Q9P1P5 (TAAR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 2
Short name=TaR-2
Short name=Trace amine receptor 2

Alternative name(s):
G-protein coupled receptor 58

Gene names

Name:	TAAR2
Synonyms:	GPR58

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Not expressed in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain or liver.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred by curator Ref.2. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Traceable author statement Ref.2. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P1P5-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P1P5-2)

Also known as: Small;

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Trace amine-associated receptor 2		PRO_0000070146
Regions
	Topological domain	1 – 48	48	Extracellular Potential
	Transmembrane	49 – 69	21	Helical; Name=1; Potential
	Topological domain	70 – 79	10	Cytoplasmic Potential
	Transmembrane	80 – 100	21	Helical; Name=2; Potential
	Topological domain	101 – 118	18	Extracellular Potential
	Transmembrane	119 – 139	21	Helical; Name=3; Potential
	Topological domain	140 – 162	23	Cytoplasmic Potential
	Transmembrane	163 – 183	21	Helical; Name=4; Potential
	Topological domain	184 – 207	24	Extracellular Potential
	Transmembrane	208 – 228	21	Helical; Name=5; Potential
	Topological domain	229 – 263	35	Cytoplasmic Potential
	Transmembrane	264 – 284	21	Helical; Name=6; Potential
	Topological domain	285 – 299	15	Extracellular Potential
	Transmembrane	300 – 322	23	Helical; Name=7; Potential
	Topological domain	323 – 351	29	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	24	1	N-linked (GlcNAc...) Potential
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Glycosylation	289	1	N-linked (GlcNAc...) Potential
	Disulfide bond	116 ↔ 201		By similarity
Natural variations
	Alternative sequence	1 – 45	45	Missing in isoform 2.		VSP_016301
Experimental info
	Sequence conflict	178	1	V → A in AAF27278. Ref.1
	Sequence conflict	301	1	T → K in AAH67463. Ref.4
	Sequence conflict	329	1	I → V in AAH67462. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified November 22, 2005. Version 2. Checksum: 7AA0BAAC58E2F11D	FASTA	351	40,134
	10 20 30 40 50 60 MAVSSEQHEL SHFKRTQTKK EKFNCSEYGN RSCPENERSL GVRVAMYSFM AGSIFITIFG 70 80 90 100 110 120 NLAMIISISY FKQLHTPTNF LILSMAITDF LLGFTIMPYS MIRSVENCWY FGLTFCKIYY 130 140 150 160 170 180 SFDLMLSITS IFHLCSVAID RFYAICYPLL YSTKITIPVI KRLLLLCWSV PGAFAFGVVF 190 200 210 220 230 240 SEAYADGIEG YDILVACSSS CPVMFNKLWG TTLFMAGFFT PGSMMVGIYG KIFAVSRKHA 250 260 270 280 290 300 HAINNLRENQ NNQVKKDKKA AKTLGIVIGV FLLCWFPCFF TILLDPFLNF STPVVLFDAL 310 320 330 340 350 TWFGYFNSTC NPLIYGFFYP WFRRALKYIL LGKIFSSCFH NTILCMQKES E
	Isoform 2 (Small) [UniParc]. Checksum: 2D935D280DDE2A03	FASTA	306	34,953
	10 20 30 40 50 60 MYSFMAGSIF ITIFGNLAMI ISISYFKQLH TPTNFLILSM AITDFLLGFT IMPYSMIRSV 70 80 90 100 110 120 ENCWYFGLTF CKIYYSFDLM LSITSIFHLC SVAIDRFYAI CYPLLYSTKI TIPVIKRLLL 130 140 150 160 170 180 LCWSVPGAFA FGVVFSEAYA DGIEGYDILV ACSSSCPVMF NKLWGTTLFM AGFFTPGSMM 190 200 210 220 230 240 VGIYGKIFAV SRKHAHAINN LRENQNNQVK KDKKAAKTLG IVIGVFLLCW FPCFFTILLD 250 260 270 280 290 300 PFLNFSTPVV LFDALTWFGY FNSTCNPLIY GFFYPWFRRA LKYILLGKIF SSCFHNTILC MQKESE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of additional members of the G protein-coupled receptor family." Lee D.K., Lynch K.R., Nguyen T., Im D.-S., Cheng R., Saldivia V.R., Liu Y., Liu I.S.C., Heng H.H.Q., Seeman P., George S.R., O'Dowd B.F., Marchese A. Biochim. Biophys. Acta 1490:311-323(2000) [PubMed: 10684976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C. Genomics 85:372-385(2005) [PubMed: 15718104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF112460 Genomic DNA. Translation: AAF27278.1. AY703480 mRNA. Translation: AAV70150.1. AY702304 mRNA. Translation: AAV70122.1. AL513524 Genomic DNA. Translation: CAH72103.1. BC067461 mRNA. Translation: AAH67461.1. BC067462 mRNA. Translation: AAH67462.1. BC067463 mRNA. Translation: AAH67463.1.
IPI	IPI00005616. IPI00651630.
RefSeq	NP_001028252.1. NM_001033080.1. NP_055441.2. NM_014626.3.
UniGene	Hs.272382.
3D structure databases
ProteinModelPortal	Q9P1P5.
SMR	Q9P1P5. Positions 44-331.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9P1P5.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9P1P5.
Polymorphism databases
DMDM	82592527.
Proteomic databases
PRIDE	Q9P1P5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367931; ENSP00000356908; ENSG00000146378.
GeneID	9287.
KEGG	hsa:9287.
UCSC	uc003qdl.1. human. uc010kfr.1. human.
Organism-specific databases
CTD	9287.
GeneCards	GC06M132939.
H-InvDB	HIX0200942.
HGNC	HGNC:4514. TAAR2.
MIM	604849. gene.
neXtProt	NX_Q9P1P5.
PharmGKB	PA28903.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06311.
GeneTree	ENSGT00550000074214.
HOGENOM	HBG445348.
HOVERGEN	HBG106962.
InParanoid	Q9P1P5.
OMA	CSEYGNG.
PhylomeDB	Q9P1P5.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9P1P5.
Bgee	Q9P1P5.
CleanEx	HS_TAAR2.
Genevestigator	Q9P1P5.
GermOnline	ENSG00000146378. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	34797.
SOURCE	Search...

Entry information

Entry name

TAAR2_HUMAN

Accession

Primary (citable) accession number: Q9P1P5
Secondary accession number(s): Q5QD02 , Q6NWS1, Q6NWS2, Q6NWS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.