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Protein

Putative trace amine-associated receptor 3

Gene

TAAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • trace-amine receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative trace amine-associated receptor 3
Short name:
TaR-3
Short name:
Trace amine receptor 3
Short name:
hTaar3
Alternative name(s):
G-protein coupled receptor 57
Gene namesi
Name:TAAR3
Synonyms:GPR57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4513. TAAR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence analysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6812CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 15061ExtracellularSequence analysisAdd
BLAST
Transmembranei151 – 16818Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini169 – 1724CytoplasmicSequence analysis
Transmembranei173 – 19321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini194 – 1985ExtracellularSequence analysis
Transmembranei199 – 22325Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 25734CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 2879ExtracellularSequence analysis
Transmembranei288 – 30821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 34335CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi38257784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Putative trace amine-associated receptor 3PRO_0000070149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9P1P4.

Expressioni

Tissue specificityi

Not expressed in the pons, thalamus, globus pallidus, caudate, putamen or cerebellum.

Structurei

3D structure databases

ProteinModelPortaliQ9P1P4.
SMRiQ9P1P4. Positions 46-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiQ9P1P4.
PhylomeDBiQ9P1P4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTYIPEDL SSCPKFVNKI LSSHQPLFSC PGDNVFGYDW SHDYPLFGNL
60 70 80 90 100
VIMVSISHFK QLHSPTNFLI LSMATTDFLL GFVIMPYSIM RSVESCWYFG
110 120 130 140 150
DGFCKFHTSF DMMLRLTSIF HLCSIAIDRF YAVCYPLHYT TKMTNSTIKQ
160 170 180 190 200
LLAFCWSVPA LFSFGLVLSE ADVSGMQSYK ILVACFNFCA LTFNKFWGTI
210 220 230 240 250
LFTTCFFTPG SIMVGIYGKI FIVSKQHARV ISHVPENTKG AVKKHLSKKK
260 270 280 290 300
DRKAAKTLGI VMGVFLACWL PCFLAVLIDP YLDYSTPILI LDLLVWLRYF
310 320 330 340
NSTCNPLIHG FFNPWFQKAF KYIVSGKIFS SHSETANLFP EAH
Length:343
Mass (Da):39,065
Last modified:October 1, 2000 - v1
Checksum:iDC513D15ABBC026F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112461 Genomic DNA. Translation: AAF27279.1.
UniGeneiHs.730091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112461 Genomic DNA. Translation: AAF27279.1.
UniGeneiHs.730091.

3D structure databases

ProteinModelPortaliQ9P1P4.
SMRiQ9P1P4. Positions 46-327.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi38257784.

Proteomic databases

PRIDEiQ9P1P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiTAAR3.
HGNCiHGNC:4513. TAAR3.
neXtProtiNX_Q9P1P4.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiQ9P1P4.
PhylomeDBiQ9P1P4.

Enzyme and pathway databases

ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ9P1P4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR3_HUMAN
AccessioniPrimary (citable) accession number: Q9P1P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Seems to be a non functional due to its divergence in positions 20 to 45 (due to a frameshift) but does not seem to be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.