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Protein

Disks large-associated protein 2

Gene

DLGAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Biological processi

  • neuron-neuron synaptic transmission Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31660-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 2
Short name:
DAP-2
Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name:
SAPAP2
Gene namesi
Name:DLGAP2
Synonyms:DAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2906. DLGAP2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • neurofilament Source: UniProtKB
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9228.
OpenTargetsiENSG00000198010.
ENSG00000283494.
PharmGKBiPA27362.

Polymorphism and mutation databases

DMDMi160395585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742911 – 1054Disks large-associated protein 2Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei386PhosphoserineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei662PhosphoserineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei715PhosphoserineBy similarity1
Modified residuei738PhosphothreonineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1
Modified residuei978PhosphoserineBy similarity1
Modified residuei1007PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P1A6.
PaxDbiQ9P1A6.
PeptideAtlasiQ9P1A6.
PRIDEiQ9P1A6.

PTM databases

iPTMnetiQ9P1A6.
PhosphoSitePlusiQ9P1A6.

Expressioni

Tissue specificityi

Expressed in brain and kidney.

Gene expression databases

BgeeiENSG00000198010.
CleanExiHS_DLGAP2.
ExpressionAtlasiQ9P1A6. baseline and differential.
GenevisibleiQ9P1A6. HS.

Organism-specific databases

HPAiHPA030320.

Interactioni

Subunit structurei

Interacts with DLG1 and DLG4/PSD-95.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629932EBI-1753397,EBI-401755
KRT40Q6A1623EBI-1753397,EBI-10171697
KRTAP4-2Q9BYR53EBI-1753397,EBI-10172511
NCK1P163334EBI-1753397,EBI-389883

Protein-protein interaction databases

BioGridi114659. 7 interactors.
IntActiQ9P1A6. 15 interactors.
MINTiMINT-2820358.
STRINGi9606.ENSP00000400258.

Structurei

3D structure databases

ProteinModelPortaliQ9P1A6.
SMRiQ9P1A6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiQ9P1A6.
PhylomeDBiQ9P1A6.
TreeFamiTF321382.

Family and domain databases

InterProiIPR030525. DLGAP2.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF3. PTHR12353:SF3. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1A6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEAGD LVQPGISFPG
60 70 80 90 100
PAEEDLDPQY SWSPTQHFNE ERYSPAPRSM KGLSGSRTQP PLCSGHTCGL
110 120 130 140 150
APPEDCEHLH HGPDARPPYL LSPADSCPGG RHRCSPRSSV HSECVMMPVV
160 170 180 190 200
LGDHVSSSTF PRMHYSSHYD TRDDCAVAHA GAKINRIPAN LLDQFEKQLP
210 220 230 240 250
LHRDGFHTLQ YQRTSAAAEQ RSESPGRIRH LVHSVQKLFT KSHSLEGSSK
260 270 280 290 300
SNANGTKADG RADDHHHAHH AKHSKRSKSK ERKPEGKPRP GMSSWWSSDD
310 320 330 340 350
NLDSDSTYRT PSVLNRHHLG PVAHCYPDAL QSPFGDLSLK TSKSNNDVKC
360 370 380 390 400
SACEGLALTP DAKYLKRSSW STLTVSQAKE AYRKSSLNLD KPLLHQDAKP
410 420 430 440 450
ALRPCHYLQV PQDEWGGYPT GGKDEEIPCR RMRSGSYIKA MGDEESGESD
460 470 480 490 500
SSPKTSPKSA ILPEPLLKSI GQRPLGEHQT QTYLQAASDV PVGHSLDPAA
510 520 530 540 550
NYNSPKFRSR NQSYMRAVST LSQASCVSQV SEAEINGQFE SVCESVFSEV
560 570 580 590 600
ESQAMDALDL PGCFRTRSHS YLRAIQAGYS QDDECIPMMT PSDITSTIRS
610 620 630 640 650
TAAVSYTNYK KTPPPVPPRT TSKPLISVTA QSSTESTQDA YQDSRAQRMS
660 670 680 690 700
PWPQDSRGLY NSTDSLDSNK AMNLALETAA AQRHLPESQS SSVRTSDKAI
710 720 730 740 750
LVSKAEELLK SRCSSIGIQD SEFPEHQPYP RSDVETATDS DTESRGLREY
760 770 780 790 800
HSVGVQVEDE KRHGRFKRSN SVTAAVQADL ELEGFPGHIT TEDKGLQFGS
810 820 830 840 850
SFQRHSEPST PTQYSAVRTV RTQGLFSYRE DYRTQVDTST LPPPDPWLEP
860 870 880 890 900
AIDTVETGRM SPCRRDGSWF LKLLHAETKR MEGWCKEMER EAEENDLSEE
910 920 930 940 950
ILGKIRSAVG SAQLLMSQKF QQFYWLCQQN MDPSAMPRPT SQDLAGYWDM
960 970 980 990 1000
LQLSIEDVSM KFDELQRLRL NDWKMMESPE RKEERKVPPP IPKKPPKGKF
1010 1020 1030 1040 1050
PITREKSLDL PDRQRQEARR RLMAAKRAAS FRQNSASERA DSIEIYIPEA

QTRL
Length:1,054
Mass (Da):117,620
Last modified:October 23, 2007 - v4
Checksum:iC03A1240B32442AA
GO
Isoform 2 (identifier: Q9P1A6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     720-733: Missing.

Show »
Length:1,040
Mass (Da):115,934
Checksum:iB7D05C8A6A3FBCEE
GO
Isoform 3 (identifier: Q9P1A6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:975
Mass (Da):108,908
Checksum:i1E65227B3E3FA7DC
GO

Sequence cautioni

The sequence EAW51475 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti463P → Q in EAW51474 (Ref. 3) Curated1
Sequence conflicti463P → Q in EAW51475 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023073419P → Q.Corresponds to variant rs2301963dbSNPEnsembl.1
Natural variantiVAR_036750620T → M.Corresponds to variant rs7463888dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0060111 – 79Missing in isoform 3. 3 PublicationsAdd BLAST79
Alternative sequenceiVSP_006012720 – 733Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119817 mRNA. Translation: AAF34344.1.
AF119818 mRNA. Translation: AAF34345.1.
AF009204 mRNA. Translation: AAB71661.1.
AC100797 Genomic DNA. No translation available.
AC026950 Genomic DNA. No translation available.
AC110288 Genomic DNA. No translation available.
CH471181 Genomic DNA. Translation: EAW51474.1.
CH471181 Genomic DNA. Translation: EAW51475.1. Sequence problems.
BC141862 mRNA. Translation: AAI41863.1.
AB000275 mRNA. Translation: BAA23256.1.
CCDSiCCDS47760.1. [Q9P1A6-3]
PIRiT03306.
RefSeqiNP_001264090.1. NM_001277161.1.
NP_004736.2. NM_004745.4. [Q9P1A6-3]
UniGeneiHs.113287.

Genome annotation databases

EnsembliENST00000421627; ENSP00000400258; ENSG00000198010. [Q9P1A6-1]
ENST00000637152; ENSP00000490912; ENSG00000283494. [Q9P1A6-3]
GeneIDi9228.
KEGGihsa:9228.
UCSCiuc003wpl.4. human. [Q9P1A6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119817 mRNA. Translation: AAF34344.1.
AF119818 mRNA. Translation: AAF34345.1.
AF009204 mRNA. Translation: AAB71661.1.
AC100797 Genomic DNA. No translation available.
AC026950 Genomic DNA. No translation available.
AC110288 Genomic DNA. No translation available.
CH471181 Genomic DNA. Translation: EAW51474.1.
CH471181 Genomic DNA. Translation: EAW51475.1. Sequence problems.
BC141862 mRNA. Translation: AAI41863.1.
AB000275 mRNA. Translation: BAA23256.1.
CCDSiCCDS47760.1. [Q9P1A6-3]
PIRiT03306.
RefSeqiNP_001264090.1. NM_001277161.1.
NP_004736.2. NM_004745.4. [Q9P1A6-3]
UniGeneiHs.113287.

3D structure databases

ProteinModelPortaliQ9P1A6.
SMRiQ9P1A6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114659. 7 interactors.
IntActiQ9P1A6. 15 interactors.
MINTiMINT-2820358.
STRINGi9606.ENSP00000400258.

PTM databases

iPTMnetiQ9P1A6.
PhosphoSitePlusiQ9P1A6.

Polymorphism and mutation databases

DMDMi160395585.

Proteomic databases

MaxQBiQ9P1A6.
PaxDbiQ9P1A6.
PeptideAtlasiQ9P1A6.
PRIDEiQ9P1A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421627; ENSP00000400258; ENSG00000198010. [Q9P1A6-1]
ENST00000637152; ENSP00000490912; ENSG00000283494. [Q9P1A6-3]
GeneIDi9228.
KEGGihsa:9228.
UCSCiuc003wpl.4. human. [Q9P1A6-1]

Organism-specific databases

CTDi9228.
DisGeNETi9228.
GeneCardsiDLGAP2.
H-InvDBHIX0021309.
HIX0034229.
HGNCiHGNC:2906. DLGAP2.
HPAiHPA030320.
MIMi605438. gene.
neXtProtiNX_Q9P1A6.
OpenTargetsiENSG00000198010.
ENSG00000283494.
PharmGKBiPA27362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiQ9P1A6.
PhylomeDBiQ9P1A6.
TreeFamiTF321382.

Enzyme and pathway databases

BioCyciZFISH:G66-31660-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiDLGAP2. human.
GeneWikiiDLGAP2.
GenomeRNAii9228.
PROiQ9P1A6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198010.
CleanExiHS_DLGAP2.
ExpressionAtlasiQ9P1A6. baseline and differential.
GenevisibleiQ9P1A6. HS.

Family and domain databases

InterProiIPR030525. DLGAP2.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF3. PTHR12353:SF3. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLGP2_HUMAN
AccessioniPrimary (citable) accession number: Q9P1A6
Secondary accession number(s): A1QCF8
, A1QCF9, A5D8Y2, O14488, O14664, Q9P1A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.