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Q9P1U1

- ARP3B_HUMAN

UniProt

Q9P1U1 - ARP3B_HUMAN

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Protein

Actin-related protein 3B

Gene

ACTR3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9P1U1.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3B
Alternative name(s):
ARP3-beta
Actin-like protein 3B
Actin-related protein ARP4
Gene namesi
Name:ACTR3B
Synonyms:ARP11, ARP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:17256. ACTR3B.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 418417Actin-related protein 3BPRO_0000342358Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei240 – 2401N6-acetyllysineBy similarity
Modified residuei244 – 2441N6-acetyllysineBy similarity
Modified residuei251 – 2511N6-acetyllysineBy similarity
Modified residuei254 – 2541N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9P1U1.
PaxDbiQ9P1U1.
PRIDEiQ9P1U1.

PTM databases

PhosphoSiteiQ9P1U1.

Expressioni

Tissue specificityi

Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential.2 Publications

Gene expression databases

BgeeiQ9P1U1.
CleanExiHS_ACTR3B.
ExpressionAtlasiQ9P1U1. baseline and differential.
GenevestigatoriQ9P1U1.

Interactioni

Subunit structurei

Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

BioGridi121429. 15 interactions.
IntActiQ9P1U1. 3 interactions.
MINTiMINT-1397170.
STRINGi9606.ENSP00000256001.

Structurei

3D structure databases

ProteinModelPortaliQ9P1U1.
SMRiQ9P1U1. Positions 3-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP3 subfamily.Curated

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00550000074695.
HOGENOMiHOG000233339.
HOVERGENiHBG003771.
InParanoidiQ9P1U1.
OMAiGDPRKWI.
OrthoDBiEOG7TMZRM.
PhylomeDBiQ9P1U1.
TreeFamiTF300644.

Family and domain databases

InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF170. PTHR11937:SF170. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P1U1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR
60 70 80 90 100
VLRGVDDLDF FIGDEAIDKP TYATKWPIRH GIIEDWDLME RFMEQVVFKY
110 120 130 140 150
LRAEPEDHYF LMTEPPLNTP ENREYLAEIM FESFNVPGLY IAVQAVLALA
160 170 180 190 200
ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV AEGYVIGSCI KHIPIAGRDI
210 220 230 240 250
TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVK EFAKYDVDPR
260 270 280 290 300
KWIKQYTGIN AINQKKFVID VGYERFLGPE IFFHPEFANP DFMESISDVV
310 320 330 340 350
DEVIQNCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLRLS
360 370 380 390 400
EELSGGRIKP KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY
410
EEYGPSICRH NPVFGVMS
Length:418
Mass (Da):47,608
Last modified:October 1, 2000 - v1
Checksum:iBC1040ED5D3B832F
GO
Isoform 2 (identifier: Q9P1U1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-88: Missing.

Show »
Length:331
Mass (Da):38,031
Checksum:i0FF9348637DC9879
GO
Isoform 3 (identifier: Q9P1U1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-387: Missing.

Show »
Length:348
Mass (Da):39,698
Checksum:iB9EC2A327C56C6CB
GO

Sequence cautioni

The sequence AAP97150.1 differs from that shown. Reason: Frameshift at several positions.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501R → Q.
Corresponds to variant rs2260545 [ dbSNP | Ensembl ].
VAR_048188

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 8887Missing in isoform 2. 2 PublicationsVSP_034418Add
BLAST
Alternative sequencei318 – 38770Missing in isoform 3. 1 PublicationVSP_041474Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF023453 mRNA. Translation: AAC98904.1.
AF086920 mRNA. Translation: AAP97150.1. Sequence problems.
AK294292 mRNA. Translation: BAG57575.1.
AK315534 mRNA. Translation: BAG37914.1.
AC072057 Genomic DNA. No translation available.
AC092180 Genomic DNA. No translation available.
BC015207 mRNA. Translation: AAH15207.1.
BC008682 mRNA. Translation: AAH08682.1.
CCDSiCCDS34782.1. [Q9P1U1-3]
CCDS5934.1. [Q9P1U1-1]
RefSeqiNP_001035225.1. NM_001040135.2. [Q9P1U1-3]
NP_065178.1. NM_020445.5. [Q9P1U1-1]
UniGeneiHs.647117.

Genome annotation databases

EnsembliENST00000256001; ENSP00000256001; ENSG00000133627. [Q9P1U1-1]
ENST00000377776; ENSP00000367007; ENSG00000133627. [Q9P1U1-3]
ENST00000397282; ENSP00000380452; ENSG00000133627.
GeneIDi57180.
KEGGihsa:57180.
UCSCiuc003wle.2. human. [Q9P1U1-1]
uc003wlf.2. human. [Q9P1U1-3]

Polymorphism databases

DMDMi74753111.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF023453 mRNA. Translation: AAC98904.1 .
AF086920 mRNA. Translation: AAP97150.1 . Sequence problems.
AK294292 mRNA. Translation: BAG57575.1 .
AK315534 mRNA. Translation: BAG37914.1 .
AC072057 Genomic DNA. No translation available.
AC092180 Genomic DNA. No translation available.
BC015207 mRNA. Translation: AAH15207.1 .
BC008682 mRNA. Translation: AAH08682.1 .
CCDSi CCDS34782.1. [Q9P1U1-3 ]
CCDS5934.1. [Q9P1U1-1 ]
RefSeqi NP_001035225.1. NM_001040135.2. [Q9P1U1-3 ]
NP_065178.1. NM_020445.5. [Q9P1U1-1 ]
UniGenei Hs.647117.

3D structure databases

ProteinModelPortali Q9P1U1.
SMRi Q9P1U1. Positions 3-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121429. 15 interactions.
IntActi Q9P1U1. 3 interactions.
MINTi MINT-1397170.
STRINGi 9606.ENSP00000256001.

PTM databases

PhosphoSitei Q9P1U1.

Polymorphism databases

DMDMi 74753111.

Proteomic databases

MaxQBi Q9P1U1.
PaxDbi Q9P1U1.
PRIDEi Q9P1U1.

Protocols and materials databases

DNASUi 57180.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256001 ; ENSP00000256001 ; ENSG00000133627 . [Q9P1U1-1 ]
ENST00000377776 ; ENSP00000367007 ; ENSG00000133627 . [Q9P1U1-3 ]
ENST00000397282 ; ENSP00000380452 ; ENSG00000133627 .
GeneIDi 57180.
KEGGi hsa:57180.
UCSCi uc003wle.2. human. [Q9P1U1-1 ]
uc003wlf.2. human. [Q9P1U1-3 ]

Organism-specific databases

CTDi 57180.
GeneCardsi GC07P152456.
HGNCi HGNC:17256. ACTR3B.
neXtProti NX_Q9P1U1.
PharmGKBi PA142672645.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5277.
GeneTreei ENSGT00550000074695.
HOGENOMi HOG000233339.
HOVERGENi HBG003771.
InParanoidi Q9P1U1.
OMAi GDPRKWI.
OrthoDBi EOG7TMZRM.
PhylomeDBi Q9P1U1.
TreeFami TF300644.

Enzyme and pathway databases

SignaLinki Q9P1U1.

Miscellaneous databases

GeneWikii ACTR3B.
GenomeRNAii 57180.
NextBioi 63219.
PROi Q9P1U1.

Gene expression databases

Bgeei Q9P1U1.
CleanExi HS_ACTR3B.
ExpressionAtlasi Q9P1U1. baseline and differential.
Genevestigatori Q9P1U1.

Family and domain databases

InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
PTHR11937:SF170. PTHR11937:SF170. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
PROSITEi PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells."
    Jay P., Berge-Lefranc J.-L., Massacrier A., Roessler E., Wallis D., Muenke M., Gastaldi M., Taviaux S., Cau P., Berta P.
    Eur. J. Biochem. 267:2921-2928(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. "Cloning of a novel human cDNA homology to human actin-related protein Arp3(ARP3) mRNA."
    Ding J.B., Yu L., Zhang M., Dai F.Y., Jiang J.X., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Peripheral blood.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Colon and Skin.
  6. "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma."
    Shindo-Okada N., Shimizu K.
    Biochem. Biophys. Res. Commun. 280:61-67(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells."
    Shindo-Okada N., Iigo M.
    Biochem. Biophys. Res. Commun. 312:889-896(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiARP3B_HUMAN
AccessioniPrimary (citable) accession number: Q9P1U1
Secondary accession number(s): A8MTG1
, B4DFW4, Q7Z526, Q96BT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3