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Q9P1U1

- ARP3B_HUMAN

UniProt

Q9P1U1 - ARP3B_HUMAN

Protein

Actin-related protein 3B

Gene

ACTR3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    Actin-binding, ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9P1U1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein 3B
    Alternative name(s):
    ARP3-beta
    Actin-like protein 3B
    Actin-related protein ARP4
    Gene namesi
    Name:ACTR3B
    Synonyms:ARP11, ARP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17256. ACTR3B.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cell projection By similarity

    GO - Cellular componenti

    1. cell projection Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672645.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 418417Actin-related protein 3BPRO_0000342358Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei240 – 2401N6-acetyllysineBy similarity
    Modified residuei244 – 2441N6-acetyllysineBy similarity
    Modified residuei251 – 2511N6-acetyllysineBy similarity
    Modified residuei254 – 2541N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9P1U1.
    PaxDbiQ9P1U1.
    PRIDEiQ9P1U1.

    PTM databases

    PhosphoSiteiQ9P1U1.

    Expressioni

    Tissue specificityi

    Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential.2 Publications

    Gene expression databases

    ArrayExpressiQ9P1U1.
    BgeeiQ9P1U1.
    CleanExiHS_ACTR3B.
    GenevestigatoriQ9P1U1.

    Interactioni

    Subunit structurei

    Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Protein-protein interaction databases

    BioGridi121429. 15 interactions.
    IntActiQ9P1U1. 3 interactions.
    MINTiMINT-1397170.
    STRINGi9606.ENSP00000256001.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P1U1.
    SMRiQ9P1U1. Positions 3-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family. ARP3 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5277.
    HOGENOMiHOG000233339.
    HOVERGENiHBG003771.
    InParanoidiQ9P1U1.
    OMAiGDPRKWI.
    OrthoDBiEOG7TMZRM.
    PhylomeDBiQ9P1U1.
    TreeFamiTF300644.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P1U1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR    50
    VLRGVDDLDF FIGDEAIDKP TYATKWPIRH GIIEDWDLME RFMEQVVFKY 100
    LRAEPEDHYF LMTEPPLNTP ENREYLAEIM FESFNVPGLY IAVQAVLALA 150
    ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV AEGYVIGSCI KHIPIAGRDI 200
    TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVK EFAKYDVDPR 250
    KWIKQYTGIN AINQKKFVID VGYERFLGPE IFFHPEFANP DFMESISDVV 300
    DEVIQNCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLRLS 350
    EELSGGRIKP KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY 400
    EEYGPSICRH NPVFGVMS 418
    Length:418
    Mass (Da):47,608
    Last modified:October 1, 2000 - v1
    Checksum:iBC1040ED5D3B832F
    GO
    Isoform 2 (identifier: Q9P1U1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-88: Missing.

    Show »
    Length:331
    Mass (Da):38,031
    Checksum:i0FF9348637DC9879
    GO
    Isoform 3 (identifier: Q9P1U1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         318-387: Missing.

    Show »
    Length:348
    Mass (Da):39,698
    Checksum:iB9EC2A327C56C6CB
    GO

    Sequence cautioni

    The sequence AAP97150.1 differs from that shown. Reason: Frameshift at several positions.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti250 – 2501R → Q.
    Corresponds to variant rs2260545 [ dbSNP | Ensembl ].
    VAR_048188

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 8887Missing in isoform 2. 2 PublicationsVSP_034418Add
    BLAST
    Alternative sequencei318 – 38770Missing in isoform 3. 1 PublicationVSP_041474Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023453 mRNA. Translation: AAC98904.1.
    AF086920 mRNA. Translation: AAP97150.1. Sequence problems.
    AK294292 mRNA. Translation: BAG57575.1.
    AK315534 mRNA. Translation: BAG37914.1.
    AC072057 Genomic DNA. No translation available.
    AC092180 Genomic DNA. No translation available.
    BC015207 mRNA. Translation: AAH15207.1.
    BC008682 mRNA. Translation: AAH08682.1.
    CCDSiCCDS34782.1. [Q9P1U1-3]
    CCDS5934.1. [Q9P1U1-1]
    RefSeqiNP_001035225.1. NM_001040135.2. [Q9P1U1-3]
    NP_065178.1. NM_020445.5. [Q9P1U1-1]
    UniGeneiHs.647117.

    Genome annotation databases

    EnsembliENST00000256001; ENSP00000256001; ENSG00000133627. [Q9P1U1-1]
    ENST00000377776; ENSP00000367007; ENSG00000133627. [Q9P1U1-3]
    ENST00000397282; ENSP00000380452; ENSG00000133627. [Q9P1U1-2]
    GeneIDi57180.
    KEGGihsa:57180.
    UCSCiuc003wle.2. human. [Q9P1U1-1]
    uc003wlf.2. human. [Q9P1U1-3]

    Polymorphism databases

    DMDMi74753111.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023453 mRNA. Translation: AAC98904.1 .
    AF086920 mRNA. Translation: AAP97150.1 . Sequence problems.
    AK294292 mRNA. Translation: BAG57575.1 .
    AK315534 mRNA. Translation: BAG37914.1 .
    AC072057 Genomic DNA. No translation available.
    AC092180 Genomic DNA. No translation available.
    BC015207 mRNA. Translation: AAH15207.1 .
    BC008682 mRNA. Translation: AAH08682.1 .
    CCDSi CCDS34782.1. [Q9P1U1-3 ]
    CCDS5934.1. [Q9P1U1-1 ]
    RefSeqi NP_001035225.1. NM_001040135.2. [Q9P1U1-3 ]
    NP_065178.1. NM_020445.5. [Q9P1U1-1 ]
    UniGenei Hs.647117.

    3D structure databases

    ProteinModelPortali Q9P1U1.
    SMRi Q9P1U1. Positions 3-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121429. 15 interactions.
    IntActi Q9P1U1. 3 interactions.
    MINTi MINT-1397170.
    STRINGi 9606.ENSP00000256001.

    PTM databases

    PhosphoSitei Q9P1U1.

    Polymorphism databases

    DMDMi 74753111.

    Proteomic databases

    MaxQBi Q9P1U1.
    PaxDbi Q9P1U1.
    PRIDEi Q9P1U1.

    Protocols and materials databases

    DNASUi 57180.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256001 ; ENSP00000256001 ; ENSG00000133627 . [Q9P1U1-1 ]
    ENST00000377776 ; ENSP00000367007 ; ENSG00000133627 . [Q9P1U1-3 ]
    ENST00000397282 ; ENSP00000380452 ; ENSG00000133627 . [Q9P1U1-2 ]
    GeneIDi 57180.
    KEGGi hsa:57180.
    UCSCi uc003wle.2. human. [Q9P1U1-1 ]
    uc003wlf.2. human. [Q9P1U1-3 ]

    Organism-specific databases

    CTDi 57180.
    GeneCardsi GC07P152456.
    HGNCi HGNC:17256. ACTR3B.
    neXtProti NX_Q9P1U1.
    PharmGKBi PA142672645.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5277.
    HOGENOMi HOG000233339.
    HOVERGENi HBG003771.
    InParanoidi Q9P1U1.
    OMAi GDPRKWI.
    OrthoDBi EOG7TMZRM.
    PhylomeDBi Q9P1U1.
    TreeFami TF300644.

    Enzyme and pathway databases

    SignaLinki Q9P1U1.

    Miscellaneous databases

    GeneWikii ACTR3B.
    GenomeRNAii 57180.
    NextBioi 63219.
    PROi Q9P1U1.

    Gene expression databases

    ArrayExpressi Q9P1U1.
    Bgeei Q9P1U1.
    CleanExi HS_ACTR3B.
    Genevestigatori Q9P1U1.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells."
      Jay P., Berge-Lefranc J.-L., Massacrier A., Roessler E., Wallis D., Muenke M., Gastaldi M., Taviaux S., Cau P., Berta P.
      Eur. J. Biochem. 267:2921-2928(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Embryo.
    2. "Cloning of a novel human cDNA homology to human actin-related protein Arp3(ARP3) mRNA."
      Ding J.B., Yu L., Zhang M., Dai F.Y., Jiang J.X., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala and Peripheral blood.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Colon and Skin.
    6. "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma."
      Shindo-Okada N., Shimizu K.
      Biochem. Biophys. Res. Commun. 280:61-67(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells."
      Shindo-Okada N., Iigo M.
      Biochem. Biophys. Res. Commun. 312:889-896(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiARP3B_HUMAN
    AccessioniPrimary (citable) accession number: Q9P1U1
    Secondary accession number(s): A8MTG1
    , B4DFW4, Q7Z526, Q96BT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3