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Protein

Costars family protein ABRACL

Gene

ABRACL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Costars family protein ABRACL
Alternative name(s):
ABRA C-terminal-like protein
Gene namesi
Name:ABRACL
Synonyms:C6orf115
ORF Names:HSPC280, PRO2013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21230. ABRACL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884626.

Polymorphism and mutation databases

BioMutaiABRACL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181Costars family protein ABRACLPRO_0000089521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9P1F3.
MaxQBiQ9P1F3.
PaxDbiQ9P1F3.
PRIDEiQ9P1F3.
TopDownProteomicsiQ9P1F3.

PTM databases

iPTMnetiQ9P1F3.
PhosphoSiteiQ9P1F3.

Expressioni

Gene expression databases

BgeeiQ9P1F3.
CleanExiHS_C6orf115.
ExpressionAtlasiQ9P1F3. baseline and differential.
GenevisibleiQ9P1F3. HS.

Organism-specific databases

HPAiHPA030217.

Interactioni

Protein-protein interaction databases

BioGridi121847. 5 interactions.
IntActiQ9P1F3. 4 interactions.

Structurei

Secondary structure

1
81
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1715Combined sources
Beta strandi24 – 296Combined sources
Helixi30 – 4011Combined sources
Helixi46 – 5510Combined sources
Beta strandi58 – 603Combined sources
Helixi69 – 713Combined sources
Beta strandi75 – 784Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L2ONMR-A1-81[»]
ProteinModelPortaliQ9P1F3.
SMRiQ9P1F3. Positions 1-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the costars family.Curated

Phylogenomic databases

eggNOGiKOG3376. Eukaryota.
ENOG410XR7V. LUCA.
GeneTreeiENSGT00470000042287.
HOGENOMiHOG000030934.
HOVERGENiHBG050912.
InParanoidiQ9P1F3.
OMAiNVEHEVN.
OrthoDBiEOG7PGDTD.
PhylomeDBiQ9P1F3.

Family and domain databases

InterProiIPR027817. Costars_dom.
[Graphical view]
PfamiPF14705. Costars. 1 hit.
[Graphical view]
SMARTiSM01283. Costars. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P1F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVDHEVNLL VEEIHRLGSK NADGKLSVKF GVLFRDDKCA NLFEALVGTL
60 70 80
KAAKRRKIVT YPGELLLQGV HDDVDIILLQ D
Length:81
Mass (Da):9,056
Last modified:October 1, 2000 - v1
Checksum:i1F0DCE7A1D22B171
GO

Sequence cautioni

The sequence AAF28958.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116682 mRNA. Translation: AAF71102.1.
AF161398 mRNA. Translation: AAF28958.1. Different initiation.
AL590308 Genomic DNA. Translation: CAI14831.1.
CH471051 Genomic DNA. Translation: EAW47902.1.
BC014953 mRNA. Translation: AAH14953.1.
CCDSiCCDS43509.1.
RefSeqiNP_067066.1. NM_021243.2.
UniGeneiHs.600861.

Genome annotation databases

EnsembliENST00000367660; ENSP00000356632; ENSG00000146386.
GeneIDi58527.
KEGGihsa:58527.
UCSCiuc003qil.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116682 mRNA. Translation: AAF71102.1.
AF161398 mRNA. Translation: AAF28958.1. Different initiation.
AL590308 Genomic DNA. Translation: CAI14831.1.
CH471051 Genomic DNA. Translation: EAW47902.1.
BC014953 mRNA. Translation: AAH14953.1.
CCDSiCCDS43509.1.
RefSeqiNP_067066.1. NM_021243.2.
UniGeneiHs.600861.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L2ONMR-A1-81[»]
ProteinModelPortaliQ9P1F3.
SMRiQ9P1F3. Positions 1-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121847. 5 interactions.
IntActiQ9P1F3. 4 interactions.

PTM databases

iPTMnetiQ9P1F3.
PhosphoSiteiQ9P1F3.

Polymorphism and mutation databases

BioMutaiABRACL.

Proteomic databases

EPDiQ9P1F3.
MaxQBiQ9P1F3.
PaxDbiQ9P1F3.
PRIDEiQ9P1F3.
TopDownProteomicsiQ9P1F3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367660; ENSP00000356632; ENSG00000146386.
GeneIDi58527.
KEGGihsa:58527.
UCSCiuc003qil.2. human.

Organism-specific databases

CTDi58527.
GeneCardsiABRACL.
H-InvDBHIX0006257.
HGNCiHGNC:21230. ABRACL.
HPAiHPA030217.
neXtProtiNX_Q9P1F3.
PharmGKBiPA134884626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3376. Eukaryota.
ENOG410XR7V. LUCA.
GeneTreeiENSGT00470000042287.
HOGENOMiHOG000030934.
HOVERGENiHBG050912.
InParanoidiQ9P1F3.
OMAiNVEHEVN.
OrthoDBiEOG7PGDTD.
PhylomeDBiQ9P1F3.

Miscellaneous databases

GenomeRNAii58527.
NextBioi65090.
PROiQ9P1F3.

Gene expression databases

BgeeiQ9P1F3.
CleanExiHS_C6orf115.
ExpressionAtlasiQ9P1F3. baseline and differential.
GenevisibleiQ9P1F3. HS.

Family and domain databases

InterProiIPR027817. Costars_dom.
[Graphical view]
PfamiPF14705. Costars. 1 hit.
[Graphical view]
SMARTiSM01283. Costars. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal liver.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-16.
    Tissue: Platelet.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the human HSPC280 protein."
    Lin J., Zhou T., Wang J.
    Protein Sci. 20:216-223(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-81.

Entry informationi

Entry nameiABRAL_HUMAN
AccessioniPrimary (citable) accession number: Q9P1F3
Secondary accession number(s): Q5SZC8, Q9P0A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.