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Protein

Trace amine-associated receptor 2

Gene

TAAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • trace-amine receptor activity Source: GO_Central

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 2
Short name:
TaR-2
Short name:
Trace amine receptor 2
Alternative name(s):
G-protein coupled receptor 58
Gene namesi
Name:TAAR2
Synonyms:GPR58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4514. TAAR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini70 – 7910CytoplasmicSequence analysis
Transmembranei80 – 10021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 11818ExtracellularSequence analysisAdd
BLAST
Transmembranei119 – 13921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini140 – 16223CytoplasmicSequence analysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini184 – 20724ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini229 – 26335CytoplasmicSequence analysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini285 – 29915ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32223Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini323 – 35129CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28903.

Polymorphism and mutation databases

BioMutaiTAAR2.
DMDMi82592527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Trace amine-associated receptor 2PRO_0000070146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 201PROSITE-ProRule annotation
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9P1P5.
PRIDEiQ9P1P5.

PTM databases

iPTMnetiQ9P1P5.
PhosphoSiteiQ9P1P5.

Expressioni

Tissue specificityi

Not expressed in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain or liver.

Gene expression databases

BgeeiENSG00000146378.
CleanExiHS_TAAR2.
GenevisibleiQ9P1P5. HS.

Interactioni

Protein-protein interaction databases

BioGridi114702. 1 interaction.
STRINGi9606.ENSP00000356908.

Structurei

3D structure databases

ProteinModelPortaliQ9P1P5.
SMRiQ9P1P5. Positions 45-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ9P1P5.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG091G06VI.
PhylomeDBiQ9P1P5.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1P5-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVSSEQHEL SHFKRTQTKK EKFNCSEYGN RSCPENERSL GVRVAMYSFM
60 70 80 90 100
AGSIFITIFG NLAMIISISY FKQLHTPTNF LILSMAITDF LLGFTIMPYS
110 120 130 140 150
MIRSVENCWY FGLTFCKIYY SFDLMLSITS IFHLCSVAID RFYAICYPLL
160 170 180 190 200
YSTKITIPVI KRLLLLCWSV PGAFAFGVVF SEAYADGIEG YDILVACSSS
210 220 230 240 250
CPVMFNKLWG TTLFMAGFFT PGSMMVGIYG KIFAVSRKHA HAINNLRENQ
260 270 280 290 300
NNQVKKDKKA AKTLGIVIGV FLLCWFPCFF TILLDPFLNF STPVVLFDAL
310 320 330 340 350
TWFGYFNSTC NPLIYGFFYP WFRRALKYIL LGKIFSSCFH NTILCMQKES

E
Length:351
Mass (Da):40,134
Last modified:November 22, 2005 - v2
Checksum:i7AA0BAAC58E2F11D
GO
Isoform 2 (identifier: Q9P1P5-2) [UniParc]FASTAAdd to basket
Also known as: Small

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:306
Mass (Da):34,953
Checksum:i2D935D280DDE2A03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781V → A in AAF27278 (PubMed:10684976).Curated
Sequence conflicti301 – 3011T → K in AAH67463 (PubMed:15489334).Curated
Sequence conflicti329 – 3291I → V in AAH67462 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545Missing in isoform 2. 2 PublicationsVSP_016301Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112460 Genomic DNA. Translation: AAF27278.1.
AY703480 mRNA. Translation: AAV70150.1.
AY702304 mRNA. Translation: AAV70122.1.
AL513524 Genomic DNA. Translation: CAH72103.1.
BC067461 mRNA. Translation: AAH67461.1.
BC067462 mRNA. Translation: AAH67462.1.
BC067463 mRNA. Translation: AAH67463.1.
CCDSiCCDS34541.1. [Q9P1P5-1]
CCDS5157.1. [Q9P1P5-2]
RefSeqiNP_001028252.1. NM_001033080.1. [Q9P1P5-1]
NP_055441.2. NM_014626.3. [Q9P1P5-2]
UniGeneiHs.272382.

Genome annotation databases

EnsembliENST00000275191; ENSP00000275191; ENSG00000146378. [Q9P1P5-2]
ENST00000367931; ENSP00000356908; ENSG00000146378. [Q9P1P5-1]
GeneIDi9287.
KEGGihsa:9287.
UCSCiuc003qdl.1. human. [Q9P1P5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112460 Genomic DNA. Translation: AAF27278.1.
AY703480 mRNA. Translation: AAV70150.1.
AY702304 mRNA. Translation: AAV70122.1.
AL513524 Genomic DNA. Translation: CAH72103.1.
BC067461 mRNA. Translation: AAH67461.1.
BC067462 mRNA. Translation: AAH67462.1.
BC067463 mRNA. Translation: AAH67463.1.
CCDSiCCDS34541.1. [Q9P1P5-1]
CCDS5157.1. [Q9P1P5-2]
RefSeqiNP_001028252.1. NM_001033080.1. [Q9P1P5-1]
NP_055441.2. NM_014626.3. [Q9P1P5-2]
UniGeneiHs.272382.

3D structure databases

ProteinModelPortaliQ9P1P5.
SMRiQ9P1P5. Positions 45-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114702. 1 interaction.
STRINGi9606.ENSP00000356908.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9P1P5.
PhosphoSiteiQ9P1P5.

Polymorphism and mutation databases

BioMutaiTAAR2.
DMDMi82592527.

Proteomic databases

PaxDbiQ9P1P5.
PRIDEiQ9P1P5.

Protocols and materials databases

DNASUi9287.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275191; ENSP00000275191; ENSG00000146378. [Q9P1P5-2]
ENST00000367931; ENSP00000356908; ENSG00000146378. [Q9P1P5-1]
GeneIDi9287.
KEGGihsa:9287.
UCSCiuc003qdl.1. human. [Q9P1P5-1]

Organism-specific databases

CTDi9287.
GeneCardsiTAAR2.
HGNCiHGNC:4514. TAAR2.
MIMi604849. gene.
neXtProtiNX_Q9P1P5.
PharmGKBiPA28903.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ9P1P5.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG091G06VI.
PhylomeDBiQ9P1P5.
TreeFamiTF343107.

Enzyme and pathway databases

ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiTAAR2.
GenomeRNAii9287.
PROiQ9P1P5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146378.
CleanExiHS_TAAR2.
GenevisibleiQ9P1P5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR2_HUMAN
AccessioniPrimary (citable) accession number: Q9P1P5
Secondary accession number(s): Q5QD02
, Q6NWS1, Q6NWS2, Q6NWS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.