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Protein

Actin-related protein 3B

Gene

ACTR3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9P1U1

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3B
Alternative name(s):
ARP3-beta
Actin-like protein 3B
Actin-related protein ARP4
Gene namesi
Name:ACTR3B
Synonyms:ARP11, ARP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000133627.17
HGNCiHGNC:17256 ACTR3B
neXtProtiNX_Q9P1U1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi57180
OpenTargetsiENSG00000133627
PharmGKBiPA142672645

Polymorphism and mutation databases

BioMutaiACTR3B
DMDMi74753111

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003423581 – 418Actin-related protein 3BAdd BLAST418

Proteomic databases

EPDiQ9P1U1
MaxQBiQ9P1U1
PaxDbiQ9P1U1
PeptideAtlasiQ9P1U1
PRIDEiQ9P1U1

PTM databases

iPTMnetiQ9P1U1
PhosphoSitePlusiQ9P1U1

Expressioni

Tissue specificityi

Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential.2 Publications

Gene expression databases

BgeeiENSG00000133627
CleanExiHS_ACTR3B
GenevisibleiQ9P1U1 HS

Organism-specific databases

HPAiHPA047016
HPA051683

Interactioni

Subunit structurei

Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121429, 30 interactors
IntActiQ9P1U1, 21 interactors
STRINGi9606.ENSP00000256001

Structurei

3D structure databases

ProteinModelPortaliQ9P1U1
SMRiQ9P1U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP3 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0678 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00550000074695
HOGENOMiHOG000233339
HOVERGENiHBG003771
InParanoidiQ9P1U1
KOiK18584
OMAiICPDIVR
OrthoDBiEOG091G0BPD
PhylomeDBiQ9P1U1
TreeFamiTF300644

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR015623 Arp3
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF170 PTHR11937:SF170, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1U1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR
60 70 80 90 100
VLRGVDDLDF FIGDEAIDKP TYATKWPIRH GIIEDWDLME RFMEQVVFKY
110 120 130 140 150
LRAEPEDHYF LMTEPPLNTP ENREYLAEIM FESFNVPGLY IAVQAVLALA
160 170 180 190 200
ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV AEGYVIGSCI KHIPIAGRDI
210 220 230 240 250
TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVK EFAKYDVDPR
260 270 280 290 300
KWIKQYTGIN AINQKKFVID VGYERFLGPE IFFHPEFANP DFMESISDVV
310 320 330 340 350
DEVIQNCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLRLS
360 370 380 390 400
EELSGGRIKP KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY
410
EEYGPSICRH NPVFGVMS
Length:418
Mass (Da):47,608
Last modified:October 1, 2000 - v1
Checksum:iBC1040ED5D3B832F
GO
Isoform 2 (identifier: Q9P1U1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:330
Mass (Da):37,900
Checksum:i3E9370B5EA5742A0
GO
Isoform 3 (identifier: Q9P1U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-387: Missing.

Show »
Length:348
Mass (Da):39,698
Checksum:iB9EC2A327C56C6CB
GO

Sequence cautioni

The sequence AAP97150 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048188250R → Q. Corresponds to variant dbSNP:rs2260545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0344181 – 88Missing in isoform 2. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_041474318 – 387Missing in isoform 3. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023453 mRNA Translation: AAC98904.1
AF086920 mRNA Translation: AAP97150.1 Sequence problems.
AK294292 mRNA Translation: BAG57575.1
AK315534 mRNA Translation: BAG37914.1
AC072057 Genomic DNA No translation available.
AC092180 Genomic DNA No translation available.
BC015207 mRNA Translation: AAH15207.1
BC008682 mRNA Translation: AAH08682.1
CCDSiCCDS34782.1 [Q9P1U1-3]
CCDS5934.1 [Q9P1U1-1]
RefSeqiNP_001035225.1, NM_001040135.2 [Q9P1U1-3]
NP_065178.1, NM_020445.5 [Q9P1U1-1]
UniGeneiHs.647117

Genome annotation databases

EnsembliENST00000256001; ENSP00000256001; ENSG00000133627 [Q9P1U1-1]
ENST00000377776; ENSP00000367007; ENSG00000133627 [Q9P1U1-3]
ENST00000397282; ENSP00000380452; ENSG00000133627 [Q9P1U1-2]
GeneIDi57180
KEGGihsa:57180
UCSCiuc003wle.3 human [Q9P1U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARP3B_HUMAN
AccessioniPrimary (citable) accession number: Q9P1U1
Secondary accession number(s): A8MTG1
, B4DFW4, Q7Z526, Q96BT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health