structure databases

ProteinModelPortaliQ9P1V8.
SMRiQ9P1V8. Positions 547-606.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9P1V8.
PhosphoSiteiQ9P1V8.

Polymorphism and mutation databases

BioMutaiSAMD15.
DMDMi74753112.

Proteomic databases

PaxDbiQ9P1V8.
PRIDEiQ9P1V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216471; ENSP00000216471; ENSG00000100583. [Q9P1V8-1]
GeneIDi161394.
KEGGihsa:161394.
UCSCiuc001xtq.2. human. [Q9P1V8-1]

Organism-specific databases

CTDi161394.
GeneCardsiSAMD15.
HGNCiHGNC:18631. SAMD15.
HPAiHPA030673.
HPA030677.
neXtProtiNX_Q9P1V8.
PharmGKBiPA134903169.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFK7. Eukaryota.
ENOG4111WA8. LUCA.
GeneTreeiENSGT00630000089942.
HOVERGENiHBG081285.
InParanoidiQ9P1V8.
OMAiVPEDYDS.
OrthoDBiEOG7TJ3MK.
PhylomeDBiQ9P1V8.
TreeFamiTF351017.

Miscellaneous databases

GenomeRNAii161394.
NextBioi88058.
PROiQ9P1V8.

Gene expression databases

BgeeiQ9P1V8.
CleanExiHS_C14orf174.
ExpressionAtlasiQ9P1V8. baseline and differential.
GenevisibleiQ9P1V8. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiSAM15_HUMAN
AccessioniPrimary (citable) accession number: Q9P1V8
Secondary accession number(s): Q2M3P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.