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Protein

DNA-directed RNA polymerase I subunit RPA12

Gene

ZNRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 41C4-typeSequence analysisAdd BLAST22
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase I subunit RPA12
Alternative name(s):
Zinc ribbon domain-containing protein 1
Gene namesi
Name:ZNRD1
Synonyms:RPA12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000066379.14
HGNCiHGNC:13182 ZNRD1
MIMi607525 gene
neXtProtiNX_Q9P1U0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30834
OpenTargetsiENSG00000066379
PharmGKBiPA37754

Polymorphism and mutation databases

DMDMi71649339

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214601 – 126DNA-directed RNA polymerase I subunit RPA12Add BLAST126

Proteomic databases

EPDiQ9P1U0
MaxQBiQ9P1U0
PaxDbiQ9P1U0
PeptideAtlasiQ9P1U0
PRIDEiQ9P1U0

Expressioni

Gene expression databases

BgeeiENSG00000066379
CleanExiHS_ZNRD1
ExpressionAtlasiQ9P1U0 baseline and differential
GenevisibleiQ9P1U0 HS

Organism-specific databases

HPAiHPA055074

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.By similarity

Protein-protein interaction databases

BioGridi119050, 22 interactors
IntActiQ9P1U0, 20 interactors
STRINGi9606.ENSP00000331111

Structurei

3D structure databases

ProteinModelPortaliQ9P1U0
SMRiQ9P1U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 41C4-typeSequence analysisAdd BLAST22
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2907 Eukaryota
COG1594 LUCA
GeneTreeiENSGT00390000008126
HOGENOMiHOG000228133
HOVERGENiHBG055084
InParanoidiQ9P1U0
KOiK03000
OMAiVFYTCTS
OrthoDBiEOG091G0V6T
PhylomeDBiQ9P1U0
TreeFamiTF313881

Family and domain databases

CDDicd10507 Zn-ribbon_RPA12, 1 hit
InterProiView protein in InterPro
IPR019761 DNA-dir_RNA_pol-M_15_CS
IPR012164 Rpa12/Rpb9/Rpc10/TFS
IPR034004 Zn_ribbon_RPA12_C
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF01096 TFIIS_C, 1 hit
PIRSFiPIRSF005586 RNApol_RpoM, 1 hit
SMARTiView protein in SMART
SM00440 ZnF_C2C2, 1 hit
PROSITEiView protein in PROSITE
PS01030 RNA_POL_M_15KD, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P1U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF
60 70 80 90 100
EGKVVKTSVV FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR
110 120
QMRSADEGQT VFYTCTNCKF QEKEDS
Length:126
Mass (Da):13,904
Last modified:October 1, 2000 - v1
Checksum:iC678AC7132A91432
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05228714Q → H. Corresponds to variant dbSNP:rs17187658Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024617 mRNA Translation: AAF40469.1
AF230337 mRNA Translation: AAG50159.1
AF230338 Genomic DNA Translation: AAG50160.1
CR457109 mRNA Translation: CAG33390.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
AL845439 Genomic DNA No translation available.
BX088647 Genomic DNA No translation available.
BC010898 mRNA Translation: AAH10898.1
BC050608 mRNA Translation: AAH50608.1
CCDSiCCDS4670.1
RefSeqiNP_001265714.1, NM_001278785.1
NP_001265715.1, NM_001278786.1
NP_055411.1, NM_014596.5
NP_740753.1, NM_170783.3
UniGeneiHs.57813

Genome annotation databases

EnsembliENST00000332435; ENSP00000331111; ENSG00000066379
ENST00000359374; ENSP00000352333; ENSG00000066379
ENST00000376782; ENSP00000365978; ENSG00000066379
ENST00000376785; ENSP00000365981; ENSG00000066379
ENST00000383613; ENSP00000373108; ENSG00000206502
ENST00000400659; ENSP00000383500; ENSG00000206502
ENST00000400660; ENSP00000383501; ENSG00000206502
ENST00000400662; ENSP00000383503; ENSG00000206502
ENST00000412396; ENSP00000396922; ENSG00000233795
ENST00000417275; ENSP00000397636; ENSG00000233795
ENST00000417738; ENSP00000407715; ENSG00000235176
ENST00000420100; ENSP00000410530; ENSG00000236808
ENST00000428913; ENSP00000414110; ENSG00000224859
ENST00000429558; ENSP00000410954; ENSG00000235176
ENST00000431032; ENSP00000416599; ENSG00000236949
ENST00000431416; ENSP00000395065; ENSG00000235176
ENST00000432227; ENSP00000399302; ENSG00000236808
ENST00000432545; ENSP00000405264; ENSG00000236949
ENST00000432904; ENSP00000414720; ENSG00000236808
ENST00000433264; ENSP00000393236; ENSG00000236949
ENST00000437373; ENSP00000410127; ENSG00000236949
ENST00000437507; ENSP00000412369; ENSG00000235443
ENST00000441251; ENSP00000413265; ENSG00000235176
ENST00000442585; ENSP00000394779; ENSG00000233795
ENST00000443142; ENSP00000391809; ENSG00000235443
ENST00000443494; ENSP00000395397; ENSG00000235443
ENST00000444027; ENSP00000396661; ENSG00000236808
ENST00000444794; ENSP00000407364; ENSG00000233795
ENST00000446493; ENSP00000399966; ENSG00000224859
ENST00000451875; ENSP00000387914; ENSG00000224859
ENST00000453694; ENSP00000405636; ENSG00000235443
ENST00000455948; ENSP00000402198; ENSG00000224859
GeneIDi30834
KEGGihsa:30834
UCSCiuc003noz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPA12_HUMAN
AccessioniPrimary (citable) accession number: Q9P1U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health