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Protein

Sterile alpha motif domain-containing protein 15

Gene

SAMD15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 15
Short name:
SAM domain-containing protein 15
Gene namesi
Name:SAMD15
Synonyms:C14orf174, FAM15A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100583.4
HGNCiHGNC:18631 SAMD15
neXtProtiNX_Q9P1V8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100583
PharmGKBiPA134903169

Polymorphism and mutation databases

BioMutaiSAMD15
DMDMi74753112

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794271 – 674Sterile alpha motif domain-containing protein 15Add BLAST674

Proteomic databases

PaxDbiQ9P1V8
PeptideAtlasiQ9P1V8
PRIDEiQ9P1V8

PTM databases

iPTMnetiQ9P1V8
PhosphoSitePlusiQ9P1V8

Expressioni

Gene expression databases

BgeeiENSG00000100583
CleanExiHS_C14orf174
ExpressionAtlasiQ9P1V8 baseline and differential
GenevisibleiQ9P1V8 HS

Organism-specific databases

HPAiHPA030673
HPA030677

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000216471

Structurei

3D structure databases

ProteinModelPortaliQ9P1V8
SMRiQ9P1V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini545 – 608SAMPROSITE-ProRule annotationAdd BLAST64

Phylogenomic databases

eggNOGiENOG410IFK7 Eukaryota
ENOG4111WA8 LUCA
GeneTreeiENSGT00630000089942
HOVERGENiHBG081285
InParanoidiQ9P1V8
OMAiVPEDYDS
OrthoDBiEOG091G0D1Q
PhylomeDBiQ9P1V8
TreeFamiTF351017

Family and domain databases

InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1V8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEVPEDYDS GPDEDGELEP ERPELPGLHK LYENAEPDTM AKADSKLPAE
60 70 80 90 100
IYQEPQPETE EEDFKEGEPD SAKNVQLKPG GTSQEGIAKE SKRDVPSETE
110 120 130 140 150
PGIHQEVKSE TSREMGEFFK DLEAPMDETH KESDLEPPEE AKPNVTEDVF
160 170 180 190 200
LESAMETDPD PVPPTETMSE VSGATVRERN LELLEEETEP GVPEESLRVQ
210 220 230 240 250
HEETGLEPPE QTKQDFPSEK LGESLEETDL QPPKMTKPET PEETQRESTE
260 270 280 290 300
KKRTEPPEQA RLEFLEKEPR KSSEEAGLEP PEETQPEVPE EMQRKATEEK
310 320 330 340 350
GTELPERTKP DFPDHKPRKS TDENVPEPLE EIKLEFPEEE SRKTNEETIL
360 370 380 390 400
EQSEMMKPES PEEIRKSNEK KNPQPPEETG PVLPQEINPQ VEEKTQTKPT
410 420 430 440 450
EKILELPDET KPRETHVEFS KEDRPEPIKS KYSVGNDELE HREPKRGKLS
460 470 480 490 500
LSDKFRKEYY ALGSLRESEE SIGTHYEFLQ PLQKLLNVSE ECSYSDPSES
510 520 530 540 550
QTELSEFVHE KEVVDLSQEL KERVSEDDET QPEKGTELQF EHLNWDPEEV
560 570 580 590 600
AEWISQLGFP QYKECFITNF ISGRKLIHVN CSNLPQMGIT NFEDMKAISR
610 620 630 640 650
HTQELLEIEE PLFKRSISLP YRDIIGLYLE QKGHTGIKSD SLTLSEFVKA
660 670
AGLQDYAPEI TAPEENEELP CTEP
Length:674
Mass (Da):77,151
Last modified:October 1, 2000 - v1
Checksum:i21F439D7A43AA59E
GO
Isoform 2 (identifier: Q9P1V8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-570: ECFITNF → VYKNKMF
     571-674: Missing.

Show »
Length:570
Mass (Da):65,526
Checksum:i8547FAB52E2B3800
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03089018L → P. Corresponds to variant dbSNP:rs11844594Ensembl.1
Natural variantiVAR_061613168M → I. Corresponds to variant dbSNP:rs45527334Ensembl.1
Natural variantiVAR_030891370K → E. Corresponds to variant dbSNP:rs4903576Ensembl.1
Natural variantiVAR_030892454K → E. Corresponds to variant dbSNP:rs2193595Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023431564 – 570ECFITNF → VYKNKMF in isoform 2. 1 Publication7
Alternative sequenceiVSP_023432571 – 674Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007954 Genomic DNA Translation: AAF62561.1
BC104834 mRNA Translation: AAI04835.1
BC104836 mRNA Translation: AAI04837.1
CCDSiCCDS32126.1 [Q9P1V8-1]
RefSeqiNP_001010860.1, NM_001010860.1 [Q9P1V8-1]
UniGeneiHs.421961

Genome annotation databases

EnsembliENST00000216471; ENSP00000216471; ENSG00000100583 [Q9P1V8-1]
GeneIDi161394
KEGGihsa:161394
UCSCiuc001xtq.2 human [Q9P1V8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSAM15_HUMAN
AccessioniPrimary (citable) accession number: Q9P1V8
Secondary accession number(s): Q2M3P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health